Professor Jamie Vandenberg

Professor Jamie Vandenberg

Conjoint Professor

1985         Bachelor of Science (Medical) – Distinction (University of Sydney)

1988         Bachelor of Medicine and Bachelor of Surgery – Honors (I) (University of Sydney)

1994         Doctor of Philosophy (University of Cambridge)

 

Medicine & Health
School of Clinical Medicine

Research Interests: Biophysics and pharmacology of cardiac ion channels. Genotype-Phenotype relationships in inherited arrhythmia syndromes. In silico modeling of inherited arrhythmia syndromes. Structural basis of drug binding to hERG K+ channels.

Professor Jamie Vandenberg completed his medical degree at the University of Sydney (1988) and his PhD in the Department of Biochemistry at the University of Cambridge (1994). He undertook postdoctoral studies in cardiac electrophysiology at the University of Oxford then moved to the University of Cambridge where he established an independent group looking at the molecular basis of cardiac arrhythmias. In 2002, he relocated to the Victor Chang Cardiac Research Institute, where he is currently Co-Deputy Director and Head of the Mark Cowley Lidwill Research Program in Cardiac Electrophysiology. He is a National Health and Medical Research Council Principal Research Fellow, and in 2015 was elected to the Fellowship of the Heart rhythm Society (USA) and the Australian Academy of Health and Medical Sciences. His research has focused on the molecular basis of cardiac electrical activity and understanding the genesis of cardiac arrhythmias and sudden cardiac death.  

Phone
02 9295 8771
Location
Victor Chang Cardiac Research institute Lowy Packer Building, 405 Liverpool Street, Darlinghurst, NSW 2010, Australia
  • Book Chapters | 2014
    Vandenberg JI; Ng CA; Mann SA; Perry MD, 2014, 'Voltage-Gated Potassium Channels (Kv10-Kv12)', in Reference Module in Biomedical Research, http://dx.doi.org/10.1016/B978-0-12-801238-3.04809-1
    Book Chapters | 1999
    Grace AA; Saumarez RC; Vandenberg JI, 1999, 'Genetic Engineering and Cardiac Ion Channels', in Developments in Cardiovascular Medicine, Springer Netherlands, pp. 171 - 178, http://dx.doi.org/10.1007/978-94-015-9321-2_16
  • Journal articles | 2024
    Aljassar RW; Shen Q; Albash B; Vandenberg JI; Ebrahim MA; Ng C-A, 2024, 'Integration of validated functional evidence to support the pathogenicity of KCNH2 variants', Genetics in Medicine Open, 2, pp. 101868 - 101868, http://dx.doi.org/10.1016/j.gimo.2024.101868
    Journal articles | 2024
    Balaji P; Liulu X; Sivakumar S; Chong JJH; Kizana E; Vandenberg JI; Hill AP; Hau E; Qian PC, 2024, 'Mechanistic insights and knowledge gaps in the effects of radiation therapy on cardiac arrhythmias.', Int J Radiat Oncol Biol Phys, http://dx.doi.org/10.1016/j.ijrobp.2024.08.040
    Journal articles | 2024
    Clark A; Ferkh A; Vandenberg J; Elhindi J; Thomas L, 2024, 'Altered left atrial metrics in patients with cryptogenic stroke: A systematic review and meta-analysis', European Journal of Clinical Investigation, 54, http://dx.doi.org/10.1111/eci.14175
    Journal articles | 2024
    Elliott AD; Middeldorp ME; McMullen JR; Fatkin D; Thomas L; Gwynne K; Hill AP; Shang C; Hsu MP; Vandenberg JI; Kalman JM; Sanders P; Abhayaratna W; Al-Falahi Z; Bell J; Burrell L; Delbridge L; Elliott A; Ganesan A; Hall T; Hendriks J; Hill A; Hsu M; Jenkins A; Kalman J; Kilkenny M; Kizana E; La Gerche A; McMullen J; Middeldorp M; Olaiya M; Ritchie R; Sanders P; Thijs V; Vandenberg J, 2024, 'Research Priorities for Atrial Fibrillation in Australia: A Statement From the Australian Cardiovascular Alliance Clinical Arrhythmia Theme', Heart Lung and Circulation, http://dx.doi.org/10.1016/j.hlc.2024.08.008
    Journal articles | 2024
    Lau CHY; Flood E; Hunter MJ; Williams-Noonan BJ; Corbett KM; Ng CA; Bouwer JC; Stewart AG; Perozo E; Allen TW; Vandenberg JI, 2024, 'Potassium dependent structural changes in the selectivity filter of HERG potassium channels', Nature Communications, 15, http://dx.doi.org/10.1038/s41467-024-51208-w
    Journal articles | 2024
    Lim S; Mangala MM; Holliday M; Szappanos HC; Barratt-Ross S; Li S; Thorpe J; Liang W; Ranpura GN; Vandenberg JI; Semsarian C; Hill AP; Hool LC, 2024, 'Reduced connexin-43 expression, slow conduction and repolarisation dispersion in a model of hypertrophic cardiomyopathy', DMM Disease Models and Mechanisms, 17, http://dx.doi.org/10.1242/dmm.050407
    Journal articles | 2024
    Ma J; O’Neill M; Richardson E; Ingles J; Thomson K; Solus J; Harvey G; Robertson P; Bezzina C; Roden D; Walsh R; Vandenberg J; Glazer A; Ng C, 2024, 'A Validated SCN5A Functional Assay to Adjudicate Variants of Uncertain Significance from the International Brugada Syndrome Genetics Consortia', Heart, Lung and Circulation, 33, pp. S96 - S96, http://dx.doi.org/10.1016/j.hlc.2024.04.170
    Journal articles | 2024
    Ma JG; O’Neill MJ; Richardson E; Thomson KL; Ingles J; Muhammad A; Solus JF; Davogustto G; Anderson KC; Shoemaker MB; Stergachis AB; Floyd BJ; Dunn K; Parikh VN; Chubb H; Perrin MJ; Roden DM; Vandenberg JI; Ng CA; Glazer AM, 2024, 'Multisite Validation of a Functional Assay to Adjudicate SCN5A Brugada Syndrome–Associated Variants', Circulation: Genomic and Precision Medicine, 17, pp. e004569, http://dx.doi.org/10.1161/CIRCGEN.124.004569
    Journal articles | 2024
    O'Neill M; Ng C-A; Aizawa T; Sala L; Bains S; Denjoy I; Winbo A; Ullah R; Shen Q; Tan C-Y; Kozek K; Vanags L; Mitchell D; Shen A; Wada Y; Kashiwa A; Crotti L; Dagradi F; Musu G; Spazzolini C; Neves RA; Bos JM; Giudicessi J; Lancaster M; Glazer AM; Roden DM; Leenhardt A; Salem J-E; Earle N; Stiles R; Agee T; Johnson CN; Horie M; Skinner JR; Extramiana F; Ackerman MJ; Schwartz PJ; Ohno S; Vandenberg JI; Kroncke B, 2024, 'BS-469619-003 GRANULAR VARIANT-SPECIFIC FEATURES IMPROVE KCNH2-LONG QT SYNDROME RISK STRATIFICATION', Heart Rhythm, 21, pp. S52 - S52, http://dx.doi.org/10.1016/j.hrthm.2024.03.363
    Journal articles | 2024
    O'Neill MJ; Ng C-A; Aizawa T; Sala L; Bains S; Winbo A; Ullah R; Shen Q; Tan C-Y; Kozek K; Vanags LR; Mitchell DW; Shen A; Wada Y; Kashiwa A; Crotti L; Dagradi F; Musu G; Spazzolini C; Neves R; Bos JM; Giudicessi JR; Bledsoe X; Gamazon ER; Lancaster MC; Glazer AM; Knollmann BC; Roden DM; Weile J; Roth F; Salem J-E; Earle N; Stiles R; Agee T; Johnson CN; Horie M; Skinner J; Ackerman MJ; Schwartz PJ; Ohno S; Vandenberg JI; Kroncke BM, 2024, 'Assays of Variant Effect and Automated Patch Clamping Improve KCNH2-LQTS Variant Classification and Cardiac Event Risk Stratification.', Circulation, http://dx.doi.org/10.1161/CIRCULATIONAHA.124.069828
    Journal articles | 2024
    Shen Q; Tan C; Ng C; Vandenberg J, 2024, 'Establishing an Automated Patch Clamp Assay to Assess Both Activity and Adrenergic Responses of KCNQ1 Variants', Heart, Lung and Circulation, 33, pp. S115 - S115, http://dx.doi.org/10.1016/j.hlc.2024.04.207
    Journal articles | 2024
    Tan C; Shen Q; Vandenberg J; Ng C, 2024, 'Establishing a Functional Genomics Assay to Assess Clinical Variants in CACNA1C-Related Disorders', Heart, Lung and Circulation, 33, pp. S117 - S117, http://dx.doi.org/10.1016/j.hlc.2024.04.210
    Journal articles | 2024
    TeBay C; Vandenberg JI, 2024, 'The real-world incidence of severe QT prolongation in patients taking antipsychotic drugs', Heart Rhythm, 21, pp. 329 - 330, http://dx.doi.org/10.1016/j.hrthm.2023.11.012
    Journal articles | 2024
    Thomson KL; Jiang C; Richardson E; Westphal DS; Burkard T; Wolf CM; Vatta M; Harrison SM; Ingles J; Bezzina CR; Kroncke BM; Vandenberg JI; Ng CA, 2024, 'Clinical interpretation of KCNH2 variants using a robust PS3/BS3 functional patch-clamp assay', Human Genetics and Genomics Advances, 5, pp. 100270, http://dx.doi.org/10.1016/j.xhgg.2024.100270
    Journal articles | 2023
    Copier JS; Bootsma M; Ng CA; Wilde AAM; Bertels RA; Bikker H; Christiaans I; van der Crabben SN; Hol JA; Koopmann TT; Knijnenburg J; Lommerse AAJ; van der Smagt JJ; Bezzina CR; Vandenberg JI; Verkerk AO; Barge-Schaapveld DQCM; Lodder EM, 2023, 'Reclassification of a likely pathogenic Dutch founder variant in KCNH2; implications of reduced penetrance', Human Molecular Genetics, 32, pp. 1072 - 1082, http://dx.doi.org/10.1093/hmg/ddac261
    Journal articles | 2023
    Heitmann S; Vandenberg JI; Hill AP, 2023, 'Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology', eLife, 12, http://dx.doi.org/10.7554/elife.90027.3
    Journal articles | 2023
    Kerr NP; Hill A; Vandenberg JI, 2023, 'PO-01-157 MULTIELECTRODE ARRAY RECORDINGS OF IPSC CARDIOMYOCYTES SHOW GREATER VARIABILITY BETWEEN REPLICATE DIFFERENTIATIONS THAN BETWEEN DIFFERENT IPSC LINES FROM HEALTHY INDIVIDUALS AND CORRELATE WITH EXPRESSION OF SARCOMERIC GENES', Heart Rhythm, 20, pp. S150 - S150, http://dx.doi.org/10.1016/j.hrthm.2023.03.505
    Journal articles | 2023
    Lau C; Flood E; Hunter M; Corbett K; Ng C; Bouwer J; Stewart A; Perozo E; Allen TW; Vandenberg J, 2023, 'Structural basis of rapid inactivation of HERG potassium channels', BIOPHYSICAL JOURNAL, 122, pp. 446A - 446A, http://dx.doi.org/10.1016/j.bpj.2022.11.2409
    Journal articles | 2023
    Lee W; Ng B; Mangala MM; Perry MD; Subbiah RN; Vandenberg JI; Hill AP, 2023, 'Action Potential Morphology Accurately Predicts Proarrhythmic Risk for Drugs with Potential to Prolong Cardiac Repolarization', Circulation: Arrhythmia and Electrophysiology, 16, pp. 399 - 410, http://dx.doi.org/10.1161/CIRCEP.122.011574
    Journal articles | 2023
    Ma G; O’Neill M; Richardson E; Thomson K; Ingles J; Roden D; Vandenberg J; Ng C; Glazer A, 2023, 'Utility of a High-Throughput Electrophysiology Assay to Determine Pathogenicity of SCN5A Variants Associated With Brugada Syndrome', Heart, Lung and Circulation, 32, pp. S131 - S132, http://dx.doi.org/10.1016/j.hlc.2023.06.763
    Journal articles | 2023
    Tardo DT; Peck M; Subbiah R; Vandenberg JI; Hill AP, 2023, 'The diagnostic role of T wave morphology biomarkers in congenital and acquired long QT syndrome: A systematic review', Annals of Noninvasive Electrocardiology, 28, http://dx.doi.org/10.1111/anec.13015
    Journal articles | 2023
    Thorpe J; Perry MD; Contreras O; Hurley E; Parker G; Harvey RP; Hill AP; Vandenberg JI, 2023, 'Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmia', Stem Cell Research and Therapy, 14, http://dx.doi.org/10.1186/s13287-023-03405-5
    Journal articles | 2023
    Zeng YC; Sobti M; Quinn A; Smith NJ; Brown SHJ; Vandenberg JI; Ryan RM; O’Mara ML; Stewart AG, 2023, 'Structural basis of promiscuous substrate transport by Organic Cation Transporter 1', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-42086-9
    Journal articles | 2022
    Bursill CA; Smith NJ; Palpant N; Tan I; Sunde M; Harvey RP; Lewis B; Figtree GA; Vandenberg JI, 2022, 'Don't Turn Off the Tap! The Importance of Discovery Science to the Australian Cardiovascular Sector and Improving Clinical Outcomes Into the Future', Heart Lung and Circulation, 31, pp. 1321 - 1332, http://dx.doi.org/10.1016/j.hlc.2022.06.669
    Journal articles | 2022
    Jiang C; Richardson E; Farr J; Hill AP; Ullah R; Kroncke BM; Harrison SM; Thomson KL; Ingles J; Vandenberg JI; Ng CA, 2022, 'A calibrated functional patch-clamp assay to enhance clinical variant interpretation in KCNH2-related long QT syndrome', American Journal of Human Genetics, 109, pp. 1199 - 1207, http://dx.doi.org/10.1016/j.ajhg.2022.05.002
    Journal articles | 2022
    Kerr NP; Vandenberg JI, 2022, 'The yin and yang of Tbx5 variant effects on sodium channel function', Cardiovascular Research, 118, pp. 929 - 931, http://dx.doi.org/10.1093/cvr/cvac015
    Journal articles | 2022
    Ng CA; Ullah R; Farr J; Hill AP; Kozek KA; Vanags LR; Mitchell DW; Kroncke BM; Vandenberg JI, 2022, 'A massively parallel assay accurately discriminates between functionally normal and abnormal variants in a hotspot domain of KCNH2', American Journal of Human Genetics, 109, pp. 1208 - 1216, http://dx.doi.org/10.1016/j.ajhg.2022.05.003
    Journal articles | 2022
    Ng CA; Vandenberg JI, 2022, 'When it takes two to get one into trouble', Heart Rhythm, 19, pp. 293 - 294, http://dx.doi.org/10.1016/j.hrthm.2021.10.017
    Journal articles | 2022
    Peters S; Thompson BA; Perrin M; James P; Zentner D; Kalman JM; Vandenberg JI; Fatkin D, 2022, 'Arrhythmic Phenotypes Are a Defining Feature of Dilated Cardiomyopathy-Associated SCN5A Variants: A Systematic Review', Circulation: Genomic and Precision Medicine, 15, pp. E003432, http://dx.doi.org/10.1161/CIRCGEN.121.003432
    Journal articles | 2022
    TeBay C; McArthur JR; Mangala M; Kerr N; Heitmann S; Perry MD; Windley MJ; Vandenberg JI; Hill AP, 2022, 'Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation', British Journal of Pharmacology, 179, pp. 2631 - 2646, http://dx.doi.org/10.1111/bph.15757
    Journal articles | 2022
    Windley MJ; Farr J; TeBay C; Vandenberg JI; Hill AP, 2022, 'High throughput measurement of hERG drug block kinetics using the CiPA dynamic protocol', Journal of Pharmacological and Toxicological Methods, 117, http://dx.doi.org/10.1016/j.vascn.2022.107192
    Journal articles | 2022
    2022, 'A Calibrated Functional Patch Clamp Assay to Enhance Clinical Variant Interpretation in KCNH2-Related Long QT Syndrome', Heart, Lung and Circulation, 31, pp. S37 - S37, http://dx.doi.org/10.1016/j.hlc.2022.06.003
    Journal articles | 2022
    Jiang C; Richardson E; Farr J; Hill A; Ullah R; Kroncke B; Harrison S; Thomson K; Ingles J; Vandenberg J; Ng C, 2022, 'Abstracts for the 70th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, 11-14 August 2022 Abstracts', HEART LUNG AND CIRCULATION, vol. 31, pp. S37 - S363, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000874386600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2021
    Ballouz S; Mangala MM; Perry MD; Heitmann S; Gillis JA; Hill AP; Vandenberg JI, 2021, 'Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events', Cardiovascular Research, 117, pp. 2216 - 2227, http://dx.doi.org/10.1093/cvr/cvaa280
    Journal articles | 2021
    Heitmann S; Shpak A; Vandenberg JI; Hill AP, 2021, 'Arrhythmogenic effects of ultra-long and bistable cardiac action potentials', PLoS Computational Biology, 17, pp. e1008683, http://dx.doi.org/10.1371/JOURNAL.PCBI.1008683
    Journal articles | 2021
    Ng C-A; Farr J; Young P; Windley M; Perry M; Hill A; Vandenberg J, 2021, 'HeterozygousKCNH2variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology', , http://dx.doi.org/10.1101/2021.02.02.427891
    Journal articles | 2021
    Ng CA; Farr J; Young P; Windley MJ; Perry MD; Hill AP; Vandenberg JI, 2021, 'Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-Throughput automated patch clamp electrophysiology', Biology Methods and Protocols, 6, pp. 1 - 9, http://dx.doi.org/10.1093/biomethods/bpab003
    Journal articles | 2020
    Ganesan AN; Vanoye CG; Alam F; Waddell-Smith KE; McGavigan AD; Correnti G; Haan E; Brown A; Vandenberg J; George AL, 2020, 'Long QT syndrome type 1 in an Australian indigenous patient', Circulation: Genomic and Precision Medicine, 13, pp. 93 - 94, http://dx.doi.org/10.1161/CIRCGEN.119.002813
    Journal articles | 2020
    Heitmann S; Vandenberg JI; Hill AP, 2020, 'Arrhythmogenesis as the failure of repolarization', , http://dx.doi.org/10.1101/2020.07.02.185694
    Journal articles | 2020
    Kozek KA; Glazer AM; Ng CA; Blackwell D; Egly CL; Vanags LR; Blair M; Mitchell D; Matreyek KA; Fowler DM; Knollmann BC; Vandenberg JI; Roden DM; Kroncke BM, 2020, 'High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1', Heart Rhythm, 17, pp. 2180 - 2189, http://dx.doi.org/10.1016/j.hrthm.2020.05.041
    Journal articles | 2020
    Li Z; Mirams GR; Yoshinaga T; Ridder BJ; Han X; Chen JE; Stockbridge NL; Wisialowski TA; Damiano B; Severi S; Morissette P; Kowey PR; Holbrook M; Smith G; Rasmusson RL; Liu M; Song Z; Qu Z; Leishman DJ; Steidl-Nichols J; Rodriguez B; Bueno-Orovio A; Zhou X; Passini E; Edwards AG; Morotti S; Ni H; Grandi E; Clancy CE; Vandenberg J; Hill A; Nakamura M; Singer T; Polonchuk L; Greiter-Wilke A; Wang K; Nave S; Fullerton A; Sobie EA; Paci M; Musuamba Tshinanu F; Strauss DG, 2020, 'General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy', Clinical Pharmacology and Therapeutics, 107, pp. 102 - 111, http://dx.doi.org/10.1002/cpt.1647
    Journal articles | 2020
    Ng CA; Perry MD; Liang W; Smith NJ; Foo B; Shrier A; Lukacs GL; Hill AP; Vandenberg JI, 2020, 'High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants', Heart Rhythm, 17, pp. 492 - 500, http://dx.doi.org/10.1016/j.hrthm.2019.09.020
    Journal articles | 2020
    Perry MD; Ng CA; Mangala MM; Ng TYM; Hines AD; Liang W; Xu MJO; Hill AP; Vandenberg JI, 2020, 'Pharmacological activation of IKrin models of long QT Type 2 risks overcorrection of repolarization', Cardiovascular Research, 116, pp. 1434 - 1445, http://dx.doi.org/10.1093/cvr/cvz247
    Journal articles | 2019
    Lee W; Windley MJ; Perry MD; Vandenberg JI; Hill AP, 2019, 'Protocol-dependent differences in IC50 values measured in human ether-á-go-go–related gene assays occur in a predictable way and can be used to quantify state preference of drug binding', Molecular Pharmacology, 95, pp. 537 - 550, http://dx.doi.org/10.1124/mol.118.115220
    Journal articles | 2019
    Munawar S; Vandenberg JI; Jabeen I, 2019, 'Molecular docking guided grid-independent descriptor analysis to probe the impact ofwater molecules on conformational changes of hERG inhibitors in drug trapping phenomenon', International Journal of Molecular Sciences, 20, http://dx.doi.org/10.3390/ijms20143385
    Journal articles | 2019
    Tardo D; Peck M; Hill A; Vandenberg J, 2019, 'T Wave Morphology Biomarkers in Congenital and Acquired Long QT Syndrome', Heart, Lung and Circulation, 28, pp. S229 - S229, http://dx.doi.org/10.1016/j.hlc.2019.06.223
    Journal articles | 2018
    Beattie KA; Hill AP; Bardenet R; Cui Y; Vandenberg JI; Gavaghan DJ; de Boer TP; Mirams GR, 2018, 'Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics', Journal of Physiology, 596, pp. 1813 - 1828, http://dx.doi.org/10.1113/JP275733
    Journal articles | 2018
    Lau C; Hunter MJ; Stewart A; Perozo E; Vandenberg JI, 2018, 'Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy', Journal of Physiology, 596, pp. 1107 - 1119, http://dx.doi.org/10.1113/JP274888
    Journal articles | 2018
    Lee W; Mangala M; Windley M; Perry M; Vandenberg J; Hill A, 2018, 'Novel Pre–Clinical Risk Prediction of Acquired Long QT Syndrome', Heart, Lung and Circulation, 27, pp. S180 - S180, http://dx.doi.org/10.1016/j.hlc.2018.06.309
    Journal articles | 2018
    Munawar S; Windley MJ; Tse EG; Todd MH; Hill AP; Vandenberg JI; Jabeen I, 2018, 'Experimentally validated pharmacoinformatics approach to predict hERG inhibition potential of new chemical entities', Frontiers in Pharmacology, 9, pp. 1035, http://dx.doi.org/10.3389/fphar.2018.01035
    Journal articles | 2018
    Ng T; Vandenberg J; Perry M, 2018, 'Pharmacological Activation of hERG Potassium Channels in Congenital Long QT Syndrome 2: Activator Compound ICA-105574 and its Effects on Mutant hERG Potassium Channels in Long QT Syndrome 2', Heart, Lung and Circulation, 27, pp. S61 - S61, http://dx.doi.org/10.1016/j.hlc.2018.06.039
    Journal articles | 2018
    Windley MJ; Lee W; Vandenberg JI; Hill AP, 2018, 'The temperature dependence of kinetics associated with drug block of hERG channels is compound-specific and an important factor for proarrhythmic risk prediction', Molecular Pharmacology, 94, pp. 760 - 769, http://dx.doi.org/10.1124/mol.117.111534
    Journal articles | 2017
    Chiamvimonvat N; Chen-Izu Y; Clancy CE; Deschenes I; Dobrev D; Heijman J; Izu L; Qu Z; Ripplinger CM; Vandenberg JI; Weiss JN; Koren G; Banyasz T; Grandi E; Sanguinetti MC; Bers DM; Nerbonne JM, 2017, 'Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics', Journal of Physiology, 595, pp. 2229 - 2252, http://dx.doi.org/10.1113/JP272883
    Journal articles | 2017
    Grandi E; Sanguinetti MC; Bartos DC; Bers DM; Chen-Izu Y; Chiamvimonvat N; Colecraft HM; Delisle BP; Heijman J; Navedo MF; Noskov S; Proenza C; Vandenberg JI; Yarov-Yarovoy V, 2017, 'Potassium channels in the heart: structure, function and regulation', Journal of Physiology, 595, pp. 2209 - 2228, http://dx.doi.org/10.1113/JP272864
    Journal articles | 2017
    Lee W; Windley MJ; Vandenberg JI; Hill AP, 2017, 'In vitro and in silico risk assessment in acquired long QT syndrome: The devil is in the details', Frontiers in Physiology, 8, http://dx.doi.org/10.3389/fphys.2017.00934
    Journal articles | 2017
    Phan K; Ng CA; David E; Shishmarev D; Kuchel PW; Vandenberg JI; Perry MD, 2017, 'The S1 helix critically regulates the finely tuned gating of Kv11.1 channels', Journal of Biological Chemistry, 292, pp. 7688 - 7705, http://dx.doi.org/10.1074/jbc.M117.779298
    Journal articles | 2017
    Vandenberg JI; Perozo E; Allen TW, 2017, 'Towards a Structural View of Drug Binding to hERG K+ Channels', Trends in Pharmacological Sciences, 38, pp. 899 - 907, http://dx.doi.org/10.1016/j.tips.2017.06.004
    Journal articles | 2017
    Vandenberg JI; Perry MD; Hill AP, 2017, 'Recent advances in understanding and prevention of sudden cardiac death', F1000Research, 6, http://dx.doi.org/10.12688/f1000research.11855.1
    Journal articles | 2017
    Windley MJ; Abi-Gerges N; Fermini B; Hancox JC; Vandenberg JI; Hill AP, 2017, 'Measuring kinetics and potency of hERG block for CiPA', Journal of Pharmacological and Toxicological Methods, 87, pp. 99 - 107, http://dx.doi.org/10.1016/j.vascn.2017.02.017
    Journal articles | 2016
    Christensen AH; Chatelain FC; Huttner IG; Olesen MS; Soka M; Feliciangeli S; Horvat C; Santiago CF; Vandenberg JI; Schmitt N; Olesen SP; Lesage F; Fatkin D; Martin I, 2016, 'The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size', Journal of Molecular and Cellular Cardiology, 97, pp. 24 - 35, http://dx.doi.org/10.1016/j.yjmcc.2016.04.006
    Journal articles | 2016
    Fermini B; Hancox JC; Abi-Gerges N; Bridgland-Taylor M; Chaudhary KW; Colatsky T; Correll K; Crumb W; Damiano B; Erdemli G; Gintant G; Imredy J; Koerner J; Kramer J; Levesque P; Li Z; Lindqvist A; Obejero-Paz CA; Rampe D; Sawada K; Strauss DG; Vandenberg JI, 2016, 'A new perspective in the field of cardiac safety testing through the comprehensive in vitro proarrhythmia assay paradigm', Journal of Biomolecular Screening, 21, pp. 1 - 11, http://dx.doi.org/10.1177/1087057115594589
    Journal articles | 2016
    Heide J; Zhang F; Bigos KL; Mann SA; Carr VJ; Weickert CS; Green MJ; Weinberger DR; Vandenberg JI, 2016, 'Differential response to risperidone in schizophrenia patients by KCNH2Genotype and drug metabolizer status', American Journal of Psychiatry, 173, pp. 53 - 59, http://dx.doi.org/10.1176/appi.ajp.2015.14050653
    Journal articles | 2016
    Hill AP; Perry MD; Abi-Gerges N; Couderc JP; Fermini B; Hancox JC; Knollmann BC; Mirams GR; Skinner J; Zareba W; Vandenberg JI, 2016, 'Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century', Journal of Physiology, 594, pp. 6893 - 6908, http://dx.doi.org/10.1113/JP272015
    Journal articles | 2016
    Hodkinson EC; Neijts M; Sadrieh A; Imtiaz MS; Baumert M; Subbiah RN; Hayward CS; Boomsma D; Willemsen G; Vandenberg JI; Hill AP; De Geus E, 2016, 'Heritability of ECG biomarkers in the Netherlands twin registry measured from Holter ECGs', Frontiers in Physiology, 7, http://dx.doi.org/10.3389/fphys.2016.00154
    Journal articles | 2016
    Immanuel S; Sadrieh A; Baumert M; Couderc J; Zareba W; Hill A; Vandenberg J, 2016, 'T Wave Morphology Can Distinguish Healthy Controls From LQTS Patients With Normal QT Intervals', Heart, Lung and Circulation, 25, pp. S262 - S262, http://dx.doi.org/10.1016/j.hlc.2016.06.610
    Journal articles | 2016
    Immanuel SA; Sadrieh A; Baumert M; Couderc JP; Zareba W; Hill AP; Vandenberg JI, 2016, 'T-wave morphology can distinguish healthy controls from LQTS patients', Physiological Measurement, 37, pp. 1456 - 1473, http://dx.doi.org/10.1088/0967-3334/37/9/1456
    Journal articles | 2016
    Lee W; Mann SA; Windley MJ; Imtiaz MS; Vandenberg JI; Hill AP, 2016, 'In silico assessment of kinetics and state dependent binding properties of drugs causing acquired LQTS', Progress in Biophysics and Molecular Biology, 120, pp. 89 - 99, http://dx.doi.org/10.1016/j.pbiomolbio.2015.12.005
    Journal articles | 2016
    Mann SA; Imtiaz M; Winbo A; Rydberg A; Perry MD; Couderc JP; Polonsky B; McNitt S; Zareba W; Hill AP; Vandenberg JI, 2016, 'Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes', Journal of Molecular and Cellular Cardiology, 100, pp. 25 - 34, http://dx.doi.org/10.1016/j.yjmcc.2016.09.011
    Journal articles | 2016
    Ng CA; Gravel AE; Perry MD; Arnold AA; Marcotte I; Vandenberg JI, 2016, 'Tyrosine residues from the s4-s5 linker of kv11.1 channels are critical for slow deactivation', Journal of Biological Chemistry, 291, pp. 17293 - 17302, http://dx.doi.org/10.1074/jbc.M116.729392
    Journal articles | 2016
    Perry MD; Ng CA; Phan K; David E; Steer K; Hunter MJ; Mann SA; Imtiaz M; Hill AP; Ke Y; Vandenberg JI, 2016, 'Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations', Journal of Physiology, 594, pp. 4031 - 4049, http://dx.doi.org/10.1113/JP271805
    Journal articles | 2016
    Perry MD; Vandenberg JI, 2016, 'TECRL: Connecting sequence to consequence for a new sudden cardiac death gene', EMBO Molecular Medicine, 8, pp. 1364 - 1365, http://dx.doi.org/10.15252/emmm.201606967
    Journal articles | 2016
    Windley MJ; Mann SA; Vandenberg JI; Hill AP, 2016, 'Temperature effects on kinetics of KV11.1 drug block have important consequences for in silico proarrhythmic risk prediction', Molecular Pharmacology, 90, pp. 1 - 11, http://dx.doi.org/10.1124/mol.115.103127
    Journal articles | 2015
    Fonoudi H; Ansari H; Abbasalizadeh S; Larijani MR; Kiani S; Hashemizadeh S; Zarchi AS; Bosman A; Blue GM; Pahlavan S; Perry M; Orr Y; Mayorchak Y; Vandenberg J; Talkhabi M; Winlaw DS; Harvey RP; Aghdami N; Baharvand H, 2015, 'A universal and robust integrated platform for the scalable production of human cardiomyocytes from pluripotent stem cells', Stem Cells Translational Medicine, 4, pp. 1482 - 1494, http://dx.doi.org/10.5966/sctm.2014-0275
    Journal articles | 2015
    Heide J; Vandenberg JI; Weickert CS, 2015, 'Expression of KCNH2-3.1 mRNA is increased in small neurons in the dorsolateral prefrontal cortex in patients with schizophrenia', European Journal of Psychiatry, 29, pp. 85 - 103, http://dx.doi.org/10.4321/S0213-61632015000200001
    Journal articles | 2015
    Perry MD; Ng CA; Mann SA; Sadrieh A; Imtiaz M; Hill AP; Vandenberg JI, 2015, 'Getting to the heart of hERG K+ channel gating', Journal of Physiology, 593, pp. 2575 - 2585, http://dx.doi.org/10.1113/JP270095
    Journal articles | 2014
    Hill AP; Perrin MJ; Heide J; Campbell TJ; Mann SA; Vandenberg JI, 2014, 'Kinetics of drug interaction with the Kv11.1 potassium channel', Molecular Pharmacology, 85, pp. 769 - 776, http://dx.doi.org/10.1124/mol.114.091835
    Journal articles | 2014
    Hodkinson EC; Hill AP; Vandenberg JI, 2014, 'The Romano-Ward syndrome--1964-2014: 50 years of progress.', Irish medical journal, 107, pp. 122 - 124
    Journal articles | 2014
    Ke Y; Hunter MJ; Ng CA; Perry MD; Vandenberg JI, 2014, 'Role of the cytoplasmic N-terminal cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11.1 channels', Journal of Biological Chemistry, 289, pp. 13782 - 13791, http://dx.doi.org/10.1074/jbc.M113.531277
    Journal articles | 2014
    Ng CA; Phan K; Hill AP; Vandenberg JI; Perry MD, 2014, 'Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels', Journal of Biological Chemistry, 289, pp. 25822 - 25832, http://dx.doi.org/10.1074/jbc.M114.558379
    Journal articles | 2014
    Sadrieh A; Domanski L; Pitt-Francis J; Mann SA; Hodkinson EC; Ng CA; Perry MD; Taylor JA; Gavaghan D; Subbiah RN; Vandenberg JI; Hill AP, 2014, 'Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2', Nature Communications, 5, http://dx.doi.org/10.1038/ncomms6069
    Journal articles | 2014
    Vandenberg JI; Perry MD, 2014, 'Can many subunits make light work of ion channel inactivation?', Journal of Physiology, 592, pp. 4411 - 4412, http://dx.doi.org/10.1113/jphysiol.2014.281568
    Journal articles | 2013
    Huttner IG; Trivedi G; Jacoby A; Mann SA; Vandenberg JI; Fatkin D, 2013, 'A transgenic zebrafish model of a human cardiac sodium channel mutation exhibits bradycardia, conduction-system abnormalities and early death', Journal of Molecular and Cellular Cardiology, 61, pp. 123 - 132, http://dx.doi.org/10.1016/j.yjmcc.2013.06.005
    Journal articles | 2013
    Ke Y; Ng CA; Hunter MJ; Mann SA; Heide J; Hill AP; Vandenberg JI, 2013, 'Trafficking defects in PAS domain mutant Kv11.1 channels: Roles of reduced domain stability and altered domain-domain interactions', Biochemical Journal, 454, pp. 69 - 77, http://dx.doi.org/10.1042/BJ20130328
    Journal articles | 2013
    Liang B; Soka M; Christensen AH; Olesen MS; Larsen AP; Knop FK; Wang F; Nielsen JB; Andersen MN; Humphreys D; Mann SA; Huttner IG; Vandenberg JI; Svendsen JH; Haunsø S; Preiss T; Seebohm G; Olesen SP; Schmitt N; Fatkin D, 2013, 'Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis.', J Mol Cell Cardiol, http://dx.doi.org/10.1016/j.yjmcc.2013.12.014
    Journal articles | 2013
    Mann S; Sadrieh A; Subbiah R; Domanski L; Taylor J; Vandenberg J; Hill A, 2013, 'Epistatic Interactions of Ion Channels Underlie Variability in Cardiac Electrical Activity. In-silico Analysis of the Electrocardiogram', Heart, Lung and Circulation, 22, pp. S95 - S96, http://dx.doi.org/10.1016/j.hlc.2013.05.226
    Journal articles | 2013
    Martin I; Trivedi G; Jacoby A; Mann S; Vandenberg J; Fatkin D, 2013, 'A Transgenic Zebrafish Model of a Human Cardiac Sodium Channel Mutation Exhibits Bradycardia, Conduction-System Abnormalities and Early Death', Heart, Lung and Circulation, 22, pp. S227 - S227, http://dx.doi.org/10.1016/j.hlc.2013.05.539
    Journal articles | 2013
    Ng CA; Ke Y; Perry MD; Tan PS; Hill AP; Vandenberg JI, 2013, 'C-Terminal β9-Strand of the Cyclic Nucleotide-Binding Homology Domain Stabilizes Activated States of Kv11.1 Channels', PLoS ONE, 8, pp. e77032, http://dx.doi.org/10.1371/journal.pone.0077032
    Journal articles | 2013
    Olesen M; Liang B; Soka M; Larsen AP; Knop FK; Wang F; Nielsen JB; Andersen MN; Humphreys D; Mann SA; Vandenberg JI; Svendsen JH; Haunso S; Preiss T; Seebohm G; Olesen S-P; Schmitt N; Fatkin D, 2013, 'TASK-1 potassium channel mutations in atrial fibrillation', European Heart Journal, 34, pp. 3411 - 3411, http://dx.doi.org/10.1093/eurheartj/eht309.3411
    Journal articles | 2013
    Perry MD; Wong S; Ng CA; Vandenberg JI, 2013, 'Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels', Journal of General Physiology, 142, pp. 275 - 288, http://dx.doi.org/10.1085/jgp.201310975
    Journal articles | 2013
    Sadrieh A; Mann SA; Subbiah RN; Domanski L; Taylor JA; Vandenberg JI; Hill AP, 2013, 'Quantifying the origins of population variability in cardiac electrical activity through sensitivity analysis of the electrocardiogram', Journal of Physiology, 591, pp. 4207 - 4222, http://dx.doi.org/10.1113/jphysiol.2013.251710
    Journal articles | 2013
    Vandenberg J, 2013, '2SDP-03 Ion channel gating and Japanese Puzzle Boxes(2SDP ASB-BSJ Bilateral Symposium 2013,Symposium,The 51th Annual Meeting of the Biophysical Society of Japan)', Seibutsu Butsuri, 53, pp. S99 - S99, http://dx.doi.org/10.2142/biophys.53.s99_3
    Journal articles | 2012
    Heide J; Mann SA; Vandenberg JI, 2012, 'The Schizophrenia-Associated Kv11.1-3.1 Isoform Results in Reduced Current Accumulation during Repetitive Brief Depolarizations', PLoS ONE, 7, pp. e45624, http://dx.doi.org/10.1371/journal.pone.0045624
    Journal articles | 2012
    Mann SA; Otway R; Guo G; Soka M; Karlsdotter L; Trivedi G; Ohanian M; Zodgekar P; Smith RA; Wouters MA; Subbiah RN; Walker BD; Kuchar D; Sanders P; Griffiths LR; Vandenberg JI; Fatkin D, 2012, 'Epistatic effects of potassium channel variation on cardiac repolarization and atrial fibrillation risk', Journal of the American College of Cardiology, 59, pp. 1017 - 1025, http://dx.doi.org/10.1016/j.jacc.2011.11.039
    Journal articles | 2012
    Ng CA; Perry M; Tan P; Hill A; Kuchel PW; Vandenberg JI, 2012, 'The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating', PLoS ONE, 7, pp. e31640, http://dx.doi.org/10.1371/journal.pone.0031640
    Journal articles | 2012
    Tan PS; Perry MD; Ng C; Vandenberg JI; Hill A, 2012, 'Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels', Journal of General Physiology, 140, pp. 293 - 306, http://dx.doi.org/10.1085/jgp.201110761
    Journal articles | 2012
    Vandenberg JI; Mann SA; Castro ML; Ohanian M; Guo G; Zodgekar PR; Sheu A; Stockhammer K; Fatkin D; Subbiah RN, 2012, 'R222Q SCN5A Mutation Is Associated With Reversible Ventricular Ectopy and Dilated Cardiomyopathy', Journal of the American College of Cardiology, 60, pp. 1566 - 1573, http://dx.doi.org/10.1016/j.jacc.2012.05.050
    Journal articles | 2012
    Vandenberg JI; Ng CA, 2012, 'Insights into hERG K+ channel structure and function from NMR studies', European Biophysics Journal With Biophysics Letters, 42, pp. 71 - 79, http://dx.doi.org/10.1007/s00249-012-0808-6
    Journal articles | 2012
    Vandenberg JI; Perry MD; Mann SA; Hill A, 2012, 'hERG K+ CHANNELS: STRUCTURE, FUNCTION, AND CLINICAL SIGNIFICANCE', Physiological Reviews, 92, pp. 1393 - 1478, http://dx.doi.org/10.1152/physrev.00036.2011
    Journal articles | 2012
    Vandenberg JI, 2012, 'Hodgkin and Huxley and the basis for electrical signalling: a remarkable legacy still going strong', The Journal of Physiology, 590, pp. 2569 - 2570, http://dx.doi.org/10.1113/jphysiol.2012.233411
    Journal articles | 2012
    Vandenberg JI, 2012, 'Is medroxyprogesterone safe in women with long QT syndrome?', Heart Rhythm, 9, pp. 1148 - 1149, http://dx.doi.org/10.1016/j.hrthm.2012.02.029
    Journal articles | 2011
    Ng C; Hunter M; Perry M; Mobli M; Ke Y; Kuchel PW; King GF; Stock D; Vandenberg JI; Hunter M, 2011, 'The N-terminal tail of hERG contains an amphipathic alpha-helix that regulates channel deactivation', PLoS One, 6, pp. e16191, http://dx.doi.org/10.1371/journal.pone.0016191
    Journal articles | 2011
    Szekely D; Vandenberg JI; Dokos S; Hill A, 2011, 'An improved curvilinear gradient method for parameter optimization in complex biological models', Medical and Biological Engineering and Computing, 49, pp. 289 - 296, http://dx.doi.org/10.1007/s11517-010-0667-1
    Journal articles | 2010
    Clarke O; Caputo A; Hill A; Vandenberg JI; Smith B; Gulbis J, 2010, 'Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels', Cell, 141, pp. 1018 - 1029, http://dx.doi.org/10.1016/j.cell.2010.05.003
    Journal articles | 2010
    Wang DT; Hill A; Mann SA; Tan P; Vandenberg JI, 2010, 'Mapping the sequence of conformational changes underlying selectivity filter gating in the K(v)11.1 potassium channel', Nature Structural and Molecular Biology, 18, pp. 35 - 41, http://dx.doi.org/10.1038/nsmb.1966
    Journal articles | 2009
    Ju P; Pages G; Riek RP; Chen P-C; Torres A; Bansal PS; Kuyucak S; Kuchel PW; Vandenberg JI, 2009, 'The pore domain outer helix contributes to both activation and inactivation of the hERG K+ channel', The Journal of Biological Chemistry, 284, pp. 1000 - 1006, http://dx.doi.org/10.1074/jbc.M806400200
    Journal articles | 2009
    Pages G; Torres A; Ju P; Bansal PS; Alewood P; Kuchel PW; Vandenberg JI, 2009, 'Structure of the pore-helix of the hERG K(+) channel', European Biophysics Journal, 39, pp. 111 - 120, http://dx.doi.org/10.1007/s00249-009-0433-1
    Journal articles | 2009
    Perrin MJ; Campbell TJ; Hill AP; Vandenberg JI, 2009, 'Insight into Accurate Testing of Drugs which Cause the Acquired Long-QT Syndrome', Heart, Lung and Circulation, 18, pp. S135 - S135, http://dx.doi.org/10.1016/j.hlc.2009.05.306
    Journal articles | 2009
    Zhao JT; Hill A; Varghese A; Cooper A; Swan H; Laitinen-Forsblom P; Rees M; Skinner J; Campbell TJ; Vandenberg JI, 2009, 'Not all hERG pore domain mutations have a severe phenotype: G584S has an inactivation gating defect with mild phenotype compared to G572S, which has a dominant negative trafficking defect and a severe phenotype', Journal of Cardiovascular Electrophysiology, 20, pp. 923 - 930, http://dx.doi.org/10.1111/j.1540-8167.2009.01468.x
    Journal articles | 2008
    Bansal PS; Torres A; Crossett B; Wong KK; Koh JM; Geraghty D; Vandenberg JI; Kuchel PW, 2008, 'Substrate specificity of platypus venom L-to-D-peptide isomerase', The Journal of Biological Chemistry, 283, pp. 8969 - 8975, http://dx.doi.org/10.1074/jbc.M709762200
    Journal articles | 2008
    Clarke CE; Veale E; Wyse KR; Vandenberg JI; Mathie A, 2008, 'The M1P1 loop of TASK3 K2P channels apposes the selectivity filter and influences channel function', The Journal of Biological Chemistry, 283, pp. 16985 - 16992, http://dx.doi.org/10.1074/jbc.M801368200
    Journal articles | 2008
    Kuchel PW; Perrin MJ; Campbell TJ; Vandenberg JI, 2008, 'Drug Binding to the Inactivated State Is Necessary but Not Sufficient for High-Affinity Binding to Human Ether-a-go-go-Related Gene Channels', Molecular Pharmacology, 74, pp. 1443 - 1452, http://dx.doi.org/10.1124/mol.108.049056
    Journal articles | 2008
    Perrin MJ; Subbiah RN; Vandenberg JI; Hill A, 2008, 'Human ether-a-go-go related gene (hERG) K+ channels: Function and dysfunction', Progress in Biophysics and Molecular Biology, 98, pp. 137 - 148
    Journal articles | 2007
    Fatkin D; Otway R; Vandenberg JI, 2007, 'Genes and atrial fibrillation - A new look at an old problem', Circulation, 116, pp. 782 - 792, http://dx.doi.org/10.1161/CIRCULATIONAHA.106.688889
    Journal articles | 2007
    Hill A; Campbell TJ; Bansal PS; Kuchel PW; Vandenberg JI, 2007, 'The S631A mutation causes a mechanistic switch in the block of hERG channels by CnErgl', Biophysical Journal, 93, pp. 32 - 34, http://dx.doi.org/10.1529/biophysj.107.114561
    Journal articles | 2007
    Hill A; Sunde M; Campbell TJ; Vandenberg JI, 2007, 'Mechanism of block of the hERG K+ channel by the scorpion toxin CnErg1', Biophysical Journal, 92, pp. 3915 - 3929, http://dx.doi.org/10.1529/biophysj.106.101956
    Journal articles | 2007
    Hill A; Sunde M; Vandenberg JI, 2007, 'Mechanisms of block of the hERG K+ channel by the scorpion toxin CnErg1', Biophysical Journal, pp. 124A - 124A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000243972400570&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Journal articles | 2007
    Kutteh R; Vandenberg JI; Kuyucak S, 2007, 'Molecular dynamics and continuum electrostatics studies of inactivation in the HERG potassium channel', Journal of Physical Chemistry B, 111, pp. 1090 - 1098, http://dx.doi.org/10.1021/jp066294d
    Journal articles | 2007
    Otway R; Vandenberg JI; Fatkin D, 2007, 'Atrial Fibrillation-A New Cardiac Channelopathy', Heart Lung and Circulation, 16, pp. 356 - 360, http://dx.doi.org/10.1016/j.hlc.2007.07.003
    Journal articles | 2007
    Otway R; Vandenberg JI; Guo G; Varghese A; Castro ML; Liu JJ; Zhao J; Bursill JA; Wyse KR; Crotty H; Baddeley O; Walker BD; Kuchar D; Thorburn CW; Fatkin D, 2007, 'Stretch-sensitive KCNQ1 mutation - A link between genetic and environmental factors in the pathogenesis of atrial fibrillation?', Journal of the American College of Cardiology, 49, pp. 578 - 586
    Journal articles | 2006
    Clarke CE; Hill A; Kondo M; Subbiah RN; Campbell TJ; Vandenberg JI, 2006, 'Effect of S5P alpha-helix charge mutants on inactivation of hERG K+ channels', The Journal of Physiology, 573, pp. 291 - 304
    Journal articles | 2006
    Vandenberg JI; Varghese A; Lu Y; Bursill JA; Mahaut-Smith MP; Huang CL, 2006, 'Temperature dependence of human ether-a-go-go-related gene K+ currents', American Journal of Physiology - Cell Physiology, 291, pp. C165 - C175
    Journal articles | 2005
    Lei M; Goddard C; Liu J; Leoni A; Royer A; Fung SS; Xiao G; Ma A; Zhang H; Charpentier F; Vandenberg JI; Colledge WH; Grace AA; Huang SH, 2005, 'Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a', The Journal of Physiology, 567, pp. 387 - 400, http://dx.doi.org/10.1113/jphysiol.2005.083188
    Journal articles | 2005
    Subbiah RN; Campbell TJ; Vandenberg JI, 2005, 'Ion channelopathies: What have they taught us about arrhythmias and anti-arrhythmic therapy', Clinical and Experimental Pharmacology and Physiology, 32, pp. 595 - 595
    Journal articles | 2005
    Subbiah RN; Kondo M; Campbell TJ; Vandenberg JI, 2005, 'Tryptophan scanning mutagenesis of the HERG K+ channel: the S4 domain is loosely packed and likely to be lipid exposed', The Journal of Physiology, 569, pp. 367 - 379
    Journal articles | 2004
    Davies W; Vandenberg JI; Sayeed R; Trezise AE, 2004, 'Cardiac expression of the cystic fibrosis transmembrane conductanceregulator involves novel Exon 1 usage to produce a uniqueamino-terminal protein', The Journal of Biological Chemistry, 279, pp. 15877 - 15887, http://dx.doi.org/10.1074/jbc.M313628200
    Journal articles | 2004
    Davies W; Vandenberg JI; Sayeed R; Trezise AE, 2004, 'Post-transcriptional regulation of the cystic fibrosis gene in cardiac development and hypertrophy', Biochemical and Biophysical Research Communications, 319, pp. 410 - 418, http://dx.doi.org/10.1016/j.bbrc.2004.05.008
    Journal articles | 2004
    Fahmi A; Forhead A; Fowden A; Vandenberg JI, 2004, 'Cortisol influences the ontogeny of both alpha- and beta-subunits ofthe cardiac sodium channel in fetal sheep', Journal of Endocrinology, 180, pp. 449 - 455, http://dx.doi.org/10.1677/joe.0.1800449
    Journal articles | 2004
    Martinez-Pinna J; Tolhurst G; Gurung I; Vandenberg JI; Mahaut-Smith MP, 2004, 'Sensitivity limits for voltage control of P2Y receptor-evoked Ca2+mobilization in the rat megakaryocyte', The Journal of Physiology, 555, pp. 61 - 70, http://dx.doi.org/10.1113/jphysiol.2003.056846
    Journal articles | 2004
    Subbiah RN; Campbell TJ; Vandenberg JI, 2004, 'Inherited cardiac arrhythmia syndromes: What have they taught us aboutarrhythmias and anti-arrhythmic therapy?', Clinical and Experimental Pharmacology and Physiology, 31, pp. 906 - 912
    Journal articles | 2004
    Subbiah RN; Clarke CE; Smith DG; Zha J; Campbell TJ; Vandenberg JI, 2004, 'Molecular basis of slow activation of the human ether-a-go-go relatedgene potassium channel', The Journal of Physiology, 558, pp. 417 - 431
    Journal articles | 2004
    Vandenberg JI; Torres AM; Campbell TJ; Kuchel PW, 2004, 'Erratum: The HERG K+ channel: Progress in understanding the molecular basis of its unusual gating kinetics (European Biophysics Journal (2004) 33 (89-97))', European Biophysics Journal, 33, pp. 468
    Journal articles | 2004
    Vandenberg JI; Torres AM; Campbell TJ; Kuchel PW, 2004, 'The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics (vol 33, pg 89, 2004)', EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 33, pp. 468 - 468, http://dx.doi.org/10.1007/s00249-004-0419-y
    Journal articles | 2004
    Vandenberg JI; Torres AM; Campbell TJ; Kuchel PW, 2004, 'The HERG K+ channel: Progress in understanding the molecular basis of its unusual gating kinetics', European Biophysics Journal, 33, pp. 89 - 97, http://dx.doi.org/10.1007/s00249-003-0338-3
    Journal articles | 2004
    Vandenberg JI; Torres M; Campbell TJ; Kuchel PW, 2004, 'The HERGK+ channel: Progress in understanding the molecular basis of its unusual gating kinetics.', European Biophysics Journal With Biophysics Letters, 33, pp. 80 - 97
    Journal articles | 2003
    Balasubramaniam RN; Grace AA; Saumarez R; Vandenberg JI; Huang CL, 2003, 'Electrogram prolongation and nifedipine-suppressible ventricular arrhythmias following targeted disruption of KCNE1', Journal of Physiology - Paris, 552, pp. 535 - 546, http://dx.doi.org/10.1113/jphysiol.2003.048249
    Journal articles | 2003
    Lu Y; Mahaut-Smith MP; Huang CL; Vandenberg JI, 2003, 'Mutant MiRP1 subunits modulate HERG K+ channel gating: A mechanism for pro-arrhythmia in Long QT Syndrome type 6', Journal of Physiology - Paris, 551, pp. 253 - 262
    Journal articles | 2003
    Singarayar SB; Bursill JA; Wyse KR; Bauskin AR; Wu WM; Vandenberg JI; Breit SN; Campbell TJ, 2003, 'Extracellular acidosis modulates drug block of Kv4.3 currents by flecainide and quinidine', Journal of Cardiovascular Electrophysiology, 14, pp. 641 - 650, http://dx.doi.org/10.1046/j.1540-8167.2003.03026.x
    Journal articles | 2003
    Torres A; Bansal PS; Alewood P; Bursill JA; Vandenberg JI; Kuchel PW, 2003, 'Solution structure of CnErg1 (Ergtoxin), a HERG specific scorpion toxin', FEBS Letters, 539, pp. 138 - 142, http://dx.doi.org/10.1016/S0014-5793(03)00216-3
    Journal articles | 2003
    Torres M; Bansal PS; Sunde M; Clarke CE; Bursill JA; Smith DG; Bauskin AR; Breit SN; Campbell TJ; Alewood P; Kuchel PW; Vandenberg JI, 2003, 'Structure of the HERGK+ channel S5P extracellulal linker: Role of an amphipathic a-helix in C-type inactivation.', Journal of Biochemistry, 278, pp. 42136 - 42148, http://dx.doi.org/10.1074/jbc.M212824200
    Journal articles | 2003
    Vandenberg JI; Kuchel PW, 2003, 'Nobel Prizes for Magnetic Resonance Imaging and Channel Proteins', Medical Journal of Australia, 179, pp. 611 - 613
    Journal articles | 2002
    Papadatos GA; Wallerstein PMR; Head CEG; Ratcliff R; Brady PA; Benndorf K; Saumarez RC; Trezise AEO; Huang CLH; Vandenberg JI; Colledge WH; Grace AA, 2002, 'Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a', Proceedings of the National Academy of Sciences of the United States of America, 99, pp. 6210 - 6215, http://dx.doi.org/10.1073/pnas.082121299
    Journal articles | 2002
    Zhao J; Pettigrew GJ; Thomas J; Vandenberg JI; Delriviere L; Bolton EM; Carmichael A; Martin JL; Marber MS; Lever AML, 2002, 'Lentiviral vectors for delivery of genes into neonatal and adult ventricular cardiac myocytes in vitro and in vivo', Basic Research in Cardiology, 97, pp. 348 - 358, http://dx.doi.org/10.1007/s00395-002-0360-0
    Journal articles | 2001
    Fahmi AI; Patel M; Stevens EB; Fowden AL; John JE; Lee K; Pinnock R; Morgan K; Jackson AP; Vandenberg JI, 2001, 'The sodium channel β-subunits SCN3b modulates the kinetics of SCN5a and is expressed heterogeneously in sheep heart', Journal of Physiology, 537, pp. 693 - 700, http://dx.doi.org/10.1113/jphysiol.2001.012691
    Journal articles | 2001
    Lu Y; Mahaut-Smith MP; Varghese A; Huang CL-H; Kemp PR; Vandenberg JI, 2001, 'Effects of premature stimulation on HERG K+ channels', The Journal of Physiology, 537, pp. 843 - 851, http://dx.doi.org/10.1113/jphysiol.2001.012690
    Journal articles | 2001
    Sheikh SM; Skepper JN; Chawla S; Vandenberg JI; Elneil S; Huang CL, 2001, 'Normal conduction of surface action potentials in detubulated amphibian skeletal muscle fibres.', J Physiol, 535, pp. 579 - 590, http://dx.doi.org/10.1111/j.1469-7793.2001.t01-1-00579.x
    Journal articles | 2001
    Smith GA; Vandenberg JI; Freestone NS; Dixon HBF, 2001, 'The effect of Mg2+ on cardiac muscle function: Is CaATP the substrate for priming myofibril cross-bridge formation and Ca2+ reuptake by the sarcoplasmic reticulum?', Biochemical Journal, 354, pp. 539 - 551, http://dx.doi.org/10.1042/0264-6021:3540539
    Journal articles | 2001
    Vandenberg J; Sheikh SM; Skepper JN; Chawla S; Elneil S; Huang CL, 2001, 'Normal conduction of surface action potentials in detubulated amphibian skeletal muscle fibres.', The Journal of Physiology, 535, pp. 579 - 590, http://dx.doi.org/10.1111/j.1469-7793.2001.t01-1-00579.x
    Journal articles | 2001
    Vandenberg JI; Walker BD; Campbell TJ, 2001, 'HERG K+ channels: Friend and foe', Trends in Pharmacological Sciences, 22, pp. 240 - 246, http://dx.doi.org/10.1016/S0165-6147(00)01662-X
    Journal articles | 2001
    Yu Lu M; Mahaut-Smith P; Varghese A; Huang CLH; Kemp PR; Vandenberg JI, 2001, 'Effects of premature stimulation on HERG K+ channels', Journal of Physiology, 537, pp. 843 - 851, http://dx.doi.org/10.1113/jphysiol.2001.012690
    Journal articles | 2000
    Keevil VL; Huang CL-H; Chau P-L; Sayeed RA; Vandenberg JI, 2000, 'The effect of heptanol on the electrical and contractile function of the isolated, perfused rabbit heart', Pflügers Archiv, 440, pp. 275 - 275, http://dx.doi.org/10.1007/s004240051049
    Journal articles | 2000
    Keevil VL; Huang CLH; Chau PL; Sayeed RA; Vandenberg JI, 2000, 'The effect of heptanol on the electrical and contractile function of the isolated, perfused rabbit heart', Pflugers Archiv European Journal of Physiology, 440, pp. 275 - 282, http://dx.doi.org/10.1007/s004240051049
    Journal articles | 2000
    Kirschenlohr HL; Grace AA; Vandenberg JI; Metcalfe JC; Smith GA, 2000, 'Estimation of systolic and diastolic free intracellular Ca2+ by titration of Ca2+ buffering in the ferret heart', Biochemical Journal, 346, pp. 385 - 391, http://dx.doi.org/10.1042/0264-6021:3460385
    Journal articles | 2000
    Smith GA; Dixon HBF; Kirschenlohr HL; Grace AA; Metcalfe JC; Vandenberg JI, 2000, 'Ca2+ buffering in the heart: Ca2+ binding to and activation of cardiac myofibrils', Biochemical Journal, 346, pp. 393 - 402, http://dx.doi.org/10.1042/0264-6021:3460393
    Journal articles | 2000
    Vandenberg JI; Lummis SCR, 2000, 'Ion channels - A plethora of pharmaceutical targets', Trends in Pharmacological Sciences, 21, pp. 409 - 410, http://dx.doi.org/10.1016/S0165-6147(00)01558-3
    Journal articles | 2000
    Wong KR; Trezise AEO; Crozatier B; Vandenberg JI, 2000, 'Loss of the normal epicardial to endocardial gradient of cftr mRNA expression in the hypertrophied rabbit left ventricle', Biochemical and Biophysical Research Communications, 278, pp. 144 - 149, http://dx.doi.org/10.1006/bbrc.2000.3754
    Journal articles | 2000
    Wong KR; Trezise AEO; Vandenberg JI, 2000, 'Developmental regulation of the gradient of cftr expression in the rabbit heart', Mechanisms of Development, 94, pp. 195 - 197, http://dx.doi.org/10.1016/S0925-4773(00)00312-9
    Journal articles | 1999
    Wong KR; Trezise AE; Bryant S; Hart G; Vandenberg JI, 1999, 'Molecular and functional distributions of chloride conductances in rabbit ventricle.', Am J Physiol, 277, pp. H1403 - H1409, http://dx.doi.org/10.1152/ajpheart.1999.277.4.H1403
    Journal articles | 1999
    Wong KR; Trezise AEO; Bryant S; Hart G; Vandenberg JI, 1999, 'Molecular and functional distributions of chloride conductances in rabbit ventricle', AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 277, pp. H1403 - H1409, http://dx.doi.org/10.1152/ajpheart.1999.277.4.H1403
    Journal articles | 1999
    Wong KR; Trezise AEO; Bryant S; Hart G; Vandenberg JI, 1999, 'Molecular and functional distributions of chloride conductances in rabbit ventricle', American Journal of Physiology - Heart and Circulatory Physiology, 277, http://dx.doi.org/10.1152/ajpheart.1999.277.4.h1403
    Journal articles | 1998
    Bethell HW; Vandenberg JI; Smith GA; Grace AA, 1998, 'Changes in ventricular repolarization during acidosis and low-flow ischemia.', Am J Physiol, 275, pp. H551 - H561, http://dx.doi.org/10.1152/ajpheart.1998.275.2.H551
    Journal articles | 1998
    Bethell HWL; Vandenberg JI; Smith GA; Grace AA, 1998, 'Changes in ventricular repolarization during acidosis and low-flow ischemia', AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 275, pp. H551 - H561, http://dx.doi.org/10.1152/ajpheart.1998.275.2.H551
    Journal articles | 1998
    Lowe MD; Grace AA; Vandenberg JI; Kaumann AJ, 1998, 'Action potential shortening through the putative β4-adrenoceptor in ferret ventricle: Comparison with β1- and β2-adrenoceptor-mediated effects', British Journal of Pharmacology, 124, pp. 1341 - 1344, http://dx.doi.org/10.1038/sj.bjp.0702013
    Journal articles | 1997
    Bethell HWL; Vandenberg JI; Grace AA, 1997, 'ATP-sensitive potassium channels and ventricular repolarisation', Heart, 77
    Journal articles | 1997
    Vandenberg JI; Bett GC; Powell T, 1997, 'Contribution of a swelling-activated chloride current to changes in the cardiac action potential.', Am J Physiol, 273, pp. C541 - C547, http://dx.doi.org/10.1152/ajpcell.1997.273.2.C541
    Journal articles | 1997
    Vandenberg JI; Bett GCL; Powell T, 1997, 'Contribution of a swelling-activated chloride current to changes in the cardiac action potential', AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 273, pp. C541 - C547, http://dx.doi.org/10.1152/ajpcell.1997.273.2.C541
    Journal articles | 1997
    Vandenberg JI; Bett GCL; Powell T, 1997, 'Contribution of a swelling-activated chloride current to changes in the cardiac action potential', American Journal of Physiology - Cell Physiology, 273, http://dx.doi.org/10.1152/ajpcell.1997.273.2.c541
    Journal articles | 1996
    Grace AA; Metcalfe JC; Weissberg PL; Bethell HW; Vandenberg JI, 1996, 'Angiotensin II stimulates sodium-dependent proton extrusion in perfused ferret heart.', Am J Physiol, 270, pp. C1687 - C1694, http://dx.doi.org/10.1152/ajpcell.1996.270.6.C1687
    Journal articles | 1996
    Grace AA; Metcalfe JC; Weissberg PL; Bethell HWL; Vandenberg JI, 1996, 'Angiotensin II stimulates sodium-dependent proton extrusion in perfused ferret heart', AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 270, pp. C1687 - C1694, http://dx.doi.org/10.1152/ajpcell.1996.270.6.C1687
    Journal articles | 1996
    Vandenberg JI; Carter ND; Bethell HW; Nogradi A; Ridderstråle Y; Metcalfe JC; Grace AA, 1996, 'Carbonic anhydrase and cardiac pH regulation.', Am J Physiol, 271, pp. C1838 - C1846, http://dx.doi.org/10.1152/ajpcell.1996.271.6.C1838
    Journal articles | 1996
    Vandenberg JI; Carter ND; Bethell HWL; Nogradi A; Ridderstrale Y; Metcalfe JC; Grace AA, 1996, 'Carbonic anhydrase and cardiac pH regulation', AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 271, pp. C1838 - C1846, http://dx.doi.org/10.1152/ajpcell.1996.271.6.C1838
    Journal articles | 1996
    Vandenberg JI; Rees SA; Wright AR; Powell T, 1996, 'Cell swelling and ion transport pathways in cardiac myocytes', CARDIOVASCULAR RESEARCH, 32, pp. 85 - 97, http://dx.doi.org/10.1016/S0008-6363(96)00048-X
    Journal articles | 1996
    Vandenberg JI; Rees SA; Wright AR; Powell T, 1996, 'Cell swelling and ion transport pathways in cardiac myocytes', Cardiovascular Research, 32, pp. 85 - 97, http://dx.doi.org/10.1016/0008-6363(96)00048-X
    Journal articles | 1995
    Bethell HWL; Redwood SR; Vandenberg JI; Carter ND; Camm AJ; Grace AA, 1995, 'Glibenclamide and Magnesium Have Similar Effects on Repolarisation of the Cardiac Action Potential during Low-Flow Ischaemia', Clinical Science, 89, pp. 32P - 33P, http://dx.doi.org/10.1042/cs089032pc
    Journal articles | 1995
    Bethell HWL; Vandenberg JI; Carter ND; Grace AA, 1995, 'Differential Effects of Intracellular and Extracellular Acidosis on Cardiac Action Potential Repolarisation', Clinical Science, 89, pp. 20P - 20P, http://dx.doi.org/10.1042/cs089020p
    Journal articles | 1995
    Rees SA; Vandenberg JI; Wright AR; Yoshida A; Powell T, 1995, 'Cell swelling has differential effects on the rapid and slow components of delayed rectifier potassium current in guinea pig cardiac myocytes', The Journal of General Physiology, 106, pp. 1151 - 1170, http://dx.doi.org/10.1085/jgp.106.6.1151
    Journal articles | 1995
    Wright AR; Rees SA; Vandenberg JI; Twist VW; Powell T, 1995, 'Extracellular osmotic pressure modulates sodium-calcium exchange in isolated guinea-pig ventricular myocytes', The Journal of Physiology, 488, pp. 293 - 301
    Journal articles | 1994
    Bethell H; Vandenberg JI; Crowley J; Grace AA, 1994, 'Glibenclamide Increases Action Potential Duration with Partial Inhibition of Rubidium Efflux during Early Myocardial Ischaemia', Clinical Science, 87, pp. 5P - 5P, http://dx.doi.org/10.1042/cs045005pa_pt2
    Journal articles | 1994
    Bethell HWL; Vandenberg JI; Grace AA, 1994, 'Prolongation of the Monophasic Action Potential Duration during Acidosis and Shortening during Low-Flow Ischaemia', Clinical Science, 86, pp. 19P - 19P, http://dx.doi.org/10.1042/cs086019pa
    Journal articles | 1994
    VANDENBERG JI; METCALFE JC; GRACE AA, 1994, 'INTRACELLULAR PH RECOVERY DURING RESPIRATORY-ACIDOSIS IN PERFUSED HEARTS', AMERICAN JOURNAL OF PHYSIOLOGY, 266, pp. C489 - C497, http://dx.doi.org/10.1152/ajpcell.1994.266.2.C489
    Journal articles | 1994
    Vandenberg JI; Metcalfe JC; Grace AA, 1994, 'Intracellular pH recovery during respiratory acidosis in perfused hearts', AM.J.PHYSIOL., 266
    Journal articles | 1994
    Vandenberg JI; Metcalfe JC; Grace AA, 1994, 'Intracellular pH recovery during respiratory acidosis in perfused hearts', American Journal of Physiology - Cell Physiology, 266, http://dx.doi.org/10.1152/ajpcell.1994.266.2.c489
    Journal articles | 1994
    Vandenberg JI; Metcalfe JC; Grace AA, 1994, 'Intracellular pH recovery during respiratory acidosis in perfused hearts.', Am J Physiol, 266, pp. C489 - C497, http://dx.doi.org/10.1152/ajpcell.1994.266.2.C489
    Journal articles | 1994
    Vandenberg JI; Yoshida A; Kirk K; Powell T, 1994, 'Swelling-activated and isoprenaline-activated chloride currents in guinea pig cardiac myocytes have distinct electrophysiology and pharmacology', Journal of General Physiology, 104, pp. 997 - 1017, http://dx.doi.org/10.1085/jgp.104.6.997
    Journal articles | 1993
    GRACE AA; KIRSCHENLOHR HL; METCALFE JC; SMITH GA; WEISSBERG PL; CRAGOE EJ; VANDENBERG JI, 1993, 'REGULATION OF INTRACELLULAR PH IN THE PERFUSED HEART BY EXTERNAL HCO3- AND NA+-H+ EXCHANGE', AMERICAN JOURNAL OF PHYSIOLOGY, 265, pp. H289 - H298, http://dx.doi.org/10.1152/ajpheart.1993.265.1.H289
    Journal articles | 1993
    Grace AA; Kirschenlohr HL; Metcalfe JC; Smith GA; Weissberg PL; Cragoe EJ; Vandenberg JI, 1993, 'Regulation of intracellular pH in the perfused heart by external HCO3/- and Na+-H+ exchange', American Journal of Physiology - Heart and Circulatory Physiology, 265, http://dx.doi.org/10.1152/ajpheart.1993.265.1.h289
    Journal articles | 1993
    Grace AA; Metcalfe JC; Weissberg PL; Vandenberg JI, 1993, 'Angiotensin II Stimulates Acid Extrusion in Heart', Clinical Science, 84, pp. 15P - 15P, http://dx.doi.org/10.1042/cs084015pb
    Journal articles | 1993
    Grace AA; Metcalfe JC; Weissberg PL; Vandenberg JI, 1993, 'Dissociation between Recovery of pHi and Contraction Following Acid Loading in Perfused Heart', Clinical Science, 84, pp. 15P - 15P, http://dx.doi.org/10.1042/cs084015pa
    Journal articles | 1993
    Grace AA; Metcalfe JC; Weissberg PL; Vandenberg JI, 1993, 'Na+-H+ Antiport and Na+/HCO3− Co-Influx in Recovery from Intracellular Acidosis in Perfused Heart', Clinical Science, 84, pp. 15P - 16P, http://dx.doi.org/10.1042/cs084015pc
    Journal articles | 1993
    Vandenberg JI; Metcalfe JC; Grace AA, 1993, 'Mechanisms of pHi recovery after global ischemia in the perfused heart', Circulation Research, 72, pp. 993 - 1003
    Journal articles | 1992
    Vandenberg JI; Metcaffe JC; Grace AA, 1992, 'Mechanisms of pHi recovery from intracellular acidosis in perfused ferret heart', Journal of Molecular and Cellular Cardiology, 24, pp. 137 - 137, http://dx.doi.org/10.1016/0022-2828(92)90436-4
    Journal articles | 1992
    Vandenberg JI; Metcalfe JC; Grace AA, 1992, 'Mechanisms of intracellular pH recovery following global ischaemia in the perfused ferret heart', Journal of Molecular and Cellular Cardiology, 24, pp. 116 - 116, http://dx.doi.org/10.1016/0022-2828(92)90374-9
    Journal articles | 1986
    Vandenberg JI; Kuchel PW; King GK, 1986, 'Application of progress curve analysis to in situ enzyme kinetics using 1H NMR spectroscopy', Analytical Biochemistry, 155, pp. 38 - 44, http://dx.doi.org/10.1016/0003-2697(86)90221-6
    Journal articles | 1985
    Vandenberg JI; King GF; Kuchel PW, 1985, 'Enkephalin degradation by human erythrocytes and hemolysates studied using 1H NMR spectroscopy', Archives of Biochemistry and Biophysics, 242, pp. 515 - 522, http://dx.doi.org/10.1016/0003-9861(85)90238-3
    Journal articles | 1985
    Vandenberg JI; King GF; Kuchel PW, 1985, 'The assimilation of tri- and tetrapeptides by human erythrocytes', BBA - Molecular Cell Research, 846, pp. 127 - 134, http://dx.doi.org/10.1016/0167-4889(85)90118-1
  • Working Papers | 2023
    Ma JG; O'Neill MJ; Richardson E; Thomson KL; Ingles J; Muhammad A; Solus JF; Davogustto G; Anderson KC; Benjamin Shoemaker M; Stergachis AB; Floyd BJ; Dunn K; Parikh VN; Chubb H; Perrin MJ; Roden DM; Vandenberg JI; Ng C-A; Glazer AM, 2023, Multi-site validation of a functional assay to adjudicate SCN5A Brugada Syndrome-associated variants., http://dx.doi.org10.1101/2023.12.19.23299592, https://www.ncbi.nlm.nih.gov/pubmed/38196587
    Working Papers | 2019
    Ballouz S; Mangala M; Perry M; Heitmann S; Gillis J; Hill A; Vandenberg J, 2019, Co-expression of calcium channels and delayed rectifier potassium channels protects the heart from proarrhythmic events, http://dx.doi.org10.1101/659821
    Working Papers | 2017
    Beattie K; Hill A; Bardenet R; Cui Y; Vandenberg J; Gavaghan D; de Boer T; Mirams G, 2017, Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics, http://dx.doi.org10.1101/100677
    Working Papers | 2014
    Hodkinson EC; Hill AP; Vandenberg JI, 2014, The romano-ward syndrome 1964 2014: 50 years of progress, http://dx.doi.org
  • Preprints | 2024
    Heitmann S; Vandenberg JI; Hill AP, 2024, Independent derivations of the axis of arrhythmia for predicting drug-induced torsades de pointes, http://dx.doi.org/10.1101/2024.09.18.613631
    Conference Abstracts | 2024
    Ma J; O’Neill M; Richardson E; Ingles J; Thomson K; Solus J; Harvey G; Robertson P; Bezzina C; Roden D; Walsh R; Vandenberg J; Glazer A; Ng C, 2024, 'A Validated SCN5A Functional Assay to Adjudicate Variants of Uncertain Significance from the International Brugada Syndrome Genetics Consortia', in Heart, Lung and Circulation, Elsevier BV, Vol. 33, pp. S96 - S96, http://dx.doi.org/10.1016/j.hlc.2024.04.170
    Conference Abstracts | 2024
    Shen Q; Tan C; Ng C; Vandenberg J, 2024, 'Establishing an Automated Patch Clamp Assay to Assess Both Activity and Adrenergic Responses of KCNQ1 Variants', in Heart, Lung and Circulation, Elsevier BV, Vol. 33, pp. S115 - S115, http://dx.doi.org/10.1016/j.hlc.2024.04.207
    Conference Abstracts | 2024
    Tan C; Shen Q; Vandenberg J; Ng C, 2024, 'Establishing a Functional Genomics Assay to Assess Clinical Variants in CACNA1C-Related Disorders', in Heart, Lung and Circulation, Elsevier BV, Vol. 33, pp. S117 - S117, http://dx.doi.org/10.1016/j.hlc.2024.04.210
    Preprints | 2023
    Heitmann S; Vandenberg J; Hill A, 2023, Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology, http://dx.doi.org/10.1101/2023.04.19.537441
    Preprints | 2023
    Heitmann S; Vandenberg JI; Hill AP, 2023, Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology, http://dx.doi.org/10.7554/eLife.90027
    Preprints | 2023
    Heitmann S; Vandenberg JI; Hill AP, 2023, Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology, , http://dx.doi.org/10.7554/elife.90027.1
    Preprints | 2023
    Lau CHY; Flood E; Hunter MJ; Williams-Noonan BJ; Corbett KM; Ng C-A; Bouwer JC; Stewart AG; Perozo E; Allen TW; Vandenberg JI, 2023, Potassium dependent structural changes in the selectivity filter of HERG potassium channels, http://dx.doi.org/10.1101/2023.12.14.571769
    Preprints | 2023
    Lim S; Mangala M; Holliday M; Szappanos HC; Ross S; Liang W; Ranpura G; Vandenberg J; Semsarian C; Hill A; Hool L, 2023, Slow conduction and spatial dispersion of repolarization are intrinsic properties of cardiomyocyte electrophysiology that contribute to proarrhythmia in an iPSC model of hypertrophic cardiomyopathy, , http://dx.doi.org/10.1101/2023.07.20.549952
    Preprints | 2023
    Thorpe J; Perry M; Contreras O; Hurley E; Parker G; Harvey R; Hill A; Vandenberg J, 2023, Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmia, http://dx.doi.org/10.21203/rs.3.rs-2744099/v1
    Preprints | 2022
    Copier JS; Bootsma M; Ng C; Wilde AAM; Bertels RA; Bikker H; Christiaans I; van der Crabben SN; Hol JA; Koopmann TT; Knijnenburg J; Lommerse AAJ; van der Smagt JJ; Bezzina CR; Vandenberg JI; Verkerk AO; Barge-Schaapveld DQCM; Lodder EM, 2022, Reclassification of a likely pathogenic Dutch founder variant in KCNH2; implications of reduced penetrance, http://dx.doi.org/10.1101/2022.08.05.502917
    Conference Abstracts | 2022
    Jiang C; Richardson E; Farr J; Hill A; Ullah R; Kroncke B; Harrison S; Thomson K; Ingles J; Vandenberg J; Ng C, 2022, 'A Calibrated Functional Patch Clamp Assay to Enhance Clinical Variant Interpretation in KCNH2-Related Long QT Syndrome', in Heart Lung and Circulation, Elsevier, Vol. 31, pp. s37 - s37, presented at 70th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, 11 August 2022 - 14 August 2022, http://dx.doi.org/10.1016/j.hlc.2022.06.003
    Conference Abstracts | 2022
    Jiang C; Richardson E; Farr J; Hill A; Ullah R; Kroncke B; Harrison S; Thomson K; Ingles J; Vandenberg J; Ng C, 2022, 'Abstracts for the 70th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, 11-14 August 2022 Abstracts', in HEART LUNG AND CIRCULATION, ELSEVIER SCIENCE INC, Vol. 31, pp. S37 - S363, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000874386600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2022
    TeBay C; MacArthur JR; Mangala M; Kerr N; Heitmann S; Perry MD; Windley MJ; Vandenberg JI; Hil AP, 2022, 'Comprehensive preclinical evaluation of how cardiac safety profiles of chloroquine and hydroxychloroquine are modified by disease associated factors', in JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, ELSEVIER SCIENCE INC, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000886335100044&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2022
    Ullah R; Ng CA; Vanags L; Mitchell D; Vandenberg J; Kroncke B, 2022, 'Abstract 12815: High Throughput Variant Identification in the S3-S5 Helices of KCNH2 (hERG)', in Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 146, pp. a12815 - a12815, http://dx.doi.org/10.1161/circ.146.suppl_1.12815
    Conference Abstracts | 2022
    Windley MJ; Farr J; Humphreys DT; Vandenberg JI; Hill AP, 2022, 'Assessing the feasibility of measuring hERG drug block kinetics using high throughput automated patch-clamp', in JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, ELSEVIER SCIENCE INC, Vol. 117, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000886335100019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2021
    Flood E; Lau C; Hunter M; Ng C-A; Perozo E; Allen TW; Vandenberg JI, 2021, 'Investigation of the Inactivation of HERG using Molecular Dynamics Simulations of New cryo-EM Structures', in BIOPHYSICAL JOURNAL, CELL PRESS, ELECTR NETWORK, Vol. 120, pp. 242A - 242A, presented at 65th Annual Meeting of the Biophysical-Society (BPS), ELECTR NETWORK, 22 February 2021 - 26 February 2021, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000629601401425&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2021
    Jiang C; Farr J; Hill A; Kroncke B; Ingles J; Vandenberg J; Ng CA, 2021, 'Abstract 11857: Benchmarking a Functional Assay to Assist Clinical Classification of Variants of Uncertain Significance in KCNH2 (Long QT Syndrome Type 2)', in Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 144, http://dx.doi.org/10.1161/circ.144.suppl_1.11857
    Preprints | 2021
    Jiang C; Richardson E; Farr J; Hill A; Ullah R; Kroncke B; Harrison S; Thomson K; Ingles J; Vandenberg J; Ng C-A, 2021, A calibrated functional patch clamp assay to enhance clinical variant interpretation in KCNH2-related long QT syndrome, http://dx.doi.org/10.1101/2021.12.13.472492
    Other | 2021
    Ng C-A; Ullah R; Farr J; Hill A; Kozek K; Vanags L; Mitchell D; Kroncke B; Vandenberg J, 2021, A Massively Parallel Trafficking Assay Accurately Predicts Loss of Channel Function inKCNH2Variants, http://dx.doi.org/10.1101/2021.07.10.451881
    Conference Abstracts | 2021
    Ullah R; Ng C; Farr J; Hill A; kozek K; Vanags L; Mitchell D; Vandenberg J; Kroncke B, 2021, 'Abstract 11153: Massively Parallel, High-Throughput Approach for Identifying Defective KCNH2 (hERG) Variants', in Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 144, http://dx.doi.org/10.1161/circ.144.suppl_1.11153
    Preprints | 2021
    Vandenberg J; Lau C; Flood E; Hunter M; Ng C-A; Bouwer J; Stewart A; Perozo E; Allen T, 2021, Structural Basis for Rapid Voltage Dependent Inactivation of HERG Potassium Channels, , http://dx.doi.org/10.21203/rs.3.rs-1105661/v1
    Preprints | 2020
    Kozek KA; Glazer AM; Ng C-A; Blackwell D; Egly CL; Vanags LR; Blair M; Mitchell D; Matreyek KA; Fowler DM; Knollmann BC; Vandenberg J; Roden DM; Kroncke BM, 2020, High-throughput discovery of trafficking-deficient variants in the cardiac potassium channelKCNH2: Deep mutational scan ofKCNH2trafficking, http://dx.doi.org/10.1101/2020.02.17.952606
    Preprints | 2019
    Lee W; Windley MJ; Perry MD; Vandenberg JI; Hill AP, 2019, Protocol-dependent differences in IC50 values measured in hERG assays occur in a predictable way and can be used to quantify state preference of drug binding, http://dx.doi.org/10.1101/534867
    Conference Abstracts | 2017
    Beattie KA; Bardenet R; Louttit JB; Vandenberg JI; Hill AP; Gavaghan DJ; de Boer TP; Mirams GR, 2017, 'Mathematical Modelling of hERG Channel Kinetics Using Sinusoidal Voltage Protocols', in JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, ELSEVIER SCIENCE INC, Vol. 88, pp. 195 - 196, http://dx.doi.org/10.1016/j.vascn.2017.09.089
    Conference Papers | 2017
    Windley M; Abi-Gerges N; Fermini B; Hancox J; Vandenberg J; Hill A, 2017, 'Successes and Challenges of Performing hERG Studies for CiPA', in JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, ELSEVIER SCIENCE INC, pp. 197 - 197, http://dx.doi.org/10.1016/j.vascn.2017.09.095
    Conference Papers | 2017
    Windley M; Mann S; Vandenberg J; Hill A, 2017, 'Temperature Effects on Kinetics of hERG Drug Block: Implications for In Silico Proarrhythmic Risk Prediction', in JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, ELSEVIER SCIENCE INC, pp. 203 - 203, http://dx.doi.org/10.1016/j.vascn.2017.09.116
    Conference Abstracts | 2016
    Mann SA; Vandenberg JI; Hill AP, 2016, 'Sudden Infant Death and Modulation of Late Sodium Current by Hypoxia, Investigated in Induced Pluripotent Stem Cells', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, Los Angeles, Vol. 110, pp. 30A - 30A, presented at 60th Annual Meeting of the Biophysical-Society, CA, Los Angeles, 27 February 2016 - 02 March 2016, http://dx.doi.org/10.1016/j.bpj.2015.11.227
    Datasets | 2016
    Vandenberg J; Ng CA, 2016, Faculty Opinions recommendation of Tetrameric Assembly of K+ Channels Requires ER-Located Chaperone Proteins., , http://dx.doi.org/10.3410/f.727072588.793526218
    Other | 2016
    Vandenberg JI; Hill AP, 2016, An 'alternans' way to quantify arrhythmogenic substrates, , http://dx.doi.org/10.1113/JP271838
    Other | 2015
    Martinac B; Vandenberg J, 2015, 'Shooting gallery' for membrane proteins provides new insights into complexities of their function and structural dynamics, , http://dx.doi.org/10.1113/jphysiol.2014.286559
    Conference Abstracts | 2014
    Hill AP; Mann SA; Imtiaz MS; Perry MD; Vandenberg JI, 2014, 'Using Clinical Datasets to Optimize Models of Human Ventricular Electrophysiology: Implications for In Silico Drug Screening', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Francisco, Vol. 112, pp. 465A - 465A, presented at 58th Annual Meeting of the Biophysical-Society, CA, San Francisco, 15 February 2014 - 19 February 2014, http://dx.doi.org/10.1016/j.bpj.2016.11.2493
    Conference Abstracts | 2014
    Mann SA; Vandenberg JI, 2014, 'Dynamic Action Potential Clamp Investigation of Pro-Arrhythmic Risk of Drugs Binding to hERG Potassium Channels', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Francisco, Vol. 106, pp. 553A - 553A, presented at 58th Annual Meeting of the Biophysical-Society, CA, San Francisco, 15 February 2014 - 19 February 2014, http://dx.doi.org/10.1016/j.bpj.2013.11.3075
    Conference Abstracts | 2013
    El-Ajouz S; Hill AP; Gulbis JM; Vandenberg JI, 2013, 'Understanding the Molecular Gates of KirBac3.1', in BIOPHYSICAL JOURNAL, CELL PRESS, PA, Philadelphia, Vol. 104, pp. 128A - 128A, presented at 57th Annual Meeting of the Biophysical-Society, PA, Philadelphia, 02 February 2013 - 06 February 2013, http://dx.doi.org/10.1016/j.bpj.2012.11.737
    Conference Abstracts | 2013
    Olesen M; Liang B; Soka M; Larsen AP; Knop FK; Wang F; Nielsen JB; Andersen MN; Humphreys D; Mann SA; Vandenberg JI; Svendsen JH; Haunso S; Preiss T; Seebohm G; Olesen S-P; Schmitt N; Fatkin D, 2013, 'TASK-1 potassium channel mutations in atrial fibrillation', in EUROPEAN HEART JOURNAL, OXFORD UNIV PRESS, NETHERLANDS, Amsterdam, Vol. 34, pp. 642 - 642, presented at Congress of the European-Society-of-Cardiology (ESC), NETHERLANDS, Amsterdam, 31 August 2013 - 04 September 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000327744604084&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2013
    Vandenberg JI; Conigrave A; King GF; Kirk K, 2013, 'From kinetics to imaging: an NMR odyssey--a festschrift symposium in honour of Philip William Kuchel.', in Eur Biophys J, Germany, pp. 1 - 2, Germany, http://dx.doi.org/10.1007/s00249-012-0883-8
    Conference Proceedings (Editor of) | 2013
    Vandenberg JI; Conigrave A; King GF; Kirk K, 2013, 'From kinetics to imaging: An NMR odyssey - A festschrift symposium in honour of Philip William Kuchel', Vol. 42, pp. 1 - 2, http://dx.doi.org/10.1007/s00249-012-0883-8
    Conference Abstracts | 2012
    Ke Y; Hunter M; Ng CA; Vandenberg J, 2012, 'Domain Misfolding and Destabilisation of Domain–Domain Interactions Both Contribute to Defective Trafficking of hERG EAG Domain Mutant Channels', in Heart, Lung and Circulation, Vol. 21, pp. 860 - 861, http://dx.doi.org/10.1016/j.hlc.2012.08.025
    Conference Abstracts | 2012
    Perry MD; Vandenberg JI, 2012, 'Critical Dual Role for the Pore Helix in Kv11.1 Channel Inactivation', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Diego, Vol. 102, pp. 328A - 328A, presented at 56th Annual Meeting of the Biophysical-Society, CA, San Diego, 25 February 2012 - 29 February 2012, http://dx.doi.org/10.1016/j.bpj.2011.11.1801
    Conference Abstracts | 2012
    Tan PS; Perry M; Chai AN; Vandenberg JI; Hill AP, 2012, 'Bimodal Regulation of hERG Gating by the N-Terminal Tail Revealed by Voltage Clamp Fluorometry', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Diego, Vol. 102, pp. 328A - 328A, presented at 56th Annual Meeting of the Biophysical-Society, CA, San Diego, 25 February 2012 - 29 February 2012, http://dx.doi.org/10.1016/j.bpj.2011.11.1800
    Conference Proceedings (Editor of) | 2012
    2012, 'BIOPHYSCHEM2011: A joint meeting of the Australian society for biophysics and the RACI physical chemistry division', C S I R O Publishing, Vol. 65, pp. 439 - 441, http://dx.doi.org/10.1071/CH12213
    Conference Abstracts | 2010
    Heide J; Mann SA; Vandenberg JI, 2010, 'CHARACTERIZATION OF A NOVEL HERG POTASSIUM CHANNEL ISOFORM UPREGULATED IN SCHIZOPHRENIA PATIENTS', in AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, INFORMA HEALTHCARE, Vol. 44, pp. A51 - A51, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000282954700142&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2010
    Szekely D; Dokos S; Vandenberg JI; Hill AP, 2010, 'An Improved Curvilinear Gradient Method for Parameter Estimation in Complex Model Systems: Application to Gating of A Cardiac Ion Channel', in BIOPHYSICAL JOURNAL, CELL PRESS, Vol. 98, pp. 140A - 141A, http://dx.doi.org/10.1016/j.bpj.2009.12.758
    Conference Papers | 2010
    Vandenberg JI; Kuchel PW, 2010, 'Proteins, membranes and cells: the structure-function nexus', in European Biophysics Journal, Springer, pp. 1 - 1, http://dx.doi.org/10.1007/s00249-009-0535-9
    Other | 2010
    Vandenberg JI, 2010, Oxidative stress fine-tunes the dance of hERG K+ channels, Blackwell Publishing Ltd, , http://dx.doi.org/10.1113/jphysiol.2010.195651
    Conference Papers | 2009
    Hill AP; Varghese A; Dokos S; Mann S; Vandenberg JI, 2009, 'Developing In Silico Descriptions Of Herg Channel Gating', in BIOPHYSICAL JOURNAL, CELL PRESS, pp. 191A - 191A, http://dx.doi.org/10.1016/j.bpj.2008.12.897
    Conference Abstracts | 2009
    Mann SA; Hill A; Vandenberg JI, 2009, 'Investigating Ion Channel Diseases With Dynamic Action Potential Clamp', in BIOPHYSICAL JOURNAL, CELL PRESS, Vol. 96, pp. 259A - 259A, http://dx.doi.org/10.1016/j.bpj.2008.12.1279
    Conference Proceedings (Editor of) | 2009
    Vandenberg JI; Kuchel PW, 2009, 'Proteins, membranes and cells: the structure-function nexus-ASB 2008.', Vol. 39, pp. 1
    Conference Abstracts | 2007
    Ju P; Torres A; Bansal PS; Vandenberg JI; Kuchel PW, 2007, 'Pore helix domain charged residues modulate inactivation of the hERG K+ channel', in Biophysical Journal, Biophysical Society, Baltimore, MD, pp. 123A - 123A, presented at 51st Annual Meeting of the Biophysical-Society, Baltimore, MD, 03 - 07 March 2007, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000243972400567&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Conference Papers | 2007
    Otway RT; Vandenberg JI; Guo G; Fatkin D, 2007, 'Interaction between a KCNQ1 mutation and cell stretch in familial atrial fibrillation', in BIOPHYSICAL JOURNAL, BIOPHYSICAL SOCIETY, MD, Baltimore, pp. 463A - 463A, presented at 51st Annual Meeting of the Biophysical-Society, MD, Baltimore, 03 March 2007 - 07 March 2007, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000243972403011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Other | 2006
    Vandenberg JI; Hill AP; Campbell TJ; Clarke CE, 2006, Reply from Jamie I. Vandenberg, Adam P. Hill, Terence J. Campbell, Catherine E. Clarke [2], , http://dx.doi.org/10.1113/jphysiol.2006.577102
    Conference Abstracts | 2005
    Subbiah RN; Campbell TJ; Vandenberg JI, 2005, 'Tryptophan scanning mutagenesis suggests that the voltage sensor in HERG has a peripheral location', in Heart Rhythm, Vol. 2, pp. S106 - S107, http://www.sciencedirect.com/science/article/B7GW9-4GCD5P7-5/2/a4c7846becaa57ceeccffc5c4337c1ab
    Other | 2005
    Subbiah RN; Campbell TJ; Vandenberg JI, 2005, Erratum: Inherited cardiac arrhythmia syndromes: What have they taught us about arrhythmias and anti-arrhythmic therapy? (Clinical and Experimental Pharmacology and Physiology (2004) 31 (906-912)),
    Conference Papers | 2005
    Vandenberg JI; Bansal PS; Torres AM; Kuchel PW; Alewood PA, 2005, 'Molecular basis of CnErg1 binding to HERG K+ channels', in JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, ENGLAND, Bristol Univ, Bristol, pp. 172 - 173, presented at 4th Mammalian Myocardium Meeting, ENGLAND, Bristol Univ, Bristol, 17 July 2005 - 20 July 2005, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000230435000030&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2004
    Clarke CE; Bursill JA; Zhao J; Wyse KR; Vandenberg JI, 2004, 'Sensitivity of human ether-a-go-go family channels to extracellulartetraethylammonium', in Biophysical Journal, Biophysical Society, Vol. 86, pp. 278A - 278A
    Conference Abstracts | 2004
    Subbiah RN; Clarke CE; Smith DG; Zhao J; Vandenberg JI; Campbell TJ, 2004, 'Alteration of voltage-dependence and activation kinetics of the HERGpotassium channel by mutations in the S4 sequence', in Biophysical Journal, Biophysical Society, Vol. 86, pp. 541A - 541A
    Conference Papers | 2003
    Varghese A; Lu Y; Smith MM; Huang CLH; Vandenberg JI, 2003, 'Temperature dependence of HERG inactivation', in BIOPHYSICAL JOURNAL, BIOPHYSICAL SOCIETY, TEXAS, SAN ANTONIO, pp. 544A - 544A, presented at 47th Annual Meeting of the Biophysical-Society, TEXAS, SAN ANTONIO, 01 March 2003 - 05 March 2003, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000183123802674&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2002
    Fahmi AI; Vandenberg J, 2002, 'The sodium channel beta subunit, SCN3b, increases the expression levels of SCN5a and is heterogeneously expressed in sheep cardiac tissue', in BIOPHYSICAL JOURNAL, BIOPHYSICAL SOCIETY, pp. 91A - 91A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000173252700447&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2001
    Lu Y; Mahaut-Smith MP; Huang CLH; Vandenberg JI, 2001, 'Effects of temperature on HERG K+ channel response to premature stimuli', in BIOPHYSICAL JOURNAL, BIOPHYSICAL SOCIETY, pp. 213A - 213A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000166692200975&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2001
    Varghese A; Lu Y; Huang CLH; Mahaut-Smith MP; Vandenberg JI, 2001, 'Modeling the effects of premature stimuli on HERG K+ channels', in BIOPHYSICAL JOURNAL, BIOPHYSICAL SOCIETY, pp. 638A - 638A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000166692202903&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2001
    Wallerstein PMR; Vandenberg JI; Huang CLH; Saumarez RC; Grace AA, 2001, 'Intraventricular conduction delay, electrogram fractionation and arrhythmias in the KCNE1 mutant mouse', in BIOPHYSICAL JOURNAL, BIOPHYSICAL SOCIETY, pp. 644A - 645A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000166692202930&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2000
    Furness RB; Fowden AL; Forhead AJ; Vandenberg JI, 2000, 'Developmental regulation of cardiac erg potassium channel mRNA expression in fetal sheep during late gestation', in JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, pp. 66P - 66P, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000089787600081&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2000
    Lu Y; Mahaut-Smith MP; Huang CLH; Kemp PR; Vandenberg JI, 2000, 'Effects of premature stimuli on HERG-encoded K+ currents under action potential clamp conditions', in JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, pp. 93P - 94P, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000088237300117&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2000
    Lu Y; Mahaut-Smith MP; Huang CLH; Vandenberg JI, 2000, 'MiRP1 alters activation of HERG K+ channels stably transfected in a mammalian cell line', in JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, pp. 120P - 120P, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000089787600154&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1999
    Paul LEA; Huang CL; Grace AA; Saumarez RC; Vandenberg JI, 1999, 'Analysis of Purkinje system contributions to conduction in the perfused heart', in BIOPHYSICAL JOURNAL, BIOPHYSICAL SOCIETY, pp. A85 - A85, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000081085900490&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1998
    Lowe MD; Grace AA; Vandenberg JI; Kaumann AJ, 1998, 'Electrophysiological effects mediated through the putative beta 4-adrenoceptor', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, pp. 491 - 491, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000076594402610&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1998
    Lowe MD; Grace AA; Vandenberg JI; Kaumann AJ, 1998, 'Electrophysiological effects mediated through the putative beta(4)-adrenoceptor in ventricular myocardium', in NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, SPRINGER VERLAG, pp. R623 - R623, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000075207800947&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 1997
    Saumarez RC; Vandenberg JI; Zinkin MP; Lowe MD; Taylor PJ; Ward DE; Camm AJ; Grace AA, 1997, 'Electrogram fractionation in the long QT syndrome and as modelled in perfused heart by inhibition of SCN5A-encoded ion channels', in Heart, Vol. 77
    Conference Papers | 1997
    Smith GA; Kirschenlohr HL; Grace AA; Metcalfe JC; Vandenberg JI, 1997, 'Buffering of the cardiac calcium transient by exogenous calcium indicators', in JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, pp. P132 - P132, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1997XD09100189&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1997
    Trezise AEO; Wong KR; Vandenberg JI, 1997, 'Distribution of cftr mRNA in rabbit left ventricular myocardium.', in JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, pp. P74 - P75, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1997YJ42400087&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1997
    Vandenberg JI; Grace AA; Zinkin MP; Lowe MD; Saumarez RC, 1997, 'Anthopleurin A causes cardiac electrogram fractionation following premature stimulation.', in BIOPHYSICAL JOURNAL, CELL PRESS, pp. MP129 - MP129, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1997WE74700264&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1996
    Bethell HW; Vandenberg JI; Smith GA; Grace AA, 1996, 'Ischemic potassium flux is driven by an early net inward current', in CIRCULATION, AMER HEART ASSOC, pp. 3081 - 3081, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1996VN11903073&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1996
    Wright AR; Rees SA; Vandenberg JI; Twist VW; Powell T, 1996, 'Simultaneous recording of Na+/Ca2+ exchange current and swelling activated Cl- current from isolated guinea-pig atrial myocytes', in BIOPHYSICAL JOURNAL, CELL PRESS, pp. MP287 - MP287, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1996TZ68201170&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1995
    HALL JA; KIRK J; POTTS JR; RAE CD; VANDENBERG JI; KIRK K, 1995, 'SWELLING-ACTIVATED TRANSPORT OF DIVERSE SOLUTES IN A HUMAN CANCER CELL-LINE', in JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, pp. P96 - P96, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995TB77500148&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1995
    VANDENBERG JI; REES SA; TWIST VW; WRIGHT AR; POWELL T, 1995, 'A SWELLING-ACTIVATED CHLORIDE CONDUCTANCE CONTRIBUTES TO ACTION-POTENTIAL SHORTENING IN GUINEA-PIG VENTRICULAR MYOCYTES DURING CELL SWELLING', in CIRCULATION, AMER HEART ASSOC, pp. 3059 - 3059, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995TB48003039&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1994
    BETHELL HWL; VANDENBERG JI; GRACE AA, 1994, 'PROLONGATION OF THE MONOPHASIC ACTION-POTENTIAL DURING ACIDOSIS AND SHORTENING DURING ISCHEMIA', in JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, ELSEVIER SCIENCE INC, pp. A46 - A46, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1994PP51800176&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1994
    REDWOOD S; BETHELL HWL; VANDENBERG JI; CAMM AJ; GRACE AA, 1994, 'MAGNESIUM HAS CONCENTRATION AND TIME-DEPENDENT EFFECTS ON ACTION-POTENTIAL DURATION DURING MYOCARDIAL-ISCHEMIA', in CIRCULATION, AMER HEART ASSOC, pp. 524 - 524, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1994PN41702852&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1994
    REES SA; YOSHIDA A; TWIST VW; VANDENBERG JI; POWELL T, 1994, 'SWELLING ACTIVATED DELAYED RECTIFIER POTASSIUM CURRENT IN GUINEA-PIG VENTRICULAR MYOCYTES', in HEART AND VESSELS, SPRINGER VERLAG, JAPAN, TOKYO, pp. 145 - 146, presented at Tokyo-Womens-Medical-College International Symposium 94 - Ion Channels and Cellular Function of the Heart: Molecular Mechanisms Underlying the Regulation of Cardiac Cellular Function, JAPAN, TOKYO, 08 July 1994 - 10 July 1994, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995RA84700047&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1994
    VANDENBERG JI; YOSHIDA A; KIRK K; POWELL T, 1994, 'SWELLING-ACTIVATED CHLORIDE CURRENTS IN GUINEA-PIG CARDIAC MYOCYTES', in HEART AND VESSELS, SPRINGER VERLAG, JAPAN, TOKYO, pp. 144 - 144, presented at Tokyo-Womens-Medical-College International Symposium 94 - Ion Channels and Cellular Function of the Heart: Molecular Mechanisms Underlying the Regulation of Cardiac Cellular Function, JAPAN, TOKYO, 08 July 1994 - 10 July 1994, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995RA84700046&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1994
    VANDENBERG JI; YOSHIDA A; KIRK K; TWIST VW; POWELL T, 1994, 'CELL SWELLING ACTIVATES A CHLORIDE CURRENT IN GUINEA-PIG VENTRICULAR MYOCYTES', in JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, pp. P83 - P83, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1994NA54100147&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1993
    GRACE AA; METCALFE JC; BETHELL HW; VANDENBERG JI, 1993, 'ANGIOTENSIN-II STIMULATES PROTON EXTRUSION DURING REPERFUSION', in CIRCULATION, AMER HEART ASSOC, pp. 430 - 430, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993MA68202344&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1993
    GRACE AA; METCALFE JC; WEISSBERG PL; VANDENBERG JI, 1993, 'ANGIOTENSIN-II STIMULATES ACID EXTRUSION IN ISOLATED PERFUSED FERRET HEART', in JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, pp. P415 - P415, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993KG43100411&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1993
    GRACE AA; VANDENBERG JI, 1993, 'ANGIOTENSIN-II ENHANCES CARDIAC PHI REGULATION IN THE PRESENCE OF HCO3- VIA 3 ACID-BASE TRANSPORT MECHANISMS', in CIRCULATION, AMER HEART ASSOC, pp. 331 - 331, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993MA68201813&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1993
    VANDENBERG JI; CARTER ND; GRACE AA, 1993, 'SARCOLEMMAL CARBONIC-ANHYDRASE AND REGULATION OF CARDIAC PH', in CIRCULATION, AMER HEART ASSOC, pp. 39 - 39, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993MA68200239&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1993
    VANDENBERG JI; METCALFE JC; GRACE AA, 1993, 'THE RECOVERY OF INTRACELLULAR PH DURING RESPIRATORY-ACIDOSIS IN THE ISOLATED PERFUSED FERRET HEART', in JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, pp. P414 - P414, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993KG43100410&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1992
    GRACE AA; KIRSCHENLOHR HL; SMITH GA; METCALFE JC; WEISSBERG PL; VANDENBERG JI, 1992, 'HCO3--DEPENDENCE OF RECOVERY FROM INTRACELLULAR ACIDOSIS IN THE PERFUSED FERRET HEART DURING NA+-H+ ANTIPORT INHIBITION', in JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, pp. P141 - P141, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1992HD60500136&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1992
    GRACE AA; METCALFE JC; WEISSBERG PL; VANDENBERG JI, 1992, 'RELATIVE CONTRIBUTION OF THE NA+-H+ ANTIPORT AND HCO3--DEPENDENT MECHANISMS TO PROTON EFFLUX DURING INTRACELLULAR ACIDOSIS IN PERFUSED HEART', in JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, pp. S54 - S54, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1992JJ55600082&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1992
    Grace AA; Kirschenlohr HL; Smith GA; Metcalfe JC; Weissberg PL; Vandenberg JI, 1992, 'HCO3--dependence of recovery from intracellular acidosis in the perfused ferret heart during Na+-H+ antiport inhibition', in Journal of Physiology
    Conference Papers | 1992
    VANDENBERG JI; METCALFE JC; GRACE AA, 1992, 'CONTRIBUTION OF LACTATE EFFLUX TO PHI RECOVERY FOLLOWING GLOBAL-ISCHEMIA IN THE PERFUSED FERRET HEART', in JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, pp. S54 - S54, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1992JJ55600084&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1992
    VANDENBERG JI; METCALFE JC; GRACE AA, 1992, 'MECHANISMS OF INTRACELLULAR PH RECOVERY FOLLOWING GLOBAL-ISCHEMIA IN THE PERFUSED HEART', in CIRCULATION, AMER HEART ASSOC, pp. S9 - S9, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1992JT66000023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1991
    HOEIJMAKERS HWM; VANDENBERG JI, 1991, 'APPLICATION OF AN EULER-EQUATION METHOD TO A SHARP-EDGED DELTA-WING CONFIGURATION WITH VORTEX FLOW', in COLLECTION OF TECHNICAL PAPERS - AIAA 9TH APPLIED AERODYNAMICS CONFERENCE, VOLS 1 AND 2, AMER INST AERONAUTICS & ASTRONAUTICS, MD, BALTIMORE, pp. 838 - 850, presented at 9TH APPLIED AERODYNAMICS CONF, MD, BALTIMORE, 23 September 1991 - 25 September 1991, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1991BW68G00020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts |
    Phan K; Ng C; McNitt S; Moss A; Zareba W; Perry M; Vandenberg J, 'The role of in vitro phenotypes for clinical risk stratification of sudden death in Long QT Syndrome Type 2', in Heart, Lung and Circulation, Elsevier, Vol. 24, pp. S232 - S233, presented at Heart, Lung and Circulation, http://dx.doi.org/10.1016/j.hlc.2015.06.289
    Preprints |
    Windley MJ; Farr J; Vandenberg JI; Hill AP, Translating the Measurement of Herg Kinetics and Drug Block for Cipa to a High Throughput Platform, , http://dx.doi.org/10.2139/ssrn.4065593

Current Research Grants

NHMRC Principal Research Fellowship (2017-2021) Vandenberg JI $838,875

NHMRC Program Grant (2015-2019). Finding new evidence based therapies for treating heart disease and stimulating Regeneration. RP Harvey, RM Graham, PS Macdonald, D Fatkin, SL Dunwoodie, JI Vandenberg $10,600,000

NHMRC Project Grant (2018-2020). The structural basis for promiscuity of drug binding to hERG K+ channels. JI Vandenberg, AG Stewart TW Allen, E Perozo $713,035

 

Awards

1992         International Society of Heart Research Young Investigator Travel Award

1992         American Heart Association Melvyn L. Marcus Young Investigator Award in Integrated Physiology (finalist)

1994         Gedge Prize (for best research undertaken by a student in Physiological Sciences) at University of Cambridge

2014         National Lecturer (Australian Physiological Society)

2015         Sir Bob Robertson Award (Australian Society for Biophysics)

2015         Elected Fellow of the Heart Rhythm Society, USA

2015         Elected Fellow, Australian Academy of Health and Medical Sciences

2018         Elected Fellow, International Society of Heart Research

 

Scholarships and Fellowships

1984         AMSA-AMA B.Sc.(Med.) Scholarship

1990-91   Sir Robert Menzies Memorial Scholarship in Medicine

1990-92   Overseas Research Scholar Award - Department of Education, UK

1992-93   Sydney University Medical Foundation Sir Zelman Cowan Traveling Research Fellowship 

1993-95   Zeneca Junior Research Fellowship, Pembroke College, Oxford, UK

1996-01   British Heart Foundation Basic Science Award

1996-01   British Heart Foundation Basic Science Award (resigned December 2001)

2002-06   NHMRC RD Wright Career Development Award in Biomedical Science

2007-11   NHMRC Senior Research Fellowship Level A

2012-16   NHMRC Senior Research Fellowship Level B with SEO (translation)

2017-21   NHMRC Principal Research Fellowship with SEO (translation)

Jamie Vandenberg’s work focuses on the molecular basis of inherited and drug-induced arrhythmia syndromes. He has made major contributions to understanding of the molecular and structural basis of ion channel gatingandmechanisms underlyingdrug binding to hERG K+channels, the cause of the vast majority of cases of drug-induced arrhythmias. He has also made significant contributions to understanding the molecular basis of inherited arrhythmia syndromescaused by ion channel mutations. His work exemplifies how the combination of a deep understanding of basic biology combined with the study of clinically relevant problems can have significant translational benefits both in terms of the management of families with inherited heart rhythm disorders and in the industrial setting in terms of development of better assays to assess the pro-arrhythmic risk of drugs in the preclinical setting.

Molecular and structural basis of ion channel gating

Jamie was the intellectual driving force behind the discovery of the “Japanese Puzzle Box” model of inactivation gating in hERG K+ channels. His work characterising the kinetics of hERG K+ channel gating has also become accepted as the gold standard for the field and has been adopted by the Food and Drug Administration as the reference data set for establishing in silicomodels of hERG K+ channel gating.

Drug-induced arrhythmias

In addition to providing strong evidence for the state-dependence of drug binding to hERG K+ channels, in 2014 he reported the first direct measurements of the kinetics of binding and unbinding of drugs to hERG K+ channels. This work provides the groundwork for the development of molecularly accurate in silico models of hERG drug binding that can be used to predict the pro-arrhythmic risk of drugs from preclinical screening assays.

Molecular basis of inherited arrhythmia syndromes

Together with Andrew Grace and Bill Colledge we developed the first animal model of Brugada Syndrome. By adapting a clinical premature stimulation protocol we also demonstrated that the arrhythmia mechanism in the mouse was the same as that in humans. More recently, Jamie has had a very productive collaboration with Diane Fatkin’s molecular genetics group. Together, we demonstrated how gene-environment interactions contributed to the genesis of familial atrial fibrillation, developed novel computational tools to explain the epistatic effects of potassium channel variation on cardiac repolarization and atrial fibrillation risk and identified a gene-guided therapy for a family with an inherited dilated cardiomyopathy.

Computational cardiology

Together with Adam Hill, Jamie has used computational modeling to complement their ion channel gating work for >10 years. Significant breakthroughs in recent years include the development of whole heart models based on graphical processor unit technology, which has enabled breakthrough discoveries in establishing causally cohesive links from genotype to whole organ phenotypes. His laboratory has also applied partial least square methods to permit the analysis of large populations of “genetically different” individuals to understand the variable penetrance of dominant molecular defects.

 

1. Molecular basis of gating in hERG K+ channels

  • Wang DT, Hill AP, Mann SA, Tan PS, Vandenberg JI. Mapping the sequence of conformational changes underlying selectivity filter gating in the K(v)11.1 potassium channel. Nat Struct Mol Biol. 2011 Jan;18(1):35-41.
  • Perry MD, Ng CA, Vandenberg JI. Pore Helices Play a Dynamic Role as Integrators of Domain Motion during Kv11.1 Channel Inactivation Gating. J Biol Chem. 2013; 288(16): 11482-91
  • Phan K, Ng CA, David E, Shishmarez D, Kuchel PW, Vandenberg JI, perry MD. The S1 helix critically regulates the finely-tuned gating of Kv11.1 channels. J Biol Chem (2017) In Press.

2. Genoptype-phenotype relationships in inherited arrhythmia syndromes

  • Mann SA, Castro ML, Ohanian M, Guo G, Zodgekar P, Sheu A, Stockhammer K, Thompson T, Playford D, Subbiah RN, Kuchar D, Aggarwal A, Vandenberg JI, Fatkin D. R222Q SCN5A mutation is associated with reversible ventricular ectopy and dilated cardiomyopathy J Am Coll Cardiol 2012; 60(16):1566-73
  • Perry MD, Ng CA, Phan K, David E, Steer K, Hunter MJ, Mann SA, Imtiaz M, Hill AP, Ke Y, Vandenberg JI. Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations. J Physiol. 2016; 594(14): 4031-49

3. Development of ECG biomarkers for risk of sudden cardiac arrest

  • Immanuel SA, Sadrieh A, Baumert M, Couderc JP, Zareba W, Hill AP, Vandenberg JI. T-wave morphology can distinguish healthy controls from LQTS patients. Physiol Meas. 2016; 37(9): 1456-73.

 4. Structural basis of hERG K+ channel function

  • Vandenberg JI, Perozo E, Allen TW. Towards a Structural View of Drug Binding to hERG K(+) Channels. Trends Pharmacol Sci. 2017 Oct;38(10):899-907. 
  • Ng CA, Hunter MJ, Perry MD, Mobli M, Ke Y, Kuchel PW, King GF, Stock D, Vandenberg JI. The N-Terminal Tail of hERG Contains an Amphipathic α-Helix That Regulates Channel Deactivation. PLoS One. 2011 Jan 13;6(1):e16191
  • Vandenberg JI, Perry MD, Perrin MJ, Mann SA, Ke Y, Hill AP. hERG K+ channels: Structure, Function and Clinical Significance. Physiological Reviews 2012; 92(3):1393-1478

My Research Supervision

Post-doctoral fellows:

Matt PERRY: Cardiac disease modelling using induced pluripotent stem cells

Andy NG: Genotype-phenotype relationships in Long QT syndrome

Carus LAU: Structural analysis of hERG K+ channels

Jordan THORPE: Modeling heart disease using cardiac organoids

PhD Students

Nicholas KERR: Induced pluripotent stem cell models of Brugada Syndrome

Honours Students

Whitney Liang: Investigating the role of cellular heterogeneity in cardiac electrical signalling

Emily Hurley: Modeling Atrial arrhythmias using induced pluripotent stem cells

Connie Jiang: Genotype-phenotype relationships in Long QT syndrome

Wei Han: Structural analysis of hERG K+ channels

My Teaching

School of Medical Sciences, Cardiovascular Physiology, Yr3: Cardiac Arrhythmias

Medicine Yr3: Anti-arrhythmic drugs