Stent design and strategy

Personalise
2023-11-2 angioplasty heart stent hero

Stents are meshed wired scaffolds implanted into narrowed arteries to prevent heart attacks and strokes. They still fail in 1 in 10 patients, besides being the most common treatment for the largest cause of death worldwide.

Our work aims to expand the number of numerical CFD simulations to generate input for a developed multi-object algorithm. The optimum design trade-offs for modern stents can then be determined through several iterations of solutions. 

The specific outcomes are new guidelines for clinicians to be implemented in practice, guiding clinical decision-making and new industrial designs.

Selected publications

  • Gharleghi R; Wright H; Khullar S; Liu J; Ray T; Beier S, 2019, Advanced Multi-objective Design Analysis to Identify Ideal Stent Design, in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Shenzhen, China, pp. 193 - 200, presented at MLMECH, Shenzhen, China, 13 October 2019, http://dx.doi.org/10.1007/978-3-030-33327-0_23
  • Beier S, Ormiston J, Webster M, Cater J, Norris S, Medrano-Gracia P, Young A, Cowan B. Hemodynamics in Idealized Stented Coronary Arteries: Important Stent Design Considerations. Ann Biomed Eng. 2016 Feb;44(2):315-29. doi: 10.1007/s10439-015-1387-3. Epub 2015 Jul 16. PMID: 26178872; PMCID: PMC4764643.
  • Ormiston JA, Kassab G, Finet G, Chatzizisis YS, Foin N, Mickley TJ, Chiastra C, Murasato Y, Hikichi Y, Wentzel JJ, Darremont O, Iwasaki K, Lefèvre T, Louvard Y, Beier S, Hojeibane H, Netravali A, Wooton J, Cowan B, Webster MW, Medrano-Gracia P, Stankovic G. Bench testing and coronary artery bifurcations: a consensus document from the European Bifurcation Club. EuroIntervention. 2018 Feb 2;13(15):e1794-e1803. doi: 10.4244/EIJ-D-17-00270. PMID: 29131803.
  • Xue H, Luo Z, Brown T, Beier S. Design of Self-Expanding Auxetic Stents Using Topology Optimization. Front Bioeng Biotechnol. 2020 Jul 14;8:736. doi: 10.3389/fbioe.2020.00736. PMID: 32766219; PMCID: PMC7381139.

The aim of this work is to generate CAD models from micro-CT images of stented patient replicas. The replicas represent the anatomical/geometric distribution found within a large population. The CAD models will be used to generate CFD simulations of the blood flow, revealing their effectiveness for that patient geometry.   

The outcomes are new insights into individual differences opening the pathway to a personalised stenting approach for higher treatment success.

Selected publications

  • Ormiston JO; Kassab GK; Finet GF; Chatzizisis YSC; Foin NF; Mickley TJM; Chiastra CC; Murasato YM; Hikichi TH; Wentzel JJW; Darremont OD; Iwasaki IK; Lefevre TL; Louvard YL; Beier S; Hojeibane HH; Netravali AN; Wooton JW; Cowan BC; Webster MIW; Medrano PM; Stankovic GS, 2017, Bench Testing and Coronary Artery Bifurcations: A Consensus Document from the European Bifurcation Club., Eurointervention, vol. 13, pp. e1794 - e1803, http://dx.doi.org/10.4244/EIJ-D-17-00270

  • Masoud-Ansari S; Ormiston J; Webster M; Pontre B; Cowan B; Beier S, 2019, Towards validating stent induced microflow patterns in left main coronary artery bifurcations, in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, pp. 5749 - 5752, http://dx.doi.org/10.1109/EMBC.2019.8856419

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