Dr Max Nobis

Lakis V; Lawlor RT; Newell F; Patch AM; Mafficini A; Sadanandam A; Koufariotis LT; Johnston RL; Leonard C; Wood S; Rusev B; Corbo V; Luchini C; Cingarlini S; Landoni L; Salvia R; Milella M; Chang D; Bailey P; Jamieson NB; Duthie F; Gingras MC; Muzny DM; Wheeler DA; Gibbs RA; Milione M; Chantrill LA; Timpson P; Chou A; Pajic M; Murphy A; Dwarte T; Hermann D; Vennin C; Cox TR; Pereira B; Ritchie S; Reed DA; Chambers CR; Metcalf X; Nobis M; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Xu Q; Hofmann O; Samra JS; Pavlakis N; Arena J; High HA; Asghari R; Merrett ND; Pavey D; Das A; Cosman PH; Ismail K; O’Connnor C; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forest C; Ballal M; Fletcher DR; Zeps N; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Dixon J; Scardoni M; Bassi C; Grimaldi S; Cantù C; Bonizzato G; Bersani S, 2021, 'DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association', Communications Biology, vol. 4, http://dx.doi.org/10.1038/s42003-020-01469-0

Rajal AG; Marzec KA; McCloy RA; Nobis M; Chin V; Hastings JF; Lai K; Kennerson M; Hughes WE; Vaghjiani V; Timpson P; Cain JE; Watkins DN; Croucher DR; Burgess A, 2021, 'A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma', eLife, vol. 10, http://dx.doi.org/10.7554/eLife.65234

Yan C; Zeng T; Lee K; Nobis M; Loh K; Gou L; Xia Z; Gao Z; Bensellam M; Hughes W; Lau J; Zhang L; Ip CK; Enriquez R; Gao H; Wang QP; Wu Q; Haigh JJ; Laybutt DR; Timpson P; Herzog H; Shi YC, 2021, 'Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity', Nature Communications, vol. 12, pp. 2622, http://dx.doi.org/10.1038/s41467-021-22925-3

Boyle ST; Kular J; Nobis M; Ruszkiewicz A; Timpson P; Samuel MS, 2020, 'Acute compressive stress activates RHO/ROCK-mediated cellular processes', Small GTPases, vol. 11, pp. 354 - 370, http://dx.doi.org/10.1080/21541248.2017.1413496

Nobis M; Herrmann D; Warren SC; Strathdee D; Cox TR; Anderson KI; Timpson P, 2020, 'Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse', Small GTPases, vol. 11, pp. 240 - 247, http://dx.doi.org/10.1080/21541248.2018.1438024

Lamm N; Read MN; Nobis M; Van Ly D; Page SG; Masamsetti VP; Timpson P; Biro M; Cesare AJ, 2020, 'Nuclear F-actin counteracts nuclear deformation and promotes fork repair during replication stress', Nature Cell Biology, vol. 22, pp. 1460 - 1470, http://dx.doi.org/10.1038/s41556-020-00605-6

Cipponi A; Goode DL; Bedo J; McCabe MJ; Pajic M; Croucher DR; Rajal AG; Junankar SR; Saunders DN; Lobachevsky P; Papenfuss AT; Nessem D; Nobis M; Warren SC; Timpson P; Cowley M; Vargas AC; Qiu MR; Generali DG; Keerthikumar S; Nguyen U; Corcoran NM; Long GV; Blay J-Y; Thomas DM; McCabe M, 2020, 'MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer', Science

Srijakotre N; Liu HJ; Nobis M; Man J; Yip HYK; Papa A; Abud HE; Anderson KI; Welch HCE; Tiganis T; Timpson P; McLean CA; Ooms LM; Mitchell CA, 2020, 'PtdIns(3,4,5)P3-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, pp. 28056 - 28067, http://dx.doi.org/10.1073/pnas.2006445117

Vennin C; Mélénec P; Rouet R; Nobis M; Cazet AS; Murphy KJ; Herrmann D; Reed DA; Lucas MC; Warren SC; Elgundi Z; Pinese M; Kalna G; Roden D; Samuel M; Zaratzian A; Grey ST; Da Silva A; Leung W; Johns AL; Chantrill LA; Chou A; Steinmann A; Arshi M; Dwarte T; Froio D; Pereira B; Ritchie S; Chambers CR; Metcalf X; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Grimmond SM; Hofmann O; Christ A; Bruxner T; Samra JS; Pavlakis N; High HA; Asghari R; Merrett ND; Pavey D; Das A; Cosman PH; Ismail K; O’Connnor C; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Cooper CL; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forest C; Epari KP; Ballal M; Fletcher DR; Mukhedkar S; Zeps N; Beilin M; Feeney K; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Lawlor RT; Beghelli S; Corbo V; Scardoni M; Bassi C, 2019, 'CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan', Nature Communications, vol. 10, pp. 3637, http://dx.doi.org/10.1038/s41467-019-10968-6

Kennedy SP; Han JZR; Portman N; Nobis M; Hastings JF; Murphy KJ; Latham SL; Cadell AL; Miladinovic D; Marriott GR; O'Donnell YEI; Shearer RF; Williams JT; Munoz AG; Cox TR; Watkins DN; Saunders DN; Timpson P; Lim E; Kolch W; Croucher DR, 2019, 'Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer', Breast Cancer Research, vol. 21, pp. 43, http://dx.doi.org/10.1186/s13058-019-1127-y

Koudelkova L; Pataki AC; Tolde O; Pavlik V; Nobis M; Gemperle J; Anderson K; Brabek J; Rosel D, 2019, 'Novel FRET-Based Src Biosensor Reveals Mechanisms of Src Activation and Its Dynamics in Focal Adhesions', CELL CHEMICAL BIOLOGY, vol. 26, pp. 255 - +, http://dx.doi.org/10.1016/j.chembiol.2018.10.024

Warren S; Magenau A; Nobis M; Mohammed Y; Melenec P; Phan T; Roberts M; Timpson P, 2019, 'Galene: correcting physiological motion blurring at the subcellular level in intravital FLIM data', eLife, vol. 7, http://dx.doi.org/10.7554/eLife.35800

Nobis M; Lucas M; Warren S; Murphy K; Herrmann D; Timpson P, 2019, 'Moving molecular mobility to in vivo disease settings', Gastroenterology

Nobis M; Warren SC; Lucas MC; Murphy KJ; Herrmann D; Timpson P, 2018, 'Molecular mobility and activity in an intravital imaging setting - Implications for cancer progression and targeting', Journal of Cell Science, vol. 131, http://dx.doi.org/10.1242/jcs.206995

Warren SC; Nobis M; Magenau A; Mohammed YH; Herrmann D; Moran I; Vennin C; Conway JRW; Mélénec P; Cox TR; Wang Y; Morton JP; Welch HCE; Strathdee D; Anderson KI; Phan TG; Roberts MS; Timpson P, 2018, 'Removing physiological motion from Intravital and clinical functional imaging data', eLife, vol. 7, http://dx.doi.org/10.7554/eLife.35800

Conway JRW; Warren SC; Herrmann D; Murphy KJ; Cazet AS; Vennin C; Shearer RF; Killen MJ; Magenau A; Mélénec P; Pinese M; Nobis M; Zaratzian A; Boulghourjian A; Da Silva AM; del Monte-Nieto G; Adam ASA; Harvey RP; Haigh JJ; Wang Y; Croucher DR; Sansom OJ; Pajic M; Caldon CE; Morton JP; Timpson P, 2018, 'Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer', Cell Reports, vol. 23, pp. 3312 - 3326, http://dx.doi.org/10.1016/j.celrep.2018.05.038

Nobis M; Herrmann D; Warren SC; Kadir S; Leung W; Killen M; Magenau A; Stevenson D; Lucas MC; Reischmann N; Vennin C; Conway JRW; Boulghourjian A; Zaratzian A; Law AM; Gallego-Ortega D; Ormandy CJ; Walters SN; Grey ST; Bailey J; Chtanova T; Quinn JMW; Baldock PA; Croucher PI; Schwarz JP; Mrowinska A; Zhang L; Herzog H; Masedunskas A; Hardeman EC; Gunning PW; del Monte-Nieto G; Harvey RP; Samuel MS; Pajic M; McGhee EJ; Johnsson AKE; Sansom OJ; Welch HCE; Morton JP; Strathdee D; Anderson KI; Timpson P, 2017, 'A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts', Cell Reports, vol. 21, pp. 274 - 288, http://dx.doi.org/10.1016/j.celrep.2017.09.022

Vennin C; Chin VT; Warren SC; Lucas MC; Herrmann D; Magenau A; Melenec P; Walters SN; Del Monte-Nieto G; Conway JRW; Nobis M; Allam AH; McCloy RA; Currey N; Pinese M; Boulghourjian A; Zaratzian A; Adam AAS; Heu C; Nagrial AM; Chou A; Steinmann A; Drury A; Froio D; Giry-Laterriere M; Harris NLE; Phan T; Jain R; Weninger W; McGhee EJ; Whan R; Johns AL; Samra JS; Chantrill L; Gill AJ; Kohonen-Corish M; Harvey RP; Biankin AV; Evans TRJ; Anderson KI; Grey ST; Ormandy CJ; Gallego-Ortega D; Wang Y; Samuel MS; Sansom OJ; Burgess A; Cox TR; Morton JP; Pajic M; Timpson P, 2017, 'Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis', Science Translational Medicine, vol. 9, http://dx.doi.org/10.1126/scitranslmed.aai8504

Cammareri P; Vincent DF; Hodder MC; Ridgway RA; Murgia C; Nobis M; Campbell AD; Varga J; Huels DJ; Subramani C; Prescott KL; Nixon C; Hedley A; Barry ST; Greten FR; Inman GJ; Sansom OJ, 2017, 'TGF beta pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis', CELL DEATH AND DIFFERENTIATION, vol. 24, pp. 1681 - 1693, http://dx.doi.org/10.1038/cdd.2017.92

Wildenberg ME; Koelink PJ; Diederen K; te Velde AA; Wolfkamp SCS; Nuij VJ; Peppelenbosch MP; Nobis M; Sansom OJ; Anderson KI; van der Woude CJ; D'Haens GRAM; van den Brink GR, 2017, 'The ATG16L1 risk allele associated with Crohn's disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines', MUCOSAL IMMUNOLOGY, vol. 10, pp. 352 - 360, http://dx.doi.org/10.1038/mi.2016.65

Herrmann D; Erami Z; Warren S; Nobis M; Magenau A; Lucas M; Vennin C; McGhee EJ; Leung W; Reischmann N; Mrowinska A; Schwarz JP; Kadir S; Karim SA; Campbell AD; Gallego-Ortega D; Evans J; Sansom OJ; Morton JP; Anderson KI; Timpson P, 2017, 'A biosensor mouse to predict the dissociation and spread of pancreatic cancer', CANCER RESEARCH, vol. 77, http://dx.doi.org/10.1158/1538-7445.EPSO16-PR07

Erami Z; Herrmann D; Warren SC; Nobis M; McGhee EJ; Lucas MC; Leung W; Reischmann N; Mrowinska A; Schwarz JP; Kadir S; Conway JRW; Vennin C; Karim SA; Campbell AD; Gallego-Ortega D; Magenau A; Murphy KJ; Ridgway RA; Law AM; Walters SN; Grey ST; Croucher DR; Zhang L; Herzog H; Hardeman EC; Gunning PW; Ormandy CJ; Evans TRJ; Strathdee D; Sansom OJ; Morton JP; Anderson KI; Timpson P, 2016, 'Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue', Cell Reports, vol. 14, pp. 152 - 167, http://dx.doi.org/10.1016/j.celrep.2015.12.020

Susanto O; Muinonen-Martin AJ; Nobis M; Insall RH, 2016, 'Visualizing Cancer Cell Chemotaxis and Invasion in 2D and 3D', CHEMOTAXIS: METHODS AND PROTOCOLS, vol. 1407, pp. 217 - 228, http://dx.doi.org/10.1007/978-1-4939-3480-5_17

Kalafatovic D; Nobis M; Son J; Anderson KI; Ulijn RV, 2016, 'MMP-9 triggered self-assembly of doxorubicin nanofiber depots halts tumor growth', BIOMATERIALS, vol. 98, pp. 192 - 202, http://dx.doi.org/10.1016/j.biomaterials.2016.04.039

Nobis M; Herrmann D; Timpson P; Erami Z; Anderson K, 2016, 'Imaging Molecular Dynamics for Drug Discovery', Physiology News, pp. 27 - 29, http://dx.doi.org/10.36866/pn.104.27

von Karstedt S; Conti A; Nobis M; Montinaro A; Hartwig T; Lemke J; Legler K; Annewanter F; Campbell AD; Taraborrelli L; Grosse-Wilde A; Coy JF; El-Bahrawy MA; Bergmann F; Koschny R; Werner J; Ganten TM; Schweiger T; Hoetzenecker K; Kenessey I; Hegedues B; Bergmann M; Hauser C; Egberts J-H; Becker T; Roecken C; Kalthoff H; Trauzold A; Anderson KI; Sansom OJ; Walczak H, 2015, 'Cancer Cell-Autonomous TRAIL-R Signaling Promotes KRAS-Driven Cancer Progression, Invasion, and Metastasis', CANCER CELL, vol. 27, pp. 561 - 573, http://dx.doi.org/10.1016/j.ccell.2015.02.014

Kalafatovic D; Nobis M; Javid N; Frederix PWJM; Anderson KI; Saunders BR; Ulijn RV, 2015, 'MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin', BIOMATERIALS SCIENCE, vol. 3, pp. 246 - 249, http://dx.doi.org/10.1039/c4bm00297k

Johnsson AKE; Dai Y; Nobis M; Baker MJ; McGhee EJ; Walker S; Schwarz JP; Kadir S; Morton JP; Myant KB; Huels DJ; Segonds-Pichon A; Sansom OJ; Anderson KI; Timpson P; Welch HCE, 2014, 'The Rac-FRET Mouse Reveals Tight Spatiotemporal Control of Rac Activity in Primary Cells and Tissues', Cell Reports, vol. 6, pp. 1153 - 1164, http://dx.doi.org/10.1016/j.celrep.2014.02.024

Nobis M; McGhee EJ; Herrmann D; Magenau A; Morton JP; Anderson KI; Timpson P, 2014, 'Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging', Cell Adhesion and Migration, vol. 8, pp. 478 - 486, http://dx.doi.org/10.4161/19336918.2014.970004

Lo Re D; Zhou Y; Nobis M; Anderson KI; Murphy PV, 2014, 'Synthesis of Migrastatin and its Macroketone Analogue and In Vivo FRAP Analysis of the Macroketone on E-Cadherin Dynamics', CHEMBIOCHEM, vol. 15, pp. 1459 - 1464, http://dx.doi.org/10.1002/cbic.201402061

Nobis M; Carragher NO; McGhee EJ; Morton JP; Sansom OJ; Anderson KI; Timpson P, 2013, 'Advanced intravital subcellular imaging reveals vital three-dimensional signalling events driving cancer cell behaviour and drug responses in live tissue', FEBS Journal, vol. 280, pp. 5177 - 5197, http://dx.doi.org/10.1111/febs.12348

Nobis M; McGhee EJ; Morton JP; Schwarz JP; Karim SA; Quinn J; Edward M; Campbell AD; McGarry LC; Evans TRJ; Brunton VG; Frame MC; Carragher NO; Wang Y; Sansom OJ; Timpson P; Anderson KI, 2013, 'Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of Src in pancreatic cancer', Cancer Research, vol. 73, pp. 4674 - 4686, http://dx.doi.org/10.1158/0008-5472.CAN-12-4545

Trinidad AG; Muller PAJ; Cuellar J; Klejnot M; Nobis M; Maria Valpuesta J; Vousden KH, 2013, 'Interaction of p53 with the CCT Complex Promotes Protein Folding and Wild-Type p53 Activity', MOLECULAR CELL, vol. 50, pp. 805 - 817, http://dx.doi.org/10.1016/j.molcel.2013.05.002

Timpson P; McGhee EJ; Erami Z; Nobis M; Quinn JA; Edward M; Anderson KI, 2011, 'Organotypic collagen I assay: a malleable platform to assess cell behaviour in a 3-dimensional context.', Journal of visualized experiments : JoVE, pp. 1 - 4, http://dx.doi.org/10.3791/3089

Gonzalez-Rajal A; Marzec KA; McCloy R; Nobis M; Chin V; Hastings JF; Lai K; Kennerson M; Hughes WE; Vaghjiani V; Timpson P; Cain JE; Neil Watkins D; Croucher DR; Burgess A, 'A Non-Genetic, Cell Cycle Dependent Mechanism of Platinum Resistance in Lung Adenocarcinoma', , http://dx.doi.org/10.1101/2020.11.26.400499

Murphy KJ; Reed DA; Vennin C; Conway JRW; Nobis M; Yin JX; Chambers CR; Pereira BA; Lee V; Filipe EC; Trpceski M; Ritchie S; Lucas MC; Warren SC; Skhinas JN; Magenau A; Metcalf XL; Stoehr J; Major G; Parkin A; Bidanel R; Lyons RJ; Zaratzian A; Tayao M; Da Silva A; Abdulkhalek L; Gill AJ; Johns AL; Biankin AV; Samra J; Grimmond SM; Chou A; Goetz JG; Samuel MS; Lyons JG; Burgess A; Caldon CE; Horvath LG; Daly RJ; Gadegaard N; Wang Y; Sansom OJ; Morton JP; Cox TR; Pajic M; Herrmann D; Timpson P, 2021, 'Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status', Science Advances, vol. 7, http://dx.doi.org/10.1126/sciadv.abh0363

Warren SC; Magenau A; Nobis M; Herrmann D; Mélénec P; Anderson KI; Sansom OJ; Morton JP; Welch HC; Timpson P, 2018, 'Unmixing spectrally overlapping FRET biosensors in vivo using multispectral FLIM (Conference Presentation)', in Multiphoton Microscopy in the Biomedical Sciences XVIII, SPIE, pp. 23, presented at Multiphoton Microscopy in the Biomedical Sciences XVIII, 27 January 2018 - 01 February 2018, http://dx.doi.org/10.1117/12.2290152

Koudelkova L; Pataki AC; Tolde O; Pavlik V; Nobis M; Gemperle J; Anderson K; Brrbek J; Rosel D, Novel FRET-Based Src Biosensor Reveals Mechanisms of Src Activation and Its Dynamics in Focal Adhesions, http://dx.doi.org/10.2139/ssrn.3206266