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Conjoint Associate Professor

Associate Professor Marina Pajic

Medicine & Health
School of Clinical Medicine
Phone
02 9355 5834
  • Journal articles | 2022
    Dreyer SB; Upstill-Goddard R; Legrini A; Biankin AV; Allison S; Beraldi D; Cameron E; Chang DK; Cooke SL; Cunningham R; Dreyer S; Grimwood P; Kelly S; Marshall J; McDade B; Musgrove EA; Ramsay D; Evers L; Rebus S; Rahib L; Serrels B; Jamieson NB; McKay CJ; Westwood P; Williams N; Duthie F; Shen W; Pea A; Johns AL; Gill AJ; Chantrill LA; Timpson P; Chou A; Pajic M; Dwarte T; Herrmann D; Vennin C; Cox TR; Pereira B; Ritchiee S; Reed DA; Chambers CR; Metcalf X; Nobis M; Jeong G; Kenyon L; Lyons RJ; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Grimmond SM; Hofmann O; Samra JS; Pavlakis N; Arena J; High HA; Asghari R; Merrett ND; Das A; Cosman PH; Ismail K; Stoita A; Williams D; Spigellman A; McLeod D; Kirk J; Kench JG; Grimison P; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forrest C; Ballal M; Fletcher D; Beilin M; Feeney K; Epari K; Mukhedkar S; Zeps N; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O'Rourke TJ; Fawcett JW, 2022, 'Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence', Gastroenterology, 162, pp. 320 - 324.e4, http://dx.doi.org/10.1053/j.gastro.2021.09.022
    Journal articles | 2022
    Khan T; Lyons NJ; Gough M; Kwah KKX; Cuda TJ; Snell CE; Tse BW; Sokolowski KA; Pearce LA; Adams TE; Rose SE; Puttick S; Pajic M; Adams MN; He Y; Hooper JD; Kryza T, 2022, 'CUB Domain-Containing Protein 1 (CDCP1) is a rational target for the development of imaging tracers and antibody-drug conjugates for cancer detection and therapy', Theranostics, 12, pp. 6915 - 6930, http://dx.doi.org/10.7150/thno.78171
    Journal articles | 2022
    McLean B; Istadi A; Clack T; Vankan M; Schramek D; Neely GG; Pajic M, 2022, 'A CRISPR Path to Finding Vulnerabilities and Solving Drug Resistance: Targeting the Diverse Cancer Landscape and Its Ecosystem.', Adv Genet (Hoboken), 3, pp. 2200014, http://dx.doi.org/10.1002/ggn2.202200014
    Journal articles | 2022
    Poh AR; O'Brien M; Chisanga D; He H; Baloyan D; Traichel J; Dijkstra C; Chopin M; Nutt S; Whitehead L; Boon L; Parkin A; Lowell C; Pajic M; Shi W; Nikfarjam M; Ernst M, 2022, 'Inhibition of HCK in myeloid cells restricts pancreatic tumor growth and metastasis', Cell Reports, 41, http://dx.doi.org/10.1016/j.celrep.2022.111479
    Journal articles | 2021
    Dreyer SB; Upstill-Goddard R; Paulus-Hock V; Paris C; Lampraki EM; Dray E; Serrels B; Caligiuri G; Rebus S; Plenker D; Galluzzo Z; Brunton H; Cunningham R; Tesson M; Nourse C; Bailey UM; Jones MD; Moran-Jones K; Wright DW; Duthie F; Oien K; Evers L; McKay CJ; McGregor GA; Gulati A; Brough R; Bajrami I; Pettitt S; Dziubinski ML; Candido J; Balkwill F; Barry ST; Grützmann R; Rahib L; Allison S; Bailey PJ; Biankin AV; Beraldi D; Cameron E; Chang DK; Cooke SL; Grimwood P; Kelly S; Marshall J; Martin S; McDade B; McElroy D; Musgrove EA; Ramsay D; Wright D; Hair J; Jamieson NB; Westwood P; Williams N; Johns AL; Mawson A; Scarlett CJ; Brancato MAL; Rowe SJ; Simpson SH; Martyn-Smith M; Thomas MT; Chantrill LA; Chin VT; Chou A; Cowley MJ; Humphris JL; Mead RS; Nagrial AM; Pajic M; Pettit J; Pinese M; Rooman I; Wu J; Tao J; DiPietro R; Watson C; Steinmann A; Lee HC; Wong R; Pinho AV; Giry-Laterriere M; Daly RJ; Sutherland RL; Grimmond SM; Waddell N; Kassahn KS; Miller DK; Wilson PJ; Patch AM; Song S; Harliwong I; Idrisoglu S; Nourbakhsh E; Manning S; Wani S; Gongora M; Anderson M; Holmes O; Leonard C, 2021, 'Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer', Gastroenterology, 160, pp. 362 - 377.e13, http://dx.doi.org/10.1053/j.gastro.2020.09.043
    Journal articles | 2021
    Geleta B; Park KC; Jansson PJ; Sahni S; Maleki S; Xu Z; Murakami T; Pajic M; Apte MV; Richardson DR; Kovacevic Z, 2021, 'Breaking the cycle: Targeting of NDRG1 to inhibit bi-directional oncogenic cross-talk between pancreatic cancer and stroma', FASEB Journal, 35, pp. e21347, http://dx.doi.org/10.1096/fj.202002279R
    Journal articles | 2021
    Kryza T; Khan T; Lovell S; Harrington BS; Yin J; Porazinski S; Pajic M; Koistinen H; Rantala JK; Dreyer T; Magdolen V; Reuning U; He Y; Tate EW; Hooper JD, 2021, 'Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1', Nature Chemical Biology, 17, pp. 776 - 783, http://dx.doi.org/10.1038/s41589-021-00783-w
    Journal articles | 2021
    Lakis V; Lawlor RT; Newell F; Patch AM; Mafficini A; Sadanandam A; Koufariotis LT; Johnston RL; Leonard C; Wood S; Rusev B; Corbo V; Luchini C; Cingarlini S; Landoni L; Salvia R; Milella M; Chang D; Bailey P; Jamieson NB; Duthie F; Gingras MC; Muzny DM; Wheeler DA; Gibbs RA; Milione M; Chantrill LA; Timpson P; Chou A; Pajic M; Murphy A; Dwarte T; Hermann D; Vennin C; Cox TR; Pereira B; Ritchie S; Reed DA; Chambers CR; Metcalf X; Nobis M; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Xu Q; Hofmann O; Samra JS; Pavlakis N; Arena J; High HA; Asghari R; Merrett ND; Pavey D; Das A; Cosman PH; Ismail K; O’Connnor C; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forest C; Ballal M; Fletcher DR; Zeps N; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Dixon J; Scardoni M; Bassi C; Grimaldi S; Cantù C; Bonizzato G; Bersani S, 2021, 'DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association', Communications Biology, 4, http://dx.doi.org/10.1038/s42003-020-01469-0
    Journal articles | 2021
    Liu D; Sharbeen G; Phillips P; Johns AL; Gill AJ; Chantrill LA; Timpson P; Chou A; Pajic M; Dwarte T; Herrmann D; Vennin C; Cox TR; Pereira B; Ritchie S; Reed DA; Chambers CR; Metcalf X; Nobis M; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Grimmond SM; Hofmann O; Samra JS; Pavlakis N; Arena J; High HA; Asghari R; Merrett ND; Das A; Cosman PH; Ismail K; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forrest C; Ballal M; Fletcher D; Beilin M; Feeney K; Epari K; Mukhedkar S; Zeps N; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Scarpa A; Lawlor RT; Corbo V; Bassi C; Biankin AV; Jamieson NB; Chang DK; Dreyer SB; Ford CE, 2021, 'ROR1 and ROR2 expression in pancreatic cancer', BMC Cancer, 21, pp. 1199, http://dx.doi.org/10.1186/s12885-021-08952-9
    Journal articles | 2021
    Lundy J; Gearing LJ; Gao H; West AC; McLeod L; Deswaerte V; Yu L; Porazinski S; Pajic M; Hertzog PJ; Croagh D; Jenkins BJ, 2021, 'TLR2 activation promotes tumour growth and associates with patient survival and chemotherapy response in pancreatic ductal adenocarcinoma', Oncogene, 40, pp. 6007 - 6022, http://dx.doi.org/10.1038/s41388-021-01992-2
    Journal articles | 2021
    Murphy KJ; Reed DA; Vennin C; Conway JRW; Nobis M; Yin JX; Chambers CR; Pereira BA; Lee V; Filipe EC; Trpceski M; Ritchie S; Lucas MC; Warren SC; Skhinas JN; Magenau A; Metcalf XL; Stoehr J; Major G; Parkin A; Bidanel R; Lyons RJ; Zaratzian A; Tayao M; Da Silva A; Abdulkhalek L; Gill AJ; Johns AL; Biankin AV; Samra J; Grimmond SM; Chou A; Goetz JG; Samuel MS; Lyons JG; Burgess A; Caldon CE; Horvath LG; Daly RJ; Gadegaard N; Wang Y; Sansom OJ; Morton JP; Cox TR; Pajic M; Herrmann D; Timpson P, 2021, 'Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status', Science Advances, 7, http://dx.doi.org/10.1126/sciadv.abh0363
    Journal articles | 2021
    Satgunaseelan L; Porazinski S; Strbenac D; Istadi A; Willet C; Chew T; Sadsad R; Palme CE; Lee JH; Boyer M; Yang JYH; Clark JR; Pajic M; Gupta R, 2021, 'Oral Squamous Cell Carcinoma in Young Patients Show Higher Rates of EGFR Amplification: Implications for Novel Personalized Therapy', Frontiers in Oncology, 11, pp. 750852, http://dx.doi.org/10.3389/fonc.2021.750852
    Journal articles | 2021
    Sharbeen G; McCarroll JA; Akerman A; Kopecky C; Youkhana J; Kokkinos J; Holst J; Boyer C; Erkan M; Goldstein D; Timpson P; Cox TR; Pereira BA; Chitty JL; Fey SK; Najumudeen AK; Campbell AD; Sansom OJ; Ignacio RMC; Naim S; Liu J; Russia N; Lee J; Chou A; Johns A; Gill AJ; Gonzales-Aloy E; Gebski V; Guan YF; Pajic M; Turner N; Apte MV; Davis TP; Morton JP; Haghighi KS; Kasparian J; McLean BJ; Setargew YF; Phillips PA, 2021, 'Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to slc7a11 inhibition', Cancer Research, 81, pp. 3461 - 3479, http://dx.doi.org/10.1158/0008-5472.CAN-20-2496
    Journal articles | 2020
    Brunton H; Caligiuri G; Cunningham R; Upstill-Goddard R; Bailey UM; Garner IM; Nourse C; Dreyer S; Jones M; Moran-Jones K; Wright DW; Paulus-Hock V; Nixon C; Thomson G; Jamieson NB; McGregor GA; Evers L; McKay CJ; Gulati A; Brough R; Bajrami I; Pettitt SJ; Dziubinski ML; Barry ST; Grützmann R; Brown R; Curry E; Allison S; Biankin AV; Chang DK; Cooke SL; Grimwood P; Kelly S; Marshall J; McDade B; McElroy D; Ramsay D; Rebus S; Hair J; Westwood P; Williams N; Duthie F; Johns AL; Mawson A; Scarlett CJ; Brancato MAL; Rowe SJ; Simpson SH; Martyn-Smith M; Thomas MT; Chantrill LA; Chin VT; Chou A; Cowley MJ; Humphris JL; Mead RS; Nagrial AM; Pajic M; Pettit J; Pinese M; Rooman I; Wu J; Tao J; DiPietro R; Watson C; Steinmann A; Lee HC; Wong R; Pinho AV; Giry-Laterriere M; Daly RJ; Musgrove EA; Sutherland RL; Grimmond SM; Waddell N; Kassahn KS; Miller DK; Wilson PJ; Patch AM; Song S; Harliwong I; Idrisoglu S; Nourbakhsh E; Manning S; Wani S; Gongora M; Anderson M; Holmes O; Leonard C; Taylor D; Wood S; Xu C; Nones K; Fink JL; Christ A; Bruxner T; Cloonan N; Newell F; Pearson JV; Quinn M, 2020, 'HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer', Cell Reports, 31, http://dx.doi.org/10.1016/j.celrep.2020.107625
    Journal articles | 2020
    Campbell PJ; Getz G; Korbel JO; Stuart JM; Jennings JL; Stein LD; Perry MD; Nahal-Bose HK; Ouellette BFF; Li CH; Rheinbay E; Nielsen GP; Sgroi DC; Wu CL; Faquin WC; Deshpande V; Boutros PC; Lazar AJ; Hoadley KA; Louis DN; Dursi LJ; Yung CK; Bailey MH; Saksena G; Raine KM; Buchhalter I; Kleinheinz K; Schlesner M; Zhang J; Wang W; Wheeler DA; Ding L; Simpson JT; O’Connor BD; Yakneen S; Ellrott K; Miyoshi N; Butler AP; Royo R; Shorser SI; Vazquez M; Rausch T; Tiao G; Waszak SM; Rodriguez-Martin B; Shringarpure S; Wu DY; Demidov GM; Delaneau O; Hayashi S; Imoto S; Habermann N; Segre AV; Garrison E; Cafferkey A; Alvarez EG; Heredia-Genestar JM; Muyas F; Drechsel O; Bruzos AL; Temes J; Zamora J; Baez-Ortega A; Kim HL; Mashl RJ; Ye K; DiBiase A; Huang KL; Letunic I; McLellan MD; Newhouse SJ; Shmaya T; Kumar S; Wedge DC; Wright MH; Yellapantula VD; Gerstein M; Khurana E; Marques-Bonet T; Navarro A; Bustamante CD; Siebert R; Nakagawa H; Easton DF; Ossowski S; Tubio JMC; De La Vega FM; Estivill X; Yuen D; Mihaiescu GL; Omberg L; Ferretti V; Sabarinathan R; Pich O; Gonzalez-Perez A; Taylor-Weiner A; Fittall MW; Demeulemeester J; Tarabichi M; Roberts ND, 2020, 'Pan-cancer analysis of whole genomes', Nature, 578, pp. 82 - 93, http://dx.doi.org/10.1038/s41586-020-1969-6
    Journal articles | 2020
    Castillo L; Young AIJ; Mawson A; Schafranek P; Steinmann AM; Nessem D; Parkin A; Johns A; Chou A; Law AMK; Lucas MC; Murphy KJ; Deng N; Gallego-Ortega D; Caldon CE; Timpson P; Pajic M; Ormandy CJ; Oakes SR, 2020, 'MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma', Oncogene, 39, pp. 1821 - 1829, http://dx.doi.org/10.1038/s41388-019-1091-0
    Journal articles | 2020
    Chou A; Brown IS; Kumarasinghe MP; Perren A; Riley D; Kim Y; Pajic M; Steinmann A; Rathi V; Jamieson NB; Verheij J; van Roessel S; Nahm CB; Mittal A; Samra J; Gill AJ, 2020, 'RET gene rearrangements occur in a subset of pancreatic acinar cell carcinomas', Modern Pathology, 33, pp. 657 - 664, http://dx.doi.org/10.1038/s41379-019-0373-y
    Journal articles | 2020
    Cipponi A; Goode DL; Bedo J; McCabe MJ; Pajic M; Croucher DR; Rajal AG; Junankar SR; Saunders DN; Lobachevsky P; Papenfuss AT; Nessem D; Nobis M; Warren SC; Timpson P; Cowley M; Vargas AC; Qiu MR; Generali DG; Keerthikumar S; Nguyen U; Corcoran NM; Long GV; Blay J-Y; Thomas DM; McCabe M, 2020, 'MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer', Science
    Journal articles | 2020
    Dreyer SB; Pinese M; Jamieson NB; Scarlett CJ; Colvin EK; Pajic M; Johns AL; Humphris JL; Wu J; Cowley MJ; Chou A; Nagrial AM; Chantrill L; Chin VT; Jones MD; Moran-Jones K; Carter CR; Dickson EJ; Samra JS; Merrett ND; Gill AJ; Kench JG; Duthie F; Miller DK; Cooke S; Aust D; Knösel T; Rümmele P; Grützmann R; Pilarsky C; Nguyen NQ; Musgrove EA; Bailey PJ; McKay CJ; Biankin AV; Chang DK, 2020, 'Precision Oncology in Surgery: Patient Selection for Operable Pancreatic Cancer', Annals of Surgery, 272, pp. 366 - 376, http://dx.doi.org/10.1097/SLA.0000000000003143
    Journal articles | 2020
    Kokkinos J; Ignacio RMC; Sharbeen G; Boyer C; Gonzales-Aloy E; Goldstein D; McCarroll JA; Phillips PA, 2020, 'Targeting the undruggable in pancreatic cancer using nano-based gene silencing drugs', Biomaterials, 240, pp. 119742, http://dx.doi.org/10.1016/j.biomaterials.2019.119742
    Journal articles | 2020
    Kryza T; Khan T; Puttick S; Li C; Sokolowski KA; Tse BWC; Cuda T; Lyons N; Gough M; Yin J; Parkin A; Deryugina EI; Quigley JP; Law RHP; Whisstock JC; Riddell AD; Barbour AP; Wyld DK; Thomas PA; Rose S; Snell CE; Pajic M; He Y; Hooper JD, 2020, 'Effective targeting of intact and proteolysed CDCP1 for imaging and treatment of pancreatic ductal adenocarcinoma', Theranostics, 10, pp. 4116 - 4133, http://dx.doi.org/10.7150/thno.43589
    Journal articles | 2020
    Lau MT; Ghazanfar S; Parkin A; Chou A; Rouaen JR; Littleboy JB; Nessem D; Khuong TM; Nevoltris D; Schofield P; Langley D; Christ D; Yang J; Pajic M; Neely GG, 2020, 'Systematic functional identification of cancer multi-drug resistance genes', Genome Biology, 21, pp. 27, http://dx.doi.org/10.1186/s13059-020-1940-8
    Journal articles | 2020
    Li CH; Prokopec SD; Sun RX; Yousif F; Schmitz N; Al-Shahrour F; Atwal G; Bailey PJ; Biankin AV; Boutros PC; Campbell PJ; Chang DK; Cooke SL; Deshpande V; Faltas BM; Faquin WC; Garraway L; Getz G; Grimmond SM; Haider S; Hoadley KA; Jiao W; Kaiser VB; Karlić R; Kato M; Kübler K; Lazar AJ; Li CH; Louis DN; Margolin A; Martin S; Nahal-Bose HK; Nielsen GP; Nik-Zainal S; Omberg L; P’ng C; Perry MD; Polak P; Rheinbay E; Rubin MA; Semple CA; Sgroi DC; Shibata T; Siebert R; Smith J; Stein LD; Stobbe MD; Sun RX; Thai K; Wright DW; Wu CL; Yuan K; Zhang J; Aaltonen LA; Abascal F; Abeshouse A; Aburatani H; Adams DJ; Agrawal N; Ahn KS; Ahn SM; Aikata H; Akbani R; Akdemir KC; Al-Ahmadie H; Al-Sedairy ST; Alawi M; Albert M; Aldape K; Alexandrov LB; Ally A; Alsop K; Alvarez EG; Amary F; Amin SB; Aminou B; Ammerpohl O; Anderson MJ; Ang Y; Antonello D; Anur P; Aparicio S; Appelbaum EL; Arai Y; Aretz A; Arihiro K; Ariizumi SI; Armenia J; Arnould L; Asa S; Assenov Y; Aukema S; Auman JT; Aure MR; Awadalla P; Aymerich M; Bader GD; Baez-Ortega A, 2020, 'Sex differences in oncogenic mutational processes', Nature Communications, 11, http://dx.doi.org/10.1038/s41467-020-17359-2
    Journal articles | 2020
    Man J; Pajic M; Joshua AM, 2020, 'Fats and mets, KRAS-driven lipid dysregulation affects metastatic potential in pancreatic cancer', Cancer Research, 80, pp. 4886 - 4887, http://dx.doi.org/10.1158/0008-5472.CAN-20-3082
    Journal articles | 2020
    Porazinski S; Parkin A; Pajic M, 2020, 'Rho-ROCK Signaling in Normal Physiology and as a Key Player in Shaping the Tumor Microenvironment', , 1223, pp. 99 - 127, http://dx.doi.org/10.1007/978-3-030-35582-1_6
    Journal articles | 2020
    Thejer BM; Adhikary PP; Kaur A; Teakel SL; Van Oosterum A; Seth I; Pajic M; Hannan KM; Pavy M; Poh P; Jazayeri JA; Zaw T; Pascovici D; Ludescher M; Pawlak M; Cassano JC; Turnbull L; Jazayeri M; James AC; Coorey CP; Roberts TL; Kinder SJ; Hannan RD; Patrick E; Molloy MP; New EJ; Fehm TN; Neubauer H; Goldys EM; Weston LA; Cahill MA, 2020, 'PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth', BMC Molecular and Cell Biology, 21, pp. 24, http://dx.doi.org/10.1186/s12860-020-00256-3
    Journal articles | 2020
    Vennin C; Rath N; Pajic M; Olson MF; Timpson P, 2020, 'Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy', Small GTPases, 11, pp. 45 - 52, http://dx.doi.org/10.1080/21541248.2017.1345712
    Journal articles | 2019
    Blatter S; Pajic M; Guyader C; Gonggrijp M; Kersbergen A; Küçükosmanoğlu A; Sol W; Drost R; Jonkers J; Borst P; Rottenberg S, 2019, 'Targeting drug tolerance of residual BRCA1-mutated mouse mammary tumours', Journal of Comparative Pathology, 166, pp. 101 - 101, http://dx.doi.org/10.1016/j.jcpa.2018.10.008
    Journal articles | 2019
    Chou A; Pajic M; Gill A, 2019, 'Gene-rearrangement is frequent in pancreatic acinar cell carcinoma', Pathology, 51, pp. S7 - S7, http://dx.doi.org/10.1016/j.pathol.2018.12.010
    Journal articles | 2019
    Parkin A; Man J; Timpson P; Pajic M, 2019, 'Targeting the complexity of Src signalling in the tumour microenvironment of pancreatic cancer: from mechanism to therapy', FEBS Journal, 286, pp. 3510 - 3539, http://dx.doi.org/10.1111/febs.15011
    Journal articles | 2019
    Wang K; Huynh N; Wang X; Pajic M; Parkin A; Man J; Baldwin GS; Nikfarjam M; He H, 2019, 'PAK inhibition by PF-3758309 enhanced the sensitivity of multiple chemotherapeutic reagents in patient-derived pancreatic cancer cell lines', American Journal of Translational Research, 11, pp. 3353 - 3364, https://www.ncbi.nlm.nih.gov/pubmed/31312349
    Journal articles | 2018
    Campbell H; Fleming N; Roth I; Mehta S; Wiles A; Williams G; Vennin C; Arsic N; Parkin A; Pajic M; Munro F; McNoe L; Black M; McCall J; Slatter TL; Timpson P; Reddel R; Roux P; Print C; Baird MA; Braithwaite AW, 2018, 'Δ133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signaling', Nature Communications, 9, http://dx.doi.org/10.1038/s41467-017-02408-0
    Journal articles | 2018
    Chou A; Froio D; Nagrial AM; Parkin A; Murphy KJ; Chin VT; Wohl D; Steinmann A; Stark R; Drury A; Walters SN; Vennin C; Burgess A; Pinese M; Chantrill LA; Cowley MJ; Molloy TJ; Waddell N; Johns A; Grimmond SM; Chang DK; Biankin AV; Sansom OJ; Morton JP; Grey ST; Cox TR; Turchini J; Samra J; Clarke SJ; Timpson P; Gill AJ; Pajic M, 2018, 'Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer', Gut, 67, pp. 2142 - 2155, http://dx.doi.org/10.1136/gutjnl-2017-315144
    Journal articles | 2018
    Chou A; Itchins M; de Reuver PR; Arena J; Clarkson A; Sheen A; Sioson L; Cheung V; Perren A; Nahm C; Mittal A; Samra JS; Pajic M; Gill AJ, 2018, 'ATRX loss is an independent predictor of poor survival in pancreatic neuroendocrine tumors', Human Pathology, 82, pp. 249 - 257, http://dx.doi.org/10.1016/j.humpath.2018.07.032
    Journal articles | 2018
    Chou A; Kim Y; Samra JS; Pajic M; Gill AJ, 2018, 'BRAF gene rearrangements can be identified by FISH studies in pancreatic acinar cell carcinoma', Pathology, 50, pp. 345 - 348, http://dx.doi.org/10.1016/j.pathol.2017.09.027
    Journal articles | 2018
    Conway JRW; Warren SC; Herrmann D; Murphy KJ; Cazet AS; Vennin C; Shearer RF; Killen MJ; Magenau A; Mélénec P; Pinese M; Nobis M; Zaratzian A; Boulghourjian A; Da Silva AM; del Monte-Nieto G; Adam ASA; Harvey RP; Haigh JJ; Wang Y; Croucher DR; Sansom OJ; Pajic M; Caldon CE; Morton JP; Timpson P, 2018, 'Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer', Cell Reports, 23, pp. 3312 - 3326, http://dx.doi.org/10.1016/j.celrep.2018.05.038
    Journal articles | 2018
    Hoque M; Abbassi RH; Froio D; Man J; Johns TG; Stringer BW; Day BW; Pajic M; Kassiou M; Munoz L, 2018, 'Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors', Pharmacological Research, 134, pp. 166 - 178, http://dx.doi.org/10.1016/j.phrs.2018.06.023
    Journal articles | 2018
    Molloy T; Parkin A; Chou A; Samra J; Timpson P; Gill A; Pajic M, 2018, 'PO-195 Integrative analysis of in vivo models of pancreatic cancer reveals complex mechanisms behind treatment failure and provides new tools for effective targeting', ESMO Open, 3, pp. A303 - A303, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.713
    Journal articles | 2018
    Murphy K; Vennin C; Cox T; Wang Y; Morton J; Sansom O; Pajic M; Herrmann D; Timpson P, 2018, 'PO-229 Transient tissue ‘priming’ via FAK inhibition to impair pancreatic ductal adenocarcinoma (PDAC) progression to improve sensitivity to gemcitabine/abraxane', ESMO Open, 3, pp. A316 - A317, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.746
    Journal articles | 2018
    Pajic M; Froio D; Daly S; Doculara L; Millar E; Graham PH; Drury A; Steinmann A; De Bock CE; Boulghourjian A; Zaratzian A; Carroll S; Toohey J; O'Toole SA; Harris AL; Buffa FM; Gee HE; Hollway GE; Molloy TJ, 2018, 'miR-139-5p modulates radiotherapy resistance in breast cancer by repressing multiple gene networks of DNA repair and ROS defense', Cancer Research, 78, pp. 501 - 515, http://dx.doi.org/10.1158/0008-5472.CAN-16-3105
    Journal articles | 2018
    Parkin A; Man J; Chou A; Nagrial AM; Samra J; Gill AJ; Timpson P; Pajic M, 2018, 'The Evolving Understanding of the Molecular and Therapeutic Landscape of Pancreatic Ductal Adenocarcinoma.', Diseases, 6, http://dx.doi.org/10.3390/diseases6040103
    Journal articles | 2018
    Parkin A; Steinmann A; Froio D; Drury A; Vogel N; Murphy K; Deng N; Gill A; Timpson P; Pajic M, 2018, 'PO-046 Dual inhibition of JAK and Src: a novel and promising therapeutic combination for pancreatic cancer', ESMO Open, 3, pp. A245 - A245, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.579
    Journal articles | 2018
    Rath N; Munro J; Cutiongco MF; Jagiełło A; Gadegaard N; McGarry L; Unbekandt M; Michalopoulou E; Kamphorst JJ; Sumpton D; Mackay G; Vennin C; Pajic M; Timpson P; Olson MF, 2018, 'Rho kinase inhibition by AT13148 blocks pancreatic ductal adenocarcinoma invasion and tumor growth', Cancer Research, 78, pp. 3321 - 3336, http://dx.doi.org/10.1158/0008-5472.CAN-17-1339
    Journal articles | 2018
    Salaymeh Y; Farago M; Sebban S; Pikarsky E; Katzav S, 2018, 'PO-196 Vav1 and Mutant K-Ras synergize in pancreatic ductal adenocarcinoma development: lessons from mouse models', ESMO Open, 3, pp. A303 - A303, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.714
    Journal articles | 2018
    Vennin C; Murphy KJ; Morton JP; Cox TR; Pajic M; Timpson P, 2018, 'Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer', Gastroenterology, 154, pp. 820 - 838, http://dx.doi.org/10.1053/j.gastro.2017.11.280
    Journal articles | 2017
    Balachandran VP; Łuksza M; Zhao JN; Makarov V; Moral JA; Remark R; Herbst B; Askan G; Bhanot U; Senbabaoglu Y; Wells DK; Cary CIO; Grbovic-Huezo O; Attiyeh M; Medina B; Zhang J; Loo J; Saglimbeni J; Abu-Akeel M; Zappasodi R; Riaz N; Smoragiewicz M; Larkin Kelley Z; Basturk O; Gönen M; Levine AJ; Allen PJ; Fearon DT; Merad M; Gnjatic S; Iacobuzio-Donahue CA; Wolchok JD; Dematteo RP; Chan TA; Greenbaum BD; Merghoub T; Leach SD; Johns AL; Scott Mead R; Gill AJ; Chang DK; McKay SH; Chantrill LA; Chin VT; Chou A; Humphris JL; Pajic M; Steinmann A; Arshi M; Drury A; Froio D; Morgan A; Timpson P; Hermann D; Vennin C; Warren S; Pinese M; Wu J; Pinho AV; Tucker K; Andrews L; Samra JS; Arena J; Pavlakis N; High HA; Mittal A; Biankin AV; Bailey P; Martin S; Musgrove EA; Jones MD; Nourse C; Jamieson NB; Stoita A; Williams D; Spigelman A; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Xu C; Grimmond SM; Hofmann O; Wilson PJ; Christ A; Bruxner T; Asghari R; Merrett ND; Pavey D; Das A; Goodwin A; Cosman PH; Ismail K, 2017, 'Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer', Nature, 551, pp. S12 - S16, http://dx.doi.org/10.1038/nature24462
    Journal articles | 2017
    Chin VT; Vennin C; Timpson P; Pajic M, 2017, 'Effective modulation of stromal signaling through ROCK inhibition: Is it all in the timing?', Molecular and Cellular Oncology, 4, http://dx.doi.org/10.1080/23723556.2017.1333973
    Journal articles | 2017
    Conway JRW; Vennin C; Cazet AS; Herrmann D; Murphy KJ; Warren SC; Wullkopf L; Boulghourjian A; Zaratzian A; Da Silva AM; Pajic M; Morton JP; Cox TR; Timpson P, 2017, 'Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology', Scientific Reports, 7, http://dx.doi.org/10.1038/s41598-017-17177-5
    Journal articles | 2017
    Hardie R-A; van Dam E; Cowley M; Han T-L; Balaban S; Pajic M; Pinese M; Iconomou M; Shearer RF; McKenna J; Miller D; Waddell N; Pearson JV; Grimmond SM; Sazanov L; Biankin AV; Villas-Boas S; Hoy AJ; Turner N; Saunders DN, 2017, 'Mitochondrial mutations and metabolic adaptation in pancreatic cancer', CANCER & METABOLISM, 5, http://dx.doi.org/10.1186/s40170-017-0164-1
    Journal articles | 2017
    Harris NLE; Vennin C; Conway JRW; Vine KL; Pinese M; Cowley MJ; Shearer RF; Lucas MC; Herrmann D; Allam AH; Pajic M; Morton JP; Biankin AV; Ranson M; Timpson P; Saunders DN, 2017, 'SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer', Oncogene, 36, pp. 4288 - 4298, http://dx.doi.org/10.1038/onc.2017.63
    Journal articles | 2017
    Humphris JL; Patch AM; Nones K; Bailey PJ; Johns AL; McKay S; Chang DK; Miller DK; Pajic M; Kassahn KS; Quinn MCJ; Bruxner TJC; Christ AN; Harliwong I; Idrisoglu S; Manning S; Nourse C; Nourbakhsh E; Stone A; Wilson PJ; Anderson M; Fink JL; Holmes O; Kazakoff S; Leonard C; Newell F; Waddell N; Wood S; Mead RS; Xu Q; Wu J; Pinese M; Cowley MJ; Jones MD; Nagrial AM; Chin VT; Chantrill LA; Mawson A; Chou A, 2017, 'Hypermutation In Pancreatic Cancer', Gastroenterology, 152, pp. 68 - 74.e2, http://dx.doi.org/10.1053/j.gastro.2016.09.060
    Journal articles | 2017
    Johns AL; McKay SH; Humphris JL; Pinese M; Chantrill LA; Mead RS; Tucker K; Andrews L; Goodwin A; Leonard C; High HA; Nones K; Waddell N; Patch AM; Merrett ND; Pavlakis N; Kassahn KS; Samra JS; Miller DK; Chang DK; Pajic M; Pearson JV; Grimmond SM; Zeps N; Gill AJ; Biankin AV; Chin VT; Chou A; Steinmann A; Arshi M; Drury A; Froio D; Morgan A; Timpson P; Hermann D; Vennin C; Warren S; Wu J; Pinho AV; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Wood S; Xu C; Hofmann O; Wilson PJ; Christ A; Bruxner T; Samra S; Arena J; Mittal A; Asghari R; Pavey D; Das A; Cosman PH; Ismail K; O'Connnor C; Williams D; Spigellman A; Lam W; McLeod D; Nagrial AM; Kirk J; James V; Grimison P; Cooper CL; Sandroussi C; Forest C; Epari KP; Ballal M; Fletcher DR; Mukhedkar S; Beilin M; Feeney K; Nguyen NQ; Ruszkiewicz AR; Worthley C; Brooke-Smith ME; Papangelis V; Clouston AD; Martin P; Barbour AP; O'Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Hruban RH; Wolfgang CL; Hodgin M; Lawlor RT; Beghelli S; Corbo V; Scardoni M; Bassi C; Bailey P; Martin S; Musgrove EA, 2017, 'Lost in translation: Returning germline genetic results in genome-scale cancer research', Genome Medicine, 9, http://dx.doi.org/10.1186/s13073-017-0430-4
    Journal articles | 2017
    Martinelli P; Carrillo-De Santa Pau E; Cox T; Sainz B; Dusetti N; Greenhalf W; Rinaldi L; Costello E; Ghaneh P; Malats N; Büchler M; Pajic M; Biankin AV; Iovanna J; Neoptolemos J; Real FX, 2017, 'GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer', Gut, 66, pp. 1665 - 1676, http://dx.doi.org/10.1136/gutjnl-2015-311256
    Journal articles | 2017
    Nobis M; Herrmann D; Warren SC; Kadir S; Leung W; Killen M; Magenau A; Stevenson D; Lucas MC; Reischmann N; Vennin C; Conway JRW; Boulghourjian A; Zaratzian A; Law AM; Gallego-Ortega D; Ormandy CJ; Walters SN; Grey ST; Bailey J; Chtanova T; Quinn JMW; Baldock PA; Croucher PI; Schwarz JP; Mrowinska A; Zhang L; Herzog H; Masedunskas A; Hardeman EC; Gunning PW; del Monte-Nieto G; Harvey RP; Samuel MS; Pajic M; McGhee EJ; Johnsson AKE; Sansom OJ; Welch HCE; Morton JP; Strathdee D; Anderson KI; Timpson P, 2017, 'A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts', Cell Reports, 21, pp. 274 - 288, http://dx.doi.org/10.1016/j.celrep.2017.09.022
    Journal articles | 2017
    Pajic M; Blatter S; Guyader C; Gonggrijp M; Kersbergen A; Küçükosmanoğlu A; Sol W; Drost R; Jonkers J; Borst P; Rottenberg S, 2017, 'Selected alkylating agents can overcome drug tolerance of G 0 -like tumor cells and eradicate BRCA1-deficient mammary tumors in mice', Clinical Cancer Research, 23, pp. 7020 - 7033, http://dx.doi.org/10.1158/1078-0432.CCR-17-1279
    Journal articles | 2017
    Scarpa A; Chang DK; Nones K; Corbo V; Patch AM; Bailey P; Lawlor RT; Johns AL; Miller DK; Mafficini A; Rusev B; Scardoni M; Antonello D; Barbi S; Sikora KO; Cingarlini S; Vicentini C; McKay S; Quinn MCJ; Bruxner TJC; Christ AN; Harliwong I; Idrisoglu S; McLean S; Nourse C; Nourbakhsh E; Wilson PJ; Anderson MJ; Fink JL; Newell F; Waddell N; Holmes O; Kazakoff SH; Leonard C; Wood S; Xu Q; Nagaraj SH; Amato E; Dalai I; Bersani S; Cataldo I; Dei Tos AP; Capelli P; Davì MV; Landoni L; Malpaga A; Miotto M; Whitehall VLJ; Leggett BA; Harris JL; Harris J; Jones MD; Humphris J; Chantrill LA; Chin V; Nagrial AM; Pajic M; Scarlett CJ; Pinho A; Rooman I; Toon C; Wu J; Pinese M; Cowley M; Barbour A; Mawson A; Humphrey ES; Colvin EK; Chou A; Lovell JA; Jamieson NB; Duthie F; Gingras MC; Fisher WE; Dagg RA; Lau LMS; Lee M; Pickett HA; Reddel RR; Samra JS; Kench JG; Merrett ND; Epari K; Nguyen NQ; Zeps N; Falconi M; Simbolo M; Butturini G; Van Buren G; Partelli S; Fassan M; Khanna KK; Gill AJ; Wheeler DA; Gibbs RA; Musgrove EA; Bassi C; Tortora G; Pederzoli P; Pearson JV, 2017, 'Whole-genome landscape of pancreatic neuroendocrine tumours', Nature, 543, pp. 65 - 71, http://dx.doi.org/10.1038/nature21063
    Journal articles | 2017
    Vennin C; Chin VT; Warren SC; Lucas MC; Herrmann D; Magenau A; Melenec P; Walters SN; Del Monte-Nieto G; Conway JRW; Nobis M; Allam AH; McCloy RA; Currey N; Pinese M; Boulghourjian A; Zaratzian A; Adam AAS; Heu C; Nagrial AM; Chou A; Steinmann A; Drury A; Froio D; Giry-Laterriere M; Harris NLE; Phan T; Jain R; Weninger W; McGhee EJ; Whan R; Johns AL; Samra JS; Chantrill L; Gill AJ; Kohonen-Corish M; Harvey RP; Biankin AV; Evans TRJ; Anderson KI; Grey ST; Ormandy CJ; Gallego-Ortega D; Wang Y; Samuel MS; Sansom OJ; Burgess A; Cox TR; Morton JP; Pajic M; Timpson P, 2017, 'Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis', Science Translational Medicine, 9, http://dx.doi.org/10.1126/scitranslmed.aai8504
    Journal articles | 2017
    Vennin C; Cox TR; Pajic M; Timpson P, 2017, 'Transient targeting of the pancreatic cancer stroma as a 'finetuned' anti-tumor and anti-metastatic therapy', Oncotarget, 8, pp. 84635 - 84636, http://dx.doi.org/10.18632/oncotarget.21468
    Journal articles | 2016
    Bailey P; Chang DK; Nones K; Johns AL; Patch AM; Gingras MC; Miller DK; Christ AN; Bruxner TJC; Quinn MC; Nourse C; Murtaugh LC; Harliwong I; Idrisoglu S; Manning S; Nourbakhsh E; Wani S; Fink L; Holmes O; Chin V; Anderson MJ; Kazakoff S; Leonard C; Newell F; Waddell N; Wood S; Xu Q; Wilson PJ; Cloonan N; Kassahn KS; Taylor D; Quek K; Robertson A; Pantano L; Mincarelli L; Sanchez LN; Evers L; Wu J; Pinese M; Cowley MJ; Jones MD; Colvin EK; Nagrial AM; Humphrey ES; Chantrill LA; Mawson A; Humphris J; Chou A; Pajic M; Scarlett CJ; Pinho AV; Giry-Laterriere M; Rooman I; Samra JS; Kench JG; Lovell JA; Merrett ND; Toon CW; Epari K; Nguyen NQ; Barbour A; Zeps N; Moran-Jones K; Jamieson NB; Graham JS; Duthie F; Oien K; Hair J; Grützmann R; Maitra A; Iacobuzio-Donahue CA; Wolfgang CL; Morgan RA; Lawlor RT; Corbo V; Bassi C; Rusev B; Capelli P; Salvia R; Tortora G; Mukhopadhyay D; Petersen GM; Munzy DM; Fisher WE; Karim SA; Eshleman JR; Hruban RH; Pilarsky C; Morton JP; Sansom OJ; Scarpa A; Musgrove EA; Bailey UMH; Hofmann O; Sutherland RL; Wheeler DA; Gill AJ; Gibbs RA; Pearson JV; Waddell N, 2016, 'Genomic analyses identify molecular subtypes of pancreatic cancer', Nature, 531, pp. 47 - 52, http://dx.doi.org/10.1038/nature16965
    Journal articles | 2016
    Carter DR; Sutton SK; Pajic M; Murray J; Sekyere EO; Fletcher J; Beckers A; De Preter K; Speleman F; George RE; Haber M; Norris MD; Cheung BB; Marshall GM, 2016, 'Glutathione biosynthesis is upregulated at the initiation of MYCN-driven neuroblastoma tumorigenesis', Molecular Oncology, 10, pp. 866 - 878, http://dx.doi.org/10.1016/j.molonc.2016.02.004
    Journal articles | 2016
    Chou A; Steinmann A; Froio D; Drury A; Wohl D; Chin V; Nagrial A; Gill A; Pajic M, 2016, 'Combination of CDK4/6 inhibitor PD-0332991 with standard chemotherapy is synergistic in RB high pancreatic cancer', European Journal of Cancer, 61, pp. S182 - S182, http://dx.doi.org/10.1016/s0959-8049(16)61645-3
    Journal articles | 2016
    Gingras MC; Covington KR; Chang DK; Donehower LA; Gill AJ; Ittmann MM; Creighton CJ; Johns AL; Shinbrot E; Dewal N; Fisher WE; Pilarsky C; Grützmann R; Overman MJ; Jamieson NB; Van Buren G; Drummond J; Walker K; Hampton OA; Xi L; Muzny DM; Doddapaneni H; Lee SL; Bellair M; Hu J; Han Y; Dinh HH; Dahdouli M; Samra JS; Bailey P; Waddell N; Pearson JV; Harliwong I; Wang H; Aust D; Oien KA; Hruban RH; Hodges SE; McElhany A; Saengboonmee C; Duthie FR; Grimmond SM; Biankin AV; Wheeler DA; Gibbs RA; Jones MD; Mawson A; Scarlett CJ; Brancato MAL; Rowe SJ; Simpson SH; Smith Martyn M; Thomas MT; Chantrill LA; Chin VT; Angela C; Cowley MJ; Humphris JL; Mead S; Nagrial AM; Pajic M; Pettit J; Pinese M; Rooman I; Wu J; Tao J; DiPietro R; Watson C; Steinmann A; Lee HC; Wong R; Pinho AV; Giry-Laterriere M; Daly RJ; Musgrove EA; Sutherland RL; Kassahn KS; Miller DK; Wilson PJ; Patch AM; Song S; Idrisoglu S; Nourse C; Nourbakhsh E; Manning S; Wani S; Gongora M; Anderson M; Holmes O; Leonard C; Taylor D; Wood S; Xu C; Nones K; Fink LJ; Christ A; Bruxner T; Cloonan N; Newell F; Quinn M, 2016, 'Ampullary Cancers Harbor ELF3 Tumor Suppressor Gene Mutations and Exhibit Frequent WNT Dysregulation', Cell Reports, 14, pp. 907 - 919, http://dx.doi.org/10.1016/j.celrep.2015.12.005
    Journal articles | 2016
    Humphrey ES; Su SP; Nagrial AM; Hochgrä Fe F; Pajic M; Lehrbach GM; Parton RG; Yap AS; Horvath LG; Chang DK; Biankin AV; Wu J; Daly RJ, 2016, 'Resolution of novel pancreatic ductal adenocarcinoma subtypes by global phosphotyrosine profiling', Molecular and Cellular Proteomics, 15, pp. 2671 - 2685, http://dx.doi.org/10.1074/mcp.M116.058313
    Journal articles | 2016
    O'Connor LO; Rulten SL; Cranston AN; Odedra R; Brown H; Jaspers JE; Jones L; Knights C; Evers B; Ting A; Bradbury RH; Pajic M; Rottenberg S; Jonkers J; Rudge D; Martin NMB; Caldecott KW; Lau A; O'Connor MJ, 2016, 'The PARP inhibitor AZD2461 provides insights into the role of PARP3 inhibition for both synthetic lethality and tolerability with chemotherapy in preclinical models', Cancer Research, 76, pp. 6084 - 6094, http://dx.doi.org/10.1158/0008-5472.CAN-15-3240
    Journal articles | 2015
    Chantrill LA; Nagrial AM; Watson C; Johns AL; Martyn-Smith M; Simpson S; Mead S; Jones MD; Samra JS; Gill AJ; Watson N; Chin VT; Humphris JL; Chou A; Brown B; Morey A; Pajic M; Grimmond SM; Chang DK; Thomas D; Sebastian L; Sjoquist K; Yip S; Pavlakis N; Asghari R; Harvey S; Grimison P; Simes J; Biankin AV, 2015, 'Precision medicine for advanced pancreas cancer: The individualized molecular pancreatic cancer therapy (IMPaCT) Trial', Clinical Cancer Research, 21, pp. 2029 - 2037, http://dx.doi.org/10.1158/1078-0432.CCR-15-0426
    Journal articles | 2015
    Chin VT; Nagrial AM; Chou A; Biankin AV; Gill AJ; Timpson P; Pajic M, 2015, 'Rho-associated kinase signalling and the cancer microenvironment: Novel biological implications and therapeutic opportunities', Expert Reviews in Molecular Medicine, 17, http://dx.doi.org/10.1017/erm.2015.17
    Journal articles | 2015
    Grimont A; Pinho AV; Cowley MJ; Augereau C; Mawson A; Giry-Laterriere M; Van den Steen G; Waddell N; Pajic M; Sempoux C; Wu J; Grimmond SM; Biankin AV; Lemaigre FP; Rooman I; Jacquemin P, 2015, 'SOX9 regulates ERBB signalling in pancreatic cancer development', GUT, 64, pp. 1790 - 1799, http://dx.doi.org/10.1136/gutjnl-2014-307075
    Journal articles | 2015
    Nagrial AM; Chin VT; Sjoquist KM; Pajic M; Horvath LG; Biankin AV; Yip D, 2015, 'Second-line treatment in inoperable pancreatic adenocarcinoma: A systematic review and synthesis of all clinical trials', Critical Reviews in Oncology/Hematology, 96, pp. 483 - 497, http://dx.doi.org/10.1016/j.critrevonc.2015.07.007
    Journal articles | 2015
    Pajic M; Herrmann D; Vennin C; Conway JRW; Chin VT; Johnsson AKE; Welch HCE; Timpson P, 2015, 'The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment', Small GTPases, 6, pp. 123 - 133, http://dx.doi.org/10.4161/21541248.2014.973749
    Journal articles | 2015
    Susanto JM; Colvin EK; Pinese M; Chang DK; Pajic M; Mawson A; Caldon CE; Musgrove EA; Henshall SM; Sutherland RL; Biankin AV; Scarlett CJ, 2015, 'The epigenetic agents suberoylanilide hydroxamic acid and 5-AZA-2′ deoxycytidine decrease cell proliferation, induce cell death and delay the growth of MiaPaCa2 pancreatic cancer cells in vivo', International Journal of Oncology, 46, pp. 2223 - 2230, http://dx.doi.org/10.3892/ijo.2015.2894
    Journal articles | 2015
    Vennin C; Pajic M; Timpson P, 2015, 'Imaging fibrosis in pancreatic cancer using second harmonic generation', Pancreatology, 15, pp. 200 - 201, http://dx.doi.org/10.1016/j.pan.2015.02.004
    Journal articles | 2015
    Waddell N; Pajic M; Patch AM; Chang DK; Kassahn KS; Bailey P; Johns AL; Miller D; Nones K; Quek K; Quinn MCJ; Robertson AJ; Fadlullah MZH; Bruxner TJC; Christ AN; Harliwong I; Idrisoglu S; Manning S; Nourse C; Nourbakhsh E; Wani S; Wilson PJ; Markham E; Cloonan N; Anderson MJ; Fink JL; Holmes O; Kazakoff SH; Leonard C; Newell F; Poudel B; Song S; Taylor D; Waddell N; Wood S; Xu Q; Wu J; Pinese M; Cowley MJ; Lee HC; Jones MD; Nagrial AM; Humphris J; Chantrill LA; Chin V; Steinmann AM; Mawson A; Humphrey ES; Colvin EK; Chou A; Scarlett CJ; Pinho AV; Giry-Laterriere M; Rooman I; Samra JS; Kench JG; Pettitt JA; Merrett ND; Toon C; Epari K; Nguyen NQ; Barbour A; Zeps N; Jamieson NB; Graham JS; Niclou SP; Bjerkvig R; Grützmann R; Aust D; Hruban RH; Maitra A; Iacobuzio-Donahue CA; Wolfgang CL; Morgan RA; Lawlor RT; Corbo V; Bassi C; Falconi M; Zamboni G; Tortora G; Tempero MA; Gill AJ; Eshleman JR; Pilarsky C; Scarpa A; Musgrove EA; Pearson JV; Biankin AV; Grimmond SM, 2015, 'Whole genomes redefine the mutational landscape of pancreatic cancer', Nature, 518, pp. 495 - 501, http://dx.doi.org/10.1038/nature14169
    Journal articles | 2014
    Al-Ejeh F; Pajic M; Shi W; Kalimutho M; Miranda M; Nagrial AM; Chou A; Biankin AV; Grimmond SM; Brown MP; Khanna KK, 2014, 'Gemcitabine and CHK1 inhibition potentiate EGFR-directed radioimmunotherapy against pancreatic ductal adenocarcinoma', Clinical Cancer Research, 20, pp. 3187 - 3197, http://dx.doi.org/10.1158/1078-0432.CCR-14-0048
    Journal articles | 2014
    Chou A; Gill AJ; Kang J; Lee C; Sergio M; APGI ; Musgrove L; Morey AL; Grimmond S; Biankin AV; Pajic M, 2014, '9. Cyclin-Dependent kinase inhibitor as a potential novel therapeutic agent for pancreatic cancer', Pathology, 46, pp. S109 - S109, http://dx.doi.org/10.1097/01.pat.0000443699.20071.3b
    Journal articles | 2014
    Grimont A; Pinho AV; Cowley MJ; Augereau C; Mawson A; Giry-Laterriere M; Van den Steen G; Waddell N; Pajic M; Sempoux C; Wu J; Grimmond SM; Biankin AV; Lemaigre FP; Rooman I; Jacquemin P, 2014, 'SOX9 regulates ERBB signalling in pancreatic cancer development', Gut, 64, pp. 1790 - 1799, http://dx.doi.org/10.1136/gutjnl-2014-307075
    Journal articles | 2014
    Humphris JL; Johns AL; Simpson SH; Cowley MJ; Pajic M; Chang DK; Nagrial AM; Chin VT; Chantrill LA; Pinese M; Mead RS; Gill AJ; Samra JS; Kench JG; Musgrove EA; Tucker KM; Spigelman AD; Waddell N; Grimmond SM; Biankin AV, 2014, 'Clinical and pathologic features of familial pancreatic cancer', Cancer, 120, pp. 3669 - 3675, http://dx.doi.org/10.1002/cncr.28863
    Journal articles | 2014
    Johns AL; Miller DK; Simpson SH; Gill AJ; Kassahn KS; Humphris JL; Samra JS; Tucker K; Andrews L; Chang DK; Waddell N; Pajic M; Pearson JV; Grimmond SM; Biankin AV; Zeps N; Martyn-Smith M; Tang H; Papangelis V; Beilin M, 2014, 'Returning individual research results for genome sequences of pancreatic cancer', Genome Medicine, 6, http://dx.doi.org/10.1186/gm558
    Journal articles | 2014
    Kemp MW; Molloy TJ; Pajic M; Chapman E, 2014, 'An analysis of reported motivational orientation in students undertaking doctoral studies in the biomedical sciences', BMC Medical Education, 14, http://dx.doi.org/10.1186/1472-6920-14-38
    Journal articles | 2014
    Nagrial AM; Chang DK; Nguyen NQ; Johns AL; Chantrill LA; Humphris JL; Chin VT; Samra JS; Gill AJ; Pajic M; Pinese M; Colvin EK; Scarlett CJ; Chou A; Kench JG; Sutherland RL; Horvath LG; Biankin AV, 2014, 'Adjuvant chemotherapy in elderly patients with pancreatic cancer', British Journal of Cancer, 110, pp. 313 - 319, http://dx.doi.org/10.1038/bjc.2013.722
    Journal articles | 2014
    Nones K; Waddell N; Song S; Patch AM; Miller D; Johns A; Wu J; Kassahn KS; Wood D; Bailey P; Fink L; Manning S; Christ AN; Nourse C; Kazakoff S; Taylor D; Leonard C; Chang DK; Jones MD; Thomas M; Watson C; Pinese M; Cowley M; Rooman I; Pajic M; Butturini G; Malpaga A; Corbo V; Crippa S; Falconi M; Zamboni G; Castelli P; Lawlor RT; Gill AJ; Scarpa A; Pearson JV; Biankin AV; Grimmond SM, 2014, 'Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling', International Journal of Cancer, 135, pp. 1110 - 1118, http://dx.doi.org/10.1002/ijc.28765
    Journal articles | 2014
    Sjoquist KM; Chin VT; Chantrill LA; O'Connor C; Hemmings C; Chang DK; Chou A; Pajic M; Johns AL; Nagrial AM; Biankin AV; Yip D, 2014, 'Personalising pancreas cancer treatment: When tissue is the issue', World Journal of Gastroenterology, 20, pp. 7849 - 7863, http://dx.doi.org/10.3748/wjg.v20.i24.7849
    Journal articles | 2013
    Alexandrov LB; Nik-Zainal S; Wedge DC; Aparicio SAJR; Behjati S; Biankin AV; Bignell GR; Bolli N; Borg A; Børresen-Dale A-L; Boyault S; Burkhardt B; Butler AP; Caldas C; Davies HR; Desmedt C; Eils R; Eyfjörd JE; Foekens JA; Greaves M; Hosoda F; Hutter B; Ilicic T; Imbeaud S; Imielinski M; Jäger N; Jones DTW; Knappskog S; Kool M; Lakhani SR; López-Otín C; Martin S; Munshi NC; Nakamura H; Northcott PA; Pajic M; Papaemmanuil E; Paradiso A; Pearson JV; Puente XS; Raine K; Ramakrishna M; Richardson AL; Richter J; Rosenstiel P; Schlesner M; Schumacher TN; Span PN; Teague JW; Totoki Y; Tutt ANJ; Valdés-Mas R; Van Buuren MM; Van 'T Veer L; Vincent-Salomon A; Waddell N; Yates LR; Zucman-Rossi J; Futreal PA; McDermott U; Lichter P; Meyerson M; Grimmond SM; Siebert R; Campo E; Shibata T; Pfister SM; Campbell PJ; Stratton MR, 2013, 'Erratum: Signatures of mutational processes in human cancer', Nature, 502, pp. 258 - 258, http://dx.doi.org/10.1038/nature12666
    Journal articles | 2013
    Alexandrov LB; Nik-Zainal S; Wedge DC; Aparicio SAJR; Behjati S; Biankin AV; Bignell GR; Bolli N; Borg A; Børresen-Dale AL; Boyault S; Burkhardt B; Butler AP; Caldas C; Davies HR; Desmedt C; Eils R; Eyfjörd JE; Foekens JA; Greaves M; Hosoda F; Hutter B; Ilicic T; Imbeaud S; Imielinsk M; Jäger N; Jones DTW; Jonas D; Knappskog S; Koo M; Lakhani SR; López-Otín C; Martin S; Munshi NC; Nakamura H; Northcott PA; Pajic M; Papaemmanuil E; Paradiso A; Pearson JV; Puente XS; Raine K; Ramakrishna M; Richardson AL; Richter J; Rosenstiel P; Schlesner M; Schumacher TN; Span PN; Teague JW; Totoki Y; Tutt ANJ; Valdés-Mas R; Van Buuren MM; Van 'T Veer L; Vincent-Salomon A; Waddell N; Yates LR; Zucman-Rossi J; Andrew Futreal P; McDermott U; Lichter P; Meyerson M; Grimmond SM; Siebert R; Campo E; Shibata T; Pfister SM; Campbell PJ; Stratton MR, 2013, 'Signatures of mutational processes in human cancer', Nature, 500, pp. 415 - 421, http://dx.doi.org/10.1038/nature12477
    Journal articles | 2013
    Chang DK; Jamieson N; Johns A; Scarlett CJ; Pajic M; Biankin AV; et A, 2013, 'Histomolecular phenotypes and outcome in adenocarcinoma of the ampulla of vater', Journal of Clinical Oncology, 31, pp. 1348 - 1356, http://dx.doi.org/10.1200/JCO.2012.46.8868
    Journal articles | 2013
    Chin VT; Nagrial A; Chantrill LA; Chang DK; Chou A; Humprhis J; Cowley M; Wu J; DiPetro R; Watson C; Spielman C; Steinmann A; Pinese M; Pettitt J; Johns A; Waddell N; Grimmond S; Timpson P; Biankin AV; Pajic M, 2013, 'From functional genomics to precision medicine: The therapeutic potential of targeting ROCK signaling in pancreatic cancer.', Journal of Clinical Oncology, 31, pp. e15029 - e15029, http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e15029
    Journal articles | 2013
    Chou A; Waddell N; Cowley MJ; Gill AJ; Chang DK; Patch AM; Nones K; Wu J; Pinese M; Johns AL; Miller DK; Kassahn KS; Nagrial AM; Wasan H; Goldstein D; Toon CW; Chin V; Chantrill L; Humphris J; Mead RS; Rooman I; Samra JS; Pajic M; Musgrove EA; Pearson JV; Morey AL; Grimmond SM; Biankin AV, 2013, 'Clinical and molecular characterization of HER2 amplified-pancreatic cancer', Genome Medicine, 5, http://dx.doi.org/10.1186/gm482
    Journal articles | 2013
    Kassahn KS; Holmes O; Nones K; Patch AM; Miller DK; Christ AN; Harliwong I; Bruxner TJ; Xu Q; Anderson M; Wood S; Leonard C; Taylor D; Newell F; Song S; Idrisoglu S; Nourse C; Nourbakhsh E; Manning S; Wani S; Steptoe A; Pajic M; Cowley MJ; Pinese M; Chang DK; Gill AJ; Johns AL; Wu J; Wilson PJ; Fink L; Biankin AV; Waddell N; Grimmond SM; Pearson JV, 2013, 'Somatic point mutation calling in low cellularity tumors', PLoS ONE, 8, http://dx.doi.org/10.1371/journal.pone.0074380
    Journal articles | 2013
    Kemp MW; Molloy TJ; Pajic M; Chapman E, 2013, 'Peer relationships and the biomedical doctorate: A key component of the contemporary learning environment', Journal of Higher Education Policy and Management, 35, pp. 370 - 385, http://dx.doi.org/10.1080/1360080X.2013.812055
    Journal articles | 2013
    Kemp MW; Pajic M; Molloy TJ; Chapman E, 2013, 'Perceived assessment requirements in the contemporary biomedical doctorate: A case-study from a research intensive australian university', International Journal of Doctoral Studies, 8, pp. 105 - 120, http://dx.doi.org/10.28945/1893
    Journal articles | 2012
    Harliwong I; Gudkov AV; De Ridder J; Burkhart CA; Knosel T; Rummele P; Pajic M; Sartorelli AC; van der Weyden L, 2012, 'Impact of intertumoral heterogeneity on predicting chemotheraphy response of BRCA1-deficient mammary tumors', Cancer Research, 72, pp. 2350 - 2361, http://dx.doi.org/10.1158/0008-5472.CAN-11-4201
    Journal articles | 2012
    Perez-Mancera P; Rust AG; van der Weyden L; Kristiansen GO; Kristiansen GO; Li A; Sarver AL; Silverstein KAT; Grutzmann R; Aust DE; Rummele P; Knosel T; Herd C; Stemple D; Kettleborough R; Brosnan JA; Li A; Richard GM; Knight S; Yu J; Stegeman S; Collier LS; Ten Hoeve JJ; De Ridder J; Klein A; Goggins M; Hruban R; Chang D; Biankin AV; Pinese M; Grimmond S; Wessels L; Wood S; Iacobuzio-donahue CA; Pilarsky CP; Largaespada DA; Adams DJ; Tuveson DA, 2012, 'The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma', Nature, 486, pp. 266 - 270, http://dx.doi.org/10.1038/nature11114
    Journal articles | 2012
    Song S; Nones K; Miller DK; Harliwong I; Pinese M; Kassahn KS; Pajic M; Gill A; Johns A; Anderson ML; Holmes O; Leonard C; Taylor DF; Wood SA; Xu Q; Newell FS; Cowley MJ; Wu J; Wilson PJ; Fink L; Biankin AV; Waddell NJ; Grimmond S; Pearson JV, 2012, 'qpure: A tool to estimate tumor cellularity from genome-wide single-nucleotide polymorphism profiles', PLoS ONE, 7, pp. e45835, http://dx.doi.org/10.1371/journal.pone.0045835
    Journal articles | 2011
    Chang DK; Colvin EK; Scarlett CJ; Pajic M; Pinese M; Gill AJ; Musgrove EA; Sutherland R; Kench J; Biankin AV; New South Wales Pancreatic Cancer Network , 2011, 'A molecular prognostic nomogram for resectable pancreatic cancer.', J Clin Oncol, 29, pp. 154, http://www.ncbi.nlm.nih.gov/pubmed/27985628
    Journal articles | 2011
    Chang DK; Colvin EK; Scarlett CJ; Pajic M; Pinese M; Gill AJ; Musgrove EA; Sutherland R; Kench J; Biankin AV, 2011, 'A molecular prognostic nomogram for resectable pancreatic cancer', JOURNAL OF CLINICAL ONCOLOGY, 29, http://dx.doi.org/10.1200/jco.2011.29.4_suppl.154
    Journal articles | 2011
    Chang DK; Johns A; Scarlett CJ; Pajic M; Chou A; Toon C; Samra JS; Sutherland R; Gill AJ; Biankin AV; New South Wales Pancreatic Cancer Network , 2011, 'Molecular pathologic phenotypes and outcome in adenocarcinoma of the ampulla of Vater.', J Clin Oncol, 29, pp. 196, http://www.ncbi.nlm.nih.gov/pubmed/27985359
    Journal articles | 2011
    Chang DK; Johns A; Scarlett CJ; Pajic M; Chou A; Toon C; Samra JS; Sutherland R; Gill AJ; Biankin AV, 2011, 'Molecular pathologic phenotypes and outcome in adenocarcinoma of the ampulla of Vater', JOURNAL OF CLINICAL ONCOLOGY, 29, http://dx.doi.org/10.1200/jco.2011.29.4_suppl.196
    Journal articles | 2010
    Borst P; Rottenberg S; Jonkers J; Zander S; Pajic M; Jaspers J, 2010, 'The contribution of ABC transporters to drug resistance in a realistic mouse mammary tumor model', Cancer Genetics and Cytogenetics, 203, pp. 64 - 64, http://dx.doi.org/10.1016/j.cancergencyto.2010.07.044
    Journal articles | 2010
    Chang D; Johns A; Scarlett C; Pajic M; Chou A; Jones M; Samra J; Henshall S; Musgrove E; Sutherland R; Gill A; Biankin A, 2010, 'Histology and Molecular Pathology Define Clinically Relevant Phenotypes in Carcinoma of the Ampulla of Vater', PANCREAS, 39, pp. 1313 - 1314, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000282946600067&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2010
    Pajic M; Kersbergen A; Van Diepen F; Pfauth A; Jonkers J; Borst P; Rottenberg S, 2010, 'Tumor-initiating cells are not enriched in cisplatin-surviving BRCA1;p53-deficient mammary tumor cells in vivo', Cell Cycle, 9, pp. 3804 - 3815, http://dx.doi.org/10.4161/cc.9.18.13002
    Journal articles | 2010
    Rottenberg S; Pajic M; Jonkers J, 2010, 'Studying drug resistance using genetically engineered mouse models for breast cancer.', Methods in molecular biology (Clifton, N.J.), 596, pp. 33 - 45, http://dx.doi.org/10.1007/978-1-60761-416-6_3
    Journal articles | 2010
    Scarlett CJ; Chang DK; Stoddart ES; Colvin EK; Mawson A; Jones MD; Tobelmann PE; Pajic M; Daly RJ; Biankin AV, 2010, 'High S100A2 Calcium-Binding Protein Expression Defines a Metastatic Phenotype in Pancreatic Cancer', PANCREAS, 39, pp. 1345 - 1346, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000282946600205&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2010
    Zander SAL; Kersbergen A; Van Der Burg E; De Water N; Van Tellingen O; Gunnarsdottir S; Jaspers JE; Pajic M; Nygren AOH; Jonkers J; Borst P; Rottenberg S, 2010, 'Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan', Cancer Research, 70, pp. 1700 - 1710, http://dx.doi.org/10.1158/0008-5472.CAN-09-3367
    Journal articles | 2009
    Pajic M; Iyer JK; Kersbergen A; Van Der Burg E; Nygren AOH; Jonkers J; Borst P; Rottenberg S, 2009, 'Moderate increase in Mdr1a/1b expression causes in vivo resistance to doxorubicin in a mouse model for hereditary breast cancer', Cancer Research, 69, pp. 6396 - 6404, http://dx.doi.org/10.1158/0008-5472.CAN-09-0041
    Journal articles | 2007
    Chung S; Wei A; Connor DE; Webb GC; Molloy TJ; Pajic M; Diwan AD, 2007, 'Nucleus pulposus cellular longevity by telomerase gene therapy', Spine, 32, pp. 1188 - 1196, http://dx.doi.org/10.1097/BRS.0b013e31805471a3
    Journal articles | 2007
    Rottenberg S; Nygren AOH; Pajic M; Van Leeuwen FWB; Van Der Heijden I; Van Wetering KD; Liu X; De Visser KE; Gilhuijs KG; Van Tellingen O; Schouten JP; Jonkers J; Borst P, 2007, 'Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer', Proceedings of the National Academy of Sciences of the United States of America, 104, pp. 12117 - 12122, http://dx.doi.org/10.1073/pnas.0702955104
    Journal articles | 2005
    Pajic M; Norris MD; Cohn RJ; Haber M, 2005, 'The role of the multidrug resistance-associated protein 1 gene in neuroblastoma biology and clinical outcome', Cancer Letters, 228, pp. 241 - 246, http://dx.doi.org/10.1016/j.canlet.2005.01.060
    Journal articles | 2004
    Pajic M; Bebawy M; Hoskins JM; Roufogalis BD; Rivory LP, 2004, 'Effect of short-term morphine exposure on P-glycoprotein expression and activity in cancer cell lines', Oncology Reports, 11, pp. 1091 - 1095, http://dx.doi.org/10.3892/or.11.5.1091
    Journal articles | 1987
    Ivanovic V; Filipovic V; Pajic M; Santini A, 1987, 'Tertiary dentine formation in dogs' teeth in response to lining materials.', J Dent, 15, pp. 85 - 87, http://dx.doi.org/10.1016/0300-5712(87)90006-6
  • Working Papers | 2020
    Thejer B; Adhikary P; Kaur A; Teakel S; Oosterum AV; Seth I; Pajic M; Hannan K; Pavy M; Poh P; Jazayeri J; Zaw T; Pascovici D; Ludescher M; Pawlak M; Cassano J; Turnbull L; Jazayeri M; James A; Coorey C; Roberts T; Kinder S; Hannan R; Patrick E; Molloy M; J E; Fehm T; Neubauer H; Goldys E; Weston L; CAHILL M, 2020, PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth, http://dx.doi.org10.21203/rs.2.22342/v3
    Working Papers | 2019
    Thejer B; Adhikary P; Kaur A; Teakel S; Van Oosterum A; Seth I; Pajic M; Hannan K; Pavy M; Poh P; Jazayeri J; Zaw T; Pascovici D; Ludescher M; Pawlak M; Cassano J; Turnbull L; Jazayeri M; James A; Coorey C; Roberts T; Kinder S; Hannan R; Patrick E; Molloy M; New E; Fehm T; Neubauer H; Goldys E; Weston L; Cahill M, 2019, PGRMC1 phosphorylation and cell plasticity 1: glycolysis, mitochondria, tumor growth, Cold Spring Harbor Laboratory, http://dx.doi.org10.1101/737718
  • Preprints | 2023
    Colino-Sanguino Y; Fuente LRDL; Gloss B; Law A; Handler K; Pajic M; Salomon R; Gallego-Ortega D; Valdes-Mora F, 2023, Systematic comparison of high throughput Single-Cell RNA-Seq platforms in complex tissues, , http://dx.doi.org/10.1101/2023.04.04.535585
    Preprints | 2022
    Kokkinos J; Sharbeen G; Ignacio RMC; Pandzic E; Youkhana J; Boyer C; Haghighi KS; Gunawarman M; Goldstein D; Gebski V; Pajic M; Pitiyarachchi O; Davis ME; Schulstad G; Arkell OSM; Kopecky C; Gonzales-Aloy E; Erkan M; Morton JP; Kavallaris M; Gunning PW; Hardeman EC; Johns A; Gill AJ; Whan RM; Mawson A; McCarroll JA; Phillips PA, 2022, βIII-Tubulin is a Brake on Extrinsic Cell-Death in Pancreatic Cancer, , http://dx.doi.org/10.1101/2022.09.29.510034
    Preprints | 2020
    Kryza T; Khan T; Lovell S; Harrington BS; Yin J; Porazinski S; Pajic M; Koistinen H; Rantala J; Dreyer T; Magdolen V; Reuning U; He Y; Tate E; Hooper JD, 2020, Substrate-biased activity-based probes identify the urokinase-plasminogen axis as a master regulator of metastatic signaling by orphan membrane receptor CDCP1, , http://dx.doi.org/10.21203/rs.3.rs-92391/v1
    Preprints | 2020
    Thejer BM; Adhikary PP; Kaur A; Teakel SL; Oosterum AV; Seth I; Pajic M; Hannan KM; Pavy M; Poh P; Jazayeri JA; Zaw T; Pascovici D; Ludescher M; Pawlak M; Cassano JC; Turnbull L; Jazayeri M; James AC; Coorey CP; Roberts TL; Kinder SJ; Hannan RD; Patrick E; Molloy MP; J. E; Fehm TN; Neubauer H; Goldys EM; Weston LA; CAHILL M, 2020, PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth, , http://dx.doi.org/10.21203/rs.2.22342/v1
    Preprints | 2020
    Thejer BM; Adhikary PP; Kaur A; Teakel SL; Oosterum AV; Seth I; Pajic M; Hannan KM; Pavy M; Poh P; Jazayeri JA; Zaw T; Pascovici D; Ludescher M; Pawlak M; Cassano JC; Turnbull L; Jazayeri M; James AC; Coorey CP; Roberts TL; Kinder SJ; Hannan RD; Patrick E; Molloy MP; J. E; Fehm TN; Neubauer H; Goldys EM; Weston LA; CAHILL M, 2020, PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth, , http://dx.doi.org/10.21203/rs.2.22342/v2
    Preprints | 2019
    Dreyer SB; Upstill-Goddard R; Paulus-Hock V; Paris C; Lampraki E-M; Dray E; Serrels B; Caligiuri G; Rebus S; Brunton H; Cunningham R; Nourse C; Bailey U-M; Jones M; Moran-Jones K; Wright DW; Duthie F; Oien K; Evers L; McKay CJ; McGregor GA; Gulati A; Brough R; Bajrami I; Pettitt S; Dziubinski ML; Candido J; Balkwill F; Barry ST; Grützmann R; Rahib L; Johns A; Pajic M; Froeling FEM; Beer P; Musgrove EA; Petersen GM; Ashworth A; Frame MC; Crawford HC; Simeone DM; Lord C; Mukhopadhyay D; Pilarsky C; Cooke SL; Jamieson NB; Morton JP; Sansom OJ; Bailey PJ; Biankin AV; Chang DK, 2019, Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer, , http://dx.doi.org/10.1101/713545
    Preprints | 2018
    Wang K; Huynh N; Wang X; Pajic M; Parkin A; Man J; Baldwin G; He H; Nikfarjam M, 2018, The PAK Inhibitor PF-3758309 Promotes the Inhibitory Effects of Multiple Chemotherapeutic Reagents on Patient-Derived Pancreatic Cancer Cell Lines, , http://dx.doi.org/10.20944/preprints201809.0322.v1
    Conference Abstracts | 2017
    Chin VT; Nagrial A; Conway J; Vennin C; Chantrill LA; Chou A; Steinmann A; Gill AJ; Humprhis J; Drury A; Froio D; Morgan A; Biankin A; Timpson P; Pajic M, 2017, 'Effect of Rho/ROCK pathway inhibition on metastasis-free and overall survival in biomarker selected, orthotopic, patient-derived models of pancreatic cancer.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, IL, Chicago, Vol. 35, presented at 53rd Annual Clinical Science Meeting of the American-Society-of-Clinical-Oncology (ASCO) / Symposium on Old Targets, New Drugs - Her2 and MET, IL, Chicago, 02 June 2017 - 07 June 2017, http://dx.doi.org/10.1200/JCO.2017.35.15_suppl.e15759
    Conference Papers | 2016
    Chou A; Steinmann A; Froio D; Drury A; Wohl D; Chin V; Nagrial A; Gill A; Pajic M, 2016, 'Combination of CDK4/6 inhibitor PD-0332991 with standard chemotherapy is synergistic in RB high pancreatic cancer', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, pp. S182 - S182, http://dx.doi.org/10.1016/S0959-8049(16)61645-3
    Conference Abstracts | 2015
    Chin VT; Conway J; Nagrial A; Chantrill LA; Chou A; Steinmann A; Gill A; Pinese M; Wu J; Johns A; Dury A; Biankin A; Timpson P; Pajic M, 2015, 'Targeting the Rho-ROCK pathway to treat pancreatic cancer: The use of unique preclinical models to ascertain the effects on cancer growth and metastasis', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, CA, San Francisco, Vol. 33, presented at Gastrointestinal Cancers Symposium, CA, San Francisco, 15 January 2015 - 17 January 2015, http://dx.doi.org/10.1200/jco.2015.33.3_suppl.312
    Conference Papers | 2014
    Chin V; Nagrial A; Chantrill L; Sjoquist K; O'Connor C; Pajic M; Biankin A; Yip D, 2014, 'PHARMACOLOGIC INTERVENTIONS FOR ADVANCED PANCREATIC CANCER (PC) - A META-ANALYSIS COMPARING GEMCITABINE ALONE (G) VERSUS GEMCITABINE COMBINATIONS (GCs)', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, pp. 48 - 48, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000339716500014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2014
    Chin VT; Nagrial A; Chantrill LA; Sjoquist KM; O'Connor C; Pajic M; Blankin AV; Yip D, 2014, 'Targeted therapies in the treatment of advanced pancreatic adenocarcinoma (PC): A systematic review and meta-analysis of randomized trials', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, IL, Chicago, presented at 50th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 30 May 2014 - 03 June 2014, http://dx.doi.org/10.1200/jco.2014.32.15_suppl.e15209
    Conference Presentations | 2014
    Chou A; Chin VT; Nagrial AM; Gill AJ; Timpson P; Chang DK; Waddell N; Wu J; Grimmond SM; Biankin AV; Pajic M, 2014, 'From functional genomics to precision medicine: Using well annotated models to define personalised treatment strategies for pancreatic cancer', Vol. 34, pp. S8 - S8, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000341276000017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2014
    Nagrial A; Chin V; Steinmann A; Chou A; Grimmond S; Horvath L; Pajic M; Biankin A, 2014, 'GENOMIC CLASSIFIER FOR PANCREATIC DUCTAL ADENOCARCINOMA THERAPEUTIC RESPONSE', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, pp. 44 - 44, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000339716500009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Presentations | 2014
    Pinho AV; Grimont A; Cowley MJ; Augereau C; Mawson A; Giry-Laterriere M; Van den Steen G; Waddell N; Pajic M; Sempoux C; Wu J; Grimmond SM; Biankin AV; Lemaigre FP; Jacquemin P; Rooman I, 2014, 'SOX9 regulates EGFR/ERBB signaling in pancreatic cancer', Vol. 74, presented at 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR), CA, San Diego, 05 April 2014 - 09 April 2014, http://dx.doi.org/10.1158/1538-7445.AM2014-LB-73
    Conference Papers | 2013
    Chang DK; Pinese M; Scarlett CJ; Pajic M; Colvin EK; Johns AL; Wu J; Cowley MJ; Humphris JL; Chou A; Nguyen NQ; Nagrial AM; Chantrill L; Chin VT; Musgrove EA; Altekruse S; Gill AJ; Kench JG; Biankin AV, 2013, 'A molecular pre-operative prognostic nomogram for resectable pancreatic cancer', in Cancer Research, American Association for Cancer Research, Washington, DC, presented at 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Washington, DC, 06 April 2013 - 10 April 2013, http://dx.doi.org/10.1158/1538-7445.AM2013-1156
    Conference Posters | 2013
    Chin V; Nagrial A; Chang D; Chantrill L; Cowley M; Wu J; Spielman C; Steinmann A; Pinese M; Pettitt J; Johns A; Gill A; Timpson P; Biankin A; Pajic M, 2013, 'From function genomics to precision medicine: the therapeutic potential of targeting rock signalling in pancreatic cancer', Chicago, IL, Vol. 9, pp. 53 - 53, presented at ASCO Annual Meeting, Chicago, IL, 31 May 2013 - 04 June 2013, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000329462300024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2013
    Chin VT; Nagrial A; Chantrill LA; Chang DK; Chou A; Humprhis J; Cowley M; Wu J; DiPetro R; Watson C; Spielman C; Steinmann A; Pinese M; Pettitt J; Johns A; Waddell N; Grimmond S; Timpson P; Biankin AV; Pajic M, 2013, 'From functional genomics to precision medicine: The therapeutic potential of targeting ROCK signaling in pancreatic cancer.', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, IL, Chicago, Vol. 31, presented at 49th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 31 May 2013 - 04 June 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335419603693&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2013
    Pajic M; Graham PH; Millar EKA; O'Toole SA; Molloy TJ, 2013, 'MicroRNA-regulated pathways of radiotherapy sensitivity and resistance in breast cancer', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, NETHERLANDS, Amsterdam, pp. S232 - S232, presented at European Cancer Congress 2013 - 17th ECCO / 38th ESMO / 32nd ESTRO, NETHERLANDS, Amsterdam, 27 September 2013 - 01 October 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000326843601304&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2012
    Chang DK; Chou A; Nguyen NQ; Nagrial AM; Chantrill LA; Chin VT; Musgrove EA; Sutherland RL; Gill AJ; Altekruse S; Kench JG; Scarlett CJ; Biankin AV; Pinese M; Pajic M; Colvin EK; Johns AL; Humphris JL; Wu J; Cowley MJ, 2012, 'Abstract B64: A molecular preoperative prognostic nomogram for resectable pancreatic cancer.', in Tumor Biology, American Association for Cancer Research, presented at Abstracts: AACR Special Conference on Pancreatic Cancer: Progress and Challenges; June 18-21, 2012; Lake Tahoe, NV, http://dx.doi.org/10.1158/1538-7445.panca2012-b64
    Conference Abstracts | 2012
    Humphris J; Johns A; Simpson S; Chang D; Cowley MJ; Pajic M; Jones M; Simpson S; Mead S; Biankin A, 2012, 'Risk factors for pancreatic cancer in patients with and without a family history of pancreatic cancer', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY-BLACKWELL, Vol. 27, pp. 127 - 127, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000308642600262&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Presentations | 2012
    Humphris J; Tao J; Chang D; Johns A; Cowley MJ; Pajic M; Jones M; Simpson S; Mead S; Biankin A, 2012, 'Somatic mutations in pancreatic ductal adenocarcinoma using amplicon sequencing from formalin fixed paraffin embedded tissue', Vol. 27, pp. 20 - 20, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000308642600042&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2012
    Molloy T; Pajic M; Holzhauser S; Graham P; Millar EKA; Sutherland RL, 2012, 'Identifying Putative MiRNAs Mediators of Radiotherapy Resistance in Breast Cancer', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, SPAIN, Barcelona, pp. S270 - S270, presented at 22nd Biennial Congress of the European-Association-for-Cancer-Research, SPAIN, Barcelona, 07 July 2012 - 10 July 2012, http://dx.doi.org/10.1016/S0959-8049(12)71723-9
    Conference Abstracts | 2012
    Pajic M; Chang DK; Kassahn KS; Wu J; Cowley M; Waddell N; Johns A; Grimmond SM; Biankin AV, 2012, 'Proffered Paper: Testing Individualised Treatment Strategies in Preclinical Models of Pancreatic Cancer', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, SPAIN, Barcelona, Vol. 48, pp. S22 - S22, presented at 22nd Biennial Congress of the European-Association-for-Cancer-Research, SPAIN, Barcelona, 07 July 2012 - 10 July 2012, http://dx.doi.org/10.1016/S0959-8049(12)70795-5
    Conference Papers | 2010
    Borst P; Rottenberg S; Jonkers J; Zander S; Pajic M; Jaspers J, 2010, 'Abstract PL6-1: Resistance to targeted therapies in a realistic mouse breast cancer model', in Clinical Cancer Research, American Association for Cancer Research (AACR), presented at Abstracts: AACR International Conference on Translational Cancer Medicine--; Mar 21–24, 2010; Amsterdam, The Netherlands, http://dx.doi.org/10.1158/1078-0432.tcme10-pl6-1
    Conference Papers | 2010
    Rottenberg S; Pajic M; Kersbergen A; Banishki N; Xu G; Jonkers J; Borst P, 2010, 'Abstract A14: Lack of tumor eradication of chemotherapy-sensitive BRCA1;p53-deficient mouse mammary tumors', in Clinical Cancer Research, American Association for Cancer Research (AACR), pp. A14 - A14, presented at Abstracts: AACR International Conference on Translational Cancer Medicine--; Mar 21-24, 2010; Amsterdam, The Netherlands, http://dx.doi.org/10.1158/1078-0432.tcme10-a14
    Conference Papers | 2006
    Burkhart CA; Watt F; Pajic M; Murray J; Xue C; Flemming C; Smith J; Marshall GM; Haber M; Norris MD; Gudkov AV, 2006, 'Selective Sensitization of murine tumors to chemotherapy by a novel class of non-toxic small molecule inhibitors of MRP1', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000454606201252&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2006
    Murray J; Burkhart CA; Watt F; Pajic M; Flemming C; Smith J; Gudkov AV; Haber M; Norris MD, 2006, 'Sensitisation of neuroblastorna tumours to chemotherapy by use of a novel class of MRP1 small molecule inhibitor', in EJC SUPPLEMENTS, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 4, pp. 54 - 54, http://dx.doi.org/10.1016/S1359-6349(06)70175-6
    Preprints |
    Brunton H; Caligiuri G; Cunningham R; Upstill-Goddard R; Bailey U-M; Garner IM; Nourse C; Dreyer S; Jones M; Moran-Jones K; Wright DW; Paulus-Hock V; Nixon C; Thomson G; Jamieson N; McGregor GA; Evers L; McKay CJ; Gulati A; Brough R; Bajrami I; Pettit S; Dziubinski ML; Barry ST; Grützmann R; Brown R; Curry E; Laboratory GPO; Initiative APCG; Pajic M; Musgrove EA; Petersen G; Shanks E; Ashworth A; Crawford HC; Simeone DM; Froeling FEM; Lord CJ; Mukhopadhyay D; Pilarsky C; Grimmond SE; Morton JP; Sansom OJ; Chang DK; Bailey P; Biankin AV, <i>HNF4A</i> and <i>GATA6</i> Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer, , http://dx.doi.org/10.2139/ssrn.3430714