Professor H. Robert   Yang
Professor

Professor H. Robert Yang

Science
Biotech & Biomolecular Science

Education

  • Bachelor of Medicine (1993), Peking University Health Science Centre, Beijing, China
  • PhD (1998), Columbia University, New York, USA

Professional Experience

  • 2014-2019: NHMRC Senior Research Fellow B
  • 2013-current: Professor, School of BABS
  • 2010-2013: Inaugural ARC Future Fellow
  • 2009-2012: Associate Professor, School of BABS
  • 2007-2008: Senior Lecturer, School of BABS, UNSW
  • 1999-2007: Lecturer/Assistant Professor/Associate Professor with tenure, Department of Biochemistry, National University of Singapore
  • 1999 (April-July): Visiting Fellow, Harvard University

Research Program and Contribution

Our long-term research interests focus on two fundamental yet emerging areas in cell and medical biology:

1.  Intracellular lipid (e.g., cholesterol and phosphatidylserine) sorting/transport, and its role in cancer, heart and neurodegenerative diseases.
2.  The biogenesis and dynamics of lipid droplets, adipocyte development, obesity and diabetes.

These two areas are closely linked because lipid droplets may play a crucial role in cellular lipid transport, and lipid droplets are a primary storage site for both free and esterified cholesterol.

Cellular lipid trafficking is a difficult subject to study given the lack of effective approaches to label lipids in live cells. However, it is an important cell biological question because lipids are actively sorted and transported in all eukaryotic cells. In addition, many human diseases such as atherosclerosis, Alzheimer’s and cancer are linked to aberrant lipid transport.

My early work led to the identification of two key enzymes that catalyze sterol esterification, an important homeostatic step for storing excess sterols (Yang et al., Science, 1996). Our laboratory subsequently identified novel molecules and schemes that govern cellular lipid transport (Wang et al., EMBO J, 2005; Du et al, J Cell Biol., 2011; Ghai et al, Nature Communications, 2017; Dong et al., Nat Comms, 2019; Wang et al., Molecular Cell, 2019; Du et al., JCB, 2020; Qian et al., Cell, 2020). Currently we aim to identify and characterize novel proteins that regulate the trafficking of cholesterol or phosphatidylserine between cellular organelles.

Lipid droplets are key cellular organelles that regulate energy storage and metabolism.  We have identified a number of factors that impact the size of lipid droplets (Fei et al, J Cell Biol., 2008; Fei et al, PLoS Genetics, 2011). One such protein, seipin, also plays an important role in human adipocyte development and maintenance (Cui et al., Human Mol Gen., 2011; Liu et al, Diabetes, 2014; Pagac et al, Cell Reports, 2016; Yan et al, Developmental Cell, 2018). Currently, we aim to understand how lipid droplets are formed from the ER and the exact role of seipin in this process.

Honors and Awards

  • UNSW Dean of Science Research Excellence Award (2019)
  • NHMRC Senior Research Fellowship B (2014-2019)
  • Inaugural ARC Future Fellowship (2010-2014)
  • Yong Loo Lin School of Medicine Research Excellence Young Scientist Award (2006)
  • Finalist, Singapore National Young Scientist Award (2005)
  • National University of Singapore (NUS) Technopreneurship 21 Award (2004)
  • National University of Singapore (NUS) Young Scientist Award (2002)

Editorial Service

  • Member of Editorial Board, Journal of Cell Biology (Since March 1st, 2021)
  • Member of Editorial Board, BBA-Molecular Cell Biology of Lipids

Selected Publications

Li YE, Wang Y, Du X, Zhang T, Mak HY, Hancock SE, McEwen H, Pandzic E, Whan RM, Aw YC, Lukmantara IE, Yuan Y, Dong X, Don A, Turner N, Qi S and Yang H. (2021)  TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine. Journal of Cell Biology; 220 (6), e202103105. Highlighted by Faculty Opinions https://facultyopinions.com/prime/740025624#tab=recommendations 

Yan R., Cao P., Song W., Qian H., Du X., Coates H.W., Zhao X., Li Y., Gao S., Gong X., Liu X., Sui J., Lei J., Yang H., Brown A.J., Zhou Q., Yan C. and Yan N. (2021) A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. SCIENCE, 371(6533):eabb2224. doi:10.1126/science.abb2224. 

Du X. and Yang H. (2021) Seipin regulates the formation of nuclear lipid droplets from a distance. Journal of Cell Biology; 220 (1): e202011166.

Qian H., Wu X., Du X., Yao X., Zhao X., Lee J., Yang H*, and Yan N*. (2020) Structural basis of low pH-dependent lysosomal cholesterol egress by NPC1 and NPC2. CELL, 182: 1-14.  * Co-corresponding authors.

Gao M., Liu L., Wang X., Mak H.Y., Liu G. and Yang H. (2020) GPAT3 deficiency alleviates insulin resistance and hepatic steatosis in a mouse model of severe congenital generalized lipodystrophy. Human Molecular Genetics. 1; 29: 432-443.

Du X., Zhou L., Aw Y.C., Mak H.Y., Xu Y., Rae J., Wang W., Zadoorian A., Hancock S.E., Osborne B., Chen X., Wu J.W., Turner N., Parton R.G., Li P. and Yang H. (2020) ORP5 Localizes to ER-Lipid Droplet Contacts and Regulates the Level of PI(4)P on Lipid Droplets. Journal of Cell Biology, 219, 1-16. Highlighted by JCB

Qian H., Zhao X., Yan R., Gao S., Sun X., Du X., Yang H., Wong CCL. and Yan N. (2020) Structural basis for catalysis and substrate specificity of human ACAT1. NATURE, 581: 333-338.

Luo J., Yang H. and Song B.L. (2020) Mechanisms and Regulation of Cholesterol Homeostasis. Nature Reviews Molecular Cell Biology. 21(4): 225-245. 

Xu Y., Du X., Turner N., Brown AJ and Yang H. (2019) Enhanced acyl-CoA: cholesterol acyltransferase activity increases cholesterol levels on lipid droplet surface and impairs adipocyte function. Journal of Biological Chemistry, 294: 19306-19321.

Xu Y., Mak H.Y., Lukmantara I., Li Y.E., Hoehn K.L., Huang X., Du X. and Yang H. (2019) CDP-DAG Synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms. Journal of Biological Chemistry, 294, 1-16; doi:10.1074/jbc.RA119.009992

Gao M., Huang X., Song B.L. and Yang H. (2019) The biogenesis of lipid droplets: lipids take center stage. Progress in Lipid Research, 75: 100989. published online July 24th.

Wang H., Ma, Q., Qi, Y., Dong, J., Du, X., Rae, J., Brown A.J., Parton R.G., Wu J.W. and Yang H. (2019) ORP2 delivers cholesterol to the plasma membrane in exchange for phosphatidylinositol 4, 5-bisphosphate (PI(4,5)P2). Molecular Cell, 73, 1–16. Cover Story. Highlighted by Nature Reviews

Dong J., Du X., Wang H., Wang J., Lu C., Chen X., Zhu Z., Luo Z., Yu L., Brown A.J., Yang H* and Wu JW*. (2019) Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2. Nature Communications, 10: 829. * co-corresponding authors. 

Gao M. and Yang H. (2018) VPS13: A lipid transfer protein making contacts at multiple cellular locations.  Journal of Cell Biology, 217: 3322-3324.  

Yan R., Qian H., Lukmantara I., Gao M., Du, X., Yan N. and Yang H. (2018) Human SEIPIN Binds Anionic Phospholipids. Developmental Cell, 47, 1–9. Highlighted by F1000Prime

Du X, Zadoorian A, Lukmantara I, Qi Y, Brown AJ & Yang H. (2018) Oxysterol-binding protein-related protein 5 (ORP5) promotes cell proliferation by activation of mTORC1 signaling. Journal of Biological Chemistry, 293: 3806-3818.

Du X, Turner N & Yang H. (2018) The role of oxysterol binding proteins in cancer. Seminars in Cell and Developmental Biology, 81: 149-153.

Ghai R, Du X, Wang H, Dong J, Ferguson C, Brown AJ, Parton RG, Wu JW & Yang H. (2017)  ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P2) and regulate its level at the plasma membrane. Nature Communications, 8:757. Highlighted by F1000Prime

Qi Y, Kapterian TS, Du X, Ma Q, Fei W, Zhang Y, Huang X, Dawes IW & Yang H. (2016). CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development. Journal of Lipid Research, 57:767-80.

Pagac M, Cooper DE, Qi Y, Lukmantara IE, Mak HY, Wu Z, Tian Y, Liu Z, Lei M, Du X, Ferguson C, Kotevski D, Sadowski P, Chen W, Boroda S, Harris TE, Liu G, Parton RG, Huang X, Coleman RA & Yang H. (2016) SEIPIN regulates lipid droplet expansion and adipocyte development through modulating the activity of glycerol-3-phosphate acyltransferase. Cell Reports, 17: 1546–1559.

Chu BB, Liao YC, Qi W, Xie C, Du X, Wang J, Yang H, Miao HH, Li BL & Song BL. (2015) Cholesterol transport through a lysosome-peroxisome membrane contact. CELL, 161: 291-306.

Du X, Brown AJ & Yang H. (2015). Novel mechanisms of intracellular cholesterol transport: membrane contact sites and oxysterol binding proteins. Current Opinion in Cell Biology, 35; 37-42.

Liu L, Jiang QQ, Wang, X, Zhang Y, Lin RC, Lan S, Shui, G, Zhou L, Li P, Wang Y, Cui X, Gao MM, Zhang L, Lv Y, Xu G, Liu G, Zhao D & Yang H. (2014) Adipose-specific knockout of seipin/BSCL2 results in progressive lipodystrophy. Diabetes, 63:1–12 doi 10.2337/db13-0729

Du X, Kazim AS, Dawes IW, Brown AJ & Yang H. (2013) The AAA ATPase VPS4/SKD1 Regulates Endosomal Cholesterol Trafficking Independently of ESCRT-III. Traffic, 14: 107-19.

Yang H*, Galea A, Sytnyk V & Crossley M. (2012) Controlling the size of lipid droplets: protein and lipid factors. Current Opinion in Cell Biology, 24:509-16. (* corresponding author)

Cui X, Wang Y, Meng L, Fei W, Deng J, Xu G, Peng X, Ju S, Liu G, Zhao L & Yang H. (2012) Overexpression of a short isoform of human seipin/BSCL2 in mouse adipose tissue results in mild lipodystrophy. Am J Physiol Endocrinol Metab, 302: E705-13.

Du X, Kazim A, Brown AJ & Yang H. (2012) An essential role of Hrs/Vps27 in endosomal cholesterol trafficking. Cell Reports, 1: 29-35. (Inaugural Issue)

Fei W, Shui G, Zhang Y, Krahmer N, Ferguson C, Kapterian TS, Lin RC, Dawes IW, Brown AJ, Li P, Huang X, Parton RG, Wenk MR, Walther TC & Yang H. (2011) 
A role for phosphatidic acid in the formation of “supersized” lipid droplets. PLoS Genetics, 7: e1002201. Highlighted by F1000Prime

Cui X, Wang Y, Tang Y, Liu Y, Zhao L, Deng J, Xu G, Peng X, Ju S, Liu, G & Yang H. (2011) Seipin ablation in mice results in severe generalized lipodystrophy. Human Molecular Genetics, 20: 3022-30

Fei W, Du X & Yang H. (2011) Seipin, adipogenesis and lipid droplets. Trends in Endocrinology and Metabolism, 22: 204-10.

Du X, Kumar J, Ferguson C, Schulz TA, Ong YS, Hong W, Prinz WA, Parton RG, Brown AJ & Yang H. (2011) A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking. Journal of Cell Biology, 192: 121-135.

Fei W, Wang H, Fu X, Bielby C & Yang H. (2009) Conditions of endoplasmic reticulum stress stimulate lipid droplet formation in Saccharomyces cerevisiaeBiochemical Journal 424:61-7.

Low CP, Shui GH, Liew LP, Buttner S, Madeo F, Dawes IW, Wenk MR & Yang H. (2008) Caspase-dependent and -independent lipotoxic cell-death pathways in fission yeast. Journal of Cell Science, 121:  2671-2684. Editorial highlight by JCS

Fei W, Shui G, Gaeta B, Du X, Kuerschner L, Li P, Brown AJ, Wenk MR, Parton RG & Yang H. (2008) Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast. Journal of Cell Biology, 180: 473-482. Highlighted by BioCentury Science Business Xchange

Yang H. (2006) Nonvesicular sterol transport: two protein families and a sterol sensor? Trends Cell Biol. 16: 427-32. Epub 2006 Jul 28.

Wang P, Zhang Y, Li H, Chieu HK, Munn AL & Yang H. (2005) AAA ATPases regulate membrane association of yeast oxysterol binding proteins and cellular sterol metabolism. EMBO Journal, 24: 2989-99

Zhang Q, Chieu HK, Low CP, Zhang S, Heng CK & Yang H. (2003) Schizosaccharomyces pombe cells deficient in triacylglycerols synthesis undergo apoptosis upon entry into the stationary phase. Journal of Biological Chemistry, 278: 47145-55

Yang H, Bard M, Bruner DA, Gleeson A, Deckelbaum RJ, Aljinovic G, Pohl T, Rothstein R & Sturley SL. (1996) Sterol Esterification in Yeast: A two gene process. Science, 272, 1353-1356.

 

Phone
(+61 2) 9385 8133
Location
Room: 3104, Building E26

Publications

  • Books | 2013
    Professor H. Robert Yang
    Book Chapters | 2005
    Professor H. Robert Yang
    Yang H, 2005, 'Metabolism of storage neutral lipids in yeast', in Daum G (ed.), Cell Biology and Dynamics of Yeast Lipids, edn. Original, Research Signpost, pp. 219 - 246
  • Journal articles | 2021
    Professor H. Robert Yang
    Li YE; Wang Y; Du X; Zhang T; Mak HY; Hancock SE; McEwen H; Pandzic E; Whan RM; Aw YC; Lukmantara IE; Yuan Y; Dong X; Don A; Turner N; Qi S; Yang H, 2021, 'TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine', The Journal of cell biology, vol. 220, http://dx.doi.org/10.1083/jcb.202103105
    Journal articles | 2021
    Professor H. Robert Yang
    Zoni V; Khaddaj R; Lukmantara I; Shinoda W; Yang H; Schneiter R; Vanni S, 2021, 'Seipin accumulates and traps diacylglycerols and triglycerides in its ring-like structure', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, http://dx.doi.org/10.1073/pnas.2017205118
    Journal articles | 2021
    Professor H. Robert Yang
    Xiang J; Zhang S; Xu R; Chu H; Biswas S; Yu S; Miao D; Li W; Li S; Brown AJ; Yang H; Xu Y; Li B; Liu H, 2021, 'Elevated HB-EGF expression in neural stem cells causes middle age obesity by suppressing Hypocretin/Orexin expression', FASEB Journal, vol. 35, pp. e21345, http://dx.doi.org/10.1096/fj.202001945R
    Journal articles | 2021
    Professor H. Robert Yang
    Yan R; Cao P; Song W; Qian H; Du X; Coates HW; Zhao X; Li Y; Gao S; Gong X; Liu X; Sui J; Lei J; Yang H; Brown AJ; Zhou Q; Yan C; Yan N, 2021, 'A structure of human scap bound to insig-2 suggests how their interaction is regulated by sterols', Science, vol. 371, http://dx.doi.org/10.1126/science.abb2224
    Journal articles | 2021
    Professor H. Robert Yang
    Zhang T; Li YE; Yuan Y; Du X; Wang Y; Dong X; Yang H; Qi S, 2021, 'TMEM41B and VMP1 are phospholipid scramblases', Autophagy, pp. 1 - 3, http://dx.doi.org/10.1080/15548627.2021.1937898
    Journal articles | 2021
    Professor H. Robert Yang
    Du X; Yang H, 2021, 'Seipin regulates the formation of nuclear lipid droplets from a distance', Journal of Cell Biology, vol. 220, http://dx.doi.org/10.1083/JCB.202011166
    Journal articles | 2021
    Professor H. Robert Yang
    Chu BB; Liao YC; Qi W; Xie C; Du X; Wang J; Yang H; Miao HH; Li BL; Song BL, 2021, 'Erratum: Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts (Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts (2015) 161(2) (291–306), (S0092867415001853), (10.1016/j.cell.2015.02.019))', Cell, vol. 184, pp. 289, http://dx.doi.org/10.1016/j.cell.2020.12.023
    Journal articles | 2020
    Professor H. Robert Yang
    Luo J; Yang H; Song BL, 2020, 'Mechanisms and regulation of cholesterol homeostasis', Nature Reviews Molecular Cell Biology, vol. 21, pp. 225 - 245, http://dx.doi.org/10.1038/s41580-019-0190-7
    Journal articles | 2020
    Professor H. Robert Yang
    Dou YQ; Kong P; Li CL; Sun HX; Li WW; Yu Y; Nie L; Zhao LL; Miao SB; Li XK; Dong C; Zhang JW; Liu Y; Huo XX; Chi K; Gao X; Zhang N; Weng L; Yang H; Zhang F; Han M, 2020, 'Smooth muscle SIRT1 reprograms endothelial cells to suppress angiogenesis after ischemia', Theranostics, vol. 10, pp. 1197 - 1212, http://dx.doi.org/10.7150/thno.39320
    Journal articles | 2020
    Professor H. Robert Yang
    Du X; Zhou L; Aw YC; Mak HY; Xu Y; Rae J; Wang W; Zadoorian A; Hancock SE; Osborne B; Chen X; Wu JW; Turner N; Parton RG; Li P; Yang H, 2020, 'ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets', Journal of Cell Biology, vol. 219, http://dx.doi.org/10.1083/jcb.201905162
    Journal articles | 2020
    Professor H. Robert Yang
    Gao M; Liu L; Wang X; Mak HY; Liu G; Yang H, 2020, 'GPAT3 deficiency alleviates insulin resistance and hepatic steatosis in a mouse model of severe congenital generalized lipodystrophy', Human Molecular Genetics, vol. 29, pp. 432 - 443, http://dx.doi.org/10.1093/hmg/ddz300
    Journal articles | 2020
    Professor H. Robert Yang
    Qian H; Wu X; Du X; Yao X; Zhao X; Lee J; Yang H; Yan N, 2020, 'Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2', Cell
    Journal articles | 2020
    Professor H. Robert Yang
    Qian H; Zhao X; Yan R; Yao X; Gao S; Sun X; Du X; Yang H; Wong CCL; Yan N, 2020, 'Structural basis for catalysis and substrate specificity of human ACAT1', Nature, vol. 581, pp. 333 - 338, http://dx.doi.org/10.1038/s41586-020-2290-0
    Journal articles | 2020
    Professor H. Robert Yang
    Liu L; Liang C; Wang X; Ding X; Lu Y; Dong J; Han M; Yang H; Gao M; Liao J, 2020, 'Erratum: Author Correction: Surgical fat removal exacerbates metabolic disorders but not atherogenesis in LDLR-/- mice fed on high-fat diet (Scientific reports (2019) 9 1 (17848))', Scientific reports, vol. 10, pp. 2181, http://dx.doi.org/10.1038/s41598-020-58201-5
    Journal articles | 2020
    Professor H. Robert Yang
    Gao M; Yang C; Wang X; Guo M; Yang L; Gao S; Zhang X; Ruan G; Li X; Tian W; Lu G; Dong X; Ma S; Li W; Wang Y; Zhu H; He J; Yang H; Liu G; Xian X, 2020, 'ApoC2 deficiency elicits severe hypertriglyceridemia and spontaneous atherosclerosis: A rodent model rescued from neonatal death', Metabolism: Clinical and Experimental, vol. 109, pp. 154296, http://dx.doi.org/10.1016/j.metabol.2020.154296
    Journal articles | 2020
    Professor H. Robert Yang
    Zhao M; Zhao L; Xiong X; He Y; Huang W; Liu Z; Ji L; Pan B; Guo X; Wang L; Cheng S; Xu M; Yang H; Yin Y; Garcia-Barrio MT; Chen YE; Meng X; Zheng L, 2020, 'TMAVA, a Metabolite of Intestinal Microbes, Is Increased in Plasma From Patients With Liver Steatosis, Inhibits γ-Butyrobetaine Hydroxylase, and Exacerbates Fatty Liver in Mice', Gastroenterology, vol. 158, pp. 2266 - 2281.e27, http://dx.doi.org/10.1053/j.gastro.2020.02.033
    Journal articles | 2020
    Professor H. Robert Yang
    Du X; Yang H, 2020, 'Triacylglycerol Measurement in HeLa Cells.', Bio Protoc, vol. 10, pp. e3852, http://dx.doi.org/10.21769/BioProtoc.3852
    Journal articles | 2020
    Professor H. Robert Yang
    Aw YC; Brown AJ; Wu J-W; Yang H, 2020, 'ORP1L, ORP1S, and ORP2: Lipid Sensors and Transporters', Contact, vol. 3, pp. 251525642095681 - 251525642095681, http://dx.doi.org/10.1177/2515256420956818
    Journal articles | 2019
    Professor H. Robert Yang
    Wang H; Ma Q; Qi Y; Dong J; Du X; Rae J; Wang J; Wu WF; Brown AJ; Parton RG; Wu JW; Yang H, 2019, 'ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P 2 )', Molecular Cell, vol. 73, pp. 458 - 473.e7, http://dx.doi.org/10.1016/j.molcel.2018.11.014
    Journal articles | 2019
    Professor H. Robert Yang
    Luo J; Jiang LY; Yang H; Song BL, 2019, 'Intracellular Cholesterol Transport by Sterol Transfer Proteins at Membrane Contact Sites', Trends in Biochemical Sciences, vol. 44, pp. 273 - 292, http://dx.doi.org/10.1016/j.tibs.2018.10.001
    Journal articles | 2019
    Professor H. Robert Yang
    Gao G; Sheng Y; Yang H; Chua BT; Xu L, 2019, 'DFCP1 associates with lipid droplets', Cell Biology International, vol. 43, pp. 1492 - 1504, http://dx.doi.org/10.1002/cbin.11199
    Journal articles | 2019
    Professor H. Robert Yang
    Xu Y; Mak HY; Lukmantara I; Li YE; Hoehn KL; Huang X; Du X; Yang H, 2019, 'CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms', Journal of Biological Chemistry, vol. 294, pp. 16740 - 16755, http://dx.doi.org/10.1074/jbc.RA119.009992
    Journal articles | 2019
    Professor H. Robert Yang
    Gao M; Huang X; Song BL; Yang H, 2019, 'The biogenesis of lipid droplets: Lipids take center stage', Progress in Lipid Research, vol. 75, http://dx.doi.org/10.1016/j.plipres.2019.100989
    Journal articles | 2019
    Professor H. Robert Yang
    Lv X; Liu J; Qin Y; Liu Y; Jin M; Dai J; Chua BT; Yang H; Li P, 2019, 'Identification of gene products that control lipid droplet size in yeast using a high-throughput quantitative image analysis', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1864, pp. 113 - 127, http://dx.doi.org/10.1016/j.bbalip.2018.11.001
    Journal articles | 2019
    Professor H. Robert Yang
    Liu L; Liang C; Wang X; Ding X; Lu Y; Dong J; Han M; Yang H; Liao J; Gao M, 2019, 'Surgical fat removal exacerbates metabolic disorders but not atherogenesis in LDLR−/− mice fed on high-fat diet', Scientific Reports, vol. 9, pp. 17848, http://dx.doi.org/10.1038/s41598-019-54392-8
    Journal articles | 2019
    Professor H. Robert Yang
    Xu Y; Du X; Turner N; Brown AJ; Yang H, 2019, 'Enhanced acyl-CoA:cholesterol acyltransferase activity increases cholesterol levels on the lipid droplet surface and impairs adipocyte function', Journal of Biological Chemistry, vol. 294, pp. 19306 - 19321, http://dx.doi.org/10.1074/jbc.RA119.011160
    Journal articles | 2019
    Professor H. Robert Yang
    Dong J; Du X; Wang H; Wang J; Lu C; Chen X; Zhu Z; Luo Z; Yu L; Brown AJ; Yang H; Wu JW, 2019, 'Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P 2 /PI(3,4)P 2', Nature Communications, vol. 10, pp. 829, http://dx.doi.org/10.1038/s41467-019-08791-0
    Journal articles | 2019
    Professor H. Robert Yang
    Yang H, 2019, 'Extended synaptotagmins, peroxisome-endoplasmic reticulum contact and cholesterol transport', Science China Life Sciences, vol. 62, pp. 1266 - 1269, http://dx.doi.org/10.1007/s11427-019-9573-9
    Journal articles | 2018
    Professor H. Robert Yang
    Xu D; Li Y; Wu L; Li Y; Zhao D; Yu J; Huang T; Ferguson C; Parton RG; Yang H; Li P, 2018, 'Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions', Journal of Cell Biology, vol. 217, pp. 975 - 995, http://dx.doi.org/10.1083/jcb.201704184
    Journal articles | 2018
    Professor H. Robert Yang
    Yan R; Qian H; Lukmantara I; Gao M; Du X; Yan N; Yang H, 2018, 'Human SEIPIN Binds Anionic Phospholipids', Dev. Cell, vol. 47, pp. 248 - 256, http://dx.doi.org/10.1016/j.devcel.2018.09.010
    Journal articles | 2018
    Professor H. Robert Yang
    Gao M; Yang H, 2018, 'VPs13: A lipid transfer protein making contacts at multiple cellular locations', Journal of Cell Biology, vol. 217, pp. 3322 - 3324, http://dx.doi.org/10.1083/JCB.201808151
    Journal articles | 2018
    Professor H. Robert Yang
    Du X; Turner N; Yang H, 2018, 'The role of oxysterol-binding protein and its related proteins in cancer', Seminars in Cell and Developmental Biology, vol. 81, pp. 149 - 153, http://dx.doi.org/10.1016/j.semcdb.2017.07.017
    Journal articles | 2018
    Professor H. Robert Yang
    Du X; Zadoorian A; Lukmantara IE; Qi Y; Brown AJ; Yang H, 2018, 'Oxysterol-binding protein–related protein 5 (ORP5) promotes cell proliferation by activation of MTORC1 signaling', Journal of Biological Chemistry, vol. 293, pp. 3806 - 3818, http://dx.doi.org/10.1074/jbc.RA117.001558
    Journal articles | 2017
    Professor H. Robert Yang
    Luo J; Jiang L; Yang H; Song BL, 2017, 'Routes and mechanisms of post-endosomal cholesterol trafficking: A story that never ends', Traffic, vol. 18, pp. 209 - 217, http://dx.doi.org/10.1111/tra.12471
    Journal articles | 2017
    Professor H. Robert Yang
    Bai Z; Chai XR; Yoon MJ; Kim HJ; Lo KA; Zhang ZC; Xu D; Siang DTC; Walet ACE; Xu SH; Chia SY; Chen P; Yang H; Ghosh S; Sun L, 2017, 'Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding RNA regulators', PLoS Biology, vol. 15, http://dx.doi.org/10.1371/journal.pbio.2002176
    Journal articles | 2017
    Professor H. Robert Yang
    Qi Y; Sun L; Yang H, 2017, 'Lipid droplet growth and adipocyte development: mechanistically distinct processes connected by phospholipids', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1862, pp. 1273 - 1283, http://dx.doi.org/10.1016/j.bbalip.2017.06.016
    Journal articles | 2017
    Professor H. Robert Yang
    Du X; Lukmantara I; Yang H, 2017, 'CRISPR/Cas9-mediated generation of niemann–pick C1 knockout cell line', Methods in Molecular Biology, vol. 1583, pp. 73 - 83, http://dx.doi.org/10.1007/978-1-4939-6875-6_7
    Journal articles | 2017
    Professor H. Robert Yang
    Ghai R; Du X; Wang H; Dong J; Ferguson C; Brown AJ; Parton RG; Wu JW; Yang H, 2017, 'ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane', Nature Communications, vol. 8, http://dx.doi.org/10.1038/s41467-017-00861-5
    Journal articles | 2017
    Professor H. Robert Yang
    Reid DW; Xu D; Chen P; Yang H; Sun L, 2017, 'Integrative analyses of translatome and transcriptome reveal important translational controls in brown and white adipose regulated by microRNAs', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-06077-3
    Journal articles | 2016
    Professor H. Robert Yang
    Liu X; Xie B; Qi Y; Du X; Wang S; Zhang Y; Paxinos G; Yang H; Liang H, 2016, 'The expression of SEIPIN in the mouse central nervous system', Brain Structure and Function, vol. 221, pp. 4111 - 4127, http://dx.doi.org/10.1007/s00429-015-1151-3
    Journal articles | 2016
    Professor H. Robert Yang
    Pagac M; Cooper DE; Qi Y; Lukmantara IE; Mak HY; Wu Z; Tian Y; Liu Z; Lei M; Du X; Ferguson C; Kotevski D; Sadowski P; Chen W; Boroda S; Harris TE; Liu G; Parton RG; Huang X; Coleman RA; Yang H, 2016, 'SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase', Cell Reports, vol. 17, pp. 1546 - 1559, http://dx.doi.org/10.1016/j.celrep.2016.10.037
    Journal articles | 2016
    Professor H. Robert Yang
    Qi Y; Kapterian TS; Du X; Ma Q; Fei W; Zhang Y; Huang X; Dawes IW; Yang H, 2016, 'CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development', Journal of Lipid Research, vol. 57, pp. 767 - 780, http://dx.doi.org/10.1194/jlr.M060574
    Journal articles | 2016
    Professor H. Robert Yang
    Wang M; Gao M; Liao J; Qi Y; Du X; Wang Y; Li L; Liu G; Yang H, 2016, 'Adipose tissue deficiency results in severe hyperlipidemia and atherosclerosis in the low-density lipoprotein receptor knockout mice', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1861, pp. 410 - 418, http://dx.doi.org/10.1016/j.bbalip.2016.02.018
    Journal articles | 2015
    Professor H. Robert Yang
    Chu B-B; Liao Y-C; Qi W; Xie C; Du X; Wang J; Yang H; Miao H-H; Li B-L; Song B-L, 2015, 'Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts', Cell, vol. 161, pp. 291 - 306, http://dx.doi.org/10.1016/j.cell.2015.02.019
    Journal articles | 2015
    Professor H. Robert Yang
    Zhou L; Park SY; Xu L; Xia X; Ye J; Su L; Jeong KH; Hur JH; Oh H; Tamori Y; Zingaretti CM; Cinti S; Argente J; Yu M; Wu L; Ju S; Guan F; Yang H; Choi CS; Savage DB; Li P, 2015, 'Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice', Nature Communications, vol. 6, http://dx.doi.org/10.1038/ncomms6949
    Journal articles | 2015
    Professor H. Robert Yang
    Du X; Brown AJ; Yang H, 2015, 'Novel mechanisms of intracellular cholesterol transport: oxysterol-binding proteins and membrane contact sites', Current Opinion in Cell Biology, vol. 35, pp. 37 - 42, http://dx.doi.org/10.1016/j.ceb.2015.04.002
    Journal articles | 2015
    Professor H. Robert Yang
    Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, vol. 471, pp. 243 - 253, http://dx.doi.org/10.1042/BJ20150602
    Journal articles | 2015
    Professor H. Robert Yang
    He X; Leow KY; Yang H; Heng CK, 2015, 'Functional characterization of two single nucleotide polymorphisms of acyl-coenzyme A: Cholesterol acyltransferase 2', Gene, vol. 566, pp. 236 - 241, http://dx.doi.org/10.1016/j.gene.2015.04.061
    Journal articles | 2014
    Professor H. Robert Yang
    Liu L; Jiang Q; Wang X; Zhang Y; Lin RCY; Lam SM; Shui G; Zhou L; Li P; Wang Y; Cui X; Gao M; Zhang L; Lv Y; Xu G; Liu G; Zhao D; Yang H, 2014, 'Adipose-specific knockout of Seipin/Bscl2 results in progressive lipodystrophy', Diabetes, vol. 63, pp. 2320 - 2331, http://dx.doi.org/10.2337/db13-0729
    Journal articles | 2014
    Professor H. Robert Yang
    Wu L; Xu D; Zhou L; Xie B; Yu L; Yang H; Huang L; Ye J; Deng H; Yuan YA; Chen S; Li P, 2014, 'Rab8a-AS160-MSS4 regulatory circuit controls lipid droplet fusion and growth', Developmental Cell, vol. 30, pp. 378 - 393, http://dx.doi.org/10.1016/j.devcel.2014.07.005
    Journal articles | 2014
    Professor H. Robert Yang
    Jiang M; Gao M; Wu C; He H; Guo X; Zhou Z; Yang H; Xiao X; Liu G; Sha J, 2014, 'Lack of testicular seipin causes teratozoospermia syndrome in men', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, pp. 7054 - 7059, http://dx.doi.org/10.1073/pnas.1324025111
    Journal articles | 2014
    Professor H. Robert Yang
    Sun Z; Gong J; Wu H; Xu W; Wu L; Xu D; Gao J; Wu JW; Yang H; Yang M; Li P, 2014, 'Erratum: Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes (Nature Communications (2013) 4 (1594) 10.1038/ncomms2581))', Nature Communications, vol. 5, http://dx.doi.org/10.1038/ncomms5985
    Journal articles | 2013
    Professor H. Robert Yang
    Yang H; Li P; Gong J; Sun Z, 2013, 'Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes.', Nature communications, vol. 4, pp. 1594, http://dx.doi.org/10.1038/ncomms2581
    Journal articles | 2013
    Professor H. Robert Yang
    Lu Y; Tayebi N; Li H; Saha N; Yang H; Heng CK, 2013, 'Association of CETP Taq1B and -629C > A polymorphisms with coronary artery disease and lipid levels in the multi-ethnic Singaporean population', Lipids in Health and Disease, vol. 12, http://dx.doi.org/10.1186/1476-511X-12-85
    Journal articles | 2013
    Professor H. Robert Yang
    Tong J; Yang H; Yang H; Eom SH; Im YJ, 2013, 'Structure of Osh3 reveals a conserved mode of phosphoinositide binding in oxysterol-binding proteins', Structure, vol. 21, pp. 1203 - 1213, http://dx.doi.org/10.1016/j.str.2013.05.007
    Journal articles | 2013
    Professor H. Robert Yang
    Aung-Htut MT; Lam YT; Lim YL; Rinnerthaler M; Gelling CL; Breitenbach M; Yang H; Dawes IW, 2013, 'Maintenance of mitochondrial morphology by autophagy and its role in high glucose effects on chronological lifespan of Saccharomyces cerevisiae', Oxidative Medicine and Cellular Longevity, vol. 2013, pp. 1 - 13, http://dx.doi.org/10.1155/2013/636287
    Journal articles | 2013
    Professor H. Robert Yang
    Du X; Kazim AS; Dawes IW; Brown AJ; Yang H, 2013, 'The AAA ATPase VPS4/SKD1 regulates endosomal cholesterol trafficking independently of ESCRT-III.', Traffic, vol. 14, pp. 107 - 119, http://dx.doi.org/10.1111/tra.12015
    Journal articles | 2013
    Professor H. Robert Yang
    Du X; Yang H, 2013, 'Endosomal cholesterol trafficking: protein factors at a glance.', ACTA Biochimica et Biophysica Sinica, vol. 45, pp. 11 - 17, http://dx.doi.org/10.1093/abbs/gms095&#65279
    Journal articles | 2012
    Professor H. Robert Yang
    Yang H; Liu P; Ding Y, 2012, 'Identification of the major functional proteins of prokaryotic lipid droplets', Journal of Lipid Research, vol. 53, pp. 399 - 411, http://dx.doi.org/10.1194/jlr.M021899
    Journal articles | 2012
    Professor H. Robert Yang
    Yang H; Fei W, 2012, 'Genome-wide screens for gene products regulating lipid droplet dynamics', Methods in Cell Biology, vol. 108, pp. 303 - 316, http://dx.doi.org/10.1016/B978-0-12-386487-1.00014-6
    Journal articles | 2012
    Professor H. Robert Yang
    Tian N; Leshchyns'ka I; Welch J; Diakowski W; Yang H; Schachner M; Sytnyk V, 2012, 'Lipid raft-dependent endocytosis of close homolog of adhesion molecule L1 (CHL1) promotes neuritogenesis.', The Journal of Biological Chemistry, vol. 287, pp. 44447 - 44463, http://dx.doi.org/10.1074/jbc.M112.394973
    Journal articles | 2012
    Professor H. Robert Yang
    Cui X; Wang Y; Meng L; Fei W; Deng J; Xu G; Peng X; Ju SH; Zhang L; Liu G; Zhao L; Yang H, 2012, 'Overexpression of a short human seipin/bscl2 isoform in mouse adipose tissue results in mild lipodystrophy', American Journal of Physiology - Endocrinology and Metabolism, vol. 302, pp. 705 - 713, http://dx.doi.org/10.1152/ajpendo.00237.2011
    Journal articles | 2012
    Professor H. Robert Yang
    Ta MT; Kapterian T; Fei W; Du X; Brown AJ; Dawes IW; Yang H, 2012, 'Accumulation of squalene is associated with the clustering of lipid droplets.', FEBS Journal, vol. 279, pp. 4231 - 4244, http://dx.doi.org/10.1111/febs.12015
    Journal articles | 2012
    Professor H. Robert Yang
    Du X; Kazim A; Brown AJ; Yang H, 2012, 'An essential role of Hrs/Vps27 in endosomal cholesterol trafficking', Cell Reports, vol. 1, pp. 29 - 35, http://dx.doi.org/10.1016/j.celrep.2011.10.004
    Journal articles | 2012
    Professor H. Robert Yang
    Yang H; Sytnyk V; Crossley M; Galea AM, 2012, 'Controlling the size of lipid droplets: Lipid and protein factors', Current Opinion in Cell Biology, vol. 24, pp. 509 - 516, http://dx.doi.org/10.1016/j.ceb.2012.05.012
    Journal articles | 2011
    Professor H. Robert Yang
    Fei W; Shui G; Zhang Y; Krahmer N; Ferguson C; Kapterian T; Lin RCY; Dawes IW; Brown AJ; Li P; Huang X; Parton R; Wenk M; Walther TC; Yang H, 2011, 'A role for phosphatidic acid in the formation of “supersized” lipid droplets', PLOS Genetics, vol. 7, pp. e1002201 1 - e1002201 11, http://dx.doi.org/10.1371/journal.pgen.1002201
    Journal articles | 2011
    Professor H. Robert Yang
    Lam YT; Aung MT; Lim YL; Yang H; Dawes IW, 2011, 'Changes in reactive oxygen species begin early during replicative aging of Saccharomyces cerevisiae cells', Free Radical Biology and Medicine, vol. 50, pp. 963 - 970, http://dx.doi.org/10.1016/j.freeradbiomed.2011.01.013
    Journal articles | 2011
    Professor H. Robert Yang
    Cui X; Wang Y; Tang Y; Liu G; Yang H; Liu Y; Zhao L; Deng J; Xu G; Peng X; Ju SH, 2011, 'Seipin ablation in mice results in severe generalized lipodystrophy', Human Molecular Genetics, vol. 20, pp. 3022 - 3030, http://dx.doi.org/10.1093/hmg/ddr205
    Journal articles | 2011
    Professor H. Robert Yang
    Fei W; Zhong L; Ta T; Yang H, 2011, 'The size and phospholipid composition of lipid droplets can influence their proteome', Biochemical and Biophysical Research Communications, vol. 415, pp. 455 - 462, http://dx.doi.org/10.1016/j.bbrc.2011.10.091
    Journal articles | 2011
    Professor H. Robert Yang
    Fei W; Du XR; Yang H, 2011, 'Seipin, adipogenesis and lipid droplets.', Trends in Endocrinology and Metabolism, vol. 22, pp. 204 - 210, http://dx.doi.org/10.1016/j.tem.2011.02.004
    Journal articles | 2011
    Professor H. Robert Yang
    Yang H; Parton RG; Li P; Shui G; Gong J, 2011, 'Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites', Journal of Cell Biology, vol. 195, pp. 953 - 963, http://dx.doi.org/10.1083/jcb.201104142
    Journal articles | 2011
    Professor H. Robert Yang
    tian Y; Bi J; Shui G; Wenk M; Yang H; Huang X, 2011, 'Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation', PLOS Genetics, vol. 7, pp. e1001364, http://dx.doi.org/10.1371/journal.pgen.1001364
    Journal articles | 2011
    Professor H. Robert Yang
    Du XR; Kumar J; Ferguson C; Schulz TA; Ong YS; Hong W; Prinz WA; Parton RG; Brown AJ; Yang H, 2011, 'A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking', Journal of Cell Biology, vol. 192, pp. 121 - 135, http://dx.doi.org/10.1083/jcb.201004142
    Journal articles | 2011
    Professor H. Robert Yang
    Fei W; Li H; Shui G; Kapterian TS; Bielby C; Du X; Brown AJ; Li P; Wenk M; Liu P; Yang H, 2011, 'Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis.', Journal of Lipid Research, vol. 52, pp. 2136 - 2147, http://dx.doi.org/10.1194/jlr.M017566
    Journal articles | 2011
    Professor H. Robert Yang
    Du X; Yang H, 2011, 'Sterol-binding proteins and endosomal cholesterol transport', Frontiers in Biology, vol. 6, pp. 190 - 196
    Journal articles | 2010
    Professor H. Robert Yang
    Yang H, 2010, 'Toward one step analysis of cellular lipidomes using liquid', Molecular Biosystems, vol. 6, pp. 1008 - 1017, http://dx.doi.org/10.1039/b913353d
    Journal articles | 2010
    Professor H. Robert Yang
    Shui G; Guan XL; Gopalakrishnan P; Xue Y; Goh JSY; Yang H; Wenk MR, 2010, 'Characterization of substrate preference for Slc1p and Cst26p in saccharomyces cerevisiae using lipidomic approaches and an LPAAT activity assay', PLoS ONE, vol. 5, http://dx.doi.org/10.1371/journal.pone.0011956
    Journal articles | 2010
    Professor H. Robert Yang
    Shui G; Guan XL; Gopalakrishnan P; Xue Y; Goh JSY; Yang H; Wenk MR, 2010, 'Characterization of substrate preference for Slc1p and Cst26p in Saccharomyces cerevisiae using lipidomic approaches and an LPAAT activity assay', PLoS One, vol. 4, pp. 11956, http://www.ncbi.nlm.nih.gov/pubmed/20694142
    Journal articles | 2009
    Professor H. Robert Yang
    Fei W; Wang H; Fu X; Christopher B; Yang H, 2009, 'Conditions of endoplasmic reticulum stress stimulate lipid droplet formation in saccharomyces cerevisiae', Biochemical Journal, vol. 424, pp. 61 - 67, http://dx.doi.org/10.1042/BJ20090785
    Journal articles | 2008
    Professor H. Robert Yang
    Toh SK; Gong J; Du GG; Li J; Yang S; Ye JM; Yao H; Zhang Y; Xue B; Li Q; Yang H; Wen Z; Li P, 2008, 'Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of Fsp27 deficient mice', PLoS One, vol. 3, pp. 2890 - 2891, http://dx.doi.org/10.1371/journal.pone.0002890
    Journal articles | 2008
    Professor H. Robert Yang
    Fei W; Alfaro G; Muthusamy B; Klaassen Z; Graham T; Yang H; Beh C, 2008, 'Genome-wide analysis of sterol-lipid storage and trafficking in Saccharomyces cerevisiae', Eukaryotic Cell, vol. 7, pp. 401 - 414, http://dx.doi.org/10.1128/EC.00386-07
    Journal articles | 2008
    Professor H. Robert Yang
    Low C; Shui G; Liew L; Buttner S; Madeo F; Dawes IW; Wenk M; Yang H, 2008, 'Caspase-dependent and -independent lipotoxic cell-death pathways in fission yeast', Journal of Cell Science, vol. 121, pp. 2671 - 2684, http://dx.doi.org/10.1242/jcs.028977
    Journal articles | 2008
    Professor H. Robert Yang
    Fei W; Shui G; Gaeta BA; Du XR; Kuerschner L; Liu P; Brown AJ; Wenk M; Parton R; Yang H, 2008, 'Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast', Journal of Cell Biology, vol. 180, pp. 473 - 482, http://dx.doi.org/10.1083/icb.200711136
    Journal articles | 2008
    Professor H. Robert Yang
    Kristiana I; Yang H; Brown AJ, 2008, 'Different kinetics of cholesterol delivery to components of the cholesterol homeostatic machinery: Implications for cholesterol trafficking to the endoplasmic reticulum', Biochimica et Biophysica ACTA - Molecular and Cell Biology of Lipids, vol. 1781, pp. 724 - 730, http://dx.doi.org/10.1016/j.bbalip.2008.08.006
    Journal articles | 2008
    Professor H. Robert Yang
    Low C; Yang H, 2008, 'Programmed cell death in fission yeast Schizosaccharomyces pombe', Biochimica et Biophysica ACTA - Molecular Cell Research, vol. 1783, pp. 1335 - 1349, http://dx.doi.org/10.1016/j.bbamcr.2008.02.002
    Journal articles | 2006
    Professor H. Robert Yang
    Chen X; Hu ZP; Yang XX; Huang M; Gao Y; Tang W; Chan SY; Dai X; Ye J; Ho PCL; Duan W; Yang HY; Zhu YZ; Zhou SF, 2006, 'Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer', International Immunopharmacology, vol. 6, pp. 499 - 508, http://dx.doi.org/10.1016/j.intimp.2005.08.026
    Journal articles | 2006
    Professor H. Robert Yang
    Tian Q; Zhang J; Chan SY; Tan T; Duan W; Huang M; Zhu Y; Chan E; Yu Q; Nie YQ; Ho P; Li Q; Ng K; Yang H; Wei HE; Bian JS; Zhou S, 2006, 'Topotecan is a substrate for multidrug resistance associated protein 4', Current Drug Metabolism, vol. 7, pp. 105 - 118, http://dx.doi.org/10.2174/138920006774832550
    Journal articles | 2006
    Professor H. Robert Yang
    Zhang J; Huang M; Guan S; Bi HC; Pan Y; Duan W; Chan SY; Chen X; Hong YH; Bian JS; Yang H; Zhou S, 2006, 'A mechanistic study of the intestinal absorption of Cryptotanshinone, the major active constituent of Salvia miltiorrhiza', Journal of Pharmacology and Experimental Therapeutics, vol. 317, pp. 1285 - 1294, http://dx.doi.org/10.1124/jpet.105.100701
    Journal articles | 2006
    Professor H. Robert Yang
    Yang H, 2006, 'Nonvesicular sterol transport: two protein families and a sterol sensor?', Trends in Cell Biology, vol. 16, pp. 427 - 432, http://dx.doi.org/10.1016/j.tcb.2006.07.002
    Journal articles | 2005
    Professor H. Robert Yang
    Tian Q; Zhang J; Tan T; Chan E; Duan W; Chan S; Boelsterli UA; Ho P; Yang H; Bian JS; Huang M; Zhu Y; Xiong W; Li XR; Zhou S, 2005, 'Human multidrug resistance associated protein 4 confers resistance to camptothecins', Pharmaceutical Research, vol. 22, pp. 1837 - 1853, http://dx.doi.org/10.1007/s11095-005-7595-z
    Journal articles | 2005
    Professor H. Robert Yang
    Gao Y; Gao H; Chan E; Tang W; Xu A; Yang H; Huang M; Lan J; Li X; Duan W; Xu C; Zhou S, 2005, 'Antitumor activity and underlying mechanisms of ganopoly, the refined polysaccharides extracted from ganoderma lucidum, in mice', Immunological Investigations, vol. 34, pp. 171 - 198, http://dx.doi.org/10.1081/IMM-200055813
    Journal articles | 2005
    Professor H. Robert Yang
    Hu Z; Yang XQ; Ho P; Chan E; Chan S; Xu C; Li XR; Zhu YZ; Duan W; Chen X; Huang M; Yang H; Zhou S, 2005, 'St John`s Wort modulates the toxicities and pharmacokinetics of CPT-11 (irinotecan) in rats', Pharmaceutical Research, vol. 22, pp. 902 - 914, http://dx.doi.org/10.1007/s11095-005-4585-0
    Journal articles | 2005
    Professor H. Robert Yang
    Zhou S; Huang M; Xu A; Yang H; Duan W; Paxton JW, 2005, 'Prediction of herb-drug metabolic interactions: A simulation study', Phytotherapy Research, vol. 19, pp. 464 - 471, http://dx.doi.org/10.1002/ptr.1559
    Journal articles | 2005
    Professor H. Robert Yang
    Wang Q; Ting WL; Yang H; Wong PT, 2005, 'High doses of simavastatin upregulate dopamine D(1) and D(2) receptor expression in the rat prefrontal cortex: possible involvement of endothelial nitric oxide synthase', British Journal of Pharmacology, vol. 144, pp. 933 - 939, http://dx.doi.org/10.1038/sj.bjp.0706106
    Journal articles | 2005
    Professor H. Robert Yang
    Wang P; Duan W; Munn AL; Yang H, 2005, 'Molecular characterization of Oshop, an oxysterol binding protein homolog in the yeast Saccharomyces cerevisiae', FEBS Journal, vol. 272, pp. 4703 - 4715, http://dx.doi.org/10.1111/j.1742-4658.2005.04886.x
    Journal articles | 2005
    Professor H. Robert Yang
    Low CP; Liew LP; Pervaiz S; Yang H, 2005, 'Apoptosis and lipoapoptosis in the fission yeast Schizosaccharomyces pombe', FEMS Yeast Research, vol. 5, pp. 1199 - 1206, http://dx.doi.org/10.1016/j.femsyr.2005.07.004
    Journal articles | 2005
    Professor H. Robert Yang
    Wang P; Zhang Y; Li H; Chieu HK; Munn AL; Yang H, 2005, 'AAA ATPases regulate membrane association of yeast oxysterol binding proteins and cellular sterol metabolism', European Molecular Biology Organization, vol. 24, pp. 2989 - 2999, http://dx.doi.org/10.1038/sj.emboj.7600764
    Journal articles | 2005
    Professor H. Robert Yang
    Lim G; Zhu Y; Wang C; Tan B; Armstrong J; Dokland T; Yang H; Zhu YZ, 2005, 'The last five amino acid residues at the C-terminus of PRK1/PKN are essential for full lipid responsiveness', Cellular Signalling, vol. 17, pp. 1084 - 1097, http://dx.doi.org/10.1016/j.cellsig.2004.12.003
    Journal articles | 2005
    Professor H. Robert Yang
    He X; Lu Y; Saha N; Yang H; Heng CK, 2005, 'Acyl-CoA: Cholesterol acyltransferase-2 gene polymorphisms and their association with plasma lipids and coronary artery disease risks', Human Genetics, vol. 118, pp. 393 - 403, http://dx.doi.org/10.1007/s00439-005-0055-3
    Journal articles | 2005
    Professor H. Robert Yang
    Tian Q; Zhang J; Tan TMC; Chan E; Duan W; Chan SY; Boelsterli UA; Ho PC-L; Yang H; Bian J-S; Huang M; Zhu Y-Z; Xiong W; Li X; Zhou S, 2005, 'Human multidrug resistance associated protein 4 confers resistance to camptothecins.', Pharm Res, vol. 22, pp. 1837 - 1853, http://dx.doi.org/10.1007/s11095-005-7595-z
    Journal articles | 2005
    Professor H. Robert Yang
    Low C; Liew L; Pervaiz S; Yang H, 2005, 'Apoptosis and lipoapoptosis in yeast', Human Genetics, vol. 5, pp. 1199 - 1206
    Journal articles | 2004
    Professor H. Robert Yang
    Armstrong J; Yang H; Duan W; Whiteman M, 2004, 'Cytochrome bc1 regulates the mitochondrial permeability transition by two distinct pathways', The Journal of Biological Chemistry, vol. 279, pp. 50420 - 50428, http://dx.doi.org/10.1074/jbc.M408882200
    Journal articles | 2004
    Professor H. Robert Yang
    Armstrong JS; Whiteman M; Yang H; Jones DP; Sternberg P, 2004, 'Cysteine starvation activates the redox-dependent mitochondrial permeability transition in retinal pigment epithelial cells', Investigative Ophthalmology and Visual Science, vol. 45, pp. 4183 - 4189, http://dx.doi.org/10.1167/iovs.04-0570
    Journal articles | 2004
    Professor H. Robert Yang
    Kim K; Shin YK; Park J; Kim JH; Yang H; Han DM; Paik Y, 2004, 'Molecular cloning and biochemical characterization of Candida albicans acyl-CoA:sterol acyltransferase, a potential target of antifungal agents', Biochemical and Biophysical Research Communications, vol. 2319, pp. 911 - 919, http://dx.doi.org/10.1016/j.bbrc.2004.05.076
    Journal articles | 2004
    Professor H. Robert Yang
    Armstrong J; Whiteman M; Yang H; Jones DP, 2004, 'The redox regulation of intermediary metabolism by a superoxide-acontase rheostat', BioEssays, vol. 26, pp. 894 - 900, http://dx.doi.org/10.1002/bies.20071
    Journal articles | 2004
    Professor H. Robert Yang
    Zhang SP; Ren J; Zhang Q; Munn AL; Armstrong J; Yang H, 2004, 'Ncr1p, the yeast ortholog of mammalian Niemann Pick C1 protein, is dispensable for endocytic transport.', Traffic (Malden), vol. 5, pp. 1017 - 1030, http://dx.doi.org/10.1111/j.1600-0854.2004.00241.x
    Journal articles | 2004
    Professor H. Robert Yang
    Zhang SP; Ren J; Zhang Q; Armstrong J; Munn AL; Yang H, 2004, 'Cysteine starvation activates the redox-dependent mitochondrial permeability transition in retinal pigment epithelial cells', Traffic (Malden), vol. 5, pp. 1017 - 1030
    Journal articles | 2003
    Professor H. Robert Yang
    Tan JH; Low PS; Tan YS; Tong MC; Saha N; Yang H; Heng CK, 2003, 'ABCA1 gene polymorphisms and their associations with coronary artery disease and plasma lipids in males from three ethnic populations in Singapore', Human Genetics, vol. 113, pp. 106 - 117
    Journal articles | 2003
    Professor H. Robert Yang
    Zhang Q; Chieu HK; Low C; Zhang SP; Heng CK; Yang H, 2003, 'Schizosaccharomyces pombe cells deficient in Triacylglycerols synthesis undergo apoptosis upon entry into the stationary phase', The Journal of Biological Chemistry, vol. 278, pp. 47145 - 47155, http://dx.doi.org/10.1074/jbc.M306998200
    Journal articles | 2003
    Professor H. Robert Yang
    Yeo SC; Xu LL; Ren J; Boulton VJ; Wagle MD; Liu CF; Ren G; Wong P; Zahn DR; Sasajala P; Yang H; Piper RD; Munn AL, 2003, 'Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae', Journal of Cell Science, vol. 116, pp. 3957 - 3970, http://dx.doi.org/10.1242/jcs.00751
    Journal articles | 2003
    Professor H. Robert Yang
    Woo WH; Yang H; Wong KP; Halliwell B, 2003, 'Sulphite oxidase gene expression in human brain and in other human and rat tissues', Biochemical and Biophysical Research Communications, vol. 305, pp. 619 - 623, http://dx.doi.org/10.1016/S0006-291X(03)00833-7
    Journal articles | 2001
    Professor H. Robert Yang
    Li T; Duan W; Yang H; Lee MK; Bte Mustafa F; Lee BH; Teo TS, 2001, 'Identification of two proteins, S14 and UIP1, that interact with UCH37', FEBS Letters, vol. 488, pp. 201 - 205, http://dx.doi.org/10.1016/S0014-5793(00)02436-4
    Journal articles | 2000
    Professor H. Robert Yang
    Li T; Naqvi NI; Yang H; Teo TS, 2000, 'Identification of a 26S proteasome-associated UCH in fission yeast', Biochemical and Biophysical Research Communications, vol. 272, pp. 270 - 275, http://dx.doi.org/10.1006/bbrc.2000.2767
    Journal articles | 1998
    Professor H. Robert Yang
    Liang JS; Wu X; Jiang H; Zhou M; Yang H; Angkeow P; Huang LS; Sturley SL; Ginsberg H, 1998, 'Translocation efficiency, susceptibility to proteasomal degradation, and lipid responsiveness of apolipoprotein B are determined by the presence of β sheet domains', Journal of Biological Chemistry, vol. 273, pp. 35216 - 35221, http://dx.doi.org/10.1074/jbc.273.52.35216
    Journal articles | 1997
    Professor H. Robert Yang
    Yang H; Cromley D; Wang H; Billheimer JT; Sturley SL, 1997, 'Functional expression of a cDNA to human acyl-coenzyme A:cholesterol acyltransferase in yeast. Species-dependent substrate specificity and inhibitor sensitivity', Journal of Biological Chemistry, vol. 272, pp. 3980 - 3985, http://dx.doi.org/10.1074/jbc.272.7.3980
    Journal articles | 1996
    Professor H. Robert Yang
    Yang H; Bard M; Bruner DA; Gleeson A; Deckelbaum RJ; Aljinovic G; Pohl TM; Rothstein R; Sturley SL, 1996, 'Sterol esterification in yeast: A two-gene process', Science, vol. 272, pp. 1353 - 1356, http://dx.doi.org/10.1126/science.272.5266.1353
    Journal articles | 1996
    Professor H. Robert Yang
    Arthington-Skaggs BA; Crowell DN; Yang H; Sturley SL; Bard M, 1996, 'Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post-squalene portion of the yeast ergosterol pathway', FEBS Letters, vol. 392, pp. 161 - 165, http://dx.doi.org/10.1016/0014-5793(96)00807-1
    Journal articles | 1995
    Professor H. Robert Yang
    Piper RC; Cooper AA; Yang H; Stevens TH, 1995, 'VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae', Journal of Cell Biology, vol. 131, pp. 603 - 617, http://dx.doi.org/10.1083/jcb.131.3.603

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