The Systems Immunology and Computational Biology utilise inter-disciplinary approaches to study the complex interactions between pathogen, host and environmental factors which underpin human diseases. The units are led by a collaborative team of clinicians and scientists encompassing the clinical disciplines of infectious diseases, hepatology and epidemiology, as well as translational studies in the disciplines of immunology, virology and systems biology (bioinformatics, statistics and mathematical modelling).
Our group has a strong focus on immunology. We have recently developed single cell RNAseq to study the transcriptomic profile of antigens specific T cells. Our goal is to understand how an immune response changes over time during an infection. We are very interested in new technologies and interdisciplinary approaches to study responses.
The Systems Medicine group focuses on computational and statistical analyses that help understanding complex traits in human diseases, viral infections and host immune responses.
We are a vibrant and interdisciplinary group, interested in a systems biology approach, hence working across bioinformatics, mathematical models, statistics, virology, immunology and epidemiology. We are currently focusing on HCV immunovirology, as well as network analyses of co-evolving genomes, and also mathematical modelling of T cell trafficking and immune escape in viral infections.
Current research projects include:
The group is supported by NHMRC Program and Project grants, funding from NSW Health, and support from a range of non-governmental funding agencies.
Associate Professor Fabio Luciani
T: +61 (2) 9385 3838