Dr Xin Jiang
Senior Research Fellow

Dr Xin Jiang

School of Biotech & Biomolecular Science

Dr. Xin Jiang is a biochemist/structural biologist working on the mechanism investigation of membrane proteins. Mentored by Prof. Yigong Shi, Xin was awarded his Ph.D. degree in 2017 from Tsinghua University, where he received systematic training in protein expression, purification, engineering, and characterization. He joined Prof. Nieng Yan's lab at Princeton University in 2018 for his postdoctoral training. During his postdoctoral period, Xin systematically revealed the molecular mechanism underlying the glucose and lactate transport cycle in human and Plasmodium. Later, Dr. Xin Jiang joined the BABS of UNSW in 2019 as a senior research fellow. 

  • Journal articles | 2022
    Jiang X, 2022, 'An overview of the Plasmodium falciparum hexose transporter and its therapeutic interventions', Proteins: Structure, Function and Bioinformatics, http://dx.doi.org/10.1002/prot.26351
    Journal articles | 2021
    Huang J; Yuan Y; Zhao N; Pu D; Tang Q; Zhang S; Luo S; Yang X; Wang N; Xiao Y; Zhang T; Liu Z; Sakata-Kato T; Jiang X; Kato N; Yan N; Yin H, 2021, 'Orthosteric–allosteric dual inhibitors of PfHT1 as selective antimalarial agents', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, http://dx.doi.org/10.1073/pnas.2017749118
    Journal articles | 2021
    Peng X; Wang N; Zhu A; Xu H; Li J; Zhou Y; Wang C; Xiao Q; Guo L; Liu F; Jia ZJ; Duan H; Hu J; Yuan W; Geng J; Yan C; Jiang X; Deng D, 2021, 'Structural characterization of the Plasmodium falciparum lactate transporter PfFNT alone and in complex with antimalarial compound MMV007839 reveals its inhibition mechanism', PLoS Biology, vol. 19, http://dx.doi.org/10.1371/journal.pbio.3001386
    Journal articles | 2021
    Wang N; Jiang X; Zhang S; Zhu A; Yuan Y; Xu H; Lei J; Yan C, 2021, 'Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates', Cell, vol. 184, pp. 370 - 383.e13, http://dx.doi.org/10.1016/j.cell.2020.11.043
    Journal articles | 2020
    Gao M; Huang J; Jiang X; Yuan Y; Pang H; Luo S; Wang N; Yao C; Lin Z; Pu D; Zhang S; Sun P; Liu Z; Xiao Y; Wang Q; Hu Z; Yin H, 2020, 'Regulation of aerobic glycolysis to decelerate tumor proliferation by small molecule inhibitors targeting glucose transporters', PROTEIN & CELL, vol. 11, pp. 446 - 451, http://dx.doi.org/10.1007/s13238-020-00725-7
    Journal articles | 2020
    Jiang X; Yuan Y; Huang J; Zhang S; Luo S; Wang N; Pu D; Zhao N; Tang Q; Hirata K; Yang X; Jiao Y; Sakata-Kato T; Wu JW; Yan C; Kato N; Yin H; Yan N, 2020, 'Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum', Cell, vol. 183, pp. 258 - 268.e12, http://dx.doi.org/10.1016/j.cell.2020.08.015
    Journal articles | 2019
    Jiang X; Wu J; Ke M; Zhang S; Yuan Y; Lin JY; Yan N, 2019, 'Engineered XylE as a tool for mechanistic investigation and ligand discovery of the glucose transporters GLUTs', Cell Discov, vol. 5, pp. 14 - 14, http://dx.doi.org/10.1038/s41421-019-0082-1
    Journal articles | 2017
    Ke M; Yuan Y; Jiang X; Yan N; Gong H, 2017, 'Molecular determinants for the thermodynamic and functional divergence of uniporter GLUT1 and proton symporter XylE', PLoS Comput. Biol., vol. 13, pp. e1005603 - e1005603, http://dx.doi.org/10.1371/journal.pcbi.1005603
    Journal articles | 2016
    Jiang X; Smirnova I; Kasho V; Wu J; Hirata K; Ke M; Pardon E; Steyaert J; Yan N; Kaback HR, 2016, 'Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation', Proc. Natl. Acad. Sci. U.S.A., vol. 113, pp. 12420 - 12425, http://dx.doi.org/10.1073/pnas.1615414113
    Journal articles | 2015
    Deng D; Sun P; Yan C; Ke M; Jiang X; Xiong L; Ren W; Hirata K; Yamamoto M; Fan S; Yan N, 2015, 'Molecular basis of ligand recognition and transport by glucose transporters', Nature, vol. 526, pp. 391 - 396, http://dx.doi.org/10.1038/nature14655
    Journal articles | 2013
    Zhang X; Xia M; Li Y; Liu H; Jiang X; Ren W; Wu J; DeCaen P; Yu F; Huang S; He J; Clapham DE; Yan N; Gong H, 2013, 'Analysis of the selectivity filter of the voltage-gated sodium channel Na(v)Rh', Cell Res., vol. 23, pp. 409 - 422, http://dx.doi.org/10.1038/cr.2012.173
  • Preprints |
    Huang J; Yuan Y; Zhao N; Pu D; Tang Q; Zhang S; Luo S; Yang X; Wang N; Xiao Y; Zhang T; Liu Z; Sakata-Kato T; Jiang X; Kato N; Yan N; Yin H, Orthosteric-allosteric dual inhibitors of PfHT1 as selective anti-malarial agents, http://dx.doi.org/10.1101/2020.08.25.260232

We are interested in understanding the molecular mechanism of membrane proteins and their therapeutic application. Specifically, we work on two different aspects of research fields.

The first aspect of our research interest is to reveal the function and mechanism of the plasmodium membrane proteins, followed by drug development. For instance, the plasmodium transporters play critical roles in absorbing nutrition, extruding metabolic waste, and maintaining osmotic balance. Inhibition of these membrane transport proteins can efficiently hamper the proliferation of plasmodium, which provides a novel path to cure malaria. Importantly, current clinical antimalarial agents are not targeting the membrane transporters. Therefore, the novel transporter inhibitors are promising medicines to fight against the multidrug-resistant plasmodium that increasingly threatens the campaign for malaria elimination.

The other research topic is in collaboration with senior lipid researchers in BABS. Currently, we try to understand the molecular mechanisms of several membrane proteins that play important roles in lipid and cholesterol biogenesis.