Dr Wei   Deng
Senior Lecturer

Dr Wei Deng

Engineering
Grad Sch: Biomedical Eng

Dr Wei Deng is a Senior Lecturer of Engineering at University of New South Wales Australia and also an Honorary Senior Research Fellow of Science and Engineering at Macquarie University Australia.

Dr Deng was one of co-founders of a startup company, RadioDynamic Therapeutics Inc. (2020). 

Publications

  • Book Chapters | 2020
    Dr Wei Deng
    Chen W; Deng W; Goldys E, 2020, 'Recent developments of liposome nanosystems for cancer treatments', in Functional Lipid Nanosystems in Cancer
    Book Chapters | 2017
    Dr Wei Deng
    Xie F; Deng W; Goldys E, 2017, 'Compatibility of metal-induced fluorescence enhancement with applications in analytical chemistry and biosensing', in Geddes CD (ed.), Surface Plasmon Enhanced, Coupled and Controlled Fluorescence, John Wiley & Sons, pp. 13 - 36, https://primoa.library.unsw.edu.au/permalink/f/238ui7/UNSW_ALMA51213057550001731
    Book Chapters | 2011
    Dr Wei Deng
    Deng W; Goldys E; Jin D, 2011, 'Metal nanostructure-enhanced fluorescence and its biological applications', in Kane D; Micolich AP; Rabeau J (ed.), Nanotechnology in Australia: Showcase of Early Career Research,, Pan Stanford Publishing, Singapore, pp. 347 - 373, http://dx.doi.org/10.4032/9789814310031
    Book Chapters | 2011
    Dr Wei Deng
    Deng W; Goldys E; Jin D, 2011, 'Metal nanostructure-enhanced fluorescence and its biological applications', in Nanotechnology in Australia Showcase of Early Career Research, Pan Stanford Publishing, pp. 347 - 373
  • Journal articles | 2021
    Dr Wei Deng
    Sang R; Stratton B; Engel A; Deng W, 2021, 'Liposome technologies towards colorectal cancer therapeutics', Acta Biomaterialia, http://dx.doi.org/10.1016/j.actbio.2021.03.055
    Journal articles | 2021
    Dr Wei Deng
    Yang B; Song BP; Shankar S; Guller A; Deng W, 2021, 'Recent advances in liposome formulations for breast cancer therapeutics', Cellular and Molecular Life Sciences, http://dx.doi.org/10.1007/s00018-021-03850-6
    Journal articles | 2020
    Dr Wei Deng
    Aksoy YA; Deng W; Stoddart J; Chung R; Guillemin G; Cole NJ; Neely GG; Hesselson D, 2020, '“STRESSED OUT”: The role of FUS and TDP-43 in amyotrophic lateral sclerosis', International Journal of Biochemistry and Cell Biology, vol. 126, http://dx.doi.org/10.1016/j.biocel.2020.105821
    Journal articles | 2020
    Dr Wei Deng
    Chen W; Goldys EM; Deng W, 2020, 'Light-induced liposomes for cancer therapeutics', Progress in Lipid Research, vol. 79, http://dx.doi.org/10.1016/j.plipres.2020.101052
    Journal articles | 2020
    Dr Wei Deng
    Gu X; Gu X; Gu X; Shen C; Li H; Goldys EM; Deng W, 2020, 'X-ray induced photodynamic therapy (PDT) with a mitochondria-targeted liposome delivery system', Journal of Nanobiotechnology, vol. 18, pp. 87, http://dx.doi.org/10.1186/s12951-020-00644-z
    Journal articles | 2020
    Dr Wei Deng
    Deng W; McKelvey KJ; Guller A; Fayzullin A; Campbell JM; Clement S; Habibalahi A; Wargocka Z; Liang L; Shen C; Howell VM; Engel AF; Goldys EM, 2020, 'Application of Mitochondrially Targeted Nanoconstructs to Neoadjuvant X-ray-Induced Photodynamic Therapy for Rectal Cancer', ACS Central Science, vol. 6, pp. 715 - 726, http://dx.doi.org/10.1021/acscentsci.9b01121
    Journal articles | 2020
    Dr Wei Deng
    Aksoy YA; Yang B; Chen W; Hung T; Kuchel RP; Zammit NW; Grey ST; Goldys EM; Deng W, 2020, 'Spatial and Temporal Control of CRISPR-Cas9-Mediated Gene Editing Delivered via a Light-Triggered Liposome System', ACS Applied Materials and Interfaces, vol. 12, pp. 52433 - 52444, http://dx.doi.org/10.1021/acsami.0c16380
    Journal articles | 2020
    Dr Wei Deng
    Clement S; Campbell JM; Deng W; Guller A; Nisar S; Liu G; Wilson BC; Goldys EM, 2020, 'Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer', Advanced Science, vol. 7, http://dx.doi.org/10.1002/advs.202003584
    Journal articles | 2018
    Dr Wei Deng
    Deng W; Goldys EM; Zhao Z, 2018, 'Release of doxorubicin from liposomes by x-ray radiation', Nanomedicine: Nanotechnology, Biology and Medicine, vol. 14, pp. 1753 - 1753, http://dx.doi.org/10.1016/j.nano.2017.11.048
    Journal articles | 2018
    Dr Wei Deng
    Deng W; Chen W; Clement S; Guller A; Zhao Z; Engel A; Goldys EM, 2018, 'Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation', Nat Commun, vol. 9, pp. 2713 - 2713, http://dx.doi.org/10.1038/s41467-018-05118-3
    Journal articles | 2018
    Dr Wei Deng
    Chen W; Deng W; Xu X; Zhao X; Vo JN; Anwer AG; Williams TC; Cui H; Goldys EM, 2018, 'Photoresponsive endosomal escape enhances gene delivery using liposome-polycation-DNA (LPD) nanovectors', Journal of Materials Chemistry B, vol. 6, pp. 5269 - 5281, http://dx.doi.org/10.1039/c8tb00994e
    Journal articles | 2018
    Dr Wei Deng
    Clement S; Chen W; Deng W; Goldys EM, 2018, 'X-ray radiation-induced and targeted photodynamic therapy with folic acid-conjugated biodegradable nanoconstructs', International Journal of Nanomedicine, vol. 13, pp. 3553 - 3570, http://dx.doi.org/10.2147/IJN.S164967
    Journal articles | 2017
    Dr Wei Deng
    Chen W; Deng W; Goldys EM, 2017, 'Light-Triggerable Liposomes for Enhanced Endolysosomal Escape and Gene Silencing in PC12 Cells', Molecular Therapy - Nucleic Acids, vol. 7, pp. 366 - 377, http://dx.doi.org/10.1016/j.omtn.2017.04.015
    Journal articles | 2017
    Dr Wei Deng
    Kautzka Z; Clement S; Goldys EM; Deng W, 2017, 'Light-triggered liposomal cargo delivery platform incorporating photosensitizers and gold nanoparticles for enhanced singlet oxygen generation and increased cytotoxicity', International Journal of Nanomedicine, vol. 12, pp. 969 - 977, http://dx.doi.org/10.2147/IJN.S126553
    Journal articles | 2017
    Dr Wei Deng
    Clement S; Sobhan M; Deng W; Camilleri E; Goldys EM, 2017, 'Nanoparticle-mediated singlet oxygen generation from photosensitizers', Journal of Photochemistry and Photobiology A: Chemistry, vol. 332, pp. 66 - 71, http://dx.doi.org/10.1016/j.jphotochem.2016.08.009
    Journal articles | 2016
    Dr Wei Deng
    Clement S; Deng W; Camilleri E; Wilson BC; Goldys EM, 2016, 'X-ray induced singlet oxygen generation by nanoparticle-photosensitizer conjugates for photodynamic therapy: Determination of singlet oxygen quantum yield', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep19954
    Journal articles | 2016
    Dr Wei Deng
    Deng W; Kautzka Z; Chen W; Goldys EM, 2016, 'PLGA nanocomposites loaded with verteporfin and gold nanoparticles for enhanced photodynamic therapy of cancer cells', RSC Advances, vol. 6, pp. 112393 - 112402, http://dx.doi.org/10.1039/c6ra21997g
    Journal articles | 2015
    Dr Wei Deng
    Wargocki P; Deng W; Anwer AG; Goldys EM, 2015, 'Medically relevant assays with a simple smartphone and tablet based fluorescence detection system', Sensors (Switzerland), vol. 15, pp. 11653 - 11664, http://dx.doi.org/10.3390/s150511653
    Journal articles | 2015
    Dr Wei Deng
    Clement S; Deng W; Drozdowicz-Tomsia K; Liu D; Zachreson C; Goldys EM, 2015, 'Bright, water-soluble CeF3 photo-, cathodo-, and X-ray luminescent nanoparticles', Journal of Nanoparticle Research, vol. 17, http://dx.doi.org/10.1007/s11051-014-2833-0
    Journal articles | 2015
    Dr Wei Deng
    Deng W; Farnham MMJ; Goldys EM; Mohammed S; Pilowsky PM, 2015, 'Gene interference with morpholinos in a gold nanoparticle-based delivery platform in rat PC12 cells', Journal of Biomedical Nanotechnology, vol. 11, pp. 2111 - 2123, http://dx.doi.org/10.1166/jbn.2015.2171
    Journal articles | 2014
    Dr Wei Deng
    Zhang L; Zheng X; Deng W; Lu Y; Lechevallier S; Ye Z; Goldys EM; Dawes JM; Piper JA; Yuan J; Verelst M; Jin D, 2014, 'Practical implementation, characterization and applications of a multi-colour time-gated luminescence microscope', Scientific Reports, vol. 4, http://dx.doi.org/10.1038/srep06597
    Journal articles | 2014
    Dr Wei Deng
    Deng W; Goldys EM, 2014, 'Chemical sensing with nanoparticles as optical reporters: From noble metal nanoparticles to quantum dots and upconverting nanoparticles', Analyst, vol. 139, pp. 5321 - 5334, http://dx.doi.org/10.1039/c4an01272k
    Journal articles | 2014
    Dr Wei Deng
    Deng W; Goldys EM; Farnham MMJ; Pilowsky PM, 2014, 'Optogenetics, the intersection between physics and neuroscience: Light stimulation of neurons in physiological conditions', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol. 307, pp. R1292 - R1302, http://dx.doi.org/10.1152/ajpregu.00072.2014
    Journal articles | 2013
    Dr Wei Deng
    Deng W; Xie F; Baltar HTMCM; Goldys EM, 2013, 'Metal-enhanced fluorescence in the life sciences: Here, now and beyond', Physical Chemistry Chemical Physics, vol. 15, pp. 15695 - 15708, http://dx.doi.org/10.1039/c3cp50206f
    Journal articles | 2012
    Dr Wei Deng
    Deng W; Goldys EM, 2012, 'Plasmonic approach to enhanced fluorescence for applications in biotechnology and the life sciences', Langmuir, vol. 28, pp. 10152 - 10163, http://dx.doi.org/10.1021/la300332x
    Journal articles | 2011
    Dr Wei Deng
    Deng W; Sudheendra L; Zhao J; Fu J; Jin D; Kennedy IM; Goldys EM, 2011, 'Upconversion in NaYF4:Yb, Er nanoparticles amplified by metal nanostructures', Nanotechnology, vol. 22, http://dx.doi.org/10.1088/0957-4484/22/32/325604
    Journal articles | 2011
    Dr Wei Deng
    Deng W; Jin D; Drozdowicz-Tomsia K; Yuan J; Wu J; Goldys EM, 2011, 'Ultrabright Eu-doped plasmonic Ag@SiO 2 nanostructures: Time-gated bioprobes with single particle sensitivity and negligible background', Advanced Materials, vol. 23, pp. 4649 - 4654, http://dx.doi.org/10.1002/adma.201102027
    Journal articles | 2011
    Dr Wei Deng
    Lu Y; Jin D; Leif RC; Deng W; Piper JA; Yuan J; Duan Y; Huo Y, 2011, 'Automated detection of rare-event pathogens through time-gated luminescence scanning microscopy', Cytometry Part A, vol. 79 A, pp. 349 - 355, http://dx.doi.org/10.1002/cyto.a.21045
    Journal articles | 2011
    Dr Wei Deng
    Sreenivasan VKA; Ivukina EA; Deng W; Kelf TA; Zdobnova TA; Lukash SV; Veryugin BV; Stremovskiy OA; Zvyagin AV; Deyev SM, 2011, 'Barstar:barnase - A versatile platform for colloidal diamond bioconjugation', Journal of Materials Chemistry, vol. 21, pp. 65 - 68, http://dx.doi.org/10.1039/c0jm02819c
    Journal articles | 2010
    Dr Wei Deng
    Deng W; Jin D; Drozdowicz-Tomsia K; Yuan J; Goldys EM, 2010, 'Europium chelate (BHHCT-Eu3+) and its metal nanostructure enhanced luminescence applied to bioassays and time-gated bioimaging', Langmuir, vol. 26, pp. 10036 - 10043, http://dx.doi.org/10.1021/la100158g
    Journal articles | 2009
    Dr Wei Deng
    Deng W; Drozdowicz-Tomsia K; Jin D; Goldys EM, 2009, 'Enhanced flow cytometry-based bead immunoassays using metal nanostructures', Analytical Chemistry, vol. 81, pp. 7248 - 7255, http://dx.doi.org/10.1021/ac900947h
  • Conference Papers | 2019
    Dr Wei Deng
    Goldys EM; Clement S; Deng W, 2019, 'Combining ionising radiation with nanoconstructs: towards new options in cancer therapy (Invited talk)', in Proc. SPIE. 10862, Molecular-Guided Surgery: Molecules, Devices, and Applications V, San Francisco USA, presented at SPIE BIOS, San Francisco USA, http://dx.doi.org/10.1117/12.2511905
    Conference Papers | 2019
    Dr Wei Deng
    Deng W; Chen W; Clement S; Guller A; Zhao Z; Engel A; Goldys E, 2019, 'Controlled drug release from a X-ray triggered liposomal delivery platform for colorectal cancer treatment (Conference Presentation)', in Proc. SPIE. 10860, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVIII, SPIE, San Francisco, USA, presented at SPIE BIOS, San Francisco, USA, http://dx.doi.org/10.1117/12.2506321
    Conference Papers | 2019
    Dr Wei Deng
    Clement S; Anwer A; Deng W; Wilson BC; Allen C; Goldys E, 2019, 'Nuclear targeted x-ray activated photodynamic therapy: a solution to treat pancreatic cancer', in Proc. SPIE. 10860, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVIII, San Francisco, USA, presented at SPIE BIOS, San Francisco, USA, http://dx.doi.org/10.1117/12.2508957
    Conference Presentations | 2019
    Dr Wei Deng
    Clement S; Anwer A; Deng W; Wilson BC; Goldys E, 2019, 'Targeted drug delivery for X-ray induced Photodynamic Therapy', presented at 10th International Nanomedicine Conference, Sydney Australia, 24 June 2019 - 26 June 2019
    Conference Presentations | 2019
    Dr Wei Deng
    Clement S; Deng W; Angel A; Goldys E, 2019, 'Using Mitochondria-Targeted Nanocarriers and Low Dose X-Rays for Combined Photodynamic Therapy (PDT) of Colorectal Cancer (Conference Presentation)', presented at 10th International Nanomedicine Conference, Sydney, Australila, 24 June 2019 - 26 June 2019
    Conference Papers | 2018
    Dr Wei Deng
    Clement S; Chen W; Deng W; Goldys E, 2018, 'Biodegradable nanoconstructs for targeted deep tumour therapy', in Proc. SPIE. 10476, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII, San Francisco, USA, presented at SPIE BIOS, San Francisco, USA, http://dx.doi.org/10.1117/12.2289254
    Conference Papers | 2018
    Dr Wei Deng
    Kautzka Z; Clement S; Goldys EM; Deng W, 2018, 'Light-triggered liposomal cargo delivery platform incorporating photosensitizers and gold nanoparticles for enhanced singlet oxygen generation and increased cytotoxicity', in Progress in Biomedical Optics and Imaging - Proceedings of SPIE, http://dx.doi.org/10.1117/12.2286552
    Conference Papers | 2018
    Dr Wei Deng
    Kautzka Z; Clement S; Goldys E; Deng W, 2018, 'Light-triggered liposomal cargo delivery platform incorporating photosensitizers and gold nanoparticles for enhanced singlet oxygen generation and increased cytotoxicity (Conference Presentation)', San Francisco, USA, presented at SPIE BIOS, San Francisco, USA, http://dx.doi.org/10.1117/12.2508957
    Conference Presentations | 2018
    Dr Wei Deng
    Deng W; Chen W; Clement S; Guller A; Zhao Z; Engel A; Goldys E, 2018, 'Controlled drug release from a liposomal delivery platform triggered by X-ray radiation', presented at Sydney Cancer Conference, Sydney, Australia, 11 October 2018 - 12 October 2018
    Conference Papers | 2016
    Dr Wei Deng
    Clement S; Deng W; Camilleri E; Wilson B; Goldys E, 2016, 'Towards photodynamic therapy with ionizing radiation: nanoparticle-mediated singlet oxygen generation (Conference Presentation)', in Parak WJ; Osinski M; Liang XJ (eds.), COLLOIDAL NANOPARTICLES FOR BIOMEDICAL APPLICATIONS XI, SPIE-INT SOC OPTICAL ENGINEERING, San Francisco, CA, presented at Conference on Colloidal Nanoparticles for Biomedical Applications XI, San Francisco, CA, 13 February 2016 - 15 February 2016, http://dx.doi.org/10.1117/12.2209206
    Conference Papers | 2016
    Dr Wei Deng
    Deng W; Kautzka Z; Goldys EM, 2016, 'Enhanced singlet oxygen generation from PLGA loaded with verteporfin and gold nanoparticles', in Proceedings of SPIE - The International Society for Optical Engineering, http://dx.doi.org/10.1117/12.2242362
    Conference Papers | 2016
    Dr Wei Deng
    Chen W; Deng W; Goldys EM, 2016, 'Enhanced gene silencing mediated by photoresponsive liposomes', in Proceedings of SPIE - The International Society for Optical Engineering, http://dx.doi.org/10.1117/12.2244465
    Conference Papers | 2016
    Dr Wei Deng
    Clement S; Deng W; Camilleri E; Wilson BC; Goldys E, 2016, 'Towards photodynamic therapy with ionising radiation: nanoparticle-mediated singlet oxygen generation (Conference Presentation)', in Proc. SPIE. 9722, Colloidal Nanoparticles for Biomedical Applications XI, San Francisco, USA, presented at BIOS SPIE Photonic West, San Francisco, USA, http://dx.doi.org/10.1117/12.2209206
    Conference Presentations | 2015
    Dr Wei Deng
    Clement S; Deng W; Camilleri E; Wilson BC; Goldys E, 2015, 'Scintillating Nanoparticles - Photosensitizer Conjugates towards X-ray activated Photo Dynamic Therapy (PDT)', presented at SPIE Micro+Nano Materials, Devices, and Systems, Sydney, Australia
    Conference Papers | 2011
    Dr Wei Deng
    Goldys EM; Deng W; Calander NP; Drozdowicz-Tomsia K; Jin D, 2011, 'Nanoscale plasmonic resonators with high Purcell factor: Spontaneous and stimulated emission', in Progress in Biomedical Optics and Imaging - Proceedings of SPIE, http://dx.doi.org/10.1117/12.881170
    Conference Papers | 2011
    Dr Wei Deng
    Deng W; Jin D; Drozdowicz-Tomsia K; Yuan J; Wu J; Goldys EM, 2011, 'Plasmonic Ag/SiO2 composite nanoparticles doped with europium chelate and their metal enhanced fluorescence', in Progress in Biomedical Optics and Imaging - Proceedings of SPIE, http://dx.doi.org/10.1117/12.872833
    Conference Papers | 2011
    Dr Wei Deng
    Jin D; Lu Y; Zhao J; Deng W; Lu J; Piper JA, 2011, 'Advances in lanthanide bioprobes and high-throughput background-free biophotonics sensing', in Optics InfoBase Conference Papers, pp. 80 - 82
    Conference Papers | 2011
    Dr Wei Deng
    Jin D; Lu Y; Zhao J; Deng W; Lu J; Piper JA, 2011, 'Advances in lanthanide bioprobes and high-throughput background-free biophotonics sensing', in 2011 Int. Quantum Electron. Conf., IQEC 2011 and Conf. Lasers and Electro-Optics, CLEO Pacific Rim 2011 Incorporating the Australasian Conf. Optics, Lasers and Spectroscopy and the Australian Conf., pp. 80 - 82, http://dx.doi.org/10.1109/IQEC-CLEO.2011.6194134
    Conference Papers | 2010
    Dr Wei Deng
    Deng W; Drozdowicz-Tomsia K; Jin D; Goldys EM, 2010, 'Silver nanostructure coated beads enhance fluorescence for sensitive immunoassays and bioimaging', in ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology, pp. 108 - 111, http://dx.doi.org/10.1109/ICONN.2010.6045197

Awards

Grants

  • NHMRC Ideas Grant, “New therapeutic option for lymph node metastasis in rectal cancer: radiation-triggered photodynamic therapy in deep tissue”(2020, 3 years)
  • National Foundation for Medical Research and Innovation project grant, “Nanostrategy for X-ray triggered chemotherapy towards rectal cancer treatment” (2020-2021) 
  • Career Development Fellowship, Cancer Institute NSW 2020, 3 years

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