Dr Joanne   Reed
Conjoint Senior Lecturer

Dr Joanne Reed

2009 – PhD, Flinders University of South Australia - Australia
2004 – Bachelor of Biotechnology (Honours – First Class), Flinders University of South Australia - Australia

medicine-health
St Vincent's Clinical School

Joanne’s research focuses on autoimmune diseases, particularly the origin and role of autoantibodies. Joanne completed her PhD at Flinders University, investigating antigen expression and autoantibody specificity in Sjogren’s syndrome and lupus.

Upon completion of her PhD she received an NHMRC Fellowship to undertake postdoctoral training at New York University. At NYU, Joanne studied how autoantibodies mediate tissue injury in neonatal lupus.

In 2013 Joanne returned to Australia and joined Prof Christopher Goodnow’s group at the Australian National University, with the goal of developing new genomic approaches to study autoimmune disease. She then moved with Prof Goodnow in 2015 to establish an Immunogenomics lab at the Garvan Institute.

Joanne's current research uses next generation sequencing and single cell transcriptomics to study antibody repertoires and genetic variants in patients with autoimmune disease.

 

Phone
+61292958480
Location
Garvan Institute of Medical Research

Publications

  • Book Chapters | 2018
    Dr Joanne Reed
    Goodnow CC; Christ D; Reed JH, 2018, 'Sequencing and affinity determination of antigen-specific B lymphocytes from peripheral blood', in Nevoltris D; Chames P (ed.), Antibody Engineering. Methods in Molecular Biology, Humana Press, New York, NY, pp. 287 - 309, http://dx.doi.org/10.1007/978-1-4939-8648-4_15
  • Journal articles | 2021
    Dr Joanne Reed
    Zhang Z; Jara CJ; Singh M; Xu H; Goodnow CC; Jackson KJL; Reed JH, 2021, 'Human transitional and IgMlow mature naïve B cells preserve permissive B-cell receptors', Immunology and Cell Biology, http://dx.doi.org/10.1111/imcb.12478
    Journal articles | 2021
    Dr Joanne Reed
    Boast B; Helian K; Andrews D; Li X; Cho V; Closa A; Sutton H; Reed J; Bergmann H; Roots C; Yabas M; Barthel N; Omari S; Young C; Miosge L; Eyras E; Nutt S; Hein N; Hannan K; Cockburn I; Goodnow C; Enders A, 2021, 'Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in mice', , http://dx.doi.org/10.1101/2021.01.29.428877
    Journal articles | 2020
    Dr Joanne Reed
    Lau A; Avery DT; Jackson K; Lenthall H; Volpi S; Brigden H; Russell AJ; Bier J; Reed JH; Smart JM; Cole T; Choo S; Gray PE; Berglund LJ; Hsu P; Wong M; O'Sullivan M; Boztug K; Meyts I; Uzel G; Notarangelo LD; Brink R; Goodnow CC; Tangye SG; Deenick EK, 2020, 'Activated PI3Kd breaches multiple B cell tolerance checkpoints and causes autoantibody production', Journal of Experimental Medicine, vol. 217, http://dx.doi.org/10.1084/jem_20191336
    Journal articles | 2020
    Dr Joanne Reed
    Singh M; Jackson KJL; Wang JJ; Schofield P; Field MA; Koppstein D; Peters TJ; Burnett DL; Rizzetto S; Nevoltris D; Masle-Farquhar E; Faulks ML; Russell A; Gokal D; Hanioka A; Horikawa K; Colella AD; Chataway TK; Blackburn J; Mercer TR; Langley DB; Goodall DM; Jefferis R; Gangadharan Komala M; Kelleher AD; Suan D; Rischmueller M; Christ D; Brink R; Luciani F; Gordon TP; Goodnow CC; Reed JH, 2020, 'Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody', Cell, vol. 180, pp. 878 - 894.e19, http://dx.doi.org/10.1016/j.cell.2020.01.029
    Journal articles | 2020
    Dr Joanne Reed
    Reed JH; Verstappen GM; Rischmueller M; Bryant VL, 2020, 'When B cells break bad: development of pathogenic B cells in Sjögren’s syndrome', Clinical and Experimental Rheumatology, vol. 38, pp. S271 - S282, https://pubmed.ncbi.nlm.nih.gov/33025890/
    Journal articles | 2019
    Dr Joanne Reed
    Jeelall Y; Singh M; Lai J; Ali S; Jackson K; Hollingsworth P; De Boer B; Wood B; Reed J; Goodnow C; Mclean-Tooke A; Lucas M, 2019, 'Oligoclonal lymphocytosis and cytokine derangement in a case of severe adverse drug reaction', Pathology, vol. 51, pp. S131 - S131, http://dx.doi.org/10.1016/j.pathol.2018.12.378
    Journal articles | 2019
    Dr Joanne Reed
    Burnett DL; Reed JH; Christ D; Goodnow CC, 2019, 'Clonal redemption and clonal anergy as mechanisms to balance B cell tolerance and immunity', Immunological Reviews, vol. 292, pp. 61 - 75, http://dx.doi.org/10.1111/imr.12808
    Journal articles | 2019
    Dr Joanne Reed
    Skvortsova K; Masle-Farquhar E; Luu PL; Song JZ; Qu W; Zotenko E; Gould CM; Du Q; Peters TJ; Colino-Sanguino Y; Pidsley R; Nair SS; Khoury A; Smith GC; Miosge LA; Reed JH; Kench JG; Rubin MA; Horvath L; Bogdanovic O; Lim SM; Polo JM; Goodnow CC; Stirzaker C; Clark SJ, 2019, 'DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns', Cancer Cell, vol. 35, pp. 297 - 314.e8, http://dx.doi.org/10.1016/j.ccell.2019.01.004
    Journal articles | 2018
    Dr Joanne Reed
    Wang JJ; Reed JH; Colella AD; Russell AJ; Murray-Brown W; Chataway TK; Jackson KJL; Goodnow CC; Gordon TP, 2018, 'Molecular Profiling and Clonal Tracking of Secreted Rheumatoid Factors in Primary Sjögren's Syndrome', Arthritis and Rheumatology, vol. 70, pp. 1617 - 1625, http://dx.doi.org/10.1002/art.40539
    Journal articles | 2018
    Dr Joanne Reed
    Burnett DL; Langley DB; Schofield P; Hermes JR; Chan TD; Jackson J; Bourne K; Reed JH; Patterson K; Porebski BT; Brink R; Christ D; Goodnow CC, 2018, 'Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination', Science, vol. 360, pp. 223 - 226, http://dx.doi.org/10.1126/science.aao3859
    Journal articles | 2018
    Dr Joanne Reed
    Rizzetto S; Koppstein DNP; Samir J; Singh M; Reed JH; Cai CH; Lloyd AR; Eltahla AA; Goodnow CC; Luciani F, 2018, 'B-cell receptor reconstruction from single-cell RNA-seq with VDJPuzzle', Bioinformatics (Oxford, England), vol. 34, pp. 2846 - 2847, http://dx.doi.org/10.1093/bioinformatics/bty203
    Journal articles | 2017
    Dr Joanne Reed
    Reed JH; Gorny MK; Li L; Cardozo T; Buyon JP; Clancy RM, 2017, 'Ro52 autoantibodies arise from self-reactive progenitors in a mother of a child with neonatal lupus', Journal of Autoimmunity, vol. 79, pp. 99 - 104, http://dx.doi.org/10.1016/j.jaut.2017.01.004
    Journal articles | 2017
    Dr Joanne Reed
    Rizzetto S; Koppstein DNP; Samir J; Singh M; Reed J; Cai C; Lloyd A; Eltahla A; Goodnow C; Luciani F, 2017, 'B-cell receptor reconstruction from single-cell RNA-seq with VDJPuzzle', , http://dx.doi.org/10.1101/181156
    Journal articles | 2016
    Dr Joanne Reed
    Wang JJ; Al Kindi MA; Colella AD; Dykes L; Jackson MW; Chataway TK; Reed JH; Gordon TP, 2016, 'IgV peptide mapping of native Ro60 autoantibody proteomes in primary Sjögren's syndrome reveals molecular markers of Ro/La diversification', Clinical Immunology, vol. 173, pp. 57 - 63, http://dx.doi.org/10.1016/j.clim.2016.09.001
    Journal articles | 2016
    Dr Joanne Reed
    Reed JH; Gordon TP, 2016, 'Autoimmunity: Ro60-associated RNA takes its toll on disease pathogenesis', Nature Reviews Rheumatology, vol. 12, pp. 136 - 138, http://dx.doi.org/10.1038/nrrheum.2015.148
    Journal articles | 2016
    Dr Joanne Reed
    Sabouri Z; Perotti S; Spierings E; Humburg P; Yabas M; Bergmann H; Horikawa K; Roots C; Lambe S; Young C; Andrews TD; Field M; Enders A; Reed JH; Goodnow CC, 2016, 'IgD attenuates the IgM-induced anergy response in transitional and mature B cells', Nature Communications, vol. 7, http://dx.doi.org/10.1038/ncomms13381
    Journal articles | 2016
    Dr Joanne Reed
    Clancy RM; Markham AJ; Reed JH; Blumenberg M; Halushka MK; Buyon JP, 2016, 'Targeting downstream transcription factors and epigenetic modifications following Toll-like receptor 7/8 ligation to forestall tissue injury in anti-Ro60 associated heart block', Journal of Autoimmunity, vol. 67, pp. 36 - 45, http://dx.doi.org/10.1016/j.jaut.2015.09.003
    Journal articles | 2016
    Dr Joanne Reed
    Grönwall C; Clancy RM; Getu L; Lloyd KA; Siegel DL; Reed JH; Buyon JP; Silverman GJ, 2016, 'Modulation of natural IgM autoantibodies to oxidative stress-related neo-epitopes on apoptotic cells in newborns of mothers with anti-Ro autoimmunity', Journal of Autoimmunity, vol. 73, pp. 30 - 41, http://dx.doi.org/10.1016/j.jaut.2016.05.014
    Journal articles | 2016
    Dr Joanne Reed
    Reed JH; Jackson J; Christ D; Goodnow CC, 2016, 'Clonal redemption of autoantibodies by somatic hypermutation away from self-reactivity during human immunization', Journal of Experimental Medicine, vol. 213, pp. 1255 - 1265, http://dx.doi.org/10.1084/jem.20151978
    Journal articles | 2013
    Dr Joanne Reed
    Briassouli P; Halushka MK; Reed JH; Molad Y; Fox-Talbot K; Buyon L; Guzman E; Ludomirsky A; Clancy RM; Buyon JP, 2013, 'A central role of plasmin in cardiac injury initiated by fetal exposure to maternal anti-Ro autoantibodies', Rheumatology (United Kingdom), vol. 52, pp. 1448 - 1453, http://dx.doi.org/10.1093/rheumatology/ket156
    Journal articles | 2013
    Dr Joanne Reed
    Reed JH; Jain M; Lee K; Kandimalla ER; Faridi MH; Buyon JP; Gupta V; Clancy RM, 2013, 'Complement receptor 3 influences toll-like receptor 7/8-dependent inflammation: Implications for autoimmune diseases characterized by antibody reactivity to ribonucleoproteins', Journal of Biological Chemistry, vol. 288, pp. 9077 - 9083, http://dx.doi.org/10.1074/jbc.M112.403303
    Journal articles | 2013
    Dr Joanne Reed
    Reed JH; Sim S; Wolin SL; Clancy RM; Buyon JP, 2013, 'Ro60 requires Y3 RNA for cell surface exposure and inflammation associated with cardiac manifestations of neonatal lupus', Journal of Immunology, vol. 191, pp. 110 - 116, http://dx.doi.org/10.4049/jimmunol.1202849
    Journal articles | 2012
    Dr Joanne Reed
    Reed JH; Clancy RM; Lee KH; Saxena A; Izmirly PM; Buyon JP, 2012, 'Umbilical cord blood levels of maternal antibodies reactive with p200 and full-length Ro 52 in the assessment of risk for cardiac manifestations of neonatal lupus', Arthritis Care and Research, vol. 64, pp. 1373 - 1381, http://dx.doi.org/10.1002/acr.21704
    Journal articles | 2011
    Dr Joanne Reed
    Lindop R; Arentz G; Chataway TK; Thurgood LA; Jackson MW; Reed JH; McCluskey J; Gordon TP, 2011, 'Molecular signature of a public clonotypic autoantibody in primary Sjögren's syndrome: A "forbidden" clone in systemic autoimmunity', Arthritis and Rheumatism, vol. 63, pp. 3477 - 3486, http://dx.doi.org/10.1002/art.30566
    Journal articles | 2011
    Dr Joanne Reed
    Reed JH; Clancy RM; Purcell AW; Kim MY; Gordon TP; Buyon JP, 2011, 'β2-glycoprotein I and protection from anti-SSA/Ro60- associated cardiac manifestations of neonatal lupus', Journal of Immunology, vol. 187, pp. 520 - 526, http://dx.doi.org/10.4049/jimmunol.1100122
    Journal articles | 2011
    Dr Joanne Reed
    Alvarez D; Briassouli P; Clancy RM; Zavadil J; Reed JH; Abellar RG; Halushka M; Fox-Talbot K; Barrat FJ; Buyon JP, 2011, 'A novel role of endothelin-1 in linking toll-like receptor 7-mediated inflammation to fibrosis in congenital heart block', Journal of Biological Chemistry, vol. 286, pp. 30444 - 30454, http://dx.doi.org/10.1074/jbc.M111.263657
    Journal articles | 2010
    Dr Joanne Reed
    Reed JH; Dudek NL; Osborne SE; Kaufman KM; Jackson MW; Purcell AW; Gordon TP, 2010, 'Reactivity with dichotomous determinants of Ro 60 stratifies autoantibody responses in lupus and primary Sjögren's syndrome', Arthritis and Rheumatism, vol. 62, pp. 1448 - 1456, http://dx.doi.org/10.1002/art.27370
    Journal articles | 2010
    Dr Joanne Reed
    Reed JH; Jackson MW; Gordon TP, 2010, 'Letter to the Editor', Lupus, vol. 19, pp. 107 - 108, http://dx.doi.org/10.1177/0961203309106764
    Journal articles | 2010
    Dr Joanne Reed
    Reed JH; Thurgood L; Gordon DL; Gordon TP, 2010, 'Differential activation of complement by apoptotic cells opsonized with anti-Ro60 and anti-la autoantibodies', Scandinavian Journal of Immunology, vol. 72, pp. 260 - 261, http://dx.doi.org/10.1111/j.1365-3083.2010.02420.x
    Journal articles | 2009
    Dr Joanne Reed
    Jackson MW; Spencer NJ; Reed JH; Smith AJF; Gordon TP, 2009, 'Potentiation of a functional autoantibody in narcolepsy by a cholinesterase inhibitor', Laboratory Investigation, vol. 89, pp. 1332 - 1339, http://dx.doi.org/10.1038/labinvest.2009.108
    Journal articles | 2009
    Dr Joanne Reed
    Reed J; Giannakopoulos B; Jackson M; Krilis S; Gordon T, 2009, 'Ro 60 functions as a receptor for β2-glycoprotein I on apoptotic cells', Arthritis Care & Research, vol. 60, pp. 860 - 869, http://dx.doi.org/10.1002/art.24361
    Journal articles | 2008
    Dr Joanne Reed
    Jackson MW; Reed JH; Smith AJF; Gordon TP, 2008, 'An autoantibody in narcolepsy disrupts colonic migrating motor complexes', Journal of Neuroscience, vol. 28, pp. 13303 - 13309, http://dx.doi.org/10.1523/JNEUROSCI.4489-08.2008
    Journal articles | 2008
    Dr Joanne Reed
    Reed JH; Jackson MW; Gordon TP, 2008, 'A B cell apotope of Ro 60 in systemic lupus erythematosus', Arthritis and Rheumatism, vol. 58, pp. 1125 - 1129, http://dx.doi.org/10.1002/art.23377
    Journal articles | 2008
    Dr Joanne Reed
    Reed JH; Jackson MW; Gordon TP, 2008, 'B cell apotopes of the 60-kDa Ro/SSA and La/SSB autoantigens', Journal of Autoimmunity, vol. 31, pp. 263 - 267, http://dx.doi.org/10.1016/j.jaut.2008.04.008
    Journal articles | 2007
    Dr Joanne Reed
    Reed JH; Neufing PJ; Jackson MW; Clancy RM; Macardle PJ; Buyon JP; Gordon TP, 2007, 'Different temporal expression of immunodominant Ro60/60 kDa-SSA and La/SSB apotopes', Clinical and Experimental Immunology, vol. 148, pp. 153 - 160, http://dx.doi.org/10.1111/j.1365-2249.2007.03331.x
  • Conference Papers | 2019
    Dr Joanne Reed
    Singh M; Jackson K; Wang JJ; Schofield P; Field M; Peters T; Luciani F; Gordon T; Goodnow C; Reed JH, 2019, '241 Single cell genomics of self-reactive B cells reveals the evolution from benign to pathogenic autoantibody and strategies for early diagnosis and personalised treatment', in Abstracts, Lupus Foundation of America, pp. a178.1 - a1a178, presented at 13th International Congress on Systemic Lupus Erythematosus (LUPUS 2019), San Francisco, California, USA, April 5–8, 2019, Abstract Presentations, http://dx.doi.org/10.1136/lupus-2019-lsm.241
    Conference Abstracts | 2019
    Dr Joanne Reed
    Wang JJ; Reed JH; Colella AD; Russell AJ; Murray-Brown W; Chataway TK; Jackson KJL; Goodnow CC; Gordon TP, 2019, 'Proteomic profiling and clonal tracking of secreted rheumatoid factors in primary Sjogren's syndrome', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY, Beijing, PEOPLES R CHINA, Vol. 49, pp. 776 - 777, presented at 17th International Congress of Immunology of the International-Union-of-Immunological-Societies (IUIS), Beijing, PEOPLES R CHINA, 19 October 2019 - 23 October 2019, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000490026902321&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2017
    Dr Joanne Reed
    Wang JJ; kindi MA; Colella A; Dykes L; Jackson M; Chataway T; Reed J; Gordon T, 2017, '330 Mass spectrometric sequencing of precipitating anti-ro reveals unique vh/vl peptide biomarkers', in Poster Session, Lupus Foundation of America, presented at LUPUS 2017 & ACA 2017, (12th International Congress on SLE &, 7th Asian Congress on Autoimmunity), http://dx.doi.org/10.1136/lupus-2017-000215.330
    Conference Papers | 2017
    Dr Joanne Reed
    Reed J; Gorny M; Li L; Cardozo T; Buyon J; Clancy R, 2017, '54 Ro52 autoantibodies arise from self-reactive progenitors in a mother of a child with neonatal lupus', in Poster Session, Lupus Foundation of America, presented at LUPUS 2017 & ACA 2017, (12th International Congress on SLE &, 7th Asian Congress on Autoimmunity), http://dx.doi.org/10.1136/lupus-2017-000215.54
    Conference Papers | 2012
    Dr Joanne Reed
    Lindop R; Arentz G; Thurgood LA; Reed JH; Jackson MW; Gordon TP, 2012, 'Pathogenicity and proteomic signatures of autoantibodies to Ro and La', in Immunology and Cell Biology, pp. 304 - 309, http://dx.doi.org/10.1038/icb.2011.108
    Conference Papers | 2008
    Dr Joanne Reed
    Jane AO; Szili EJ; Reed JH; Gordon TP; Voelcker NH, 2008, 'Porous silicon biosensor for the detection of autoimmune diseases', in Progress in Biomedical Optics and Imaging - Proceedings of SPIE, http://dx.doi.org/10.1117/12.759260

Awards

2017 - Lupus Travel Grant and Scientific Presentation Award
2017 - Young Garvan Award
2011 – Sjogren’s syndrome Foundation of America Outstanding Abstract Award
2009 – Australian Rheumatology Association New Investigator Award
2008/7/6 – Australian Rheumatology Association Philip Alper’s Prize and Travel Grant
2004 – Amgen Prize for best honours thesis in South Australia
2004 – Australian Biotechnology Association honours thesis prize
2004 – University Medal

Grants

2018 - NHMRC New Investigator Project Grant - Rogue B cell Clones in Patients with Autoimmune Disease

2018 - Rebecca L Cooper Project Grant - Targeting Rogue Clones in Systemic Autoimmune Rheumatic Diseases 

2017 - NSW Health Early to Mid Career Fellowship - Improving diagnosis and treatment of autoimmune disease by deep sequencing antibody repertoires

2016 - Arthritis Australia SA LSS Support Group Grant - Self-reactive immunoglobulin repertoires in Sjogren's syndrome and Lupus

2013 - Arthritis Foundation America Postdoctoral Fellowship - Role of IRF5 in mediating antibody induced tissue injury

2012 - American Heart Association Postdoctoral Fellowship - A protective role for beta2-glycoprotein I in anti-Ro60 and ssRNA mediated inflammation in congenital heart block

2010 - NHMRC CJ Martin Overseas Training Fellowship - Mechanisms of autoantibody-mediated tissue injury in congenital heart block

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