Professor Daniel U Christ
Professor

Professor Daniel U Christ

medicine-health
Garvan Institute

Daniel Christ is Head of Antibody Therapeutics and Director of the Centre of Targeted Therapy at the Garvan Institute of Medical Research in Sydney, Australia.

Christ was educated at the Swiss Federal Institute of Technology (ETH) and at Cambridge University, where he worked at the MRC Laboratory of Molecular Biology with with Nobel Laureate Sir Gregory Winter, a pioneer of the British biotechnology industry. At Cambridge, Christ and Winter developed monoclonal antibody technology, in the field of phage display and single domain antibodies. He was elected a Fellow of Trinity College (Cambridge University) at age 29 and was involved the foundation of Domantis Ltd (sold to GSK for £230 million in 2006). 

Professor Christ joined the Garvan in 2007 as Head of Antibody Therapeutics, to translate structural and genomic advances into drug candidates and treatments for cancer and inflammatory conditions. Christ is particularly well known for using both in vitro and in vivo selection strategies for generating antibodies with superior biophysical and targeting properties. His work which has allowed the functional characterisation of important targets including TNFAIP3, EBI2, IL2R as well as validating the existence of i-motif DNA structures in human cells. His contributions have been recognised by multiple prizes and appointments, including the NHMRC Excellence award, and by the award of more than 15 competitive research grants from the NHMRC and ARC in recent years. 

Christ and co-workers utilise high-troughput selection and sequencing approaches in combination with biochemical and X-ray crystallographic analyses to study and engineer the interaction between therapeutic antibodies and their targets. 

 

Location
Garvan Institute of Medical Research 384 Victoria Street Darlinghurst NSW 2010

Publications

  • Book Chapters | 2018
    Professor Daniel U Christ
    Zeraati M; Dinger ME; Christ D, 2018, 'Selection of antibody fragments against structured DNA by phage display', in Methods in Molecular Biology, pp. 197 - 209, http://dx.doi.org/10.1007/978-1-4939-8648-4_11
    Book Chapters | 2018
    Professor Daniel U Christ
    Goodnow CC; Christ D; Reed JH, 2018, 'Sequencing and affinity determination of antigen-specific B lymphocytes from peripheral blood', in Nevoltris D; Chames P (ed.), Antibody Engineering. Methods in Molecular Biology, Humana Press, New York, NY, pp. 287 - 309, http://dx.doi.org/10.1007/978-1-4939-8648-4_15
    Book Chapters | 2018
    Professor Daniel U Christ
    Christ D, 2018, 'Expression of IgG monoclonals with engineered immune effector functions', in Nevoltris D; Chames P (ed.), Antibody Engineering. Methods in Molecular Biology, Humana Press, New York, NY, pp. 313 - 334, http://dx.doi.org/10.1007/978-1-4939-8648-4_16
  • Journal articles | 2021
    Professor Daniel U Christ
    Cagdas D; Mayr D; Baris S; Worley L; Langley DB; Metin A; Aytekin ES; Atan R; Kasap N; Bal SK; Dmytrus J; Heredia RJ; Karasu G; Torun SH; Toyran M; Karakoc-Aydiner E; Christ D; Kuskonmaz B; Uçkan-Çetinkaya D; Uner A; Oberndorfer F; Schiefer AI; Uzel G; Deenick EK; Keller B; Warnatz K; Neven B; Durandy A; Sanal O; Ma CS; Özen A; Stepensky P; Tezcan I; Boztug K; Tangye SG, 2021, 'Genomic Spectrum and Phenotypic Heterogeneity of Human IL-21 Receptor Deficiency', Journal of Clinical Immunology, http://dx.doi.org/10.1007/s10875-021-01031-5
    Journal articles | 2021
    Professor Daniel U Christ
    Abayasingam A; Balachandran H; Agapiou D; Hammoud M; Rodrigo C; Keoshkerian E; Li H; Brasher NA; Christ D; Rouet R; Burnet D; Grubor-Bauk B; Rawlinson W; Turville S; Aggarwal A; Stella AO; Fichter C; Brilot F; Mina M; Post JJ; Hudson B; Gilroy N; Dwyer D; Sasson SC; Tea F; Pilli D; Kelleher A; Tedla N; Lloyd AR; Martinello M; Bull RA, 2021, 'Long-term persistence of RBD+ memory B cells encoding neutralizing antibodies in SARS-CoV-2 infection', Cell Reports Medicine, vol. 2, pp. 100228, http://dx.doi.org/10.1016/j.xcrm.2021.100228
    Journal articles | 2021
    Professor Daniel U Christ
    Rouet R; Mazigi O; Walker GJ; Langley DB; Sobti M; Schofield P; Lenthall H; Jackson J; Ubiparipovic S; Henry JY; Abayasingam A; Burnett D; Kelleher A; Brink R; Bull RA; Turville S; Stewart AG; Goodnow CC; Rawlinson WD; Christ D, 2021, 'Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies', mAbs, vol. 13, pp. 1922134, http://dx.doi.org/10.1080/19420862.2021.1922134
    Journal articles | 2021
    Professor Daniel U Christ
    Jonkhout N; Cruciani S; Santos Vieira HG; Tran J; Liu H; Liu G; Pickford R; Kaczorowski D; Franco GR; Vauti F; Camacho N; Abedini SS; Najmabadi H; Ribas de Pouplana L; Christ D; Schonrock N; Mattick JS; Novoa EM, 2021, 'Subcellular relocalization and nuclear redistribution of the RNA methyltransferases TRMT1 and TRMT1L upon neuronal activation', RNA Biology, pp. 1 - 15, http://dx.doi.org/10.1080/15476286.2021.1881291
    Journal articles | 2021
    Professor Daniel U Christ
    Tea F; Stella AO; Aggarwal A; Darley DR; Pilli D; Vitale D; Merheb V; Lee FXZ; Cunningham P; Walker GJ; Fichter C; Brown DA; Rawlinson WD; Isaacs SR; Mathivanan V; Hoffmann M; Pöhlman S; Mazigi O; Christ D; Rockett RJ; Sintchenko V; Hoad VC; Irving DO; Dore GJ; Gosbell IB; Kelleher AD; Matthews GV; Brilot F; Turville SG, 2021, 'SARS-CoV-2 neutralizing antibodies: Longevity, breadth, and evasion by emerging viral variants', PLoS Medicine, vol. 18, pp. e1003656, http://dx.doi.org/10.1371/journal.pmed.1003656
    Journal articles | 2020
    Professor Daniel U Christ
    Lau MT; Ghazanfar S; Parkin A; Chou A; Rouaen JR; Littleboy JB; Nessem D; Khuong TM; Nevoltris D; Schofield P; Langley D; Christ D; Yang J; Pajic M; Neely GG, 2020, 'Systematic functional identification of cancer multi-drug resistance genes', Genome Biology, vol. 21, pp. 27, http://dx.doi.org/10.1186/s13059-020-1940-8
    Journal articles | 2020
    Professor Daniel U Christ
    Singh M; Jackson KJL; Wang JJ; Schofield P; Field MA; Koppstein D; Peters TJ; Burnett DL; Rizzetto S; Nevoltris D; Masle-Farquhar E; Faulks ML; Russell A; Gokal D; Hanioka A; Horikawa K; Colella AD; Chataway TK; Blackburn J; Mercer TR; Langley DB; Goodall DM; Jefferis R; Gangadharan Komala M; Kelleher AD; Suan D; Rischmueller M; Christ D; Brink R; Luciani F; Gordon TP; Goodnow CC; Reed JH, 2020, 'Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody', Cell, vol. 180, pp. 878 - 894.e19, http://dx.doi.org/10.1016/j.cell.2020.01.029
    Journal articles | 2020
    Professor Daniel U Christ
    King JJ; Irving KL; Evans CW; Chikhale RV; Becker R; Morris CJ; Peña Martinez CD; Schofield P; Christ D; Hurley LH; Waller ZAE; Iyer KS; Smith NM, 2020, 'DNA G-Quadruplex and i-Motif Structure Formation Is Interdependent in Human Cells', Journal of the American Chemical Society, vol. 142, pp. 20600 - 20604, http://dx.doi.org/10.1021/jacs.0c11708
    Journal articles | 2020
    Professor Daniel U Christ
    Zaunders J; Mee Ling Munier C; McGuire HM; Law H; Howe A; Xu Y; De St Groth BF; Schofield P; Christ D; Milner B; Obeid S; Dyer WB; Saksena NK; Kelleher AD, 2020, 'Mapping the extent of heterogeneity of human CCR5R CD4R T cells in peripheral blood and lymph nodes', AIDS, vol. 34, pp. 833 - 848, http://dx.doi.org/10.1097/QAD.0000000000002503
    Journal articles | 2020
    Professor Daniel U Christ
    Burnett DL; Schofield P; Langley DB; Jackson J; Bourne K; Wilson E; Porebski BT; Buckle AM; Brink R; Goodnow CC; Christ D, 2020, 'Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, pp. 22341 - 22350, http://dx.doi.org/10.1073/pnas.2005102117
    Journal articles | 2019
    Professor Daniel U Christ
    Vennin C; Mélénec P; Rouet R; Nobis M; Cazet AS; Murphy KJ; Herrmann D; Reed DA; Lucas MC; Warren SC; Elgundi Z; Pinese M; Kalna G; Roden D; Samuel M; Zaratzian A; Grey ST; Da Silva A; Leung W; Johns AL; Chantrill LA; Chou A; Steinmann A; Arshi M; Dwarte T; Froio D; Pereira B; Ritchie S; Chambers CR; Metcalf X; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Grimmond SM; Hofmann O; Christ A; Bruxner T; Samra JS; Pavlakis N; High HA; Asghari R; Merrett ND; Pavey D; Das A; Cosman PH; Ismail K; O’Connnor C; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Cooper CL; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forest C; Epari KP; Ballal M; Fletcher DR; Mukhedkar S; Zeps N; Beilin M; Feeney K; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Lawlor RT; Beghelli S; Corbo V; Scardoni M; Bassi C, 2019, 'CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan', Nature Communications, vol. 10, pp. 3637, http://dx.doi.org/10.1038/s41467-019-10968-6
    Journal articles | 2019
    Professor Daniel U Christ
    Tsai VWW; Zhang HP; Manandhar R; Schofield P; Christ D; Lee-Ng KKM; Lebhar H; Marquis CP; Husaini Y; Brown DA; Breit SN, 2019, 'GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS', International Journal of Obesity, vol. 43, pp. 2370 - 2380, http://dx.doi.org/10.1038/s41366-019-0365-5
    Journal articles | 2019
    Professor Daniel U Christ
    Zammit NW; Siggs OM; Gray PE; Horikawa K; Langley DB; Walters SN; Daley SR; Loetsch C; Warren J; Yap JY; Cultrone D; Russell A; Malle EK; Villanueva JE; Cowley MJ; Gayevskiy V; Dinger ME; Brink R; Zahra D; Chaudhri G; Karupiah G; Whittle B; Roots C; Bertram E; Yamada M; Jeelall Y; Enders A; Clifton BE; Mabbitt PD; Jackson CJ; Watson SR; Jenne CN; Lanier LL; Wiltshire T; Spitzer MH; Nolan GP; Schmitz F; Aderem A; Porebski BT; Buckle AM; Abbott DW; Ziegler JB; Craig ME; Benitez-Aguirre P; Teo J; Tangye SG; King C; Wong M; Cox MP; Phung W; Tang J; Sandoval W; Wertz IE; Christ D; Goodnow CC; Grey ST, 2019, 'Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity', Nature Immunology, vol. 20, pp. 1299 - 1310, http://dx.doi.org/10.1038/s41590-019-0492-0
    Journal articles | 2019
    Professor Daniel U Christ
    Mazigi O; Schofield P; Langley DB; Christ D, 2019, 'Protein A superantigen: Structure, engineering and molecular basis of antibody recognition', Protein Engineering, Design and Selection, vol. 32, pp. 359 - 366, http://dx.doi.org/10.1093/protein/gzz026
    Journal articles | 2019
    Professor Daniel U Christ
    Burnett DL; Reed JH; Christ D; Goodnow CC, 2019, 'Clonal redemption and clonal anergy as mechanisms to balance B cell tolerance and immunity', Immunological Reviews, vol. 292, pp. 61 - 75, http://dx.doi.org/10.1111/imr.12808
    Journal articles | 2019
    Professor Daniel U Christ
    Luthra A; Langley DB; Schofield P; Jackson J; Abdelatti M; Rouet R; Nevoltris D; Mazigi O; Crossett B; Christie M; Christ D, 2019, 'Human Antibody Bispecifics through Phage Display Selection', Biochemistry, vol. 58, pp. 1701 - 1704, http://dx.doi.org/10.1021/acs.biochem.9b00037
    Journal articles | 2019
    Professor Daniel U Christ
    Rouet R; Christ D, 2019, 'Efficient Intracellular Delivery of CRISPR-Cas Ribonucleoproteins through Receptor Mediated Endocytosis', ACS Chemical Biology, vol. 14, pp. 554 - 561, http://dx.doi.org/10.1021/acschembio.9b00116
    Journal articles | 2019
    Professor Daniel U Christ
    Abdelatti M; Schofield P; Christ D, 2019, 'Expression of Human VH Single Domains as Fc Fusions in Mammalian Cells', Methods in molecular biology (Clifton, N.J.), vol. 1953, pp. 121 - 136, http://dx.doi.org/10.1007/978-1-4939-9145-7_8
    Journal articles | 2019
    Professor Daniel U Christ
    Zammit N; Siggs OM; Gray P; King C; Christ D; Goodnow CC; Grey S, 2019, 'Phospho-tuning immunity through Denisovan, modern human and mouse TNFAIP3 gene variants', bioRxiv, http://dx.doi.org/10.1101/589507
    Journal articles | 2018
    Professor Daniel U Christ
    Langley DB; Christ D, 2018, 'Crystal structure of duck egg lysozyme isoform II (DEL-II)', BMC Structural Biology, vol. 18, http://dx.doi.org/10.1186/s12900-018-0090-7
    Journal articles | 2018
    Professor Daniel U Christ
    Rouet R; Jackson KJL; Langley DB; Christ D, 2018, 'Next-generation sequencing of antibody display repertoires', Frontiers in Immunology, vol. 9, http://dx.doi.org/10.3389/fimmu.2018.00118
    Journal articles | 2018
    Professor Daniel U Christ
    Vazquez-Lombardi R; Nevoltris D; Luthra A; Schofield P; Zimmermann C; Christ D, 2018, 'Transient expression of human antibodies in mammalian cells', Nature Protocols, vol. 13, pp. 99 - 117, http://dx.doi.org/10.1038/nprot.2017.126
    Journal articles | 2018
    Professor Daniel U Christ
    Burnett DL; Langley DB; Schofield P; Hermes JR; Chan TD; Jackson J; Bourne K; Reed JH; Patterson K; Porebski BT; Brink R; Christ D; Goodnow CC, 2018, 'Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination', Science, vol. 360, pp. 223 - 226, http://dx.doi.org/10.1126/science.aao3859
    Journal articles | 2018
    Professor Daniel U Christ
    Zeraati M; Langley DB; Schofield P; Moye AL; Rouet R; Hughes WE; Bryan TM; Dinger ME; Christ D, 2018, 'I-motif DNA structures are formed in the nuclei of human cells', Nature Chemistry, vol. 10, pp. 631 - 637, http://dx.doi.org/10.1038/s41557-018-0046-3
    Journal articles | 2017
    Professor Daniel U Christ
    Loetsch C; Warren J; Laskowski A; Vazquez-Lombardi R; Jandl C; Langley DB; Christ D; Thorburn DR; Ryugo DK; Sprent J; Batten M; King C, 2017, 'Cytosolic Recognition of RNA Drives the Immune Response to Heterologous Erythrocytes', Cell Reports, vol. 21, pp. 1624 - 1638, http://dx.doi.org/10.1016/j.celrep.2017.10.044
    Journal articles | 2017
    Professor Daniel U Christ
    Langley DB; Crossett B; Schofield P; Jackson J; Zeraati M; Maltby D; Christie M; Burnett D; Brink R; Goodnow C; Christ D, 2017, 'Structural basis of antigen recognition: Crystal structure of duck egg lysozyme', Acta Crystallographica Section D: Structural Biology, vol. 73, pp. 910 - 920, http://dx.doi.org/10.1107/S2059798317013730
    Journal articles | 2017
    Professor Daniel U Christ
    Rouet R; Langley DB; Schofield P; Christie M; Roome B; Porebski BT; Buckle AM; Clifton BE; Jackson CJ; Stock D; Christ D, 2017, 'Structural reconstruction of protein ancestry', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, pp. 3897 - 3902, http://dx.doi.org/10.1073/pnas.1613477114
    Journal articles | 2017
    Professor Daniel U Christ
    Seow J; Morales RAV; MacRaild CA; Krishnarjuna B; McGowan S; Dingjan T; Jaipuria G; Rouet R; Wilde KL; Atreya HS; Richards JS; Anders RF; Christ D; Drinkwater N; Norton RS, 2017, 'Structure and Characterisation of a Key Epitope in the Conserved C-Terminal Domain of the Malaria Vaccine Candidate MSP2', Journal of Molecular Biology, vol. 429, pp. 836 - 846, http://dx.doi.org/10.1016/j.jmb.2017.02.003
    Journal articles | 2017
    Professor Daniel U Christ
    Vazquez-Lombardi R; Loetsch C; Zinkl D; Jackson J; Schofield P; Deenick EK; King C; Phan TG; Webster KE; Sprent J; Christ D, 2017, 'Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells', Nature Communications, vol. 8, http://dx.doi.org/10.1038/ncomms15373
    Journal articles | 2017
    Professor Daniel U Christ
    Corpuz TM; Vazquez-Lombardi R; Luong JK; Warren J; Stolp J; Christ D; King C; Brink R; Sprent J; Webster KE, 2017, 'IL-2 shapes the survival and plasticity of IL-17-producing γδ T Cells', Journal of Immunology, vol. 199, pp. 2366 - 2376, http://dx.doi.org/10.4049/jimmunol.1700335
    Journal articles | 2017
    Professor Daniel U Christ
    Kräutler NJ; Suan D; Butt D; Bourne K; Hermes JR; Chan TD; Sundling C; Kaplan W; Schofield P; Jackson J; Basten A; Christ D; Brink R, 2017, 'Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells', Journal of Experimental Medicine, vol. 214, pp. 1259 - 1267, http://dx.doi.org/10.1084/jem.20161533
    Journal articles | 2017
    Professor Daniel U Christ
    Zeraati M; Moye AL; Wong JWH; Perera D; Cowley MJ; Christ DU; Bryan TM; Dinger ME, 2017, 'Cancer-Associated noncoding mutations affect RNA G-quadruplex-mediated regulation of gene expression', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-00739-y
    Journal articles | 2016
    Professor Daniel U Christ
    Reed JH; Jackson J; Christ D; Goodnow CC, 2016, 'Clonal redemption of autoantibodies by somatic hypermutation away from self-reactivity during human immunization', Journal of Experimental Medicine, vol. 213, pp. 1255 - 1265, http://dx.doi.org/10.1084/jem.20151978
    Journal articles | 2016
    Professor Daniel U Christ
    Porebski BT; Conroy PJ; Drinkwater N; Schofield P; Vazquez-Lombardi R; Hunter MR; Hoke DE; Christ D; McGowan S; Buckle AM, 2016, 'Circumventing the stability-function trade-off in an engineered FN3 domain', Protein Engineering, Design and Selection, vol. 29, pp. 541 - 550, http://dx.doi.org/10.1093/protein/gzw046
    Journal articles | 2015
    Professor Daniel U Christ
    Vazquez-Lombardi R; Phan TG; Zimmermann C; Lowe D; Jermutus L; Christ D, 2015, 'Challenges and opportunities for non-antibody scaffold drugs', Drug Discovery Today, vol. 20, pp. 1271 - 1283, http://dx.doi.org/10.1016/j.drudis.2015.09.004
    Journal articles | 2015
    Professor Daniel U Christ
    Morales RAV; Macraild CA; Seow J; Krishnarjuna B; Drinkwater N; Rouet R; Anders RF; Christ D; McGowan S; Norton RS, 2015, 'Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate', Scientific Reports, vol. 5, http://dx.doi.org/10.1038/srep10103
    Journal articles | 2015
    Professor Daniel U Christ
    Rouet R; Dudgeon K; Christie M; Langley D; Christ D, 2015, 'Fully human VH single domains that rival the stability and cleft recognition of camelid antibodies', Journal of Biological Chemistry, vol. 290, pp. 11905 - 11917, http://dx.doi.org/10.1074/jbc.M114.614842
    Journal articles | 2015
    Professor Daniel U Christ
    Bradbury A; Plückthun A, 2015, 'Reproducibility: Standardize antibodies used in research', Nature, vol. 518, pp. 27 - 29, http://dx.doi.org/10.1038/518027a
    Journal articles | 2015
    Professor Daniel U Christ
    Butt D; Chan TD; Bourne K; Hermes JR; Nguyen A; Statham A; O'Reilly LA; Strasser A; Price S; Schofield P; Christ D; Basten A; Ma CS; Tangye SG; Phan TG; Rao VK; Brink R, 2015, 'FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production', Immunity, vol. 42, pp. 890 - 902, http://dx.doi.org/10.1016/j.immuni.2015.04.010
    Journal articles | 2015
    Professor Daniel U Christ
    Allen MD; Christie M; Jones P; Porebski BT; Roome B; Freund SMV; Buckle AM; Bycroft M; Christ D, 2015, 'Solution structure of a soluble fragment derived from a membrane protein by shotgun proteolysis', Protein Engineering, Design and Selection, vol. 28, pp. 445 - 450, http://dx.doi.org/10.1093/protein/gzv021
    Journal articles | 2014
    Professor Daniel U Christ
    Sabouri Z; Schofield P; Horikawa K; Spierings E; Kipling D; Randall KL; Langley D; Roome B; Vazquez-Lombardi R; Rouet R; Hermes J; Chan TD; Brink R; Dunn-Walters DK; Christ D; Goodnow CC, 2014, 'Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, http://dx.doi.org/10.1073/pnas.1406974111
    Journal articles | 2014
    Professor Daniel U Christ
    Kass I; Hoke DE; Costa MGS; Reboul CF; Porebski BT; Cowieson NP; Leh H; Pennacchietti E; McCoey J; Kleifeld O; Voltattorni CB; Langley D; Roome B; Mackay IR; Christ D; Perahia D; Buckle M; Paiardini A; De Biase D; Buckle AM, 2014, 'Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, http://dx.doi.org/10.1073/pnas.1403182111
    Journal articles | 2014
    Professor Daniel U Christ
    Rouet R; Lowe D; Christ D, 2014, 'Stability engineering of the human antibody repertoire', FEBS Letters, vol. 588, pp. 269 - 277, http://dx.doi.org/10.1016/j.febslet.2013.11.029
    Journal articles | 2014
    Professor Daniel U Christ
    Rouet R; Christ D, 2014, 'Bispecific antibodies with native chain structure', Nature Biotechnology, vol. 32, pp. 136 - 137, http://dx.doi.org/10.1038/nbt.2812
    Journal articles | 2014
    Professor Daniel U Christ
    Swift J; Saing S; Rouet R; Dudgeon K; Schofield P; Sewell W; Christ D; James L, 2014, 'Identification of aggregation inhibitors of the human antibody light chain repertoire by phage display', Protein Engineering, Design and Selection, vol. 27, pp. 405 - 409, http://dx.doi.org/10.1093/protein/gzu026
    Journal articles | 2013
    Professor Daniel U Christ
    Dudgeon K; Rouet R; Christ D, 2013, 'Rapid prediction of expression and refolding yields using phage display', Protein Engineering, Design and Selection, vol. 26, pp. 671 - 674, http://dx.doi.org/10.1093/protein/gzt019
    Journal articles | 2013
    Professor Daniel U Christ
    Schmitz I; Schneider C; Frohlich A; Christ D; Sparwasser T; Oxenius A, 2013, 'IL-21 Restricts Virus-driven Treg Cell Expansion in Chronic LCMV Infection', PLoS Pathogens, vol. 9, pp. Article numbere1003362, http://dx.doi.org/10.1371/journal.ppat.1003362
    Journal articles | 2013
    Professor Daniel U Christ
    Gatto D; Wood KA; Caminschi I; Murphy-durland D; Schofield PR; Christ DU; Brink R, 2013, 'The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells', Nature Immunology, vol. 14, pp. 446 - 453, http://dx.doi.org/10.1038/ni.2555
    Journal articles | 2013
    Professor Daniel U Christ
    Gatto D; Wood K; Caminschi I; Murphy-Durland D; Schofield P; Christ D; Karupiah G; Brink R, 2013, 'Erratum: The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells (Nature Immunology (2013) 14 (446-453))', Nature Immunology, vol. 14, pp. 876, http://dx.doi.org/10.1038/ni0813-876e
    Journal articles | 2013
    Professor Daniel U Christ
    Vazquez-Lombardi R; Roome B; Christ D, 2013, 'Molecular Engineering of Therapeutic Cytokines', ANTIBODIES, vol. 2, pp. 426 - 451, http://dx.doi.org/10.3390/antib2030426
    Journal articles | 2012
    Professor Daniel U Christ
    Rouet R; Lowe D; Dudgeon K; Roome B; Schofield P; Langley D; Andrews J; Whitfeld P; Jermutus L; Christ D, 2012, 'Expression of high-affinity human antibody fragments in bacteria', Nature Protocols, vol. 7, pp. 364 - 373, http://dx.doi.org/10.1038/nprot.2011.448
    Journal articles | 2012
    Professor Daniel U Christ
    Dudgeon K; Rouet R; Kokmeijer I; Schofield P; Stolp J; Langley D; Stock D; Christ DU, 2012, 'General strategy for the generation of human antibody variable domains with increased aggregation resistance', Proceedings of the National Academy of Sciences of the United States of America, vol. 109, pp. 10879 - 10884, http://dx.doi.org/10.1073/pnas.1202866109
    Journal articles | 2012
    Professor Daniel U Christ
    Dudgeon K; Rouet R; Famm K; Christ DU, 2012, 'Selection of human VH single domains with improved biophysical properties by phage display.', Methods in Molecular Biology, vol. 911, pp. 383 - 397, http://dx.doi.org/10.1007/978-1-61779-968-6_23
    Journal articles | 2012
    Professor Daniel U Christ
    Rouet R; Dudgeon K; Christ DU, 2012, 'Generation of human single domain antibody repertoires by kunkel mutagenesis', Methods in Molecular Biology, vol. 907, pp. 195 - 209, http://dx.doi.org/10.1007/978-1-61779-974-7-10
    Journal articles | 2012
    Professor Daniel U Christ
    Rouet R; Dudgeon K; Christ D, 2012, 'Generation of human single domain antibody repertoires by Kunkel mutagenesis.', Methods Mol Biol, vol. 907, pp. 195 - 209, http://dx.doi.org/10.1007/978-1-61779-974-7_10
    Journal articles | 2012
    Professor Daniel U Christ
    Dudgeon K; Rouet R; Famm K; Christ D, 2012, 'Selection of human VH single domains with improved biophysical properties by phage display.', Methods in molecular biology (Clifton, N.J.), vol. 911, pp. 383 - 397
    Journal articles | 2011
    Professor Daniel U Christ
    Lowe DJ; Dudgeon K; Rouet R; Schofield P; Jermutus L; Christ DU, 2011, 'Aggregation, stability, and formulation of human antibody therapeutics', Advances in Protein Chemistry & Structural Biology, vol. 84, pp. 41 - 61, http://dx.doi.org/10.1016/B978-0-12-386483-3.00004-5
    Journal articles | 2011
    Professor Daniel U Christ
    McGuire HM; Walters SN; Vogelzang A; Lee CM; Webster KE; Sprent J; Christ DU; Grey S; King C, 2011, 'Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models', Diabetes, vol. 60, pp. 867 - 875, http://dx.doi.org/10.2337/db10-1157
    Journal articles | 2011
    Professor Daniel U Christ
    McGuire HM; Vogelzang A; Ma CS; Hughes WE; Silveira PA; Tangye SG; Christ DU; Fulcher DA; Falcone M; King C, 2011, 'A subset of interleukin-21(+) chemokine receptor CCR9(+) T helper cells target accessory organs of the digestive system in autoimmunity', Immunity, vol. 34, pp. 602 - 615, http://dx.doi.org/10.1016/j.immuni.2011.01.021
    Journal articles | 2010
    Professor Daniel U Christ
    Lee CM; McGuire HM; Basten A; King C; Christ DU, 2010, 'Expression, purification and characterization of recombinant interleukin-21', Journal of Immunological Methods, vol. 362, pp. 185 - 189, http://dx.doi.org/10.1016/j.jim.2010.08.008
    Journal articles | 2009
    Professor Daniel U Christ
    Dudgeon K; Famm K; Christ D, 2009, 'Sequence determinants of protein aggregation in human VH domains', Protein Engineering Design and Selection, vol. 22, pp. 217 - 220, http://dx.doi.org/10.1093/protein/gzn059
    Journal articles | 2008
    Professor Daniel U Christ
    Famm K; Hansen L; Christ D; Winter G, 2008, 'Thermodynamically stable aggregation-resistant antibody domains through directed evolution', Journal of Molecular Biology, vol. 376, pp. 926 - 931, http://dx.doi.org/10.1016/j.jmb.2007.10.075
    Journal articles | 2008
    Professor Daniel U Christ
    Christ D; Chin J, 2008, 'Engineering Escherichia coli heat-resistance by synthetic gene amplification', Protein Engineering Design and Selection, vol. 21, pp. 121 - 125, http://dx.doi.org/10.1093/protein/gzm085
    Journal articles | 2007
    Professor Daniel U Christ
    Christ D; Famm K; Winter G, 2007, 'Repertoires of aggregation-resistant human antibody domains', Protein Engineering, Design and Selection, vol. 20, pp. 413 - 416, http://dx.doi.org/10.1093/protein/gzm037
    Journal articles | 2007
    Professor Daniel U Christ
    Lee CM; Iorno N; Sierro F; Christ D, 2007, 'Selection of human antibody fragments by phage display', Nature Protocols, vol. 2, pp. 3001 - 3008, http://dx.doi.org/10.1038/nprot.2007.448
    Journal articles | 2006
    Professor Daniel U Christ
    Christ D; Winter G, 2006, 'Identification of Protein Domains by Shotgun Proteolysis', Journal of Molecular Biology, vol. 358, pp. 364 - 371, http://dx.doi.org/10.1016/j.jmb.2006.01.057
    Journal articles | 2006
    Professor Daniel U Christ
    Christ D; Famm K; Winter G, 2006, 'Tapping diversity lost in transformations - In vitro amplification of ligation reactions', Nucleic Acids Research, vol. 34, http://dx.doi.org/10.1093/nar/gkl605
    Journal articles | 2003
    Professor Daniel U Christ
    Christ D; Winter G, 2003, 'Identification of functional similarities between proteins using directed evolution', Proceedings of the National Academy of Sciences of the United States of America, vol. 100, pp. 13202 - 13206, http://dx.doi.org/10.1073/pnas.2134365100
    Journal articles |
    Professor Daniel U Christ
    Rouet R; Mazigi O; Walker GJ; Langley DB; Sobti M; Schofield P; Lenthall H; Jackson J; Ubiparipovic S; Henry JY; Abayasingam A; Burnett D; Kelleher A; Brink R; Bull RA; Turville S; Stewart AG; Goodnow CC; Rawlinson WD; Christ D, 'Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies', , http://dx.doi.org/10.1101/2020.12.14.422791
  • Conference Abstracts | 2020
    Professor Daniel U Christ
    Mohamed SMA; Sia K; Friedrich K-H; Wohlmann A; Savvides S; Schofield P; Christ D; Kavallaris M; Lock RB; Bayat N, 2020, 'A Novel Engineered Single-Chain Antibody Fragment for Targeting Pediatric Philadelphia Chromosome-like Acute Lymphoblastic Leukemia', in Blood, American Society of Hematology, Vol. 136, pp. 36 - 36, http://dx.doi.org/10.1182/blood-2020-138421
    Conference Papers | 2019
    Professor Daniel U Christ
    Solinc J; Raimbault-Machado J; Dierick F; El Bernoussi L; Hoareau-Coudert B; Monceau V; Atassi F; Marazzi G; Sassoon DA; Harvey R; Christ D; Schofield P; Pavoine C; Soubrier F; Nadaud S, 2019, 'PDGFRalpha Drives Pulmonary Vascular Progenitor Cells Recruitment, Vascular Remodeling and Pulmonary Hypertension Development', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, Philadelphia, PA, presented at Scientific Sessions of the American-Heart-Association, Philadelphia, PA, 16 November 2019 - 18 November 2019, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000529998006388&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2018
    Professor Daniel U Christ
    Dierick F; Ebrahimian T; Michaud VE; Simon D; Simeone S; Harvey R; Schofield P; Christ D; Lehoux S, 2018, 'PDGF RECEPTOR ALPHA INHIBITION PREVENTS HIGH BLOOD FLOW-INDUCED ATHEROSCLEROTIC PLAQUE REGRESSION', in ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, Toronto, CANADA, Vol. 32, pp. 5 - 5, presented at International Symposium on Atherosclerosis (ISA), Toronto, CANADA, 09 June 2018 - 12 June 2018, http://dx.doi.org/10.1016/j.atherosclerosissup.2018.04.015
    Conference Abstracts | 2017
    Professor Daniel U Christ
    Manakas A; Best G; Mulligan SP; Schofield P; Christ D; Matthews J; Christopherson R, 2017, 'Cell surface activated, bispecific 'Demibodies' for highly specific CLL cell detection and killing', in LEUKEMIA & LYMPHOMA, TAYLOR & FRANCIS LTD, Vol. 58, pp. 66 - 67, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000423431100055&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2017
    Professor Daniel U Christ
    Burnett D; Schofield P; Langley D; Brink R; Christ D; Goodnow CC, 2017, 'Somatic Hypermutation Serves two independent Functions: Antibody Maturation Away From Binding Self and Towards Binding Foreign', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY, Erlangen, GERMANY, Vol. 47, pp. 3 - 3, presented at 47th Annual Meeting of the German-Society-for-Immunology (DGFI), Erlangen, GERMANY, 12 September 2017 - 15 September 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000418423100003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2016
    Professor Daniel U Christ
    Reed J; Jackson J; Christ D; Goodnow C, 2016, 'Actively acquired self-tolerance by clonal redemption of autoantibodies during human immunization', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, Melbourne, AUSTRALIA, Vol. 46, pp. 805 - 806, presented at International Congress of Immunology (ICI), Melbourne, AUSTRALIA, 21 August 2016 - 26 August 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2016
    Professor Daniel U Christ
    Suan D; Krautler N; Butt D; Bourne K; Hermes J; Schofield P; Jackson J; Phan TG; Christ D; Brink R, 2016, 'Antigen-linked rather than T-FH cell-derived signals select high affinity germinal centre B cells for plasma cell differentiation', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, Melbourne, AUSTRALIA, Vol. 46, pp. 296 - 296, presented at International Congress of Immunology (ICI), Melbourne, AUSTRALIA, 21 August 2016 - 26 August 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610400596&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2016
    Professor Daniel U Christ
    Goodnow C; Reed J; Burnett D; Brink R; Christ D; Schofield P; Perotti S; Enders A; Ziegler J; Wainstein B; Roscioli T; Gray P, 2016, 'Redemption or Revolt of Forbidden Clones: Mutations, Autoantibodies and CTLA4-Ig Therapy', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, Melbourne, AUSTRALIA, Vol. 46, pp. 3 - 3, presented at International Congress of Immunology (ICI), Melbourne, AUSTRALIA, 21 August 2016 - 26 August 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610400007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2016
    Professor Daniel U Christ
    Vazquez-Lombardi R; Webster KE; Sprent J; Christ D, 2016, 'Potent antitumor activity of IL-2-Fc fusion proteins through Fc gamma R-dependent depletion of CD4(+) CD25(+) Tregs', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, Melbourne, AUSTRALIA, Vol. 46, pp. 1209 - 1209, presented at International Congress of Immunology (ICI), Melbourne, AUSTRALIA, 21 August 2016 - 26 August 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402834&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2016
    Professor Daniel U Christ
    Burnett D; Schofield P; Christ D; Brink R; Goodnow C, 2016, 'Somatic hypermutation serves two independent functions: antibody maturation away from binding self and towards binding foreign', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, Melbourne, AUSTRALIA, Vol. 46, pp. 803 - 804, presented at International Congress of Immunology (ICI), Melbourne, AUSTRALIA, 21 August 2016 - 26 August 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2015
    Professor Daniel U Christ
    Zammit NW; Langley D; Walters SN; Malle EK; Pilgrim SM; Cultrone D; Christ D; Grey ST, 2015, 'GENETIC POLYMORPHISMS IN DONOR TISSUE DETERMINE TRANSPLANT OUTCOMES.', in TRANSPLANTATION, LIPPINCOTT WILLIAMS & WILKINS, Lorne, AUSTRALIA, pp. S45 - S45, presented at 14th Transplantation Science Symposium of the Transplantation-Society (TSS), Lorne, AUSTRALIA, 11 November 2015 - 13 November 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000368625900082&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2015
    Professor Daniel U Christ
    Zammit NW; Langley D; Walters SN; Malle EK; Pilgrim SM; Cultrone D; Christ D; Grey ST, 2015, 'Genetic polymorphisms in donor tissue determine transplant outcomes', in XENOTRANSPLANTATION, WILEY-BLACKWELL, Melbourne, AUSTRALIA, Vol. 22, pp. S75 - S75, presented at IPITA/IXA/CTS Joint Congress, Melbourne, AUSTRALIA, 15 November 2015 - 19 November 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000364594100178&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2015
    Professor Daniel U Christ
    Zammit NW; Langley D; Walters SN; Malle EK; Pilgrim SM; Cultrone D; Christ D; Grey ST, 2015, 'GENETIC POLYMORPHISMS IN DONOR TISSUE DETERMINE TRANSPLANT OUTCOMES.', in TRANSPLANTATION, LIPPINCOTT WILLIAMS & WILKINS, Melbourne, AUSTRALIA, Vol. 99, pp. S122 - S122, presented at Joint Congress of the International-Pancreas-and-Islet-Transplantation-Association, International-Xenotransplantation-Association and Cell-Transplant-Society, Melbourne, AUSTRALIA, 15 November 2015 - 19 November 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000368625700175&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2014
    Professor Daniel U Christ
    Rouet R; Langley D; Stock D; Christ D, 2014, 'Structural Evidence for Antigen Receptor Evolution', in PROTEIN SCIENCE, WILEY-BLACKWELL, San Diego, CA, pp. 251 - 251, presented at 28th Annual Symposium of the Protein-Society, San Diego, CA, 27 July 2014 - 30 July 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000339545700387&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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