Dr Laurence Don Wai Luu
Research Associate

Dr Laurence Don Wai Luu

Biotech & Biomolecular Science

Laurence Luu is a Postdoctoral Research Associate in Dr. Natalia Castaño Rodríguez's and A/Prof. Nadeem Kaakoush's research group. He is currently researching how the interactions between host immunogenetics and the microbiome leads to cancers of the gastrointestinal tract and inflammatory bowel disease.

Laurence previously completed his PhD in the Evolutionary Microbiology lab under the supervision of Prof. Ruiting Lan and Dr. Sophie Octavia where he investigated the evolution of Bordetella pertussis to vaccines. During his PhD, he discovered new proteomic adaptations that were associated with increased fitness in the current Australian epidemic B. pertussis population. This discovery garnered widespread media attention and led to a national call to improve vaccines for whooping cough.

Laurence continued his research on whooping cough in the Evolutionary Microbiology lab as a postdoctoral researcher where he applied proteomics and functional genomics to better understand the biology and molecular pathogenesis of B. pertussis infections in order to improve current vaccines and develop new treatments. He currently remains an honorary member of the lab.


Professional Experience

2019 - Current: Communication Ambassador, Australian Society for Microbiology (ASM)

2018 - Current: Postdoctoral Research Associate, School of Biotechnology and Biomolecular Sciences, UNSW

2018 - PhD in Medical Microbiology and Immunology, UNSW

2014 - Bachelor of Medical Science (Hons I), UNSW



2019 - Fresh Science

2019 - ASM NSW-ACT Branch Postdoctoral Award

2018 - Best Poster Prize at UNSW Cross-Faculty Biomedical Symposium

2017 - Runner up in UNSW Science 1-minute Thesis competition

2017 - ASM NSW-ACT Branch Student Prize

+61-2-9385 3063
L4, Biological Sciences North D26


  • Journal articles | 2021
    Payne M; Octavia S; Luu LDW; Sotomayor-Castillo C; Wang Q; Tay ACY; Sintchenko V; Tanaka MM; Lan R, 2021, 'Enhancing genomics-based outbreak detection of endemic salmonella enterica serovar typhimurium using dynamic thresholds', Microbial Genomics, vol. 7, http://dx.doi.org/10.1099/MGEN.0.000310
    Journal articles | 2021
    Li S; Huang J; Ren L; Jiang W; Wang M; Zhuang L; Zheng Q; Yang R; Zeng Y; Luu LDW; Wang Y; Tai J, 2021, 'A one-step, one-pot CRISPR nucleic acid detection platform (CRISPR-top): Application for the diagnosis of COVID-19', Talanta, vol. 233, http://dx.doi.org/10.1016/j.talanta.2021.122591
    Journal articles | 2021
    Luu LDW; Zhong L; Kaur S; Raftery MJ; Lan R, 2021, 'Comparative Phosphoproteomics of Classical Bordetellae Elucidates the Potential Role of Serine, Threonine and Tyrosine Phosphorylation in Bordetella Biology and Virulence', Frontiers in Cellular and Infection Microbiology, vol. 11, pp. 660280, http://dx.doi.org/10.3389/fcimb.2021.660280
    Journal articles | 2021
    Luu LDW; Payne M; Zhang X; Luo L; Lan R, 2021, 'Development and comparison of novel multiple cross displacement amplification (MCDA) assays with other nucleic acid amplification methods for SARS-CoV-2 detection', Scientific Reports, vol. 11, pp. 1873, http://dx.doi.org/10.1038/s41598-021-81518-8
    Journal articles | 2020
    Liu F; Chen S; Luu LDW; Lee SA; Tay ACY; Wu R; Riordan SM; Lan R; Liu L; Zhang L, 2020, 'Analysis of complete Campylobacter concisus genomes identifies genomospecies features, secretion systems and novel plasmids and their association with severe ulcerative colitis', Microbial Genomics, http://dx.doi.org/10.1099/mgen.0.000457
    Journal articles | 2020
    Luu LDW; Octavia S; Aitken C; Zhong L; Raftery MJ; Sintchenko V; Lan R, 2020, 'Surfaceome analysis of Australian epidemic Bordetella pertussis reveals potential vaccine antigens', Vaccine, vol. 38, pp. 539 - 548, http://dx.doi.org/10.1016/j.vaccine.2019.10.062
    Journal articles | 2020
    Kaur S; Peters TJ; Yang P; Luu LDW; Vuong J; Krycer JR; O’Donoghue SI, 2020, 'Temporal ordering of omics and multiomic events inferred from time-series data', npj Systems Biology and Applications, vol. 6, pp. 22, http://dx.doi.org/10.1038/s41540-020-0141-0
    Journal articles | 2020
    James LJ; Saglimbene V; Wong G; Tong A; Luu LDW; Craig J; Howard K; Howell M, 2020, 'Behavioural and pharmaceutical interventions for the prevention of skin cancers in solid organ transplant recipients: A systematic review of randomised controlled trials', BMJ Open, vol. 10, pp. e029265 - e029265, http://dx.doi.org/10.1136/bmjopen-2019-029265
    Journal articles | 2019
    Xu Z; Octavia S; Luu LDW; Payne M; Timms V; Tay CY; Keil AD; Sintchenko V; Guiso N; Lan R, 2019, 'Pertactin-negative and filamentous hemagglutinin-negative Bordetella pertussis, Australia, 2013-2017', Emerging Infectious Diseases, vol. 25, pp. 1196 - 1199, http://dx.doi.org/10.3201/eid2506.180240
    Journal articles | 2019
    Luu LDW, 2019, 'Pathogen adaptation to vaccination: The Australian Bordetella pertussis story', Microbiology Australia, vol. 40, pp. 177 - 180, http://dx.doi.org/10.1071/MA19052
    Journal articles | 2019
    Kamachi K; Otsuka N; Fumimoto R; Ozawa K; Yao SM; Chiang CS; Luu LDW; Lan R; Shibayama K; Watanabe M, 2019, 'A novel multilocus variable-number tandem repeat analysis for Bordetella parapertussis', Journal of medical microbiology, vol. 68, pp. 1671 - 1676, http://dx.doi.org/10.1099/jmm.0.001095
    Journal articles | 2018
    Wai Luu LD; Octavia S; Zhong L; Raftery MJ; Sintchenko V; Lan R, 2018, 'Comparison of the whole cell proteome and secretome of epidemic bordetella pertussis strains from the 2008–2012 Australian epidemic under sulfate-modulating conditions', Frontiers in Microbiology, vol. 9, http://dx.doi.org/10.3389/fmicb.2018.02851
    Journal articles | 2018
    Luu LDW; Octavia S; Zhong L; Raftery MJ; Sintchenko V; Lan R, 2018, 'Proteomic Adaptation of Australian Epidemic Bordetella pertussis', Proteomics, vol. 18, http://dx.doi.org/10.1002/pmic.201700237
    Journal articles | 2017
    Luu LDW; Octavia S; Zhong L; Raftery M; Sintchenko V; Lan R, 2017, 'Characterisation of the Bordetella pertussis secretome under different media', Journal of Proteomics, vol. 158, pp. 43 - 51, http://dx.doi.org/10.1016/j.jprot.2017.02.010
    Journal articles | 2016
    Safarchi A; Octavia S; Luu LDW; Tay CY; Sintchenko V; Wood N; Marshall H; McIntyre P; Lan R, 2016, 'Better colonisation of newly emerged Bordetella pertussis in the co-infection mouse model study', Vaccine, vol. 34, pp. 3967 - 3971, http://dx.doi.org/10.1016/j.vaccine.2016.06.052
    Journal articles | 2015
    Safarchi A; Octavia S; Luu LDW; Tay CY; Sintchenko V; Wood N; Marshall H; McIntyre P; Lan R, 2015, 'Pertactin negative Bordetella pertussis demonstrates higher fitness under vaccine selection pressure in a mixed infection model', Vaccine, vol. 33, pp. 6277 - 6281, http://dx.doi.org/10.1016/j.vaccine.2015.09.064
    Journal articles |
    Wai Luu LD; Payne M; Zhang X; Luo L; Lan R, 'Development and comparison of a novel multiple cross displacement amplification (MCDA) assay with other nucleic acid amplification methods for SARS-CoV-2 detection', , http://dx.doi.org/10.1101/2020.10.03.20206193
    Journal articles | 2020
    Kaur S; Peters T; Yang P; Luu LDW; Vuong J; Krycer J; O’Donoghue S, 2020, 'Temporal ordering of omics and multiomic events inferred from time series data', , http://dx.doi.org/10.1101/2020.04.14.040527
    Journal articles |
    Wang Y; Wang X; Wai Luu LD; Chen S; Jin F; Wang S; Huang X; Wang L; Zhou X; Chen X; Cui X; Li J; Tai J; Zhu X, 'Proteomic and metabolomic signatures associated with the immune response in healthy individuals immunized with an inactivated SARS-CoV-2 vaccine', , http://dx.doi.org/10.1101/2021.07.21.21260959
  • Preprints |
    Wang Y; Wang X; Luu LDW; Li J; Cui X; Yao H; Zhang X; Chen S; Fu J; Wang L; Wang C; Yuan R; Cai Q; Huang X; Huang J; Xu W; Li S; Zhu X; Tai J, Single-cell transcriptomic atlas of individuals receiving inactivated COVID-19 vaccines reveals distinct immunological responses between vaccine and natural SARS-CoV-2 infection, http://dx.doi.org/10.1101/2021.08.30.21262863