Dr Max Nobis

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E-mail

m.nobis@garvan.org.au

Journal articles | 2023

2023, 'Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma', Science Advances, 9, pp. eabp8314, http://dx.doi.org/10.1126/sciadv.abp8314

Journal articles | 2023

2023, 'Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse.', Sci Adv, 9, pp. eadf9063, http://dx.doi.org/10.1126/sciadv.adf9063

Journal articles | 2022

2022, 'Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence', Gastroenterology, 162, pp. 320 - 324.e4, http://dx.doi.org/10.1053/j.gastro.2021.09.022

Journal articles | 2022

2022, 'Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis', Nature Communications, 13, pp. 4587, http://dx.doi.org/10.1038/s41467-022-32255-7

Journal articles | 2021

2021, 'A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma', eLife, 10, http://dx.doi.org/10.7554/eLife.65234

Journal articles | 2021

2021, 'DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association', Communications Biology, 4, http://dx.doi.org/10.1038/s42003-020-01469-0

Journal articles | 2021

2021, 'Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status', Science Advances, 7, http://dx.doi.org/10.1126/sciadv.abh0363

Journal articles | 2021

2021, 'Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging', Cell Reports, 36, http://dx.doi.org/10.1016/j.celrep.2021.109689

Journal articles | 2021

2021, 'Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity', Nature Communications, 12, pp. 2622, http://dx.doi.org/10.1038/s41467-021-22925-3

Journal articles | 2021

2021, 'ROR1 and ROR2 expression in pancreatic cancer', BMC Cancer, 21, pp. 1199, http://dx.doi.org/10.1186/s12885-021-08952-9

Journal articles | 2020

Boyle ST; Kular J; Nobis M; Ruszkiewicz A; Timpson P; Samuel MS, 2020, 'Acute compressive stress activates RHO/ROCK-mediated cellular processes', Small GTPases, 11, pp. 354 - 370, http://dx.doi.org/10.1080/21541248.2017.1413496

Journal articles | 2020

Nobis M; Herrmann D; Warren SC; Strathdee D; Cox TR; Anderson KI; Timpson P, 2020, 'Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse', Small GTPases, 11, pp. 240 - 247, http://dx.doi.org/10.1080/21541248.2018.1438024

Journal articles | 2020

2020, 'A Non-Genetic, Cell Cycle Dependent Mechanism of Platinum Resistance in Lung Adenocarcinoma', , http://dx.doi.org/10.1101/2020.11.26.400499

Journal articles | 2020

2020, 'MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer', Science

Journal articles | 2020

2020, 'Nuclear F-actin counteracts nuclear deformation and promotes fork repair during replication stress', Nature Cell Biology, 22, pp. 1460 - 1470, http://dx.doi.org/10.1038/s41556-020-00605-6

Journal articles | 2020

2020, 'PtdIns(3,4,5)P3-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis', Proceedings of the National Academy of Sciences of the United States of America, 117, pp. 28056 - 28067, http://dx.doi.org/10.1073/pnas.2006445117

Journal articles | 2019

2019, 'CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan', Nature Communications, 10, pp. 3637, http://dx.doi.org/10.1038/s41467-019-10968-6

Journal articles | 2019

2019, 'Galene: correcting physiological motion blurring at the subcellular level in intravital FLIM data', eLife, 7, http://dx.doi.org/10.7554/eLife.35800

Journal articles | 2019

2019, 'Moving molecular mobility to in vivo disease settings', Gastroenterology

Journal articles | 2019

2019, 'Novel FRET-Based Src Biosensor Reveals Mechanisms of Src Activation and Its Dynamics in Focal Adhesions', CELL CHEMICAL BIOLOGY, 26, pp. 255 - +, http://dx.doi.org/10.1016/j.chembiol.2018.10.024

Journal articles | 2019

2019, 'Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer', Breast Cancer Research, 21, pp. 43, http://dx.doi.org/10.1186/s13058-019-1127-y

Journal articles | 2018

Conway JR W; Warren SC; Herrmann D; Murphy KJ; Cazet AS; Vennin C; Shearer RF; Killen MJ; Magenau A; MÃ©lÃ©nec P; Pinese M; Nobis M; Zaratzian A; Boulghourjian A; Da Silva AM; del Monte-Nieto G; Adam AS A; Harvey RP; Haigh JJ; Wang Y; Croucher DR; Sansom OJ; Pajic M; Caldon CE; Morton JP; Timpson P, 2018, 'Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer', Cell Reports, 23, pp. 3312 - 3326, http://dx.doi.org/10.1016/j.celrep.2018.05.038

Journal articles | 2018

Nobis M; Warren SC; Lucas MC; Murphy KJ; Herrmann D; Timpson P, 2018, 'Molecular mobility and activity in an intravital imaging setting - Implications for cancer progression and targeting', Journal of Cell Science, 131, http://dx.doi.org/10.1242/jcs.206995

Journal articles | 2018

Warren SC; Nobis M; Magenau A; Mohammed YH; Herrmann D; Moran I; Vennin C; Conway JR W; MÃ©lÃ©nec P; Cox TR; Wang Y; Morton JP; Welch HC E; Strathdee D; Anderson KI; Phan TG; Roberts MS; Timpson P, 2018, 'Removing physiological motion from Intravital and clinical functional imaging data', eLife, 7, http://dx.doi.org/10.7554/eLife.35800

Journal articles | 2017

Herrmann D; Erami Z; Warren S; Nobis M; Magenau A; Lucas M; Vennin C; McGhee EJ; Leung W; Reischmann N; Mrowinska A; Schwarz JP; Kadir S; Karim SA; Campbell AD; Gallego-Ortega D; Evans J; Sansom OJ; Morton JP; Anderson KI; Timpson P, 2017, 'A biosensor mouse to predict the dissociation and spread of pancreatic cancer', CANCER RESEARCH, 77, http://dx.doi.org/10.1158/1538-7445.EPSO16-PR07

Journal articles | 2017

Nobis M; Herrmann D; Warren SC; Kadir S; Leung W; Killen M; Magenau A; Stevenson D; Lucas MC; Reischmann N; Vennin C; Conway JR W; Boulghourjian A; Zaratzian A; Law AM; Gallego-Ortega D; Ormandy CJ; Walters SN; Grey ST; Bailey J; Chtanova T; Quinn JM W; Baldock PA; Croucher PI; Schwarz JP; Mrowinska A; Zhang L; Herzog H; Masedunskas A; Hardeman EC; Gunning PW; del Monte-Nieto G; Harvey RP; Samuel MS; Pajic M; McGhee EJ; Johnsson AK E; Sansom OJ; Welch HC E; Morton JP; Strathdee D; Anderson KI; Timpson P, 2017, 'A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts', Cell Reports, 21, pp. 274 - 288, http://dx.doi.org/10.1016/j.celrep.2017.09.022

Journal articles | 2017

Vennin C; Chin VT; Warren SC; Lucas MC; Herrmann D; Magenau A; Melenec P; Walters SN; Del Monte-Nieto G; Conway JR W; Nobis M; Allam AH; McCloy RA; Currey N; Pinese M; Boulghourjian A; Zaratzian A; Adam AA S; Heu C; Nagrial AM; Chou A; Steinmann A; Drury A; Froio D; Giry-Laterriere M; Harris NL E; Phan T; Jain R; Weninger W; McGhee EJ; Whan R; Johns AL; Samra JS; Chantrill L; Gill AJ; Kohonen-Corish M; Harvey RP; Biankin AV; Evans TR J; Anderson KI; Grey ST; Ormandy CJ; Gallego-Ortega D; Wang Y; Samuel MS; Sansom OJ; Burgess A; Cox TR; Morton JP; Pajic M; Timpson P, 2017, 'Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis', Science Translational Medicine, 9, http://dx.doi.org/10.1126/scitranslmed.aai8504

Journal articles | 2017

2017, 'TGF beta pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis', CELL DEATH AND DIFFERENTIATION, 24, pp. 1681 - 1693, http://dx.doi.org/10.1038/cdd.2017.92

Journal articles | 2017

2017, 'The ATG16L1 risk allele associated with Crohn's disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines', MUCOSAL IMMUNOLOGY, 10, pp. 352 - 360, http://dx.doi.org/10.1038/mi.2016.65

Journal articles | 2016

2016, 'Imaging Molecular Dynamics for Drug Discovery', Physiology News, pp. 27 - 29, http://dx.doi.org/10.36866/pn.104.27

Journal articles | 2016

2016, 'Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue', Cell Reports, 14, pp. 152 - 167, http://dx.doi.org/10.1016/j.celrep.2015.12.020

Journal articles | 2016

2016, 'MMP-9 triggered self-assembly of doxorubicin nanofiber depots halts tumor growth', BIOMATERIALS, 98, pp. 192 - 202, http://dx.doi.org/10.1016/j.biomaterials.2016.04.039

Journal articles | 2016

2016, 'Visualizing Cancer Cell Chemotaxis and Invasion in 2D and 3D', CHEMOTAXIS: METHODS AND PROTOCOLS, 1407, pp. 217 - 228, http://dx.doi.org/10.1007/978-1-4939-3480-5_17

Journal articles | 2015

2015, 'Cancer Cell-Autonomous TRAIL-R Signaling Promotes KRAS-Driven Cancer Progression, Invasion, and Metastasis', CANCER CELL, 27, pp. 561 - 573, http://dx.doi.org/10.1016/j.ccell.2015.02.014

Journal articles | 2015

2015, 'MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin', BIOMATERIALS SCIENCE, 3, pp. 246 - 249, http://dx.doi.org/10.1039/c4bm00297k

Journal articles | 2014

Johnsson AK E; Dai Y; Nobis M; Baker MJ; McGhee EJ; Walker S; Schwarz JP; Kadir S; Morton JP; Myant KB; Huels DJ; Segonds-Pichon A; Sansom OJ; Anderson KI; Timpson P; Welch HC E, 2014, 'The Rac-FRET Mouse Reveals Tight Spatiotemporal Control of Rac Activity in Primary Cells and Tissues', Cell Reports, 6, pp. 1153 - 1164, http://dx.doi.org/10.1016/j.celrep.2014.02.024

Journal articles | 2014

Nobis M; McGhee EJ; Herrmann D; Magenau A; Morton JP; Anderson KI; Timpson P, 2014, 'Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging', Cell Adhesion and Migration, 8, pp. 478 - 486, http://dx.doi.org/10.4161/19336918.2014.970004

Journal articles | 2014

2014, 'Synthesis of Migrastatin and its Macroketone Analogue and In Vivo FRAP Analysis of the Macroketone on E-Cadherin Dynamics', CHEMBIOCHEM, 15, pp. 1459 - 1464, http://dx.doi.org/10.1002/cbic.201402061

Journal articles | 2013

Nobis M; Carragher NO; McGhee EJ; Morton JP; Sansom OJ; Anderson KI; Timpson P, 2013, 'Advanced intravital subcellular imaging reveals vital three-dimensional signalling events driving cancer cell behaviour and drug responses in live tissue', FEBS Journal, 280, pp. 5177 - 5197, http://dx.doi.org/10.1111/febs.12348

Journal articles | 2013

Nobis M; McGhee EJ; Morton JP; Schwarz JP; Karim SA; Quinn J; Edward M; Campbell AD; McGarry LC; Evans TR J; Brunton VG; Frame MC; Carragher NO; Wang Y; Sansom OJ; Timpson P; Anderson KI, 2013, 'Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of Src in pancreatic cancer', Cancer Research, 73, pp. 4674 - 4686, http://dx.doi.org/10.1158/0008-5472.CAN-12-4545

Journal articles | 2013

2013, 'Interaction of p53 with the CCT Complex Promotes Protein Folding and Wild-Type p53 Activity', MOLECULAR CELL, 50, pp. 805 - 817, http://dx.doi.org/10.1016/j.molcel.2013.05.002

Journal articles | 2011

Timpson P; McGhee EJ; Erami Z; Nobis M; Quinn JA; Edward M; Anderson KI, 2011, 'Organotypic collagen I assay: a malleable platform to assess cell behaviour in a 3-dimensional context.', Journal of visualized experiments : JoVE, pp. 1 - 4, http://dx.doi.org/10.3791/3089

Journal articles | 2011

2011, 'Organotypic Collagen I Assay: A Malleable Platform to Assess Cell Behaviour in a 3-Dimensional Context', Journal of Visualized Experiments, http://dx.doi.org/10.3791/3089-v
Preprints | 2022

2022, Compression-dependent microtubule reinforcement comprises a mechanostat which enables cells to navigate confined environments, , http://dx.doi.org/10.1101/2022.02.08.479516

Conference Papers | 2018

2018, 'Unmixing spectrally overlapping FRET biosensors in vivo using multispectral FLIM (Conference Presentation)', in Periasamy A; So PT; Xie XS; König K (eds.), Multiphoton Microscopy in the Biomedical Sciences XVIII, SPIE, pp. 23, presented at Multiphoton Microscopy in the Biomedical Sciences XVIII, 27 January 2018 - 01 February 2018, http://dx.doi.org/10.1117/12.2290152

Preprints |

Novel FRET-Based Src Biosensor Reveals Mechanisms of Src Activation and Its Dynamics in Focal Adhesions, , http://dx.doi.org/10.2139/ssrn.3206266

Preprints |

Therapeutic Blockade of ER Stress and Inflammation Prevents High Fat Diet-Induced NASH and Progression to Hepatocellular Carcinoma, , http://dx.doi.org/10.2139/ssrn.4001943

My Research Supervision

Honours projects