Associate Professor David Brown

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Research Interests:
In the field of inflammation I have clinical and research interests. Clinically, I am interested in the consequences of inflammatory diseases on the CNS, vasculitides as well as treatment of connective tissue diseases. My research interests are in several areas including chronic inflammatory diseases such as atherosclerosis and rheumatoid arthritis. I am also actively researching the role of the immunity in cancer and neuroinflammatory diseases.

Broad Research Areas:
Inflammation, Neuroscience, Immunology, Pathology

Qualifications:
MBBS (Hons), PhD, FRACP, FRCPA

Specific Research Keywords:
T Cells, Cytokines, Neuroimmunology, Autoimmune Disease, Stem Cell Therapy

Phone

02 8382 4952

E-mail

d.brown@amr.org.au

Books | 2020

Brown DA, 2020, Neurons, receptors, and channels, http://dx.doi.org/10.1146/annurev-pharmtox-010919-023755
Book Chapters | 2016

2016, 'TGF beta Superfamily Cytokine MIC-1/GDF15 in Health and Inflammatory Diseases', in Compendium of Inflammatory Diseases, Springer Basel, pp. 1236 - 1245, http://dx.doi.org/10.1007/978-3-7643-8550-7_54

Book Chapters | 2016

2016, 'TGF beta Superfamily Cytokine MIC-1/GDF15 in Health and Inflammatory Diseases', in Encyclopedia of Inflammatory Diseases, Springer Basel, pp. 1 - 13, http://dx.doi.org/10.1007/978-3-0348-0620-6_54-2

Book Chapters | 2014

2014, 'MIC-1', in Encyclopedia of Cancer, Springer Berlin Heidelberg, pp. 1 - 6, http://dx.doi.org/10.1007/978-3-642-27841-9_3704-2

Book Chapters | 2014

2014, 'MIC-1', in Encyclopedia of Cancer, Springer Berlin Heidelberg, pp. 2816 - 2821, http://dx.doi.org/10.1007/978-3-662-46875-3_3704

Book Chapters | 2014

2014, 'TGF-b Superfamily Cytokine MIC-1/GDF15 in Health and Inflammatory Diseases', in Encyclopedia of Inflammatory Diseases, Springer Basel, pp. 1 - 13, http://dx.doi.org/10.1007/978-3-0348-0620-6_54-1

Book Chapters | 2011

2011, 'MIC-1', in Encyclopedia of Cancer, Springer Berlin Heidelberg, pp. 2285 - 2289, http://dx.doi.org/10.1007/978-3-642-16483-5_3704

Book Chapters |

'MIC-1', in Encyclopedia of Cancer, Springer Berlin Heidelberg, pp. 1870 - 1873, http://dx.doi.org/10.1007/978-3-540-47648-1_3704
Journal articles | 2023

Breit SN; Brown DA; Tsai VWW, 2023, 'GDF15 analogs as obesity therapeutics', Cell Metabolism, 35, pp. 227 - 228, http://dx.doi.org/10.1016/j.cmet.2023.01.002

Journal articles | 2023

Breit SN; Manandhar R; Zhang HP; Lee-Ng M; Brown DA; Tsai VWW, 2023, 'GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway', Cell Metabolism, 35, pp. 1341 - 1355.e3, http://dx.doi.org/10.1016/j.cmet.2023.06.009

Journal articles | 2023

Finney CA; Delerue F; Gold WA; Brown DA; Shvetcov A, 2023, 'Artificial intelligence-driven meta-analysis of brain gene expression identifies novel gene candidates and a role for mitochondria in Alzheimer's disease', Computational and Structural Biotechnology Journal, 21, pp. 388 - 400, http://dx.doi.org/10.1016/j.csbj.2022.12.018

Journal articles | 2023

Jiang JX; Fewings N; Gatt P; Dervish S; Silsby M; Fois AF; Duma S; Bandodkar S; Ramanathan S; Bleasel A; John B; Harris A; Lin M-W; Brown D, 2023, 'Autoantibodies, routine and novel markers of neuroinflammation in people with atypical psychiatric disease', Journal of Affective Disorders Reports, 12, pp. 100548 - 100548, http://dx.doi.org/10.1016/j.jadr.2023.100548

Journal articles | 2023

Shvetcov A; Ruitenberg MJ; Delerue F; Gold WA; Brown DA; Finney CA, 2023, 'The neuroprotective effects of estrogen and estrogenic compounds in spinal cord injury', Neuroscience and Biobehavioral Reviews, 146, pp. 105074, http://dx.doi.org/10.1016/j.neubiorev.2023.105074

Journal articles | 2023

Wu L; Tsang V; Menzies AM; Sasson SC; Carlino MS; Brown DA; Clifton-Bligh R; Gunton JE, 2023, 'Risk Factors and Characteristics of Checkpoint Inhibitor– Associated Autoimmune Diabetes Mellitus (CIADM): A Systematic Review and Delineation From Type 1 Diabetes', Diabetes Care, 46, pp. 1292 - 1299, http://dx.doi.org/10.2337/dc22-2202

Journal articles | 2023

van der Linde R; Smith S; Brown DA; Sasson SC; Tegg E, 2023, 'Measurable residual disease in adult acute myeloid leukaemia: evaluation of a multidimensional ‘radar’ flow cytometric plot analysis method', Pathology, 55, pp. 383 - 390, http://dx.doi.org/10.1016/j.pathol.2022.10.007

Journal articles | 2022

Kakar F; Swaminathan S; Brown DA; Lin MW; McDonald D; Lee AYS, 2022, 'Corrigendum to “Restricted migration of polyclonal IgG on immunofixation gel electrophoresis in a case of IgG4-related disease” [Pathology 54 (2022) 367–369] (Pathology (2022) 54(3) (367–369), (S0031302521004165), (10.1016/j.pathol.2021.05.092))', Pathology, 54, pp. 668, http://dx.doi.org/10.1016/j.pathol.2022.05.001

Journal articles | 2022

Kakar F; Swaminathan S; Brown DA; Lin MW; McDonald D; Lee AYS, 2022, 'Restricted migration of polyclonal IgG on immunofixation gel electrophoresis in a case of IgG4-related disease', Pathology, 54, pp. 367 - 369, http://dx.doi.org/10.1016/j.pathol.2021.05.092

Journal articles | 2022

Lee AYS; Brown DA; McDonald D; Lin MW, 2022, 'Longitudinal Tracking of Extractable Nuclear Antigen (ENA) Antibodies in a Quaternary Hospital Laboratory Cohort Reveals Dynamic Antibody Profiles', Journal of Applied Laboratory Medicine, 7, pp. 26 - 35, http://dx.doi.org/10.1093/jalm/jfab104

Journal articles | 2022

Lee AYS; Lee C; Brown DA; Suan D, 2022, 'Development of anti-NXP2 dermatomyositis following Comirnaty COVID-19 vaccination', Postgraduate Medical Journal, http://dx.doi.org/10.1136/postgradmedj-2022-141510

Journal articles | 2022

Lopez JA; Houston SD; Tea F; Merheb V; Lee FXZ; Smith S; McDonald D; Zou A; Liyanage G; Pilli D; Denkova M; Lechner-Scott J; Van Der Walt A; Barnett MH; Reddel SW; Broadley S; Ramanathan S; Dale RC; Brown DA; Brilot F, 2022, 'Validation of a Flow Cytometry Live Cell-Based Assay to Detect Myelin Oligodendrocyte Glycoprotein Antibodies for Clinical Diagnostics', Journal of Applied Laboratory Medicine, 7, pp. 12 - 25, http://dx.doi.org/10.1093/jalm/jfab101

Journal articles | 2022

Zammit NW; McDowell J; Warren J; Muskovic W; Gamble J; Shi YC; Kaczorowski D; Chan CL; Powell J; Ormandy C; Brown D; Oakes SR; Grey ST, 2022, 'TNFAIP3 Reduction-of-Function Drives Female Infertility and CNS Inflammation', Frontiers in Immunology, 13, http://dx.doi.org/10.3389/fimmu.2022.811525

Journal articles | 2021

Breit SN; Brown DA; Tsai VWW, 2021, 'The GDF15-GFRAL Pathway in Health and Metabolic Disease: Friend or Foe?', Annual Review of Physiology, 83, pp. 127 - 151, http://dx.doi.org/10.1146/annurev-physiol-022020-045449

Journal articles | 2021

Gardner LS; Culican S; Campbell D; Dela Cruz M; McDonald D; Brown DA; Lin MW, 2021, 'Internal audit of two antineuronal immunoblots and the role of indirect immunofluorescence in sample screening', Pathology, 53, pp. S48 - S48, http://dx.doi.org/10.1016/j.pathol.2021.06.101

Journal articles | 2021

Law SPL; Gatt PN; Schibeci SD; McKay FC; Vucic S; Hart P; Byrne SN; Brown D; Stewart GJ; Liddle C; Parnell GP; Booth DR, 2021, 'Expression of CYP24A1 and other multiple sclerosis risk genes in peripheral blood indicates response to vitamin D in homeostatic and inflammatory conditions', Genes and Immunity, 22, pp. 227 - 233, http://dx.doi.org/10.1038/s41435-021-00144-6

Journal articles | 2021

Tea F; Stella AO; Aggarwal A; Darley DR; Pilli D; Vitale D; Merheb V; Lee FXZ; Cunningham P; Walker GJ; Fichter C; Brown DA; Rawlinson WD; Isaacs SR; Mathivanan V; Hoffmann M; Pöhlman S; Mazigi O; Christ D; Rockett RJ; Sintchenko V; Hoad VC; Irving DO; Dore GJ; Gosbell IB; Kelleher AD; Matthews GV; Brilot F; Turville SG, 2021, 'SARS-CoV-2 neutralizing antibodies: Longevity, breadth, and evasion by emerging viral variants', PLoS Medicine, 18, http://dx.doi.org/10.1371/journal.pmed.1003656

Journal articles | 2021

Trend S; Leffler J; Jones AP; Cha L; Gorman S; Brown DA; Breit SN; Kermode AG; French MA; Ward NC; Hart PH, 2021, 'Associations of serum short-chain fatty acids with circulating immune cells and serum biomarkers in patients with multiple sclerosis', Scientific Reports, 11, pp. 5244, http://dx.doi.org/10.1038/s41598-021-84881-8

Journal articles | 2021

Wu L; Tsang VHM; Sasson SC; Menzies AM; Carlino MS; Brown DA; Clifton-Bligh R; Gunton JE, 2021, 'Unravelling Checkpoint Inhibitor Associated Autoimmune Diabetes: From Bench to Bedside', Frontiers in Endocrinology, 12, http://dx.doi.org/10.3389/fendo.2021.764138

Journal articles | 2020

Dai P; Campbell D; Culican S; Brown DA; Byth K; Hissaria P; Ninnes R; Nankivell B; Lin MW, 2020, 'Validation of phospholipase A2 receptor direct immunofluorescence staining in the diagnosis of primary membranous glomerulonephritis', Pathology, 52, pp. 546 - 551, http://dx.doi.org/10.1016/j.pathol.2020.04.003

Journal articles | 2020

Husaini Y; Tsai VWW; Manandhar R; Zhang HP; Lee-Ng KKM; Lebhar H; Marquis CP; Brown DA; Breit SN, 2020, 'Growth differentiation factor-15 slows the growth of murine prostate cancer by stimulating tumor immunity', PLoS ONE, 15, pp. e0233846, http://dx.doi.org/10.1371/journal.pone.0233846

Journal articles | 2020

Jiang JX; Fewings N; Dervish S; Fois AF; Duma SR; Silsby M; Bandodkar S; Ramanathan S; Bleasel A; John B; Brown DA; Lin MW, 2020, 'Novel Surrogate Markers of CNS Inflammation in CSF in the Diagnosis of Autoimmune Encephalitis', Frontiers in Neurology, 10, http://dx.doi.org/10.3389/fneur.2019.01390

Journal articles | 2020

Pollak TA; Lennox BR; Müller S; Benros ME; Prüss H; Tebartz van Elst L; Klein H; Steiner J; Frodl T; Bogerts B; Tian L; Groc L; Hasan A; Baune BT; Endres D; Haroon E; Yolken R; Benedetti F; Halaris A; Meyer JH; Stassen H; Leboyer M; Fuchs D; Otto M; Brown DA; Vincent A; Najjar S; Bechter K, 2020, 'Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin', The Lancet Psychiatry, 7, pp. 93 - 108, http://dx.doi.org/10.1016/S2215-0366(19)30290-1

Journal articles | 2020

Tea F; Pilli D; Ramanathan S; Lopez JA; Merheb V; Lee FXZ; Zou A; Liyanage G; Bassett CB; Thomsen S; Reddel SW; Barnett MH; Brown DA; Dale RC; Brilot F, 2020, 'Effects of the Positive Threshold and Data Analysis on Human MOG Antibody Detection by Live Flow Cytometry', Frontiers in Immunology, 11, http://dx.doi.org/10.3389/fimmu.2020.00119

Journal articles | 2020

Tea F; Stella AO; Aggarwal A; Darley DR; Pilli D; Vitale D; Merheb V; Lee FXZ; Cunningham P; Walker GJ; Brown DA; Rawlinson WD; Isaacs SR; Mathivanan V; Hoffman M; Pöhlmann S; Dwyer DE; Rockett R; Sintchenko V; Hoad VC; Irving DO; Dore GJ; Gosbell IB; Kelleher AD; Matthews GV; Brilot F; Turville SG, 2020, 'SARS-CoV-2 neutralizing antibodies; longevity, breadth, and evasion by emerging viral variants', , http://dx.doi.org/10.1101/2020.12.19.20248567

Journal articles | 2019

Afrasiabi A; Parnell GP; Fewings N; Schibeci SD; Basuki MA; Chandramohan R; Zhou Y; Taylor B; Brown DA; Swaminathan S; McKay FC; Stewart GJ; Booth DR, 2019, 'Evidence from genome wide association studies implicates reduced control of Epstein-Barr virus infection in multiple sclerosis susceptibility', Genome Medicine, 11, pp. 26, http://dx.doi.org/10.1186/s13073-019-0640-z

Journal articles | 2019

Bayly A; Dear L; Brown D; Nankivell B; Viswanathan S, 2019, '53. Monoclonal gammopathies affecting the kidney', Pathology, 51, pp. S164 - S165, http://dx.doi.org/10.1016/j.pathol.2018.09.051

Journal articles | 2019

Bechter K; Brown D; Najjar S, 2019, 'Editorial: Recent advances in psychiatry from psycho-neuro-immunology research: Autoimmune encephalitis, autoimmune encephalopathy, and mild encephalitis', Frontiers in Psychiatry, 10, http://dx.doi.org/10.3389/fpsyt.2019.00169

Journal articles | 2019

Hassanpour Golakani M; Mohammad MG; Li H; Gamble J; Breit SN; Ruitenberg MJ; Brown DA, 2019, 'MIC-1/GDF15 Overexpression Is Associated with Increased Functional Recovery in Traumatic Spinal Cord Injury', Journal of Neurotrauma, 36, pp. 3410 - 3421, http://dx.doi.org/10.1089/neu.2019.6421

Journal articles | 2019

Parnell GP; Schibeci SD; Fewings NL; Afrasiabi A; Law SPL; Samaranayake S; Kh'Ng JH; Fong YH; Brown DA; Liddle C; Stewart GJ; Booth DR, 2019, 'The latitude-dependent autoimmune disease risk genes ZMIZ1 and IRF8 regulate mononuclear phagocytic cell differentiation in response to Vitamin D', Human Molecular Genetics, 28, pp. 269 - 278, http://dx.doi.org/10.1093/hmg/ddy324

Journal articles | 2019

Ramanathan S; O'grady GL; Malone S; Spooner CG; Brown DA; Gill D; Brilot F; Dale RC, 2019, 'Isolated seizures during the first episode of relapsing myelin oligodendrocyte glycoprotein antibody-associated demyelination in children', Developmental Medicine and Child Neurology, 61, pp. 610 - 614, http://dx.doi.org/10.1111/dmcn.14032

Journal articles | 2019

Tea F; Lopez JA; Ramanathan S; Merheb V; Lee FXZ; Zou A; Pilli D; Patrick E; van der Walt A; Monif M; Tantsis EM; Yiu EM; Vucic S; Henderson APD; Fok A; Fraser CL; Lechner-Scott J; Reddel SW; Broadley S; Barnett MH; Brown DA; Lunemann JD; Dale RC; Brilot F; Sinclair A; Kermode AG; Kornberg A; Bye A; McGettigan B; Trewin B; Brew B; Taylor B; Bundell C; Miteff C; Troedson C; Pridmore C; Spooner C; Yiannikas C; O'Gorman C; Clark D; Suan D; Jones D; Kilfoyle D; Gill D; Wakefield D; Hofmann D; Mathey E; O'Grady G; Jones HF; Beadnall H; Butzkueven H; Joshi H; Andrews I; Sutton I; MacIntyre J; Sandbach JM; Freeman J; King J; O'Neill JH; Parratt J; Barton J; Garber J; Ahmad K; Riney K; Buzzard K; Kothur K; Cantrill LC; Menezes MP; Paine MA; Marriot M; Ghadiri M; Boggild M; Lawlor M; Badve M; Ryan M; Aaqib M; Shuey N; Jordan N; Urriola N; Lawn N; White O; McCombe P; Patel R; Leventer R; Webster R; Smith R; Gupta S; Mohammad SS; Pillai S; Hawke S; Simon S; Calvert S; Blum S; Malone S; Hodgkinson S; Nguyen TK; Hardy TA; Kalincik T; Ware T; Fung VSC, 2019, 'Characterization of the human myelin oligodendrocyte glycoprotein antibody response in demyelination', Acta Neuropathologica Communications, 7, http://dx.doi.org/10.1186/s40478-019-0786-3

Journal articles | 2019

Tsai VWW; Zhang HP; Manandhar R; Schofield P; Christ D; Lee-Ng KKM; Lebhar H; Marquis CP; Husaini Y; Brown DA; Breit SN, 2019, 'GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS', International Journal of Obesity, 43, pp. 2370 - 2380, http://dx.doi.org/10.1038/s41366-019-0365-5

Journal articles | 2018

Brown DA; Jiang J; Ramanathan S; Silvestrini R; Bleasel A; Wienholt L; Fewings N; Dumas S; Silsby M; Yin K; Fois A; Lin M-W, 2018, 'Potential surrogate markers of central nervous system inflammation in cerebrospinal fluid in the diagnosis of autoimmune encephalitis', Neurology, Psychiatry and Brain Research, 29, pp. 6 - 7, http://dx.doi.org/10.1016/j.npbr.2018.01.062

Journal articles | 2018

Brown DA, 2018, 'Current and emerging diagnostic approaches to identify autoimmune contribution to psychiatric disease', Neurology, Psychiatry and Brain Research, 29, pp. 6 - 6, http://dx.doi.org/10.1016/j.npbr.2018.01.061

Journal articles | 2018

Jiang J; Thalamuthu A; Ho JE; Mahajan A; Ek WE; Brown DA; Breit SN; Wang TJ; Gyllensten U; Chen MH; Enroth S; Januzzi JL; Lind L; Armstrong NJ; Kwok JB; Schofield PR; Wen W; Trollor JN; Johansson Å; Morris AP; Vasan RS; Sachdev PS; Mather KA, 2018, 'A meta-analysis of genome-wide association studies of growth differentiation factor-15 concentration in blood', Frontiers in Genetics, 9, http://dx.doi.org/10.3389/fgene.2018.00097

Journal articles | 2018

Ting YS; Smith SABC; Brown DA; Dodds AJ; Fay KC; Ma DDF; Milliken S; Moore JJ; Sewell WA, 2018, 'CD200 is a useful diagnostic marker for identifying atypical chronic lymphocytic leukemia by flow cytometry', International Journal of Laboratory Hematology, 40, pp. 533 - 539, http://dx.doi.org/10.1111/ijlh.12857

Journal articles | 2018

Tsai VW; Zhang HP; Manandhar R; Lee-Ng KKM; Lebhar H; Marquis CP; Husaini Y; Sainsbury A; Brown DA; Breit SN, 2018, 'Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity', International Journal of Obesity, 42, pp. 561 - 571, http://dx.doi.org/10.1038/ijo.2017.258

Journal articles | 2018

Tsai VWW; Brown DA; Breit SN, 2018, 'Targeting the divergent TGFb superfamily cytokine MIC-1/GDF15 for therapy of anorexia/ cachexia syndromes', Current Opinion in Supportive and Palliative Care, 12, pp. 404 - 409, http://dx.doi.org/10.1097/SPC.0000000000000384

Journal articles | 2018

Tsai VWW; Husaini Y; Sainsbury A; Brown DA; Breit SN, 2018, 'The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases', Cell Metabolism, 28, pp. 353 - 368, http://dx.doi.org/10.1016/j.cmet.2018.07.018

Journal articles | 2018

2018, 'Potential surrogate markers of central nervous system inflammation in cerebrospinal fluid in the diagnosis of autoimmune encephalitis', Pathology, 50, pp. S43 - S43, http://dx.doi.org/10.1016/j.pathol.2017.12.100

Journal articles | 2018

2018, 'Validation of renal biopsy phospholipase A2 receptor staining on direct immunofluorescence in the diagnosis of primary membranous glomerulonephritis', Pathology, 50, pp. S43 - S43, http://dx.doi.org/10.1016/j.pathol.2017.12.099

Journal articles | 2017

Breit SN; Tsai VWW; Brown DA, 2017, 'Targeting Obesity and Cachexia: Identification of the GFRAL Receptor–MIC-1/GDF15 Pathway', Trends in Molecular Medicine, 23, pp. 1065 - 1067, http://dx.doi.org/10.1016/j.molmed.2017.10.005

Journal articles | 2017

Danta M; Barber DA; Zhang HP; Lee-Ng M; Baumgart SWL; Tsai VWW; Husaini Y; Saxena M; Marquis CP; Errington W; Kerr S; Breit SN; Brown DA, 2017, 'Macrophage inhibitory cytokine-1/growth differentiation factor-15 as a predictor of colonic neoplasia', Alimentary Pharmacology and Therapeutics, 46, pp. 347 - 354, http://dx.doi.org/10.1111/apt.14156

Journal articles | 2017

Glass LJ; Sinclair D; Boerrigter D; Naude K; Fung SJ; Brown D; Catts VS; Tooney P; O'Donnell M; Lenroot R; Galletly C; Liu D; Weickert TW; Shannon Weickert C, 2017, 'Brain antibodies in the cortex and blood of people with schizophrenia and controls', Translational Psychiatry, 7, http://dx.doi.org/10.1038/tp.2017.134

Journal articles | 2017

Low JK; Ambikairajah A; Shang K; Brown DA; Tsai VWW; Breit SN; Karl T, 2017, 'First behavioural characterisation of a knockout mouse model for the transforming growth factor (TGF)-β superfamily cytokine, MIC-1/GDF15', PLoS ONE, 12, http://dx.doi.org/10.1371/journal.pone.0168416

Journal articles | 2017

Ong LTC; Galambos G; Brown DA, 2017, 'Primary Sjogren's syndrome associated with treatment-resistant obsessive-compulsive Disorder', Frontiers in Psychiatry, 8, http://dx.doi.org/10.3389/fpsyt.2017.00124

Journal articles | 2017

Tran DN; Smith SABC; Brown DA; Parker AJC; Joseph JE; Armstrong N; Sewell WA, 2017, 'Polychromatic flow cytometry is more sensitive than microscopy in detecting small monoclonal plasma cell populations', Cytometry Part B - Clinical Cytometry, 92, pp. 136 - 144, http://dx.doi.org/10.1002/cyto.b.21401

Journal articles | 2017

2017, 'A rare case of concurrent myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA)-associated necrotising and crescentic glomerulonephritis and membranous glomerulonephritis', Pathology, 49, pp. 100 - 103, http://dx.doi.org/10.1016/j.pathol.2016.10.008

Journal articles | 2016

Mahon KL; Lin H-M; Spielman C; Lee-Ng M; Gurney H; Mallesara G; Stockler MR; Briscoe KP; Marx GM; Breit SN; Brown DA; Horvath L, 2016, 'Phase II trial of circulating cytokines as markers of docetaxel (DTX) resistance in metastatic castrate-resistant prostate cancer (mCRPC).', Journal of Clinical Oncology, 34, pp. 5039 - 5039, http://dx.doi.org/10.1200/jco.2016.34.15_suppl.5039

Journal articles | 2016

Salao K; Jiang L; Li H; Tsai VWW; Husaini Y; Curmi PMG; Brown LJ; Brown DA; Breit SN, 2016, 'CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis', Biology Open, 5, pp. 620 - 630, http://dx.doi.org/10.1242/bio.018119

Journal articles | 2016

Tsai VWW; Lin S; Brown DA; Salis A; Breit SN, 2016, 'Anorexia-cachexia and obesity treatment may be two sides of the same coin: Role of the TGF-b superfamily cytokine MIC-1/GDF15', International Journal of Obesity, 40, pp. 193 - 197, http://dx.doi.org/10.1038/ijo.2015.242

Journal articles | 2016

2016, 'Glycine receptor antibodies in psychiatric and neurological disease', Neurology, Psychiatry and Brain Research, 22, pp. 4 - 4, http://dx.doi.org/10.1016/j.npbr.2015.12.010

Journal articles | 2015

Fisher OM; Levert-Mignon AJ; Lord SJ; Lee-Ng KKM; Botelho NK; Falkenback D; Thomas ML; Bobryshev YV; Whiteman DC; Brown DA; Breit SN; Lord RV, 2015, 'MIC-1/GDF15 in Barrett's oesophagus and oesophageal adenocarcinoma', British Journal of Cancer, 112, pp. 1384 - 1391, http://dx.doi.org/10.1038/bjc.2015.100

Journal articles | 2015

Husaini Y; Lockwood GP; Nguyen TV; Tsai VWW; Mohammad MG; Russell PJ; Brown DA; Breit SN, 2015, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15) gene deletion promotes cancer growth in TRAMP prostate cancer prone mice', PLoS ONE, 10, http://dx.doi.org/10.1371/journal.pone.0115189

Journal articles | 2015

Jiang J; Trollor JN; Brown DA; Crawford JD; Thalamuthu A; Smith E; Breit SN; Liu T; Brodaty H; Baune BT; Sachdev PS; Wen W, 2015, 'An inverse relationship between serum macrophage inhibitory cytokine-1 levels and brain white matter integrity incommunity-dwelling older individuals', Psychoneuroendocrinology, 62, pp. 80 - 88, http://dx.doi.org/10.1016/j.psyneuen.2015.07.610

Journal articles | 2015

Jiang J; Wen W; Brown DA; Crawford J; Thalamuthu A; Smith E; Breit SN; Liu T; Zhu W; Brodaty H; Baune BT; Trollor JN; Sachdev PS, 2015, 'The relationship of serum macrophage inhibitory cytokine - 1 levels with gray matter volumes in community-dwelling older individuals', PLoS ONE, 10, pp. e0123399, http://dx.doi.org/10.1371/journal.pone.0123399

Journal articles | 2015

Jones SP; Franco NF; Varney B; Sundaram G; Brown DA; De Bie J; Lim CK; Guillemin GJ; Brew BJ, 2015, 'Expression of the kynurenine pathway in human peripheral blood mononuclear cells: Implications for inflammatory and neurodegenerative disease', PLoS ONE, 10, http://dx.doi.org/10.1371/journal.pone.0131389

Journal articles | 2015

Mahon KL; Lin HM; Castillo L; Lee BY; Lee-Ng M; Chatfield MD; Chiam K; Breit SN; Brown DA; Molloy MP; Marx GM; Pavlakis N; Boyer MJ; Stockler MR; Daly RJ; Henshall SM; Horvath LG, 2015, 'Cytokine profiling of docetaxel-resistant castration-resistant prostate cancer', British Journal of Cancer, 112, pp. 1340 - 1348, http://dx.doi.org/10.1038/bjc.2015.74

Journal articles | 2015

Sasson SC; McGill K; Wienholt L; Carr A; Brown DA; Kelleher AD; Breit SN; Sewell WA, 2015, 'Comparison of the Freelite serum free light chain (SFLC) assay with serum and urine electrophoresis/immunofixation and the N Latex FLC assay', Pathology, 47, pp. 564 - 569, http://dx.doi.org/10.1097/PAT.0000000000000316

Journal articles | 2015

Tsai VWW; Macia L; Feinle-Bisset C; Manandhar R; Astrup A; Raben A; Lorenzen JK; Schmidt PT; Wiklund F; Pedersen NL; Campbell L; Kriketos A; Xu A; Pengcheng Z; Jia W; Curmi PMG; Angstmann CN; Lee-Ng KKM; Zhang HP; Marquis CP; Husaini Y; Beglinger C; Lin S; Herzog H; Brown DA; Sainsbury A; Breit SN, 2015, 'Serum levels of human MIC-1/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI', PLoS ONE, 10, http://dx.doi.org/10.1371/journal.pone.0133362

Journal articles | 2015

2015, 'Immunophenotyping of plasma cell and the utility of flow cytometry in plasma cell dyscrasias', Pathology, 47, pp. S94 - S95, http://dx.doi.org/10.1097/01.pat.0000461602.22967.40

Journal articles | 2015

2015, 'Retrospective audit of the freeliteTM serum free light chain (SFLC) assay: testing patterns, concordance with serum and urine electrophoresis/immunofixation and correlation with the N latex FLC assay', Pathology, 47, pp. S94 - S94, http://dx.doi.org/10.1097/01.pat.0000461601.28805.d5

Journal articles | 2014

Fuchs T; Trollor JN; Crawford J; Baune BT; Samaras K; Campbell L; Breit SN; Brodaty H; Sachdev P; Smith E; Brown DA, 2014, 'Macrophage inhibitory cytokine-1 is associated with cognitive impairment and predicts cognitive decline – The Sydney Memory and Aging Study', Neurology, Psychiatry and Brain Research, 20, pp. 9 - 9, http://dx.doi.org/10.1016/j.npbr.2014.01.145

Journal articles | 2014

Mohammad MG; Tsai VWW; Ruitenberg MJ; Hassanpour M; Li H; Hart PH; Breit SN; Sawchenko PE; Brown DA, 2014, 'Immune cell trafficking from the brain maintains CNS immune tolerance', Journal of Clinical Investigation, 124, pp. 1228 - 1241, http://dx.doi.org/10.1172/JCI71544

Journal articles | 2014

Tsai VWW; Manandhar R; Jrøgensen SB; Lee-Ng KKM; Zhang HP; Marquis CP; Jiang L; Husaini Y; Lin S; Sainsbury A; Sawchenko PE; Brown DA; Breit SN, 2014, 'The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract', PLoS ONE, 9, http://dx.doi.org/10.1371/journal.pone.0100370

Journal articles | 2014

2014, 'A forebrain-immune cell pathway for the maintenance of CNS immune tolerance', Neurology, Psychiatry and Brain Research, 20, pp. 8 - 9, http://dx.doi.org/10.1016/j.npbr.2014.01.144

Journal articles | 2014

2014, 'Macrophage inhibitory cytokine 1 (MIC-1/GDF15), a novel regulator of body weight and appetite and a potential therapeutic for obesity', Obesity Research & Clinical Practice, 8, pp. 105 - 105, http://dx.doi.org/10.1016/j.orcp.2014.10.191

Journal articles | 2013

Bechter K; Brown D, 2013, 'Neuroinflammation in psychiatric disorders - Evidence from research and clinic', Neurology Psychiatry and Brain Research, 19, pp. 139 - 140, http://dx.doi.org/10.1016/j.npbr.2013.12.001

Journal articles | 2013

Fuchs T; Trollor JN; Crawford J; Baune BT; Samaras K; Campbell L; Breit SN; Brodaty H; Sachdev P; Smith E, 2013, 'Macrophage inhibitory cytokine-1 is associated with cognitive impairment and predicts cognitive decline – the Sydney Memory and Ageing Study', Aging Cell, 12, pp. 882 - 889, http://dx.doi.org/10.1111/acel.12116

Journal articles | 2013

Horvath L; Chatfield MD; Lee-Ng M; Lin H-M; Castillo L; Breit SN; Brown DA; Molloy MP; Marx GM; Pavlakis N; Boyer MJ; Stockler MR; Wykes R; Henshall SM; Mahon KL, 2013, 'The role of macrophages in docetaxel (DTX) resistance in castrate-resistant prostate cancer (CRPC).', Journal of Clinical Oncology, 31, pp. e22175 - e22175, http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e22175

Journal articles | 2013

Mohammad MG; Hassanpour M; Tsai VW-W; Li H; Ruitenberg MJ; Booth D; Serrats J; Hart PH; Symonds GP; Sawchenko P; Breit SN; Brown DA, 2013, 'Dendritic cells and multiple sclerosis: Disease, tolerance and therapy', International Journal of Molecular Sciences, 14, pp. 547 - 562, http://dx.doi.org/10.3390/ijms14010547

Journal articles | 2012

Breit SN; Carrero JJ; Tsai VWW; Yagoutifam N; Luo XW; Kuffner T; Bauskin AR; Wu L; Jiang L; Baranyi P; Heimburer O; Murikami M; Apple F; Marquis C; Macia L; Lin S; Sainsbury-Salis A; Herzog H; Law MG; Stenvinkel P; Brown DA, 2012, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease', Nephrology Dialysis Transplantation, 27, pp. 70 - 75, http://dx.doi.org/10.1093/ndt/gfr575

Journal articles | 2012

Brown D; Hance KW; Rogers C; Sansbury ; Albert P; Murphy G; Laiyemo A; Wang Z; Cross A; Schatzkin A; Danta M; Srasu ; Amin J; Law MG; Breit SN; Lanza E; Brown , 2012, 'Serum Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15): A Potential Screening Tool for the Prevention of Colon Cancer?', Cancer Epidemiology Biomarkers and Prevention, 21, pp. 337 - 346, http://dx.doi.org/10.1158/1055-9965.EPI-11-0786

Journal articles | 2012

Husaini Y; Qiu MR; Lockwood G; Luo X; Shang P; Kuffner T; Tsai VW-W; Lele J; Russell PJ; Brown DA; Breit SN, 2012, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15) slows cancer development but increases metastases in TRAMP prostate cancer prone mice', PLoS One, 7, pp. e43833, http://dx.doi.org/10.1371/journal.pone.0043833

Journal articles | 2012

Macia L; Tsai VWW; Nguyen AD; Johnen H; Kuffner T; Shi Y; Lin S; Herzog H; Brown DA; Breit SN; Sainsbury-Salis A, 2012, 'Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets', PLoS One, 7, pp. e34868, http://dx.doi.org/10.1371/journal.pone.0034868

Journal articles | 2012

Tsai VW-W; Husaini Y; Manandhar R; Lee-ng KKM; Hong PZ; Harriott K; Jiang L; Lin S; Sainsbury-Salis A; Brown DA; Breit SN, 2012, 'Anorexia/cachexia of chronic diseases: a role for the TGF-beta family cytokine MIC-1/GDF15', Journal of Cachexia, Sarcopenia and Muscle, 3, pp. 239 - 243, http://dx.doi.org/10.1007/s13539-012-0082-6

Journal articles | 2011

Breit SN; Johnen H; Cook AD; Tsai VWW; Mohammad MG; Tamara K; Hong PZ; Marquis C; Lele J; Lockwood G; Lee-Ng M; Husaini Y; Wu L; Hamilton JA; Brown DA, 2011, 'The TGF-β superfamily cytokine, MIC-1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism', Growth Factors, 29, pp. 187 - 195, http://dx.doi.org/10.3109/08977194.2011.607137

Journal articles | 2011

Brown DA; Tsai VW W; Mohammad MG; Tolhurst O; Breit SN; Sawchenko PE, 2011, 'CCAAT/enhancer binding protein-delta (C/EBPdelta) regulates Th17/Treg balance via an antigen presenting cell - interleukin-10 dependent mechanism in neuroinflammation', MULTIPLE SCLEROSIS JOURNAL, 17, pp. S344 - S344, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209137301142&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Journal articles | 2009

Boyle G; Pedley J; Martyn A; Banducci K; Strutton G; Brown DA; Breit SN; Parsons PG, 2009, 'Macrophage inhibitory cytokine-1 is overexpressed in malignant melanoma and is associated with tumorigenicity', Journal of Investigative Dermatology, 129, pp. 383 - 391, http://dx.doi.org/10.1038/jid.2008.270

Journal articles | 2009

Brown DA; Lindmark F; Stattin P; Bälter K; Adami HO; Zheng SL; Xu J; Isaacs WB; Grönberg H; Breit SN; Wiklund FE, 2009, 'Macrophage inhibitory cytokine 1: A new prognostic marker in prostate cancer', Clinical Cancer Research, 15, pp. 6658 - 6664, http://dx.doi.org/10.1158/1078-0432.CCR-08-3126

Journal articles | 2009

Horvath L; Zhao L; Lee B; Brown D; Molloy M; Marx G; Boyer M; Breit S; Sutherland R; Henshall S, 2009, 'Identification of candidate biomarkers of therapeutic response to docetaxel in hormone-refractory prostate cancer by proteomic profiling.', J Clin Oncol, 27, pp. 11010, http://www.ncbi.nlm.nih.gov/pubmed/27963974

Journal articles | 2009

Shnaper S; Desbaillets I; Brown DA; Murat A; Migliavacca E; Schluep M; Ostermann S; Hamou MF; Stupp R; Breit SN; De Tribolet N; Hegi ME, 2009, 'Elevated levels of MIC-1/GDF15 in the cerebrospinal fluid of patients are associated with glioblastoma and worse outcome', International Journal of Cancer, 125, pp. 2624 - 2630, http://dx.doi.org/10.1002/ijc.24639

Journal articles | 2009

Wakchoure S; Swain T; Hentunen T; Bauskin AR; Brown DA; Breit SN; Vuopala K; Harris K; Selander K, 2009, 'Expression of macrophage inhibitory cytokine-1 in prostate cancer bone metastases induces osteoclast activation and weight loss', Prostate, 69, pp. 652 - 661, http://dx.doi.org/10.1002/pros.20913

Journal articles | 2009

Zhao L; Lee BY; Brown DA; Molloy M; Marx GM; Pavlakis N; Boyer MJ; Stockler M; Kaplan W; Breit SN; Sutherland RL; Henshall SM; Horvath LG, 2009, 'Identification of candidate biomarkers of therapeutic response to docetaxel by proteomic profiling', Cancer research, 69, pp. 7696 - 7703, http://dx.doi.org/10.1158/0008-5472.CAN-08-4901

Journal articles | 2007

Brown DA; Moore JJ; Johnen H; Smeets TJ; Bauskin AR; Kuffner T; Weedon H; Milliken ST; Tak PP; Smith MD; Breit SN, 2007, 'Serum macrophage inhibitory cytokine 1 in rheumatoid arthritis - A potential marker of erosive joint destruction', Arthritis Care & Research, 56, pp. 753 - 764, http://dx.doi.org/10.1002/art.22410

Journal articles | 2007

Brown DA; Sawchenko PE, 2007, 'Time course and distribution of inflammatory and neurodegenerative events suggest structural bases for the pathogenesis of experimental autoimmune encephalomyelitis', Journal of Comparative Neurology, 502, pp. 236 - 260, http://dx.doi.org/10.1002/cne.21307

Journal articles | 2007

Johnen H; Lin S; Kuffner T; Brown DA; Tsai V; Bauskin AR; Wu L; Pankhurst G; Jiang L; Junankar S; Hunter M; Fairlie WD; Lee NJ; Enriquez R; Baldock P; Corey E; Apple F; Murakami M; Lin E; Wang CC; During M; Sainsbury A; Herzog H; Breit SN, 2007, 'Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1', Nature Medicine, 13, pp. 1333 - 1340, http://dx.doi.org/10.1038/nm1677

Journal articles | 2007

Selander KS; Brown DA; Sequeiros GB; Hunter M; Desmond R; Parpala T; Risteli J; Breit SN; Jukkola-Vuorinen A, 2007, 'Serum macrophage inhibitory cytokine-1 concentrations correlate with the presence of prostate cancer bone metastases', Cancer Epidemiology Biomarkers and Prevention, 16, pp. 532 - 537, http://dx.doi.org/10.1158/1055-9965.EPI-06-0841

Journal articles | 2006

Bauskin AR; Brown DA; Kuffner T; Johnen H; Luo X; Hunter M; Breit SN, 2006, 'Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer', Cancer research, 66, pp. 4983 - 4986, http://dx.doi.org/10.1158/0008-5472.CAN-05-4067

Journal articles | 2006

Brown DA; Stephan C; Ward RL; Law MG; Hunter M; Bauskin AR; Amin J; Jung K; Diamandis E; Hampton GM; Russell PJ; Giles GG; Breit SN, 2006, 'Measurement of serum levels of macrophage inhibitory cytokine 1 combined with prostate-specific antigen improves prostate cancer diagnosis', Clinical Cancer Research, 12, pp. 89 - 96, http://dx.doi.org/10.1158/1078-0432.CCR-05-1331

Journal articles | 2006

Koopmann J; Rosenzweig C; Zhang ZP; Canto M; Brown DA; Hunter M; Yeo CB; Chan DJ; Breit SN; Goggins M; Hunter M, 2006, 'Serum markers in patients with resectable pancreatic adenocarcinoma: Macrophage inhibitory cytokine 1 versus CA19-9', Clinical Cancer Research, 12, pp. 442 - 446, http://dx.doi.org/10.1158/1078-0432.CCR-05-0564

Journal articles | 2006

Rasiah KK; Kench JG; Gardiner-Garden M; Biankin AV; Golovsky D; Brenner PC; Kooner R; O Neill G; Turner J; Delprado W; Lee CS; Brown DA; Breit SN; Grygiel JJ; Horvath LG; Stricker PD; Sutherland RL; Henshall SM, 2006, 'Aberrant neuropepticle Y and macrophage inhibitory cytokine-1 expression are early events in prostate cancer development and are associated with poor prognosis', Cancer epidemiology biomarkers and prevention, 15, pp. 711 - 716, http://dx.doi.org/10.1158/1055-9965.EPI-05-0752

Journal articles | 2006

Stephan C; Xu C; Brown DA; Breit SN; Michael AW; Nakamura T; Diamandis E; Meyer H; Cammann H; Jung K, 2006, 'Three new serum markers for prostate cancer detection within a percent free PSA-based artificial neural network', Prostate, 66, pp. 651 - 659, http://dx.doi.org/10.1002/pros.20381

Journal articles | 2006

Xu J; Kimball T; Lorenz J; Brown DA; Bauskin AR; Klevitsky R; Hewett T; Breit SN; Molkentin J, 2006, 'GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation', Circulation Research, 98, pp. 342 - 350, http://dx.doi.org/10.1161/01.RES.0000202804.84885.d0

Journal articles | 2005

Liu T, 2005, 'The propeptide mediates formation of stromal stores of ProMIC-1: role in determining prostate cancer outcome', Cancer Research, 65, pp. 2330 - 2336, http://dx.doi.org/10.1158/0008-5472.CAN-04-3827

Journal articles | 2005

Weber F; Byrne S; Le S; Brown DA; Breit SN; Scolyer R; Halliday GM, 2005, 'Transforming growth factor-beta(1) immobilises dendritic cells within skin tumours and facilitates tumour escape from the immune system', Cancer Immunology and Immunotherapy, 54, pp. 898 - 906, http://dx.doi.org/10.1007/s00262-004-0652-3

Journal articles | 2004

Koopmann J; Buckhaults P; Brown DA; Zahurak M; Sato N; Fukushima N; Sokoll L; Chan DW; Yeo C; Hruban R; Breit SN; Kinzler KW; Vogelstein B; Goggins M, 2004, 'Serum macrophage inhibitory cytokine 1 as a marker of pancreatic andother periampullary cancers', Clinical Cancer Research, 10, pp. 2386 - 2392, http://dx.doi.org/10.1158/1078-0432.CCR-03-0165

Journal articles | 2004

Tong S; Marjono B; Brown DA; Mulvey S; Breit SN; Manuelpillai U; Wallace EM, 2004, 'Serum concentrations of macrophage inhibitory cytokine 1 (MIC 1) as apredictor of miscarriage', Lancet, 363, pp. 129 - 130, http://dx.doi.org/10.1016/S0140-6736(03)15265-8

Journal articles | 2004

Wallace EM; Marjono B; Brown DA; Crossley J; Aitken DK; Tong S; Breit SN, 2004, 'Maternal serum and amniotic fluid levels of macrophage inhibitorycytokine 1 in Down syndrome and chromosomally normal pregnancies', Prenatal Diagnosis, 24, pp. 224 - 226, http://dx.doi.org/10.1002/pd.791

Journal articles | 2003

Brown DA; Ward RL; Buckhaults P; Liu T; Romans KE; Hawkins NJ; Bauskin AR; Kinzler KW; Vogelstein B; Breit SN, 2003, 'MIC 1 serum level and genotype: Associations with progress and prognosis of colorectal carcinoma', Clinical Cancer Research, 9, pp. 2642 - 2650

Journal articles | 2003

Delzell E; Brown DA; Matthews R, 2003, 'Mortality among hourly motor vehicle manufacturing workers', Journal of Occupational and Environmental Medicine, 45, pp. 813 - 830, http://dx.doi.org/10.1097/01.jom.0000079092.95532.49

Journal articles | 2003

Keelan JA; Wang K; Chaiworapongsa T; Romero R; Mitchell MD; Sato TA; Brown DA; Fairlie WD; Breit SN, 2003, 'Macrophase hihibitory cytokine 1 (MIC-1) in fetal membranes and amniotic fluid from pregnancies with and without preterm labour and premature rupture of membranes', Molecular Human Reproduction, 9, pp. 535 - 540, http://dx.doi.org/10.1093/molehr/gag068

Journal articles | 2003

Liu T; Bauskin AR; Zaunders J; Brown DA; Pankhurst S; Russell PJ; Breit SN, 2003, 'Macrophage inhibitory cytokine 1 reduces cell adhesion and induces apoptosis in prostate cancer cells', Cancer research, 63, pp. 5034 - 5040

Journal articles | 2003

Liu T, 2003, 'Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum', Proceedings of the National Academy of Sciences of the United States of America, 100, pp. 3410 - 3415, http://dx.doi.org/10.1073/pnas.0530278100

Journal articles | 2003

Marjono AB; Brown DA; Horton KE; Wallace EM; Breit SN; Manuelpillai U, 2003, 'Macrophage Inhibitory Cytokine-1 in Gestational Tissues and Maternal Serum in Normal and Pre-eclamptic Pregnancy', Placenta, 24, pp. 100 - 106, http://dx.doi.org/10.1053/plac.2002.0881

Journal articles | 2003

Yang H; Filipovic Z; Brown DA; Breit SN; Vassilev LT, 2003, 'Macrophage inhibitory cytokine-1: a novel biomarker for p53 pathway activation', Molecular Cancer Therapeutics, 2, pp. 1023 - 1029

Journal articles | 2002

Liu T, 2002, 'Antibody-based approach to high-volume genotyping for MIC-1 polymorphism', BioTechniques, 33, pp. 118 - 120

Journal articles | 2002

Liu T, 2002, 'Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study', Lancet, 359, pp. 2159 - 2163, http://dx.doi.org/10.1016/S0140-6736(02)09093-1

Journal articles | 2002

Talley LI; Grizzle WE; Waterbor JW; Brown D; Weiss H; Frost AR, 2002, 'Hormone receptors and proliferation in breast carcinomas of equivalent histologic grades in pre- and postmenopausal women', International Journal of Cancer, 98, pp. 118 - 127, http://dx.doi.org/10.1002/ijc.10171

Journal articles | 2000

Bauskin AR; Zhang H; Fairlie WD; He XY; Russell PJ; Moore A; Brown DM; Stanley K; Breit SN, 2000, 'The Propeptide of macrophage inhibitory cytokine (MIC-1) , a TGF-b superfamily member, act as a quality control determinant for correctly folded MIC-1.', European Molecular Biology Organization, 19, pp. 2212 - 2220, http://dx.doi.org/10.1093/emboj/19.10.2212

Journal articles | 2000

Brown DA; Delzell E, 2000, 'Motor vehicle manufacturing and prostate cancer', American Journal of Industrial Medicine, 38, pp. 59 - 70, http://dx.doi.org/10.1002/1097-0274(200007)38:1<59::AID-AJIM7>3.0.CO;2-Y

Journal articles | 2000

Moore AG; Brown DA; Fairlie WD; Bauskin AR; Brown PK; Munier MLC; Russell PK; Salamonsen LA; Wallace EM; Breit SN, 2000, 'The transforming growth factor-β superfamily cytokine macrophage inhibitory cytokine-1 is present in high concentrations in the serum of pregnant women', Journal of Clinical Endocrinology and Metabolism, 85, pp. 4781 - 4788, http://dx.doi.org/10.1210/jc.85.12.4781

Journal articles | 1997

Brown DA; Breit SN, 1997, 'Scleroderma Lung Disease', Biodrugs, 8, pp. 185 - 192, http://dx.doi.org/10.2165/00063030-199708030-00004

Journal articles | 1997

Carr AD; Brown DM; Cooper DA, 1997, 'Portal vein thrombosis in patients receiving indinavir, an HIV protease inhibitor', AIDS, 11, pp. 1657 - 1658

Journal articles | 1997

Manne U; Myers RB; Moron C; Poczatek RB; Dillard S; Weiss H; Brown D; Srivastava S; Grizzle WE, 1997, 'Prognostic significance of Bcl-2 expression and p53 nuclear accumulation in colorectal adenocarcinoma', International Journal of Cancer, 74, pp. 346 - 358, http://dx.doi.org/10.1002/(SICI)1097-0215(19970620)74:3<346::AID-IJC19>3.0.CO;2-9

Journal articles | 1996

Dean Roye G; Myers RB; Brown D; Poczatek R; Beenken SW; Grizzle WE, 1996, 'CD44 expression in dysplastic epithelium and squamous-cell carcinoma of the esophagus', International Journal of Cancer, 69, pp. 254 - 258, http://dx.doi.org/10.1002/(SICI)1097-0215(19960822)69:4<254::AID-IJC2>3.0.CO;2-W

Journal articles | 1996

Myers RB; Brown D; Oelschlager DK; Waterbor JW; Ernest Marshall M; Srivastava S; Stockard CR; Urban DA; Grizzle WE, 1996, 'Elevated serum levels of p105(erbB-2) in patients with advanced-stage prostatic adenocarcinoma', International Journal of Cancer, 69, pp. 398 - 402, http://dx.doi.org/10.1002/(SICI)1097-0215(19961021)69:5<398::AID-IJC8>3.0.CO;2-0

Journal articles | 1996

Myers RB; Srivastava S; Oelschlager DK; Brown D; Grizzle WE, 1996, 'Expression of nm23-H1 in prostatic intraepithelial neoplasia and adenocarcinoma', Human Pathology, 27, pp. 1021 - 1024, http://dx.doi.org/10.1016/S0046-8177(96)90278-6
Preprints | 2022

Finney CA; Delerue F; Gold WA; Brown DA; Shvetcov A, 2022, Artificial intelligence-driven meta-analysis of brain gene expression identifies novel gene candidates and a role for mitochondria in Alzheimer’s Disease, , http://dx.doi.org/10.1101/2022.02.02.22270347

Preprints | 2022

Shvetcov A; Ruitenberg MJ; Delerue F; Gold WA; Brown DA; Finney CA, 2022, The neuroprotective effects of estrogen and estrogenic compounds in spinal cord injury, , http://dx.doi.org/10.1101/2022.10.30.514438

Conference Abstracts | 2019

Mahon KL; Lin H-M; Lee-Ng M; Stockler MR; Gurney H; Mallesara G; Briscoe KP; Marx GM; Higano CS; De Bono JS; Chi KN; Brown D; Breit SN; Horvath L, 2019, 'Clinical validation of circulating cytokines as markers of prognosis and response to docetaxel in men with metastatic castration-resistant prostate cancer.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, CA, San Francisco, Vol. 37, presented at ASCO-SITC Clinical Immuno-Oncology Symposium, CA, San Francisco, 28 February 2019 - 02 March 2019, http://dx.doi.org/10.1200/JCO.2019.37.7_suppl.230

Conference Abstracts | 2019

Mahon KL; Lin HM; Lee-Ng M; Cain D; Jacobs C; Stockler MR; Gurney H; Mallesara G; Briscoe K; Marx G; Higano CS; de Bono JS; Chi KN; Breit SN; Brown DA; Horvath LG, 2019, 'Company Profiles', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, Vol. 15, pp. 33 - 33, http://dx.doi.org/10.1111/ajco.13198

Preprints | 2018

2018, Genetic evidence that the latency III stage of Epstein-Barr Virus infection is a therapeutic target for Multiple Sclerosis, , http://dx.doi.org/10.1101/390609

Conference Abstracts | 2016

Golakani HM; Mohammad M; Li H; Saxena M; Breit S; Ruitenberg M; Brown D, 2016, 'Dynamics of inflammatory immune response in a mouse model of traumatic spinal cord injury, potential therapeutic targets', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 566 - 566, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610401330&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Mahon K; Lin H-M; Spielman C; Lee-Ng M; Gurney H; Mallesara G; Stockler M; Briscoe K; Marx G; Breit SN; Brown D; Horvath L, 2016, 'PHASE II TRIAL OF CIRCULATING CYTOKINES AS MARKERS OF DOCETAXEL RESISTANCE IN METASTATIC CASTRATE-RESISTANT PROSTATE CANCER (mCRPC)', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, Vol. 12, pp. 37 - 37, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000380004900039&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Mohammad MG; Tsai V; Li H; Hassanpour M; Hart P; Breit S; Sawchenko P; Brown D, 2016, 'A choroid-forebrain-lymphatic pathway for the maintenance of CNS immune tolerance', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 166 - 166, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610400332&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2015

Sasson SC; McGill K; Weinholt L; Carr A; Brown DA; Kelleher AD; Breit SN; Sewell WA, 2015, 'COMPARISON OF THE FREELITE (TM) SERUM FREE LIGHT CHAIN (SFLC) ASSAY WITH SERUM AND URINE ELECTROPHORESIS/IMMUNOFIXATION AND THE N LATEX FLC ASSAY', in INTERNAL MEDICINE JOURNAL, WILEY-BLACKWELL, Vol. 45, pp. 24 - 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360834700077&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2015

Watson B; Baxter A; Flood V; Schofield L; Zhang HP; Lee-Ng M; How-Chow D; Breit SN; Brown DA; Danta M, 2015, 'MACROPHAGE INHIBITORY CYTOKINE-1 (MIC-1) IS ASSOCIATED WITH DEGREE OF LIVER FIBROSIS IN HCV-RELATED LIVER DISEASE - THE MILC STUDY', in JOURNAL OF HEPATOLOGY, ELSEVIER SCIENCE BV, AUSTRIA, Vienna, Vol. 62, pp. S337 - S337, presented at 50th International Liver Congress of the European-Association-for-the-Study-of-the-Liver, AUSTRIA, Vienna, 22 April 2015 - 26 April 2015, http://dx.doi.org/10.1016/S0168-8278(15)30319-6

Conference Abstracts | 2015

Watson B; Baxter A; Flood V; Schofield L; Zhang HP; Lee-Ng M; How-Chow D; Briet S; Brown D; Danta M, 2015, 'Macrophage inhibitory cytokine-1 (MIC-1) is associated with degree of liver fibrosis in HCV-related liver disease - the milc study', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY-BLACKWELL, Vol. 30, pp. 99 - 100, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000364505900196&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2015

2015, 'MIC1/GDF15 as a novel biomarker of colonic neoplasia', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY-BLACKWELL, Vol. 30, pp. 76 - 77, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000364505900153&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Conference Abstracts | 2014

Jiang J; Sachdev PS; Brown DA; Breit S; Crawford J; Smith E; Liu T; Trollor J; Wen W, 2014, 'Macrophage Inhibitory Cytokine-1 Is Linked to Brain Volume in Older Individuals [Poster Abstract 3194]', in Proceedings of the 20th Annual Meeting of the Organization for Human Brain Mapping (OHBM), 20th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Hamburg, Germany, presented at 20th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Hamburg, Germany, 08 June 2014 - 12 June 2014

Conference Papers | 2014

Mohammad M; Tsai VW W; Ruitenberg M; Hassanpour M; Li H; Hart P; Breit S; Sawchenko P; Brown D, 2014, 'CNS DCs modulate peripheral anti-CNS immunity', in JOURNAL OF NEUROIMMUNOLOGY, ELSEVIER SCIENCE BV, GERMANY, Mainz, pp. 82 - 82, presented at 12th International Congress of Neuroimmunology (ISNI), GERMANY, Mainz, 09 November 2014 - 13 November 2014, http://dx.doi.org/10.1016/j.jneuroim.2014.08.218

Reports | 2013

Chandratilleke D; Brown D, 2013, A CULPRIT ANTIBODY SEIZES THE DAY, WILEY-BLACKWELL, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000323685200067&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2013

Horvath L; Chatfield MD; Lee-Ng M; Lin H-M; Castillo L; Breit SN; Brown DA; Molloy MP; Marx GM; Pavlakis N; Boyer MJ; Stockier MR; Wykes R; Henshall SM; Mahon KL, 2013, 'The role of macrophages in docetaxel (DTX) resistance in castrate-resistant prostate cancer (CRPC).', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, IL, Chicago, presented at 49th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 31 May 2013 - 04 June 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335419605294&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2013

Husaini Y; Qiu MR; Lockwood G; Jiang L; Tsai VWW; Russell PJ; Brown DA; Breit SN, 2013, 'Expression of the TGF-b superfamily cytokine MIC-1/GDF15slows tumor growth but increases metastases in prostate cancer prone TRAMP mice', in BJU INTERNATIONAL, WILEY-BLACKWELL, pp. 36 - 36, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000321969100093&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2013

Mahon K; Chatfield M; Breit S; Brown D; Molloy M; Marx G; Pavlakis N; Boyer M; Stockler M; Horvath L, 2013, 'The role of macrophages in Docetaxel (DTX) resistance in castrate resistant prostate cancer (CRPC)', in BJU INTERNATIONAL, WILEY-BLACKWELL, pp. 30 - 31, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000321969100078&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2012

2012, 'A Forebrain Immune Cellular Pathway for the Prevention of CNS Autoimmunity', in JOURNAL OF NEUROIMMUNOLOGY, ELSEVIER SCIENCE BV, Boston, MA, pp. 124 - 124, presented at 11th International Congress of Neuroimmunology (ISNI), Boston, MA, 04 November 2012 - 08 November 2012, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000312764800334&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2011

Breit SN; Husaini Y; Lockwood G; Kuffner T; Tsai V; Luo XW; Jiang L; Lee-Ng M; Zhang HP; Wu L; Brown DA, 2011, 'The role of the TGF-beta superfamily cytokine MIC-1/GDF15 in biology and medicine', in CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, ITALY, Florence, pp. 40 - 40, presented at 9th Joint Meeting of the International-Cytokine-Society/International-Society-for-Interferon-and-Cytokine-Research, ITALY, Florence, 09 October 2011 - 12 October 2011, http://dx.doi.org/10.1016/j.cyto.2011.07.122

Conference Papers | 2011

Mohammad MG; Tsai VW W; Tolhurst O; Breit SN; Sawchenko PE; Brown DA, 2011, 'Dendritic cell CCAAT/enhancer binding protein delta modulates Th17/Treg responses in an IL-10 dependent manner', in MULTIPLE SCLEROSIS JOURNAL, SAGE PUBLICATIONS LTD, AUSTRALIA, Melbourne, pp. 698 - 699, presented at Progress in Multiple Sclerosis Research Conference, AUSTRALIA, Melbourne, 26 October 2011 - 28 October 2011, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000303319000140&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2010

Puls RL; Brown D; Fahey P; Amin J; Breit S; Carr A, 2010, 'Macrophage inhibitory cytokine 1 (MIC-1) serum levels in the Lipodystrophy Case Definition Study', in ANTIVIRAL THERAPY, INT MEDICAL PRESS LTD, ENGLAND, London, pp. A28 - A29, presented at 12th International Workshop on Adverse Drug Reactions and Co-Morbidities in HIV, ENGLAND, London, 04 November 2010 - 06 November 2010, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000287431200046&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2010

Puls RL; Brown D; Fahey P; Amin J; Breit S; Carr A, 2010, 'Macrophage inhibitory cytokine 1 (MIC-1) serum levels in the Lipodystrophy Case Definition Study', in ANTIVIRAL THERAPY, INT MEDICAL PRESS LTD, ENGLAND, London, pp. A28 - A29, presented at 12th International Workshop on Adverse Drug Reactions and Co-Morbidities in HIV, ENGLAND, London, 04 November 2010 - 06 November 2010, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000287431500032&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2008

Breit SN; Johnen H; Lin S; Kuffner T; Brown DA; Tsai V; Bauskin AR; Corey L; Sainsbury A; Herzog H, 2008, 'The TGF-beta superfamily cytokine MIC-1 causes tumour-induced anorexia/cachexia by modulating appetite control centres in the hypothalamus', in Cytokine, Academic Press Ltd Elsevier Science Ltd, London, England, pp. 323 - 323, presented at Cytokine, Montreal, CANADA, - , http://dx.doi.org/10.1016/j.cyto.2008.07.421

Conference Papers | 2007

Jiang L; Brown DA; Johnen H; Qiu MR; Curmi PM; Kuffner T; Brown L; Mazzanti M; Breit SN, 2007, 'Role of chloride intracellular channel protein-1 (CLIC1) in cell-mediated immunity', in Inflammation Research, Birkhauser Verlag Ag, pp. S406 - S406, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000247517900156&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Conference Papers | 2001

Brown DA; Liu T; Ward RL; Hawkins NJ; Fairlie WD; Bauskin AR; Russell PJ; Quinn DI; Grygiel JJ; Moore AG; Sutherland RL; Turner J; Kingsley EA; Breit SN, 2001, 'Macrophage inhibitory cytokine-1 (MIC-1) in epithelial neoplasia', in JOURNAL OF LEUKOCYTE BIOLOGY, FEDERATION AMER SOC EXP BIOL, pp. 90 - 90, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000171482200311&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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Associate Professor David Brown