Mr Ngee Kiat   Chua
Casual Academic

Mr Ngee Kiat Chua

Science
Biotech & Biomolecular Science
Location
Level 3 West Bioscience South E26, Upper Kensington Campus

Publications

  • Journal articles | 2021
    Mr Ngee Kiat Chua
    Jun SY; Brown AJ; Chua NK; Yoon JY; Lee JJ; Yang JO; Jang IS; Jeon SJ; Choi TIK; Kim CH; Kim NS, 2021, 'Reduction of Squalene Epoxidase by Cholesterol Accumulation Accelerates Colorectal Cancer Progression and Metastasis', Gastroenterology, vol. 160, pp. 1194 - 1207.e28, http://dx.doi.org/10.1053/j.gastro.2020.09.009
    Journal articles | 2021
    Mr Ngee Kiat Chua
    Chua NK; Brown AJ, 2021, 'The Degron Architecture of Squalene Monooxygenase and How Specific Lipids Calibrate Levels of This Key Cholesterol Synthesis Enzyme', Adv Exp Med Biol, vol. 21, pp. 1 - 12, http://dx.doi.org/10.1007/5584_2020_583
    Journal articles | 2020
    Mr Ngee Kiat Chua
    Yoshioka H; Coates HW; Chua NK; Hashimoto Y; Brown AJ; Ohgane K, 2020, 'A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, pp. 7150 - 7158, http://dx.doi.org/10.1073/pnas.1915923117
    Journal articles | 2020
    Mr Ngee Kiat Chua
    Chua NK; Coates HW; Brown AJ, 2020, 'Squalene monooxygenase: a journey to the heart of cholesterol synthesis', Progress in Lipid Research, vol. 79, pp. 101033, http://dx.doi.org/10.1016/j.plipres.2020.101033
    Journal articles | 2020
    Mr Ngee Kiat Chua
    Simonen P; Li S; Chua NK; Lampi AM; Piironen V; Lommi J; Sinisalo J; Brown AJ; Ikonen E; Gylling H, 2020, 'Amiodarone disrupts cholesterol biosynthesis pathway and causes accumulation of circulating desmosterol by inhibiting 24-dehydrocholesterol reductase', Journal of Internal Medicine, vol. 288, pp. 560 - 569, http://dx.doi.org/10.1111/joim.13095
    Journal articles | 2020
    Mr Ngee Kiat Chua
    Chua NK; Brown AJ, 2020, 'Lipid sensing tips the balance for a key cholesterol synthesis enzyme', Journal of Lipid Research, vol. 61, pp. 1363, http://dx.doi.org/10.1194/jlr.ILR120000801
    Journal articles | 2019
    Mr Ngee Kiat Chua
    Coates HW; Chua NK; Brown AJ, 2019, 'Consulting prostate cancer cohort data uncovers transcriptional control: Regulation of the MARCH6 gene', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1864, pp. 1656 - 1668, http://dx.doi.org/10.1016/j.bbalip.2019.08.006
    Journal articles | 2019
    Mr Ngee Kiat Chua
    Chua NK; Scott NA; Brown AJ, 2019, 'Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron', Biochemical Journal, vol. 476, pp. 2545 - 2560, http://dx.doi.org/10.1042/BCJ20190418
    Journal articles | 2019
    Mr Ngee Kiat Chua
    Brown AJ; Chua NK; Yan N, 2019, 'The shape of human squalene epoxidase expands the arsenal against cancer', Nat Commun, vol. 10, pp. 888 - 888, http://dx.doi.org/10.1038/s41467-019-08866-y
    Journal articles | 2019
    Mr Ngee Kiat Chua
    Chua NK; Hart-Smith G; Brown AJ, 2019, 'Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase', Journal of Biological Chemistry, vol. 294, pp. 8134 - 8147, http://dx.doi.org/10.1074/jbc.RA119.007798
    Journal articles | 2018
    Mr Ngee Kiat Chua
    Chua NK; Brown AJ, 2018, 'Mallostery: Filling a niche between quality and metabolic control', Journal of Biological Chemistry, vol. 293, pp. 14951 - 14952, http://dx.doi.org/10.1074/jbc.H118.005031
    Journal articles | 2018
    Mr Ngee Kiat Chua
    Chua NK; Howe V; Jatana N; Thukral L; Brown AJ, 2018, 'A Conserved Degron Containing an Amphipathic Helix Regulates the Cholesterol‐Mediated Turnover of Human Squalene Monooxygenase, a Rate‐Limiting Enzyme in Cholesterol Synthesis', The FASEB Journal, vol. 32, pp. 539.4 - 539.4, http://dx.doi.org/10.1096/fasebj.2018.32.1_supplement.539.4
    Journal articles | 2018
    Mr Ngee Kiat Chua
    Chua NK; Brown AJ, 2018, 'Correction: Mallostery: Filling a niche between quality and metabolic control.', Journal of Biological Chemistry, vol. 293, pp. 16176, http://dx.doi.org/10.1074/jbc.AAC118.006017
    Journal articles | 2018
    Mr Ngee Kiat Chua
    Chua NK; Coates HW; Brown AJ, 2018, 'Cholesterol, cancer, and rebooting a treatment for athlete’s foot', Science Translational Medicine, vol. 10, http://dx.doi.org/10.1126/scitranslmed.aat3741
    Journal articles | 2017
    Mr Ngee Kiat Chua
    Chua NK; Howe V; Jatana N; Thukral L; Brown AJ, 2017, 'A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis', Journal of Biological Chemistry, vol. 292, pp. 19959 - 19973, http://dx.doi.org/10.1074/jbc.M117.794230
    Journal articles | 2016
    Mr Ngee Kiat Chua
    Howe V; Sharpe LJ; Alexopoulos SJ; Kunze SV; Chua NK; Li D; Brown AJ, 2016, 'Cholesterol homeostasis: How do cells sense sterol excess?', Chemistry and Physics of Lipids, vol. 199, pp. 170 - 178, http://dx.doi.org/10.1016/j.chemphyslip.2016.02.011
    Journal articles | 2015
    Mr Ngee Kiat Chua
    Howe V; Chua NK; Stevenson J; Brown AJ, 2015, 'The regulatory domain of squalene monooxygenase contains a re-entrant loop and senses cholesterol via a conformational change', Journal of Biological Chemistry, vol. 290, pp. 27533 - 27544, http://dx.doi.org/10.1074/jbc.M115.675181
  • Conference Abstracts | 2020
    Mr Ngee Kiat Chua
    Chua N; Howe V; Jatana N; Hart-Smith G; Scott N; Thukral L; Brown A, 2020, 'Squalene Monooxygenase at the Nexus between Cholesterol Homeostasis and Proteostasis', in FASEB JOURNAL, WILEY, San Diego, CA, Vol. 34, presented at Annual Meeting on Experimental Biology, San Diego, CA, 04 April 2020 - 07 April 2020, http://dx.doi.org/10.1096/fasebj.2020.34.s1.03280
    Conference Papers | 2019
    Mr Ngee Kiat Chua
    Jun SY; Brown AJ; Yoon J-Y; Lee J-J; Chua NK; Yang JOK; Min J-S; Jang I; Jeon S-J; Choi M-H; Choi T-I; Kim C-H; Kim N-S, 2019, 'Abstract 2769: A squalene epoxidase-cholesterolaxis drives colorectal cancer progression and metastatic dissemination', in Tumor Biology, American Association for Cancer Research, presented at Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA, http://dx.doi.org/10.1158/1538-7445.am2019-2769
    Conference Abstracts | 2019
    Mr Ngee Kiat Chua
    Jun SY; Brown AJ; Yoon J-Y; Lee J-J; Chua NK; Yang JOK; Min J-S; Jang I; Jeon S-J; Choi M-H; Choi T-I; Kim C-H; Kim N-S, 2019, 'A squalene epoxidase-cholesterolaxis drives colorectal cancer progression and metastatic dissemination', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Atlanta, GA, Vol. 79, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), Atlanta, GA, 29 March 2019 - 03 April 2019, http://dx.doi.org/10.1158/1538-7445.SABCS18-2769

Awards

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