This project focuses on the synthesis of a lead compound that possess both antimicrobial and anticancer activities, and its optimization to reduce off-target toxicity by incorporating a secondary chemical agent to control the overall architecture and self-assembly behavior of the lead compound. This project contributes towards addressing critical global healthcare challenges namely antimicrobial resistance and cancer.
School
Chemical Engineering
Research Area
Antimicrobial resistance | Cancer | Infectious diseases | Self-assembly | Nanoparticles
- Research environment
- Expected outcomes
- Supervisory team
- Reference material/links
- State-of-the-art chemistry wet labs and analytical instruments, and possibly microbiology and cell biology labs too depending on the progress.
- Students will learn hands-on drug discovery skills (compound synthesis, purification and characterization) for targeted antimicrobial and anticancer applications.
- Edgar Wong Lab
- Smart Galactosidase-Responsive Antimicrobial Dendron: Towards More Biocompatible Membrane-Disruptive Agents
- Effects of Secondary Amine and Molecular Weight on the Biological Activities of Cationic Amphipathic Antimicrobial Macromolecules
- Two plus One: Combination Therapy Tri-systems Involving Two Membrane-Disrupting Antimicrobial Macromolecules and Antibiotics
- Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers