Mr Ngee Kiat Chua

Jun SY; Brown AJ; Chua NK; Yoon JY; Lee JJ; Yang JO; Jang IS; Jeon SJ; Choi TIK; Kim CH; Kim NS, 2021, 'Reduction of Squalene Epoxidase by Cholesterol Accumulation Accelerates Colorectal Cancer Progression and Metastasis', Gastroenterology, vol. 160, pp. 1194 - 1207.e28, http://dx.doi.org/10.1053/j.gastro.2020.09.009

Chua NK; Brown AJ, 2021, 'The Degron Architecture of Squalene Monooxygenase and How Specific Lipids Calibrate Levels of This Key Cholesterol Synthesis Enzyme', Adv Exp Med Biol, vol. 21, pp. 1 - 12, http://dx.doi.org/10.1007/5584_2020_583

Yoshioka H; Coates HW; Chua NK; Hashimoto Y; Brown AJ; Ohgane K, 2020, 'A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, pp. 7150 - 7158, http://dx.doi.org/10.1073/pnas.1915923117

Chua NK; Coates HW; Brown AJ, 2020, 'Squalene monooxygenase: a journey to the heart of cholesterol synthesis', Progress in Lipid Research, vol. 79, pp. 101033, http://dx.doi.org/10.1016/j.plipres.2020.101033

Simonen P; Li S; Chua NK; Lampi AM; Piironen V; Lommi J; Sinisalo J; Brown AJ; Ikonen E; Gylling H, 2020, 'Amiodarone disrupts cholesterol biosynthesis pathway and causes accumulation of circulating desmosterol by inhibiting 24-dehydrocholesterol reductase', Journal of Internal Medicine, vol. 288, pp. 560 - 569, http://dx.doi.org/10.1111/joim.13095

Chua NK; Brown AJ, 2020, 'Lipid sensing tips the balance for a key cholesterol synthesis enzyme', Journal of Lipid Research, vol. 61, pp. 1363, http://dx.doi.org/10.1194/jlr.ILR120000801

Coates HW; Chua NK; Brown AJ, 2019, 'Consulting prostate cancer cohort data uncovers transcriptional control: Regulation of the MARCH6 gene', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1864, pp. 1656 - 1668, http://dx.doi.org/10.1016/j.bbalip.2019.08.006

Chua NK; Scott NA; Brown AJ, 2019, 'Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron', Biochemical Journal, vol. 476, pp. 2545 - 2560, http://dx.doi.org/10.1042/BCJ20190418

Brown AJ; Chua NK; Yan N, 2019, 'The shape of human squalene epoxidase expands the arsenal against cancer', Nat Commun, vol. 10, pp. 888 - 888, http://dx.doi.org/10.1038/s41467-019-08866-y

Chua NK; Hart-Smith G; Brown AJ, 2019, 'Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase', Journal of Biological Chemistry, vol. 294, pp. 8134 - 8147, http://dx.doi.org/10.1074/jbc.RA119.007798

Chua NK; Brown AJ, 2018, 'Mallostery: Filling a niche between quality and metabolic control', Journal of Biological Chemistry, vol. 293, pp. 14951 - 14952, http://dx.doi.org/10.1074/jbc.H118.005031

Chua NK; Howe V; Jatana N; Thukral L; Brown AJ, 2018, 'A Conserved Degron Containing an Amphipathic Helix Regulates the Cholesterol‐Mediated Turnover of Human Squalene Monooxygenase, a Rate‐Limiting Enzyme in Cholesterol Synthesis', The FASEB Journal, vol. 32, pp. 539.4 - 539.4, http://dx.doi.org/10.1096/fasebj.2018.32.1_supplement.539.4

Chua NK; Brown AJ, 2018, 'Correction: Mallostery: Filling a niche between quality and metabolic control.', Journal of Biological Chemistry, vol. 293, pp. 16176, http://dx.doi.org/10.1074/jbc.AAC118.006017

Chua NK; Coates HW; Brown AJ, 2018, 'Cholesterol, cancer, and rebooting a treatment for athlete’s foot', Science Translational Medicine, vol. 10, http://dx.doi.org/10.1126/scitranslmed.aat3741

Chua NK; Howe V; Jatana N; Thukral L; Brown AJ, 2017, 'A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis', Journal of Biological Chemistry, vol. 292, pp. 19959 - 19973, http://dx.doi.org/10.1074/jbc.M117.794230

Howe V; Sharpe LJ; Alexopoulos SJ; Kunze SV; Chua NK; Li D; Brown AJ, 2016, 'Cholesterol homeostasis: How do cells sense sterol excess?', Chemistry and Physics of Lipids, vol. 199, pp. 170 - 178, http://dx.doi.org/10.1016/j.chemphyslip.2016.02.011

Howe V; Chua NK; Stevenson J; Brown AJ, 2015, 'The regulatory domain of squalene monooxygenase contains a re-entrant loop and senses cholesterol via a conformational change', Journal of Biological Chemistry, vol. 290, pp. 27533 - 27544, http://dx.doi.org/10.1074/jbc.M115.675181

Chua N; Howe V; Jatana N; Hart-Smith G; Scott N; Thukral L; Brown A, 2020, 'Squalene Monooxygenase at the Nexus between Cholesterol Homeostasis and Proteostasis', in FASEB JOURNAL, WILEY, San Diego, CA, Vol. 34, presented at Annual Meeting on Experimental Biology, San Diego, CA, 04 April 2020 - 07 April 2020, http://dx.doi.org/10.1096/fasebj.2020.34.s1.03280

Jun SY; Brown AJ; Yoon J-Y; Lee J-J; Chua NK; Yang JOK; Min J-S; Jang I; Jeon S-J; Choi M-H; Choi T-I; Kim C-H; Kim N-S, 2019, 'Abstract 2769: A squalene epoxidase-cholesterolaxis drives colorectal cancer progression and metastatic dissemination', in Tumor Biology, American Association for Cancer Research, presented at Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA, http://dx.doi.org/10.1158/1538-7445.am2019-2769

Jun SY; Brown AJ; Yoon J-Y; Lee J-J; Chua NK; Yang JOK; Min J-S; Jang I; Jeon S-J; Choi M-H; Choi T-I; Kim C-H; Kim N-S, 2019, 'A squalene epoxidase-cholesterolaxis drives colorectal cancer progression and metastatic dissemination', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Atlanta, GA, Vol. 79, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), Atlanta, GA, 29 March 2019 - 03 April 2019, http://dx.doi.org/10.1158/1538-7445.SABCS18-2769