Dr Max Nobis

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m.nobis@garvan.org.au

Journal articles | 2023

Hastings JF; Latham SL; Kamili A; Wheatley MS; Han JZR; Wong-Erasmus M; Phimmachanh M; Nobis M; Pantarelli C; Cadell AL; O’Donnell YEI; Leong KH; Lynn S; Geng FS; Cui L; Yan S; Achinger-Kawecka J; Stirzaker C; Norris MD; Haber M; Trahair TN; Speleman F; De Preter K; Cowley MJ; Bogdanovic O; Timpson P; Cox TR; Kolch W; Fletcher JI; Fey D; Croucher DR, 2023, 'Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma', Science Advances, 9, http://dx.doi.org/10.1126/sciadv.abp8314

Journal articles | 2023

2023, 'Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse.', Sci Adv, 9, pp. eadf9063, http://dx.doi.org/10.1126/sciadv.adf9063

Journal articles | 2022

Papanicolaou M; Parker AL; Yam M; Filipe EC; Wu SZ; Chitty JL; Wyllie K; Tran E; Mok E; Nadalini A; Skhinas JN; Lucas MC; Herrmann D; Nobis M; Pereira BA; Law AMK; Castillo L; Murphy KJ; Zaratzian A; Hastings JF; Croucher DR; Lim E; Oliver BG; Mora FV; Parker BL; Gallego-Ortega D; Swarbrick A; O’Toole S; Timpson P; Cox TR, 2022, 'Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis', Nature Communications, 13, http://dx.doi.org/10.1038/s41467-022-32255-7

Journal articles | 2022

2022, 'Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence', Gastroenterology, 162, pp. 320 - 324.e4, http://dx.doi.org/10.1053/j.gastro.2021.09.022

Journal articles | 2021

Lakis V; Lawlor RT; Newell F; Patch AM; Mafficini A; Sadanandam A; Koufariotis LT; Johnston RL; Leonard C; Wood S; Rusev B; Corbo V; Luchini C; Cingarlini S; Landoni L; Salvia R; Milella M; Chang D; Bailey P; Jamieson NB; Duthie F; Gingras MC; Muzny DM; Wheeler DA; Gibbs RA; Milione M; Chantrill LA; Timpson P; Chou A; Pajic M; Murphy A; Dwarte T; Hermann D; Vennin C; Cox TR; Pereira B; Ritchie S; Reed DA; Chambers CR; Metcalf X; Nobis M; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Xu Q; Hofmann O; Samra JS; Pavlakis N; Arena J; High HA; Asghari R; Merrett ND; Pavey D; Das A; Cosman PH; Ismail K; O’Connnor C; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forest C; Ballal M; Fletcher DR; Zeps N; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Dixon J; Scardoni M; Bassi C; Grimaldi S; Cantù C; Bonizzato G; Bersani S; Biankin A; Johns A; Herrmann D, 2021, 'DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association', Communications Biology, 4, pp. 155, http://dx.doi.org/10.1038/s42003-020-01469-0

Journal articles | 2021

Murphy KJ; Reed DA; Vennin C; Conway JRW; Nobis M; Yin JX; Chambers CR; Pereira BA; Lee V; Filipe EC; Trpceski M; Ritchie S; Lucas MC; Warren SC; Skhinas JN; Magenau A; Metcalf XL; Stoehr J; Major G; Parkin A; Bidanel R; Lyons RJ; Zaratzian A; Tayao M; Da Silva A; Abdulkhalek L; Gill AJ; Johns AL; Biankin AV; Samra J; Grimmond SM; Chou A; Goetz JG; Samuel MS; Lyons JG; Burgess A; Caldon CE; Horvath LG; Daly RJ; Gadegaard N; Wang Y; Sansom OJ; Morton JP; Cox TR; Pajic M; Herrmann D; Timpson P, 2021, 'Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status', Science Advances, 7, http://dx.doi.org/10.1126/sciadv.abh0363

Journal articles | 2021

Rajal AG; Marzec KA; McCloy RA; Nobis M; Chin V; Hastings JF; Lai K; Kennerson M; Hughes WE; Vaghjiani V; Timpson P; Cain JE; Watkins DN; Croucher DR; Burgess A, 2021, 'A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma', eLife, 10, http://dx.doi.org/10.7554/eLife.65234

Journal articles | 2021

Yan C; Zeng T; Lee K; Nobis M; Loh K; Gou L; Xia Z; Gao Z; Bensellam M; Hughes W; Lau J; Zhang L; Ip CK; Enriquez R; Gao H; Wang QP; Wu Q; Haigh JJ; Laybutt DR; Timpson P; Herzog H; Shi YC, 2021, 'Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-22925-3

Journal articles | 2021

2021, 'Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging', Cell Reports, 36, http://dx.doi.org/10.1016/j.celrep.2021.109689

Journal articles | 2021

2021, 'ROR1 and ROR2 expression in pancreatic cancer', BMC Cancer, 21, pp. 1199, http://dx.doi.org/10.1186/s12885-021-08952-9

Journal articles | 2020

Boyle ST; Kular J; Nobis M; Ruszkiewicz A; Timpson P; Samuel MS, 2020, 'Acute compressive stress activates RHO/ROCK-mediated cellular processes', Small GTPases, 11, pp. 354 - 370, http://dx.doi.org/10.1080/21541248.2017.1413496

Journal articles | 2020

Cipponi A; Goode DL; Bedo J; McCabe MJ; Pajic M; Croucher DR; Rajal AG; Junankar SR; Saunders DN; Lobachevsky P; Papenfuss AT; Nessem D; Nobis M; Warren SC; Timpson P; Cowley M; Vargas AC; Qiu MR; Generali DG; Keerthikumar S; Nguyen U; Corcoran NM; Long GV; Blay J-Y; Thomas DM; McCabe M, 2020, 'MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer', Science

Journal articles | 2020

Lamm N; Read MN; Nobis M; Van Ly D; Page SG; Masamsetti VP; Timpson P; Biro M; Cesare AJ, 2020, 'Nuclear F-actin counteracts nuclear deformation and promotes fork repair during replication stress', Nature Cell Biology, 22, pp. 1460 - 1470, http://dx.doi.org/10.1038/s41556-020-00605-6

Journal articles | 2020

Nobis M; Herrmann D; Warren SC; Strathdee D; Cox TR; Anderson KI; Timpson P, 2020, 'Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse', Small GTPases, 11, pp. 240 - 247, http://dx.doi.org/10.1080/21541248.2018.1438024

Journal articles | 2020

Srijakotre N; Liu HJ; Nobis M; Man J; Yip HYK; Papa A; Abud HE; Anderson KI; Welch HCE; Tiganis T; Timpson P; McLean CA; Ooms LM; Mitchell CA, 2020, 'PtdIns(3,4,5)P3-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis', Proceedings of the National Academy of Sciences of the United States of America, 117, pp. 28056 - 28067, http://dx.doi.org/10.1073/pnas.2006445117

Journal articles | 2020

2020, 'A Non-Genetic, Cell Cycle Dependent Mechanism of Platinum Resistance in Lung Adenocarcinoma', , http://dx.doi.org/10.1101/2020.11.26.400499

Journal articles | 2019

Kennedy SP; Han JZR; Portman N; Nobis M; Hastings JF; Murphy KJ; Latham SL; Cadell AL; Miladinovic D; Marriott GR; O'Donnell YEI; Shearer RF; Williams JT; Munoz AG; Cox TR; Watkins DN; Saunders DN; Timpson P; Lim E; Kolch W; Croucher DR, 2019, 'Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer', Breast Cancer Research, 21, http://dx.doi.org/10.1186/s13058-019-1127-y

Journal articles | 2019

Koudelkova L; Pataki AC; Tolde O; Pavlik V; Nobis M; Gemperle J; Anderson K; Brabek J; Rosel D, 2019, 'Novel FRET-Based Src Biosensor Reveals Mechanisms of Src Activation and Its Dynamics in Focal Adhesions', CELL CHEMICAL BIOLOGY, 26, pp. 255 - +, http://dx.doi.org/10.1016/j.chembiol.2018.10.024

Journal articles | 2019

Vennin C; Mélénec P; Rouet R; Nobis M; Cazet AS; Murphy KJ; Herrmann D; Reed DA; Lucas MC; Warren SC; Elgundi Z; Pinese M; Kalna G; Roden D; Samuel M; Zaratzian A; Grey ST; Da Silva A; Leung W; Johns AL; Chantrill LA; Chou A; Steinmann A; Arshi M; Dwarte T; Froio D; Pereira B; Ritchie S; Chambers CR; Metcalf X; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Grimmond SM; Hofmann O; Christ A; Bruxner T; Samra JS; Pavlakis N; High HA; Asghari R; Merrett ND; Pavey D; Das A; Cosman PH; Ismail K; O’Connnor C; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Cooper CL; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forest C; Epari KP; Ballal M; Fletcher DR; Mukhedkar S; Zeps N; Beilin M; Feeney K; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Lawlor RT; Beghelli S; Corbo V; Scardoni M; Bassi C; Christ D; Cox T; Timpson P; Phillips P; Whitelock J; Pajic M; Gill A; Croucher D, 2019, 'CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan', Nature Communications, 10, pp. 3637, http://dx.doi.org/10.1038/s41467-019-10968-6

Journal articles | 2019

2019, 'Galene: correcting physiological motion blurring at the subcellular level in intravital FLIM data', eLife, 7, http://dx.doi.org/10.7554/eLife.35800

Journal articles | 2019

2019, 'Moving molecular mobility to in vivo disease settings', Gastroenterology

Journal articles | 2018

Conway JRW; Warren SC; Herrmann D; Murphy KJ; Cazet AS; Vennin C; Shearer RF; Killen MJ; Magenau A; Mélénec P; Pinese M; Nobis M; Zaratzian A; Boulghourjian A; Da Silva AM; del Monte-Nieto G; Adam ASA; Harvey RP; Haigh JJ; Wang Y; Croucher DR; Sansom OJ; Pajic M; Caldon CE; Morton JP; Timpson P; del Monte Nieto G; Gallego-Ortega D, 2018, 'Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer', Cell Reports, 23, pp. 3312 - 3326, http://dx.doi.org/10.1016/j.celrep.2018.05.038

Journal articles | 2018

Nobis M; Warren SC; Lucas MC; Murphy KJ; Herrmann D; Timpson P, 2018, 'Molecular mobility and activity in an intravital imaging setting - Implications for cancer progression and targeting', Journal of Cell Science, 131, http://dx.doi.org/10.1242/jcs.206995

Journal articles | 2018

Warren SC; Nobis M; Magenau A; Mohammed YH; Herrmann D; Moran I; Vennin C; Conway JRW; Mélénec P; Cox TR; Wang Y; Morton JP; Welch HCE; Strathdee D; Anderson KI; Phan TG; Roberts MS; Timpson P, 2018, 'Removing physiological motion from Intravital and clinical functional imaging data', eLife, 7, http://dx.doi.org/10.7554/eLife.35800

Journal articles | 2017

Cammareri P; Vincent DF; Hodder MC; Ridgway RA; Murgia C; Nobis M; Campbell AD; Varga J; Huels DJ; Subramani C; Prescott KL; Nixon C; Hedley A; Barry ST; Greten FR; Inman GJ; Sansom OJ, 2017, 'TGF beta pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis', CELL DEATH AND DIFFERENTIATION, 24, pp. 1681 - 1693, http://dx.doi.org/10.1038/cdd.2017.92

Journal articles | 2017

Herrmann D; Erami Z; Warren S; Nobis M; Magenau A; Lucas M; Vennin C; McGhee EJ; Leung W; Reischmann N; Mrowinska A; Schwarz JP; Kadir S; Karim SA; Campbell AD; Gallego-Ortega D; Evans J; Sansom OJ; Morton JP; Anderson KI; Timpson P, 2017, 'A biosensor mouse to predict the dissociation and spread of pancreatic cancer', CANCER RESEARCH, 77, http://dx.doi.org/10.1158/1538-7445.EPSO16-PR07

Journal articles | 2017

Nobis M; Herrmann D; Warren SC; Kadir S; Leung W; Killen M; Magenau A; Stevenson D; Lucas MC; Reischmann N; Vennin C; Conway JRW; Boulghourjian A; Zaratzian A; Law AM; Gallego-Ortega D; Ormandy CJ; Walters SN; Grey ST; Bailey J; Chtanova T; Quinn JMW; Baldock PA; Croucher PI; Schwarz JP; Mrowinska A; Zhang L; Herzog H; Masedunskas A; Hardeman EC; Gunning PW; del Monte-Nieto G; Harvey RP; Samuel MS; Pajic M; McGhee EJ; Johnsson AKE; Sansom OJ; Welch HCE; Morton JP; Strathdee D; Anderson KI; Timpson P; del Monte Nieto G, 2017, 'A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts', Cell Reports, 21, pp. 274 - 288, http://dx.doi.org/10.1016/j.celrep.2017.09.022

Journal articles | 2017

Vennin C; Chin VT; Warren SC; Lucas MC; Herrmann D; Magenau A; Melenec P; Walters SN; Del Monte-Nieto G; Conway JRW; Nobis M; Allam AH; McCloy RA; Currey N; Pinese M; Boulghourjian A; Zaratzian A; Adam AAS; Heu C; Nagrial AM; Chou A; Steinmann A; Drury A; Froio D; Giry-Laterriere M; Harris NLE; Phan T; Jain R; Weninger W; McGhee EJ; Whan R; Johns AL; Samra JS; Chantrill L; Gill AJ; Kohonen-Corish M; Harvey RP; Biankin AV; Evans TRJ; Anderson KI; Grey ST; Ormandy CJ; Gallego-Ortega D; Wang Y; Samuel MS; Sansom OJ; Burgess A; Cox TR; Morton JP; Pajic M; Timpson P, 2017, 'Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis', Science Translational Medicine, 9, http://dx.doi.org/10.1126/scitranslmed.aai8504

Journal articles | 2017

Wildenberg ME; Koelink PJ; Diederen K; te Velde AA; Wolfkamp SCS; Nuij VJ; Peppelenbosch MP; Nobis M; Sansom OJ; Anderson KI; van der Woude CJ; D'Haens GRAM; van den Brink GR, 2017, 'The ATG16L1 risk allele associated with Crohn's disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines', MUCOSAL IMMUNOLOGY, 10, pp. 352 - 360, http://dx.doi.org/10.1038/mi.2016.65

Journal articles | 2016

Erami Z; Herrmann D; Warren SC; Nobis M; McGhee EJ; Lucas MC; Leung W; Reischmann N; Mrowinska A; Schwarz JP; Kadir S; Conway JRW; Vennin C; Karim SA; Campbell AD; Gallego-Ortega D; Magenau A; Murphy KJ; Ridgway RA; Law AM; Walters SN; Grey ST; Croucher DR; Zhang L; Herzog H; Hardeman EC; Gunning PW; Ormandy CJ; Evans TRJ; Strathdee D; Sansom OJ; Morton JP; Anderson KI; Timpson P; Zhang L, 2016, 'Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue', Cell Reports, 14, pp. 152 - 167, http://dx.doi.org/10.1016/j.celrep.2015.12.020

Journal articles | 2016

Kalafatovic D; Nobis M; Son J; Anderson KI; Ulijn RV, 2016, 'MMP-9 triggered self-assembly of doxorubicin nanofiber depots halts tumor growth', BIOMATERIALS, 98, pp. 192 - 202, http://dx.doi.org/10.1016/j.biomaterials.2016.04.039

Journal articles | 2016

2016, 'Imaging Molecular Dynamics for Drug Discovery', Physiology News, pp. 27 - 29, http://dx.doi.org/10.36866/pn.104.27

Journal articles | 2016

2016, 'Visualizing Cancer Cell Chemotaxis and Invasion in 2D and 3D', CHEMOTAXIS: METHODS AND PROTOCOLS, 1407, pp. 217 - 228, http://dx.doi.org/10.1007/978-1-4939-3480-5_17

Journal articles | 2015

Kalafatovic D; Nobis M; Javid N; Frederix PWJM; Anderson KI; Saunders BR; Ulijn RV, 2015, 'MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin', BIOMATERIALS SCIENCE, 3, pp. 246 - 249, http://dx.doi.org/10.1039/c4bm00297k

Journal articles | 2015

von Karstedt S; Conti A; Nobis M; Montinaro A; Hartwig T; Lemke J; Legler K; Annewanter F; Campbell AD; Taraborrelli L; Grosse-Wilde A; Coy JF; El-Bahrawy MA; Bergmann F; Koschny R; Werner J; Ganten TM; Schweiger T; Hoetzenecker K; Kenessey I; Hegedues B; Bergmann M; Hauser C; Egberts J-H; Becker T; Roecken C; Kalthoff H; Trauzold A; Anderson KI; Sansom OJ; Walczak H, 2015, 'Cancer Cell-Autonomous TRAIL-R Signaling Promotes KRAS-Driven Cancer Progression, Invasion, and Metastasis', CANCER CELL, 27, pp. 561 - 573, http://dx.doi.org/10.1016/j.ccell.2015.02.014

Journal articles | 2014

Johnsson AKE; Dai Y; Nobis M; Baker MJ; McGhee EJ; Walker S; Schwarz JP; Kadir S; Morton JP; Myant KB; Huels DJ; Segonds-Pichon A; Sansom OJ; Anderson KI; Timpson P; Welch HCE, 2014, 'The Rac-FRET Mouse Reveals Tight Spatiotemporal Control of Rac Activity in Primary Cells and Tissues', Cell Reports, 6, pp. 1153 - 1164, http://dx.doi.org/10.1016/j.celrep.2014.02.024

Journal articles | 2014

Lo Re D; Zhou Y; Nobis M; Anderson KI; Murphy PV, 2014, 'Synthesis of Migrastatin and its Macroketone Analogue and In Vivo FRAP Analysis of the Macroketone on E-Cadherin Dynamics', CHEMBIOCHEM, 15, pp. 1459 - 1464, http://dx.doi.org/10.1002/cbic.201402061

Journal articles | 2014

Nobis M; McGhee EJ; Herrmann D; Magenau A; Morton JP; Anderson KI; Timpson P, 2014, 'Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging', Cell Adhesion and Migration, 8, pp. 478 - 486, http://dx.doi.org/10.4161/19336918.2014.970004

Journal articles | 2013

Nobis M; Carragher NO; McGhee EJ; Morton JP; Sansom OJ; Anderson KI; Timpson P, 2013, 'Advanced intravital subcellular imaging reveals vital three-dimensional signalling events driving cancer cell behaviour and drug responses in live tissue', FEBS Journal, 280, pp. 5177 - 5197, http://dx.doi.org/10.1111/febs.12348

Journal articles | 2013

Nobis M; McGhee EJ; Morton JP; Schwarz JP; Karim SA; Quinn J; Edward M; Campbell AD; McGarry LC; Evans TRJ; Brunton VG; Frame MC; Carragher NO; Wang Y; Sansom OJ; Timpson P; Anderson KI, 2013, 'Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of Src in pancreatic cancer', Cancer Research, 73, pp. 4674 - 4686, http://dx.doi.org/10.1158/0008-5472.CAN-12-4545

Journal articles | 2013

Trinidad AG; Muller PAJ; Cuellar J; Klejnot M; Nobis M; Maria Valpuesta J; Vousden KH, 2013, 'Interaction of p53 with the CCT Complex Promotes Protein Folding and Wild-Type p53 Activity', MOLECULAR CELL, 50, pp. 805 - 817, http://dx.doi.org/10.1016/j.molcel.2013.05.002

Journal articles | 2011

Timpson P; McGhee EJ; Erami Z; Nobis M; Quinn JA; Edward M; Anderson KI, 2011, 'Organotypic collagen I assay: a malleable platform to assess cell behaviour in a 3-dimensional context.', Journal of visualized experiments : JoVE, pp. 1 - 4, http://dx.doi.org/10.3791/3089

Journal articles | 2011

2011, 'Organotypic Collagen I Assay: A Malleable Platform to Assess Cell Behaviour in a 3-Dimensional Context', Journal of Visualized Experiments, http://dx.doi.org/10.3791/3089-v
Preprints | 2022

2022, Compression-dependent microtubule reinforcement comprises a mechanostat which enables cells to navigate confined environments, , http://dx.doi.org/10.1101/2022.02.08.479516

Conference Papers | 2018

2018, 'Unmixing spectrally overlapping FRET biosensors in vivo using multispectral FLIM (Conference Presentation)', in Periasamy A; So PT; Xie XS; König K (eds.), Multiphoton Microscopy in the Biomedical Sciences XVIII, SPIE, pp. 23, presented at Multiphoton Microscopy in the Biomedical Sciences XVIII, 27 January 2018 - 01 February 2018, http://dx.doi.org/10.1117/12.2290152

Preprints |

Novel FRET-Based Src Biosensor Reveals Mechanisms of Src Activation and Its Dynamics in Focal Adhesions, , http://dx.doi.org/10.2139/ssrn.3206266

Preprints |

Therapeutic Blockade of ER Stress and Inflammation Prevents High Fat Diet-Induced NASH and Progression to Hepatocellular Carcinoma, , http://dx.doi.org/10.2139/ssrn.4001943

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Dr Max Nobis