Production capabilities
The manufacturing arm of the UNSW RNA Institute, the RNA Accelerator, gives clients access to RNA-based therapeutics and key intermediates at a quality and scale suitable for pre-clinical studies. The RNA Accelerator is supported by the NSW RNA Production and Research Network, which aims to make capabilities available state-wide to academic partners as well as industry.
The RNA Accelerator offers capabilities across the development and production pipeline for RNA-based therapeutics including:
- Plasmid DNA production, purification and characterisation
- mRNA production, purification and characterisation
- Synthetic RNA and DNA production, purification and characterisation (including siRNA, gRNA and oligoDNA)
- Lipid NP formulations, purification and analysis
RNA Accelerator production scales range from small research projects up to the following approximate limits:
- pDNA up to 10 L scale (20 – 50 mg per batch)
- mRNA up to 10 L scale (>1 g purified mRNA)
- Synthetic RNA and DNA (sRNA, including siRNA and up to guide RNA ≈ 80-100 nt) up to 1 g sRNA
- Lipid NP formulations up to 20 mL
