Dr Varun   Sreenivasan
Adjunct Lecturer

Dr Varun Sreenivasan

medicine-health
School of Medical Sciences

Dr. Sreenivasan obtained his Ph.D. in Physics from Macquarie University in Sydney, Australia in 2012. He completed his first post-doctoral training under the guidance of A/Prof. Brenda Farrell at the Bobby R Alford Department of Otolaryngology-Head & Neck Surgery at Baylor College of Medicine in Houston, USA. He returned to Macquarie University in 2013 after being awarded a Macquarie University Research Fellowship to develop novel ruby based photoluminescent nanoparticles for ultrasensitive long term imaging and tracking of GPCRs. Since 2016 his research is supported by the ARC DECRA fellowship. He joined the Single Molecule Science lab at the University of New South Wales in 2017, where his research is more focussed on intracellular molecular interactions that occur upon GPCR activation.

Publications

  • Book Chapters | 2021
    Dr Varun Sreenivasan
    Pillai R; Connor M; Sreenivasan VKA, 2021, 'Functionalization and bioconjugation of nanoruby for long-term, ultrasensitive imaging of Mu-opioid receptors', in Methods in Molecular Biology, pp. 59 - 70, http://dx.doi.org/10.1007/978-1-0716-0884-5_6
    Book Chapters | 2017
    Dr Varun Sreenivasan
    Rajasekharan V; Sreenivasan VKA; Farrell B, 2017, 'Force measurements for cancer cells', in Cancer Nanotechnology. Methods in Molecular Biology, Humana Press, New York, pp. 195 - 228, http://dx.doi.org/10.1007/978-1-4939-6646-2_12
    Book Chapters | 2015
    Dr Varun Sreenivasan
    Zvyagin AV; Sreenivasan VKA; Goldys EM; Panchenko VY; Deyev SM, 2015, 'Photoluminescent hybrid inorganic-protein nanostructures for imaging and sensing in vivo and in vitro', in RSC Smart Materials, edn. 16, pp. 245 - 284, http://dx.doi.org/10.1039/9781782622109-00245
    Book Chapters | 2013
    Dr Varun Sreenivasan
    Zvyagin AV; Song Z; Nadort A; Sreenivasan VKA; Deyev SM, 2013, 'Luminescent nanomaterials for molecular-specific cellular imaging', in Handbook of Nano-Optics and Nanophotonics, pp. 563 - 596, http://dx.doi.org/10.1007/978-3-642-31066-9_15
  • Journal articles | 2020
    Dr Varun Sreenivasan
    Gillis A; Sreenivasan V; Christie MJ, 2020, 'Intrinsic efficacy of opioid ligands and its importance for apparent bias, operational analysis, and therapeutic window', Molecular Pharmacology, vol. 98, pp. 410 - 424, http://dx.doi.org/10.1124/mol.119.119214
    Journal articles | 2020
    Dr Varun Sreenivasan
    Sreenivasan VKA; Graus MS; Pillai RR; Yang Z; Goyette J; Gaus K, 2020, 'Influence of FRET and fluorescent protein maturation on the quantification of binding affinity with dual-channel fluorescence cross-correlation spectroscopy', Biomedical Optics Express, vol. 11, pp. 6137 - 6153, http://dx.doi.org/10.1364/BOE.401056
    Journal articles | 2018
    Dr Varun Sreenivasan
    Yellin F; Li Y; Sreenivasan VKA; Farrell B; Johny MB; Yue D; Sun SX, 2018, 'Electromechanics and Volume Dynamics in Nonexcitable Tissue Cells', Biophysical Journal, vol. 114, pp. 2231 - 2242, http://dx.doi.org/10.1016/j.bpj.2018.03.033
    Journal articles | 2017
    Dr Varun Sreenivasan
    Mohamedali A; Ahn SB; Sreenivasan VKA; Ranganathan S; Baker MS, 2017, 'Human Prestin: A Candidate PE1 Protein Lacking Stringent Mass Spectrometric Evidence?', Journal of Proteome Research, vol. 16, pp. 4531 - 4535, http://dx.doi.org/10.1021/acs.jproteome.7b00354
    Journal articles | 2017
    Dr Varun Sreenivasan
    Raoufi-Rad N; McRobb LS; Lee VS; Bervini D; Grace M; Ukath J; Mchattan J; Sreenivasan VKA; Duong TTH; Zhao Z; Stoodley MA, 2017, 'In vivo imaging of endothelial cell adhesion molecule expression after radiosurgery in an animal model of arteriovenous malformation', PLoS ONE, vol. 12, http://dx.doi.org/10.1371/journal.pone.0185393
    Journal articles | 2017
    Dr Varun Sreenivasan
    Sreenivasan VKA; Wan Razali WA; Zhang K; Pillai RR; Saini A; Denkova D; Santiago M; Brown H; Thompson J; Connor M; Goldys EM; Zvyagin AV, 2017, 'Development of Bright and Biocompatible Nanoruby and Its Application to Background-Free Time-Gated Imaging of G-Protein-Coupled Receptors', ACS Applied Materials and Interfaces, vol. 9, pp. 39197 - 39208, http://dx.doi.org/10.1021/acsami.7b12665
    Journal articles | 2017
    Dr Varun Sreenivasan
    Rajasekharan V; Sreenivasan VKA; Myers JN; Pereira FA; Farrell B, 2017, 'Lifetime of Membrane-Cytoskeleton Bonds is Mediated by RHO-GTPases in a Cancer Cell', Biophysical Journal, vol. 112, pp. 430a - 430a, http://dx.doi.org/10.1016/j.bpj.2016.11.2296
    Journal articles | 2016
    Dr Varun Sreenivasan
    Razali WAW; Sreenivasan VKA; Bradac C; Connor M; Goldys EM; Zvyagin AV, 2016, 'Wide-field time-gated photoluminescence microscopy for fast ultrahigh-sensitivity imaging of photoluminescent probes', Journal of biophotonics, vol. 9, pp. 848 - 858, http://dx.doi.org/10.1002/jbio.201600050
    Journal articles | 2016
    Dr Varun Sreenivasan
    Reineck P; Francis A; Orth A; Lau DWM; Nixon-Luke RDV; Rastogi ID; Razali WAW; Cordina NM; Parker LM; Sreenivasan VKA; Brown LJ; Gibson BC, 2016, 'Brightness and Photostability of Emerging Red and Near-IR Fluorescent Nanomaterials for Bioimaging', Advanced Optical Materials, vol. 4, pp. 1549 - 1557, http://dx.doi.org/10.1002/adom.201600212
    Journal articles | 2016
    Dr Varun Sreenivasan
    Sreenivasan VKA; Rajasekharan V; Farrell B, 2016, 'Do Prestin Variants Persist within the Cochlea to Affect Charge Movement In Vitro?', Biophysical Journal, vol. 110, pp. 481a - 481a, http://dx.doi.org/10.1016/j.bpj.2015.11.2572
    Journal articles | 2016
    Dr Varun Sreenivasan
    Rajasekharan V; Sreenivasan VKA; Myers JN; Pereira FA; Farrell B, 2016, 'Measuring the on-Rate of Membrane-Cytoskeleton Bonds at the Near-Equilibrium Region', Biophysical Journal, vol. 110, pp. 616a - 616a, http://dx.doi.org/10.1016/j.bpj.2015.11.3307
    Journal articles | 2015
    Dr Varun Sreenivasan
    Yellin FH; Sreenivasan VKAC; Farrell B; Sun SX, 2015, 'Electomechanical Model for Non-Excitable Cells', Biophysical Journal, vol. 108, pp. 141a - 141a, http://dx.doi.org/10.1016/j.bpj.2014.11.780
    Journal articles | 2014
    Dr Varun Sreenivasan
    Razali WAW; Sreenivasan VKA; Goldys EM; Zvyagin AV, 2014, 'Large-scale production and characterization of biocompatible colloidal nanoalumina', Langmuir, vol. 30, pp. 15091 - 15101, http://dx.doi.org/10.1021/la5042629
    Journal articles | 2014
    Dr Varun Sreenivasan
    Staude I; Sreenivasan VKA; Shishkin I; Samusev K; Decker M; Neshev DN; Zvyagin AV; Kivshar YS, 2014, 'Selective placement of quantum dots on nanoscale areas of metal-free substrates', Physica Status Solidi - Rapid Research Letters, vol. 8, pp. 710 - 713, http://dx.doi.org/10.1002/pssr.201409215
    Journal articles | 2014
    Dr Varun Sreenivasan
    Yellin FH; Farrell B; Sreenivasan VKAC; Sun SX, 2014, 'Electromechanical Model for Eukaryotic Cells', Biophysical Journal, vol. 106, pp. 574a - 574a, http://dx.doi.org/10.1016/j.bpj.2013.11.3182
    Journal articles | 2014
    Dr Varun Sreenivasan
    Staude I; Sreenivasan VKA; Shishkin I; Samusev K; Decker M; Neshev DN; Zvyagin AV; Kivshar YS, 2014, 'Back Cover: Selective placement of quantum dots on nanoscale areas of metal-free substrates (Phys. Status Solidi RRL 8/2014)', physica status solidi (RRL) - Rapid Research Letters, vol. 8, pp. n/a - n/a, http://dx.doi.org/10.1002/pssr.201470544
    Journal articles | 2013
    Dr Varun Sreenivasan
    Nadort A; Sreenivasan VKA; Song Z; Grebenik EA; Nechaev AV; Semchishen VA; Panchenko VY; Zvyagin AV, 2013, 'Quantitative Imaging of Single Upconversion Nanoparticles in Biological Tissue', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0063292
    Journal articles | 2013
    Dr Varun Sreenivasan
    Decker M; Staude I; Shishkin II; Samusev KB; Parkinson P; Sreenivasan VKA; Minovich A; Miroshnichenko AE; Zvyagin A; Jagadish C; Neshev DN; Kivshar YS, 2013, 'Dual-channel spontaneous emission of quantum dots in magnetic metamaterials', Nature Communications, vol. 4, http://dx.doi.org/10.1038/ncomms3949
    Journal articles | 2013
    Dr Varun Sreenivasan
    Grebenik EA; Nadort A; Generalova AN; Nechaev AV; Sreenivasan VKA; Khaydukov EV; Semchishen VA; Popov AP; Sokolov VI; Akhmanov AS; Zubov VP; Klinov DV; Panchenko VY; Deyev SM; Zvyagin AV, 2013, 'Feasibility study of the optical imaging of a breast cancer lesion labeled with upconversion nanoparticle biocomplexes', Journal of Biomedical Optics, vol. 18, http://dx.doi.org/10.1117/1.JBO.18.7.076004
    Journal articles | 2013
    Dr Varun Sreenivasan
    Edmonds AM; Sobhan MA; Sreenivasan VKA; Grebenik EA; Rabeau JR; Goldys EM; Zvyagin AV, 2013, 'Nano-ruby: A promising fluorescent probe for background-free cellular imaging', Particle and Particle Systems Characterization, vol. 30, pp. 506 - 513, http://dx.doi.org/10.1002/ppsc.201200112
    Journal articles | 2013
    Dr Varun Sreenivasan
    Sreenivasan VKA; Zvyagin AV; Goldys EM, 2013, 'Luminescent nanoparticles and their applications in the life sciences', Journal of Physics Condensed Matter, vol. 25, http://dx.doi.org/10.1088/0953-8984/25/19/194101
    Journal articles | 2013
    Dr Varun Sreenivasan
    Sreenivasan VKA; Kelf TA; Grebenik EA; Stremovskiy OA; Say JM; Rabeau JR; Zvyagin AV; Deyev SM, 2013, 'A modular design of low-background bioassays based on a high-affinity molecular pair barstar: Barnase', Proteomics, vol. 13, pp. 1437 - 1443, http://dx.doi.org/10.1002/pmic.201200491
    Journal articles | 2013
    Dr Varun Sreenivasan
    Edmonds AM; Sobhan MA; Sreenivasan VKA; Grebenik EA; Rabeau JR; Goldys EM; Zvyagin AV, 2013, 'Fluorescent Probes: Nano-Ruby: A Promising Fluorescent Probe for Background-Free Cellular Imaging (Part. Part. Syst. Charact. 6/2013)', Particle & Particle Systems Characterization, vol. 30, pp. 483 - 483, http://dx.doi.org/10.1002/ppsc.201370022
    Journal articles | 2012
    Dr Varun Sreenivasan
    Sobhan MA; Sreenivasan VKA; Withford MJ; Goldys EM, 2012, 'Non-specific internalization of laser ablated pure gold nanoparticles in pancreatic tumor cell', Colloids and Surfaces B: Biointerfaces, vol. 92, pp. 190 - 195, http://dx.doi.org/10.1016/j.colsurfb.2011.11.046
    Journal articles | 2012
    Dr Varun Sreenivasan
    Sreenivasan VKA; Kim EJ; Goodchild AK; Connor M; Zvyagin AV, 2012, 'Targeting somatostatin receptors using in situ-bioconjugated fluorescent nanoparticles', Nanomedicine, vol. 7, pp. 1551 - 1560, http://dx.doi.org/10.2217/nnm.12.42
    Journal articles | 2011
    Dr Varun Sreenivasan
    Singh NK; Chacko JV; Sreenivasan VKA; Nag S; Maiti S, 2011, 'Ultracompact alignment-free single molecule fluorescence device with a foldable light path', Journal of Biomedical Optics, vol. 16, http://dx.doi.org/10.1117/1.3548311
    Journal articles | 2011
    Dr Varun Sreenivasan
    Nag S; Sarkar B; Bandyopadhyay A; Sahoo B; Sreenivasan VKA; Kombrabail M; Muralidharan C; Maiti S, 2011, 'Nature of the amyloid-β monomer and the monomer-oligomer equilibrium', Journal of Biological Chemistry, vol. 286, pp. 13827 - 13833, http://dx.doi.org/10.1074/jbc.M110.199885
    Journal articles | 2011
    Dr Varun Sreenivasan
    Ivukina EA; Sreenivasan VKA; Stremovskiy OA; Veryugin BV; Lukash SV; Zvyagin AV; Deyev SM; Petrov RV, 2011, 'Fluorescent nanodiamond bioconjugates on the base of barnase:barstar module', Doklady Biochemistry and Biophysics, vol. 440, pp. 231 - 233, http://dx.doi.org/10.1134/S1607672911050115
    Journal articles | 2011
    Dr Varun Sreenivasan
    Sreenivasan VKA; Stremovskiy OA; Kelf TA; Heblinski M; Goodchild AK; Connor M; Deyev SM; Zvyagin AV, 2011, 'Pharmacological characterization of a recombinant, fluorescent somatostatin receptor agonist', Bioconjugate Chemistry, vol. 22, pp. 1768 - 1775, http://dx.doi.org/10.1021/bc200104u
    Journal articles | 2011
    Dr Varun Sreenivasan
    Sreenivasan VKA; Ivukina EA; Deng W; Kelf TA; Zdobnova TA; Lukash SV; Veryugin BV; Stremovskiy OA; Zvyagin AV; Deyev SM, 2011, 'Barstar:barnase - A versatile platform for colloidal diamond bioconjugation', Journal of Materials Chemistry, vol. 21, pp. 65 - 68, http://dx.doi.org/10.1039/c0jm02819c
    Journal articles | 2010
    Dr Varun Sreenivasan
    Kelf TA; Sreenivasan VKA; Sun J; Kim EJ; Goldys EM; Zvyagin AV, 2010, 'Non-specific cellular uptake of surface-functionalized quantum dots', Nanotechnology, vol. 21, http://dx.doi.org/10.1088/0957-4484/21/28/285105
    Journal articles | 2008
    Dr Varun Sreenivasan
    Kumar N; Sahoo B; Varun KAS; Maiti S; Maiti S, 2008, 'Effect of loop length variation on quadruplex-Watson Crick duplex competition', Nucleic Acids Research, vol. 36, pp. 4433 - 4442, http://dx.doi.org/10.1093/nar/gkn402
  • Conference Papers | 2014
    Dr Varun Sreenivasan
    Staude I; Sreenivasan VK; Shishkin I; Samusev K; Decker M; Neshev DN; Zvyagin AV; Kivshar YS, 2014, 'Positioning of single quantum dots on nanoscale areas of metal-free substrates (presentation video)', in Active Photonic Materials VI, SPIE, presented at SPIE NanoScience + Engineering, http://dx.doi.org/10.1117/12.2061436
    Conference Papers | 2014
    Dr Varun Sreenivasan
    Sreenivasan VKA; Corbitt C; Farinelli F; Brownell WE; Farrell B, 2014, 'Mismatch Between the Resting Membrane Potential and the Voltage at Maximum Amplification in Outer Hair Cells (OHCS) of Mammalian Cochlea', in BIOPHYSICAL JOURNAL, CELL PRESS, San Francisco, CA, pp. 794A - 794A, presented at 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, 15 February 2014 - 19 February 2014, http://dx.doi.org/10.1016/j.bpj.2013.11.4354
    Conference Papers | 2011
    Dr Varun Sreenivasan
    Zvyagin AV; Sreenivasan VKA; Kelf TA; Deyev SM, 2011, 'Luminescent nanodiamonds for intracellular imaging', in Optics InfoBase Conference Papers
    Conference Papers | 2011
    Dr Varun Sreenivasan
    Sreenivasan VKA; Ivukina EA; Kelf TA; Stremovskiy OA; Goodchild A; Connor M; Deyev SM; Zvyagin AV, 2011, 'Interfacing nanodiamonds for single molecular optical biomedical imaging', in Optics InfoBase Conference Papers, pp. 370 - 371
    Conference Papers | 2011
    Dr Varun Sreenivasan
    Sreenivasan VKA; Ivukina EA; Keif TA; Stremovskiy OA; Goodchild A; Connor M; Deyev SM; Zvyagin AV, 2011, 'Interfacing nanodiamonds for single molecular optical-biomedical imaging', in 2011 Int. Quantum Electron. Conf., IQEC 2011 and Conf. Lasers and Electro-Optics, CLEO Pacific Rim 2011 Incorporating the Australasian Conf. Optics, Lasers and Spectroscopy and the Australian Conf., pp. 370 - 371, http://dx.doi.org/10.1109/IQEC-CLEO.2011.6193740
    Conference Papers | 2011
    Dr Varun Sreenivasan
    Nag S; Sarkar B; Banerjee A; Sahoo B; Varun KAS; Maiti S, 2011, 'The Nature of the Amyloid-beta Monomer and the Monomer-Oligomer Equilibrium', in BIOPHYSICAL JOURNAL, CELL PRESS, Baltimore, MD, pp. 202 - 202, presented at 55th Annual Meeting of the Biophysical-Society, Baltimore, MD, 05 March 2011 - 09 March 2011, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000306288601480&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2011
    Dr Varun Sreenivasan
    Zvyagin AV; Sreenivasan VKA; Kelf TA; Deyev SM, 2011, 'Luminescent nanodiamonds for intracellular imaging', in Optics InfoBase Conference Papers, http://dx.doi.org/10.1364/omp.2011.omd1
    Conference Papers | 2010
    Dr Varun Sreenivasan
    Kim EJ; Sun J; Varun KAS; Tim K; Zvyagin A; Tallapragada VJ; Goodchild A, 2010, 'Selective internalization of biotinylated SST14 conjugated to the streptavidin coated Qdots in Rat pancreatic AR42J cells and their use for the study of neuronal function', in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208189300403&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2007
    Dr Varun Sreenivasan
    Ashok PC; Nair U; Varun KAS; Namboothiri VNN; Nampoori VPN, 2007, 'Speckle metrology based study on the effect of chattering on machined surfaces', in Proceedings of SPIE - The International Society for Optical Engineering, http://dx.doi.org/10.1117/12.733099

Awards

Grants

Macquarie University Research Fellowship (MQRF), Macquarie University, 2013 - 2016

Discovery Early Career Research Fellowship (DECRA), Australian Research Council, 2016-2019

Media