The cellular functions of Eukaryotic-like proteins from microbial symbionts of sponges.
Symbiosis between microorganism and macroorganisms are common in the natural world. This is particular true for the marine environment, where macroorganisms (e.g. sponges, corals and fish) form intimate relationships with microorganisms that are important for their health and performance. However, how these symbiotic interactions are regulated, both in terms of molecular and environmental factors, is poorly understood. Previous work has made the unexpected discovery that bacterial symbionts of sponges carry genes for proteins that are evolutionary related to eukaryotic proteins. These so-called eukaryotic-like proteins (ELPs) have subsequently been found in a range of other sponge symbionts, as well as in pathogens of humans and animals. ELPs are newly discovered molecular mediators of symbioses and details on their cellular functions and the factors that control their expression are yet to be uncovered. This knowledge is important as ELPs have a widespread distribution across a range of symbioses. My work aims to define the mechanism of ELP function on a cellular level.
Supervisor: Professor Torsten Thomas; Dr. Renee Whan
Jia, Y., B. Yang, W. Dong, Z. Liu, Z. Lv, Z. Jia, L. Qiu, L. Wang, and L. Song. "A Serotonin Receptor (Cg5-Htr-1) Mediating Immune Response in Oyster Crassostrea Gigas." Dev Comp Immunol 82 (May 2018): 83-93. https://doi.org/10.1016/j.dci.2017.12.029.
Yang, B., Y. Jia, Z. Jia, W. Wang, X. Song, Y. Li, Q. Yi, L. Wang, and L. Song. "The Cyclin-Dependent Kinase 2 (Cdk2) Mediates Hematopoiesis through G1-to-S Transition in Chinese Mitten Crab Eriocheir Sinensis." Dev Comp Immunol 81 (Apr 2018): 156-66. https://doi.org/10.1016/j.dci.2017.11.022.
Lv, Z., X. Song, J. Xu, Z. Jia, B. Yang, Y. Jia, L. Qiu, L. Wang, and L. Song. "The Modulation of Smac/Diablo on Mitochondrial Apoptosis Induced by Lps in Crassostrea Gigas." Fish Shellfish Immunol 84 (Jan 2019): 587-98. https://doi.org/10.1016/j.fsi.2018.10.035.
Lv, Z., L. Qiu, Z. Liu, W. Wang, H. Chen, Y. Jia, Z. Jia, et al. "Molecular Characterization of a Cathepsin L1 Highly Expressed in Phagocytes of Pacific Oyster Crassostrea Gigas." Dev Comp Immunol 89 (Dec 2018): 152-62. https://doi.org/10.1016/j.dci.2018.08.014.
Li, Y., Z. Jia, Q. Yi, X. Song, Y. Liu, Y. Jia, L. Wang, and L. Song. "A Novel Gata-Like Zinc Finger Transcription Factor Involving in Hematopoiesis of Eriocheir Sinensis." Fish Shellfish Immunol 74 (Mar 2018): 363-71. https://doi.org/10.1016/j.fsi.2018.01.007.
Li, X., Z. Jia, W. Wang, L. Wang, Z. Liu, B. Yang, Y. Jia, et al. "Glycogen Synthase Kinase-3 (Gsk3) Regulates Tnf Production and Haemocyte Phagocytosis in the Immune Response of Chinese Mitten Crab Eriocheir Sinensis." Dev Comp Immunol 73 (Aug 2017): 144-55. https://doi.org/10.1016/j.dci.2017.03.022.