Dr Nicola Lee
Conjoint Lecturer

Dr Nicola Lee

PhD, Faculty of Medicine, UNSW 2009

Graduate Certificate in Research Management and Commercialisation, Faculty of Business, UNSW 2009

BSc/BA, Victoria University of Wellington, NZ 1999

Medicine & Health
School of Clinical Medicine

Dr Lee is a Senior Research Officer in the Eating Disorders Group at the Garvan Institute of Medical Research.

  • Journal articles | 2022
    Qi Y; Lee NJ; Ip CK; Enriquez R; Tasan R; Zhang L; Herzog H, 2022, 'NPY derived from AGRP neurons controls feeding via Y1 and energy expenditure and food foraging behaviour via Y2 signalling', Molecular Metabolism, vol. 59, pp. 101455, http://dx.doi.org/10.1016/j.molmet.2022.101455
    Journal articles | 2021
    Enriquez RF; Lee NJ; Herzog H, 2021, 'AgRP signalling negatively regulates bone mass', Journal of Neuroendocrinology, vol. 33, http://dx.doi.org/10.1111/jne.12978
    Journal articles | 2021
    Lee NJ; Herzog H, 2021, 'Coordinated regulation of energy and glucose homeostasis by insulin and the NPY system', Journal of Neuroendocrinology, vol. 33, pp. e12925, http://dx.doi.org/10.1111/jne.12925
    Journal articles | 2021
    Zhang L; Koller J; Ip CK; Gopalasingam G; Bajaj N; Lee NJ; Enriquez RF; Herzog H, 2021, 'Lack of neuropeptide FF signalling in mice leads to reduced repetitive behavior, altered drinking behavior, and fuel type selection', FASEB Journal, vol. 35, pp. e21980, http://dx.doi.org/10.1096/fj.202100703R
    Journal articles | 2020
    Lee NJ; Qi Y; Enriquez RF; Clarke I; Ip CK; Wee N; Baldock PA; Herzog H, 2020, 'Energy partitioning between fat and bone mass is controlled via a hypothalamic leptin/NPY relay', International Journal of Obesity, vol. 44, pp. 2149 - 2164, http://dx.doi.org/10.1038/s41366-020-0550-6
    Journal articles | 2020
    Lee NJ; Qi Y; Enriquez RF; Ip CK; Herzog H, 2020, 'Lack of NPY in neurotensin neurons leads to a lean phenotype', Neuropeptides, vol. 80, http://dx.doi.org/10.1016/j.npep.2019.101994
    Journal articles | 2019
    Ip CK; Zhang L; Farzi A; Qi Y; Clarke I; Reed F; Shi YC; Enriquez R; Dayas C; Graham B; Begg D; Brüning JC; Lee NJ; Hernandez-Sanchez D; Gopalasingam G; Koller J; Tasan R; Sperk G; Herzog H, 2019, 'Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions', Cell Metabolism, vol. 30, pp. 111 - 128.e6, http://dx.doi.org/10.1016/j.cmet.2019.04.001
    Journal articles | 2019
    Lee NJ; Ali N; Zhang L; Qi Y; Clarke I; Enriquez RF; Brzozowska M; Lee IC; Rogers MJ; Laybutt DR; Center JR; Baldock PA; Herzog H, 2019, 'Osteoglycin, a novel coordinator of bone and glucose homeostasis', Obesity Research & Clinical Practice, vol. 13, pp. 256 - 256, http://dx.doi.org/10.1016/j.orcp.2018.11.063
    Journal articles | 2019
    Lee NJ; Clarke IM; Zengin A; Enriquez RF; Nagy V; Penninger JM; Baldock PA; Herzog H, 2019, 'RANK deletion in neuropeptide Y neurones attenuates oestrogen deficiency-related bone loss', Journal of Neuroendocrinology, vol. 31, pp. e12687, http://dx.doi.org/10.1111/jne.12687
    Journal articles | 2019
    Yue Q; Lee N; Zhang L; Enriquez R; Herzog H, 2019, 'Distinct populations of Arc NPY neurons control specific aspects of energy homeostasis', Obesity Research & Clinical Practice, vol. 13, pp. 277 - 277, http://dx.doi.org/10.1016/j.orcp.2018.11.123
    Journal articles | 2018
    Lee NJ; Ali N; Qi J; Clarke RF; Enriquez RF; Brzozowska M; Lee IC; Rogers MJ; Laybutt DR; Center JR; Baldock PA; Herzog H, 2018, 'Osteoglycin, an Osteoblast-derived Regulator of Bone Mass and Glucose Homeostasis', Molecular Metabolism, vol. 13, pp. 30 - 44, http://dx.doi.org/10.1016/j.molmet.2018.05.004
    Journal articles | 2018
    Lee NJ; Clarke IM; Enriquez RF; Nagy V; Penninger J; Baldock PA; Herzog H, 2018, 'Central RANK signalling in NPY neurons alters bone mass in male mice', Neuropeptides, vol. 68, pp. 75 - 83, http://dx.doi.org/10.1016/j.npep.2018.02.004
    Journal articles | 2018
    Nguyen AD; Lee NJ; Wee NKY; Zhang L; Enriquez RF; Khor EC; Nie T; Wu D; Sainsbury A; Baldock PA; Herzog H, 2018, 'Uncoupling protein-1 is protective of bone mass under mild cold stress conditions', Bone, vol. 106, pp. 167 - 178, http://dx.doi.org/10.1016/j.bone.2015.05.037
    Journal articles | 2018
    Zhang L; Ip CK; Lee ICJ; Qi Y; Reed F; Karl T; Low JK; Enriquez RF; Lee NJ; Baldock PA; Herzog H, 2018, 'Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-06462-0
    Journal articles | 2016
    Baldock PA; Lee NJ; Laybutt R; Herzog H, 2016, 'The role of NPY in obesity-induced bone loss', Neuropeptides, vol. 55, pp. 7 - 7, http://dx.doi.org/10.1016/j.npep.2015.11.016
    Journal articles | 2016
    Khor E-C; Yulyaningsih E; Lee NJ; Driessler F; Kovaĉić N; Wee NKY; Kulkarni RN; Enriquez RF; Xu J; Zhang L; Herzog H; Baldock PA, 2016, 'The y6 receptor suppresses bone resorption and stimulates bone formation in mice', Neuropeptides, vol. 55, pp. 24 - 24, http://dx.doi.org/10.1016/j.npep.2015.11.068
    Journal articles | 2016
    Khor EC; Fanshawe B; Qi Y; Zolotukhin S; Kulkarni RN; Enriquez RF; Purtell L; Lee NJ; Wee NK; Croucher PI; Campbell L; Herzog H; Baldock PA, 2016, 'Prader-willi critical region, a non-translated, imprinted central regulator of bone mass: Possible role in skeletal abnormalities in Prader-Willi Syndrome', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0148155
    Journal articles | 2016
    Khor EC; Yulyaningsih E; Driessler F; Kovaĉić N; Wee NKY; Kulkarni RN; Lee NJ; Enriquez RF; Xu J; Zhang L; Herzog H; Baldock PA, 2016, 'The y6 receptor suppresses bone resorption and stimulates bone formation in mice via a suprachiasmatic nucleus relay', Bone, vol. 84, pp. 139 - 147, http://dx.doi.org/10.1016/j.bone.2015.12.011
    Journal articles | 2016
    Qi Y; Purtell L; Fu M; Lee NJ; Aepler J; Zhang L; Loh K; Enriquez RF; Baldock PA; Zolotukhin S; Campbell LV; Herzog H, 2016, 'Snord116 is critical in the regulation of food intake and body weight', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep18614
    Journal articles | 2015
    Lee NJ; Nguyen AD; Enriquez RF; Luzuriaga J; Bensellam M; Laybutt R; Baldock PA; Herzog H, 2015, 'NPY signalling in early osteoblasts controls glucose homeostasis', Molecular Metabolism, vol. 4, pp. 164 - 174, http://dx.doi.org/10.1016/j.molmet.2014.12.010
    Journal articles | 2014
    Baldock PA; Lin S; Zhang L; Karl T; Shi Y; Driessler F; Zengin A; Hörmer B; Lee NJ; Wong IPL; Lin EJD; Enriquez RF; Stehrer B; During MJ; Yulyaningsih E; Zolotukhin S; Ruohonen ST; Savontaus E; Sainsbury A; Herzog H, 2014, 'Neuropeptide Y attenuates stress-induced bone loss through suppression of noradrenaline circuits', Journal of Bone and Mineral Research, vol. 29, pp. 2238 - 2249, http://dx.doi.org/10.1002/jbmr.2205
    Journal articles | 2014
    Nguyen AD; Slack K; Schwarzer C; Lee NJ; Boey D; Macia L; Yulyaningsih E; Enriquez RF; Zhang L; Lin S; Shi YC; Baldock PA; Herzog H; Sainsbury A, 2014, 'Double deletion of orexigenic neuropeptide Y and dynorphin results in paradoxical obesity in mice', Neuropeptides, vol. 48, pp. 143 - 151, http://dx.doi.org/10.1016/j.npep.2014.03.001
    Journal articles | 2009
    Baldock PA; Lee NJ; Driessler F; Lin S; Allison SJ; Stehrer B; Enriquez R; Zhang L; Lin E; Wong I; Mcdonald M; During M; Pierroz D; Slack K; Shi Y; Yulyaningsih E; Aljanova A; Little DG; Ferrari S; Sainsbury-Salis A; Eisman JA; Herzog H, 2009, 'Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to body weight', PLoS Clinical Trials, vol. 4, pp. e8415 - e, http://dx.doi.org/10.1371/journal.pone.0008415
    Journal articles | 2009
    Lee NJ; Herzog H, 2009, 'NPY regulation of bone remodelling', Neuropeptides, vol. 43, pp. 457 - 463, http://dx.doi.org/10.1016/j.npep.2009.08.006
    Journal articles | 2008
    Boey D; Lin S; Enriquez R; Lee NJ; Slack K; Couzens M; Baldock PA; Herzog H; Sainsbury-Salis A, 2008, 'PYY transgenic mice are protected against diet-induced and genetic obesity', Neuropeptides, vol. 42, pp. 19 - 30, http://dx.doi.org/10.1016/j.npep.2007.11.003
    Journal articles | 2007
    Baldock P; Allison SJ; Lundberg P; Lee NJ; Slack K; Lin E; Enriquez R; Mcdonald M; Eisman JA; Little DG; During M; Zhang L; Gardiner EM; Yulyaningsih E; Lin S; Sainsbury A; Herzog H, 2007, 'Novel role of Y1 receptors in the coordinated regulation of bone and energy homeostasis', The Journal of Biological Chemistry, vol. 282, pp. 19092 - 19102, http://dx.doi.org/10.1074/jbc.M700644200
    Journal articles | 2007
    Johnen H; Lin S; Kuffner T; Brown DA; Tsai V; Bauskin AR; Wu L; Pankhurst G; Jiang L; Junankar S; Hunter M; Fairlie WD; Lee NJ; Enriquez R; Baldock P; Corey E; Apple F; Murakami M; Lin E; Wang CC; During M; Sainsbury A; Herzog H; Breit SN, 2007, 'Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1', Nature Medicine, vol. 13, pp. 1333 - 1340, http://dx.doi.org/10.1038/nm1677
    Journal articles | 2007
    Lin S; Lin E; Boey D; Lee NJ; Slack K; During M; Sainsbury A; Herzog H, 2007, 'Fasting inhibits the growth and reproductive axes via distinct Y2 and Y4 receptor-mediated pathways', Endocrinology, vol. 148, pp. 2056 - 2065, http://dx.doi.org/10.1210/en.2006-1408
    Journal articles | 2007
    Lundberg P; Allison SJ; Lee NJ; Baldock P; Brouard N; Rost S; Enriquez R; Sainsbury A; Lamghari M; Simmons P; Eisman JA; Gardiner EM; Herzog H, 2007, 'Greater bone formation of Y2 knockout mice is associated with increased osteoprogenitor numbers and altered Y1 receptor expression', The Journal of Biological Chemistry, vol. 282, pp. 19082 - 19091, http://dx.doi.org/10.1074/jbc.M609629200
    Journal articles | 2007
    Sainsbury A; Lin S; McNamara K; Slack K; Enriquez R; Lee NJ; Boey D; Smythe GA; Schwarzer C; Baldock P; Karl T; Lin E; Couzens M; Herzog H, 2007, 'Dynorphin knockout reduces fat mass and increases weight loss during fasting in mice', Molecular Endocrinology, vol. 21, pp. 1722 - 1735, http://dx.doi.org/10.1210/me.2006-0367
    Journal articles | 2006
    Allison SJ; Baldock P; Sainsbury A; Enriquez R; Lee NJ; Lin E; Klugman M; During M; Eisman JA; Li M; Pan L; Herzog H; Gardiner EM, 2006, 'Conditional deletion of hypothalamic Y2 receptors reverts gonadectomy-induced bone loss in adult mice', The Journal of Biological Chemistry, vol. 281, pp. 23436 - 23444, http://dx.doi.org/10.1074/jbc.M604839200
    Journal articles | 2006
    Allison SJ; Baldock P; Sainsbury A; Enriquez R; Lee NJ; Lin EJD; Klugmann M; During M; Eisman JA; Li M; Pan LC; Herzog H; Gardiner EM, 2006, 'Erratum: Conditional deletion of hypothalamic Y2 receptors reverts gonadectomy-induced bone loss in adult mice (Journal of Biological Chemistry (2006) 281, (23436-23444))', Journal of Biological Chemistry, vol. 281, pp. 38966
    Journal articles | 2006
    Arsov T; Silva D; O Bryan M; Sainsbury A; Lee NJ; Kennedy C; Manji S; Nelms K; Liu C; Vinuesa C; de Kretser D, 2006, 'Fat Aussie - A new Alstrom syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis', Molecular Endocrinology, vol. 20, pp. 1610 - 1622, http://dx.doi.org/10.1210/me.2005-0494
    Journal articles | 2006
    Boey D; Lin SC; Karl T; Baldock P; Lee NJ; Enriquez R; Couzens M; Slack K; Dallmann R; Sainsbury A; Herzog H, 2006, 'Peptide YY ablation in mice leads to the development of hyperinsulinaemia and obesity', Diabetologia, vol. 49, pp. 1360 - 1370, http://dx.doi.org/10.1007/s00125-006-0237-0
    Journal articles | 2006
    Lin E; Lee NJ; Slack K; Karl T; Duffy L; O Brien E; Matsumoto I; Dedova I; Herzog H; Sainsbury-Salis A, 2006, 'Distinct endocrine effects of chronic haloperidol or risperidone administration in male rats', Neuropharmacology, vol. 51, pp. 1129 - 1136, http://dx.doi.org/10.1016/j.neuropharm.2006.07.006
    Journal articles | 2006
    Lin E; Sainsbury A; Lee NJ; Boey D; Couzens M; Enriquez R; Slack K; Bland R; During M; Herzog H, 2006, 'Combined deletion of Y1, Y2, and Y4 receptors prevents hypothalamic neuropeptide Y overexpression-induced hyperinsulinemia despite persistence of hyperphagia and obesity', Endocrinology, vol. 147, pp. 5094 - 5101, http://dx.doi.org/10.1210/en.2006-0097
    Journal articles | 2006
    Lin S; Boey D; Lee NJ; Schwarzer C; Sainsbury-Salis A; Herzog H, 2006, 'Distribution of prodynorphin mRNA and its interaction with the NPY system in the mouse brain', Neuropeptides, vol. 40, pp. 115 - 123, http://dx.doi.org/10.1016/j.npep.2005.11.006
    Journal articles | 2006
    Sainsbury A; Bergen H; Boey D; Bamming D; Cooney GJ; Lin S; Couzens M; Stroth N; Lee NJ; Lindner D; Singewald N; Karl T; Dury L; Enriquez R; Slack K; Sperk G; Herzog H, 2006, 'Y2Y4 receptor double knockout protects against obesity due to a high-fat diet or Y1 receptor deficiency in mice', Diabetes, vol. 55, pp. 19 - 26, http://dx.doi.org/10.2337/diabetes.55.01.06.db05-0472
    Journal articles | 2006
    Sainsbury A; Bergen HT; Boey D; Bamming D; Cooney GJ; Lin S; Couzens M; Stroth N; Lee NJ; Lindner D; Singewald N; Karl T; Duffy L; Enriquez R; Slack K; Sperk G; Herzog H, 2006, 'Y2Y4 Receptor Double Knockout Protects Against Obesity Due to a High-Fat Diet or Y1 Receptor Deficiency in Mice', Diabetes, vol. 55, pp. 19 - 26, http://dx.doi.org/10.2337/diabetes.55.01.06.db05-0472
    Journal articles | 2005
    Lin S; Boey D; Couzens M; Lee NALNA; Sainsbury A; Herzog H, 2005, 'Compensatory changes in [125I]-PYY binding in Y receptor knockout mice suggest the potential existence of further Y receptor(s)', Neuropeptides, vol. 39, pp. 21 - 28, http://dx.doi.org/10.1016/j.npep.2004.10.002
    Journal articles | 2004
    Lee NJ; Rigby RJ; Gill H; Boyle JJ; Fossati-Jimack L; Morley BJ; Vyse TJ, 2004, 'Multiple loci are linked with anti-red blood cell antibody production in NZB mice - Comparison with other phenotypes implies complex modes of action', Clinical and Experimental Immunology, vol. 138, pp. 39 - 46, http://dx.doi.org/10.1111/j.1365-2249.2004.02560.x
  • Conference Papers | 2020
    Akter N; Young J; Lee N; Roy M, 2020, '3D reconstruction of retinal vascular structure from 2D OCT-a images for glaucoma diagnosis', in Optics InfoBase Conference Papers
    Conference Papers | 2017
    Lee NJ; Clarke I; Enriquez RF; Brzozowska M; Ali N; Zhang L; Lee IC; Laybutt DR; Rogers M; Center J; Herzog H; Baldock P, 2017, 'Osteoglycin, an Osteoblast-derived Regulator of Bone Mass and Glucose Homeostasis', in JOURNAL OF BONE AND MINERAL RESEARCH, WILEY, . Denver, Colorado, USA., pp. S68 - S68, presented at American Society for Bone and Mineral Research (ASBMR) 2017 Annual Meeting, . Denver, Colorado, USA., 08 September 2017 - 11 September 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000418869200202&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Conference Papers | 2012
    Lee N; Sainsbury A; Herzog H; Baldock P, 2012, 'Osteoblasts regulate glucose homeostasis through cell-specific neuropeptide signalling', in BONE, ELSEVIER SCIENCE INC, Stockholm, SWEDEN, pp. S62 - S63, presented at 39th Annual Congress of the European-Calcified-Tissue-Society (ECTS), Stockholm, SWEDEN, 19 May 2012 - 23 May 2012, http://dx.doi.org/10.1016/j.bone.2012.02.173
    Conference Papers | 2011
    Lee NJ; Driessler F; Zengin A; Wong IPL; Yulyaningsih E; Enriquez RF; Sainsbury A; Herzog H; Eisman JA; Baldock PA, 2011, 'Neuropeptide control of osteoclast activity', in BONE, ELSEVIER SCIENCE INC, Athens, GREECE, pp. S134 - S135, presented at 3rd Joint Meeting of the European-Calcified-Tissue-Society/International-Bone-and-Mineral-Society, Athens, GREECE, 07 May 2011 - 11 May 2011, http://dx.doi.org/10.1016/j.bone.2011.03.275
    Conference Papers | 2011
    Zengin A; Enriquez RF; Nguyen AD; Lee NJ; Sainsbury A; Herzog H; Eisman JA; Baldock PA, 2011, 'ANDROGENS ARE CRITICAL TO NEUROPEPTIDE Y MEDIATED CONTROL OF BONE FORMATION', in OSTEOPOROSIS INTERNATIONAL, SPRINGER LONDON LTD, Gold Coast, AUSTRALIA, pp. S521 - S521, presented at IOF Regionals 2nd Asia-Pacific Osteoporosis and Bone Meeting / ANZBMS Annual Scientific Meeting held with the JSBMR, Gold Coast, AUSTRALIA, 04 September 2011 - 08 September 2011, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000309258200043&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2011
    Zengin A; Enriquez RF; Nguyen AD; Lee NJ; Sainsbury A; Herzog H; Eisman JA; Baldock PA, 2011, 'Androgens are critical to neuropeptide Y mediated control of bone formation', in BONE, ELSEVIER SCIENCE INC, Athens, GREECE, pp. S102 - S103, presented at 3rd Joint Meeting of the European-Calcified-Tissue-Society/International-Bone-and-Mineral-Society, Athens, GREECE, 07 May 2011 - 11 May 2011, http://dx.doi.org/10.1016/j.bone.2011.03.158
    Conference Papers | 2009
    Baldock PA; Lee N; Lin S; Allison SJ; Enriquez RF; Sainsbury A; Herzog H; Eisman JA, 2009, 'Differential skeletal responses of Y1 and Y2 receptors to chronic stress', in BONE, ELSEVIER SCIENCE INC, Sydney, AUSTRALIA, pp. S57 - S57, presented at 2nd Joint Meeting of the International-Bone-and-Mineral-Society/Australian-New-Zealand-Bone-and-Mineral-Society, Sydney, AUSTRALIA, 21 March 2009 - 25 March 2009, http://dx.doi.org/10.1016/j.bone.2009.01.015
    Conference Papers | 2009
    Lee NJ; Enriquez RF; Nguyen AD; Doyle KL; Sainsbury A; Baldock PA; Herzog H, 2009, 'Osteoblast specific Y1 deletion enhances bone formation', in BONE, ELSEVIER SCIENCE INC, Sydney, AUSTRALIA, pp. S28 - S28, presented at 2nd Joint Meeting of the International-Bone-and-Mineral-Society/Australian-New-Zealand-Bone-and-Mineral-Society, Sydney, AUSTRALIA, 21 March 2009 - 25 March 2009, http://dx.doi.org/10.1016/j.bone.2009.01.066
    Conference Papers | 2008
    Lee NJ; Enriquez R; Boey D; Lin S; Slack K; Baldock P; Herzog H; Sainsbury-Salis A, 2008, 'Synergistic attenuation of obesity by Y2- and Y4-receptor double knockout in ob/ob mice', in Nutrition, Elsevier Science Inc, New York, NY, USA, pp. 892 - 899, presented at 9th Neuropeptide Y International Meeting 2008, Okinawa, JAPAN, 16 March 2008 - 19 March 2008, http://dx.doi.org/10.1016/j.nut.2008.06.019
    Preprints |
    Lee NJ; Ali N; Zhang L; Qi Y; Clarke I; Enriquez RF; Brzozowska M; C Lee I; Rogers MJ; Laybutt DR; Center JR; Baldock PA; Herzog H, Osteoglycin: A Novel Coordinator of Bone and Glucose Homeostasis, http://dx.doi.org/10.2139/ssrn.3155778

2018 - NHMRC Project Grant: Application Title: Central control of energy partitioning

2017 - Australia and New Zealand Bone and Mineral Society (ANZBMS) mid-career gap fellowship $20,000

2016 - Diabetes Australia project grant (DART) $60,000

2019    Best Poster Prize, 12th International NPY-PYY PP Meeting, July 30 2019, Edmonton, Canada     

2018    Australia and New Zealand Bone and Mineral Society (ANZBMS) Sol Posen Research Award $1,000

2016    Amgen-ANZBMS Outstanding Abstract Award, ESA/SRB/ANZBMS joint meeting, Gold Coast, Australia

2009    Roger Melick Young Investigator Award, Joint IBMS/ANZBMS Scientific Meeting, 21-25th March, Sydney, Australia

2008    ANZBMS Travel Grant to attend the 18th Annual Meeting of the ANZBMS, 28-30 August, Melbourne, Australia

2007    Commercialisation Training Scheme Scholarship for Graduate Certificate in Research Management and Commercialisation, UNSW

2007    Australian Stem Cell Centre Conference and Travel Grant to attend the International Society of Stem Cell Research (ISSCR) 5th Annual Meeting, 17-20 June 2007, Cairns, Australia

2006    Dora Lush Biomedical Postgraduate Scholarship, NHMRC

1998    Summer Research Scholarship, Australian National University

My research focuses on elucidating the neuropeptide pathways that regulate energy partitioning into fat and bone mass, to provide potential therapeutic avenues for individuals affected by both obesity and bone loss. Osteoporosis, obesity and diabetes are increasingly common as well as inter-related, and are in urgent need of more effective therapies. I have a strong belief in the view that furthering our understanding of complex diseases requires a multi-system approach. Throughout my career, my work has been focused on combining expertise across multiple disciplines and has made remarkable insights into our knowledge of the interactions between the brain, bone and metabolism.

My initial studies centered around the powerful NPY signaling pathways that integrate bone homeostasis with whole body energy and glucose balance. Exploring this entirely new paradigm of skeletal biology, I identified osteoglycin as a novel endocrine factor released from bone tissue which acts to regulate and integrate bone formation with glucose homeostasis. This discovery points to the importance of a new level of endocrine communication, acting between organ systems, and also reveals the skeleton as an origin of multiple signals that regulate energy and glucose homeostasis. The findings have revealed potential new methods for controlling bone mass, as well as fat mass and blood sugar levels and they represent a unique, cross-disciplinary approach with important implications for our understanding of the interconnectedness of whole-body homeostasis. 

More recently, my work has also focused on elucidating pathways that regulate energy partitioning with the overall aim of driving energy usage into the production of bone instead of fat. The predominant tissue to store excess energy is fat. However, increases in fat mass consequently lead to increases in body weight necessitating the readjustment of the skeleton to provide the necessary structural support to carry the extra weight. Deregulation of such processes has detrimental effects on the body leading to increased risk of fractures and immobility. While the concept of this regulation is known, the underlying mechanisms are not.