Dr Jeng Yie Chan

Chan JY; Bensellam M; Lin RCY; Liang C; Lee K; Jonas JC; Laybutt DR, 2021, 'Transcriptome analysis of islets from diabetes-resistant and diabetes-prone obese mice reveals novel gene regulatory networks involved in beta-cell compensation and failure', FASEB Journal, vol. 35, pp. e21608, http://dx.doi.org/10.1096/fj.202100009R

Chan JY; Lee K; Maxwell EL; Liang C; Laybutt DR, 2019, 'Macrophage alterations in islets of obese mice linked to beta cell disruption in diabetes', Diabetologia, vol. 62, pp. 993 - 999, http://dx.doi.org/10.1007/s00125-019-4844-y

Bensellam M; Chan JY; Lee K; Joglekar MV; Hardikar AA; Loudovaris T; Thomas HE; Jonas JC; Laybutt DR, 2019, 'Phlda3 regulates beta cell survival during stress', Scientific Reports, vol. 9, pp. 12827, http://dx.doi.org/10.1038/s41598-019-49289-5

Bensellam M; Shi YC; Chan JY; Laybutt DR; Chae H; Abou-Samra M; Pappas EG; Thomas HE; Gilon P; Jonas JC, 2019, 'Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans', Diabetologia, vol. 62, pp. 2273 - 2286, http://dx.doi.org/10.1007/s00125-019-05008-3

Chan JY; Lee K; Maxwell E; Liang C; Laybutt R, 2019, 'SAT-161 Macrophage Alterations in Islets of Obese Mice Linked to Beta Cell Compensation or Beta Cell Dedifferentiation in Diabetes', Journal of the Endocrine Society, vol. 3, http://dx.doi.org/10.1210/js.2019-sat-161

Macdonald GC; Hesselson SE; Chan JY; Jenkins AB; Laybutt DR; Hesselson D; Campbell LV, 2019, 'Deletion distal to the PAX6 coding region reveals a novel basis for familial cosegregation of aniridia and diabetes mellitus', Diabetes Research and Clinical Practice, vol. 148, pp. 64 - 71, http://dx.doi.org/10.1016/j.diabres.2018.12.002

Kammoun HL; Allen TL; Henstridge DC; Barre S; Coll RC; Lancaster GI; Cron L; Reibe S; Chan JY; Bensellam M; Laybutt DR; Butler MS; Robertson AAB; O'Neill LA; Cooper MA; Febbraio MA, 2018, 'Evidence against a role for NLRP3-driven islet inflammation in db/db mice', Molecular Metabolism, vol. 10, pp. 66 - 73, http://dx.doi.org/10.1016/j.molmet.2018.02.001

Kee AJ; Chagan J; Chan JY; Bryce NS; Lucas CA; Zeng J; Hook J; Treutlein H; Laybutt DR; Stehn JR; Gunning PW; Hardeman EC, 2018, 'On-target action of anti-tropomyosin drugs regulates glucose metabolism', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-22946-x

Loh K; Shi YC; Walters S; Bensellam M; Lee K; Dezaki K; Nakata M; Ip CK; Chan JY; Gurzov EN; Thomas HE; Waibel M; Cantley J; Kay TW; Yada T; Laybutt DR; Grey ST; Herzog H, 2017, 'Inhibition of Y1 receptor signaling improves islet transplant outcome', Nature Communications, vol. 8, http://dx.doi.org/10.1038/s41467-017-00624-2

Bensellam M; Maxwell EL; Chan JY; Luzuriaga J; West PK; Jonas JC; Gunton JE; Laybutt DR, 2016, 'Hypoxia reduces ER-to-Golgi protein trafficking and increases cell death by inhibiting the adaptive unfolded protein response in mouse beta cells', Diabetologia, vol. 59, pp. 1492 - 1502, http://dx.doi.org/10.1007/s00125-016-3947-y

Peiris H; Duffield MD; Fadista J; Jessup CF; Kashmir V; Genders AJ; McGee SL; Martin AM; Saiedi M; Morton N; Carter R; Cousin MA; Kokotos AC; Oskolkov N; Volkov P; Hough TA; Fisher EMC; Tybulewicz VLJ; Busciglio J; Coskun PE; Becker A; Belichenko PV; Mobley WC; Ryan MT; Chan JY; Laybutt DR; Coates PT; Yang S; Ling C; Groop L; Pritchard MA; Keating DJ, 2016, 'A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes', PLoS Genetics, vol. 12, http://dx.doi.org/10.1371/journal.pgen.1006033

Chan JY; Luzuriaga J; Maxwell EL; West PK; Bensellam M; Laybutt DR, 2015, 'The balance between adaptive and apoptotic unfolded protein responses regulates β-cell death under ER stress conditions through XBP1, CHOP and JNK', Molecular and Cellular Endocrinology, vol. 413, pp. 189 - 201, http://dx.doi.org/10.1016/j.mce.2015.06.025

Bensellam M; Montgomery MK; Luzuriaga J; Chan JY; Laybutt DR, 2015, 'Inhibitor of differentiation proteins protect against oxidative stress by regulating the antioxidant–mitochondrial response in mouse beta cells', Diabetologia, vol. 58, pp. 758 - 770, http://dx.doi.org/10.1007/s00125-015-3503-1

Chan JY; Luzuriaga J; Bensellam M; Biden TJ; Laybutt DR, 2013, 'Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in β-cell gene expression and progression to diabetes', Diabetes, vol. 62, pp. 1557 - 1568, http://dx.doi.org/10.2337/db12-0701

Walters SN; Luzuriaga J; Chan JY; Grey ST; Laybutt DR, 2013, 'Influence of chronic hyperglycemia on the loss of the unfolded protein response in transplanted islets', Journal of Molecular Endocrinology, vol. 51, pp. 225 - 232, http://dx.doi.org/10.1530/JME-13-0016

Chan JY; Biden TJ; Laybutt DR, 2012, 'Cross-talk between the unfolded protein response and nuclear factor-kappaB signalling pathways regulates cytokine-mediated beta cell death in MIN6 cells and isolated mouse islets', Diabetologia, vol. 55, pp. 2999 - 3009, http://dx.doi.org/10.1007/s00125-012-2657-3

Chan JY; Cooney GJ; Biden TJ; Laybutt DR, 2011, 'Differential regulation of adaptive and apoptotic unfolded protein response signalling by cytokine-induced nitric oxide production in mouse pancreatic beta cells', Diabetologia, vol. 54, pp. 1766 - 1776, http://dx.doi.org/10.1007/s00125-011-2139-z

Akerfeldt M; Howes J; Chan JY; Stevens VA; Boubenna N; McGuire HM; King C; Biden TJ; Laybutt DR, 2008, 'Cytokin-induced (beta)-cell death is independent of endoplasmic reticulum stress signalling', Diabetes, vol. 57, pp. 3034 - 3044, http://dx.doi.org/10.2337/db07-1802