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Dr Melinda Tursky

Dr Melinda Tursky

Conjoint Lecturer
Medicine & Health
School of Clinical Medicine

Melinda Tursky has specialised in the field of normal and malignant human hematopoiesis and has a strong translational interest in the pathogenesis of hematological cancers. Melinda is highly proficient in the use of in vitro and in vivo assays for normal and malignant hematopoietic stem and progenitor cells, determination of self-renewal, expansion and lineage specific differentiation capabilities, and the use of induced pluripotent stem cells for the investigation of hematopoietic disorders and leukemic progression and the testing of targeted therapeutics.

Professor David Ma and Associate Professor John Moore conduct several clinical and laboratory based research projects at St Vincent's Centre for Applied Medical Research. Contact us for more information. We are available for supervision of Biomed, ILP, Honours, Haematology Advanced Trainees, Masters and PhD students who are Australian permanent residents or citizens. Competitive full and top-up scholarships available.
E-mail
m.tursky@amr.org.au
Location
St Vincent's Centre for Applied Medical Research Haematology Research, Level 8 Lowy Packer Building 405 Liverpool Street Darlinghurst NSW 2010
  • Journal articles | 2023
    Moles E; Howard CB; Huda P; Karsa M; McCalmont H; Kimpton K; Duly A; Chen Y; Huang Y; Tursky ML; Ma D; Bustamante S; Pickford R; Connerty P; Omari S; Jolly CJ; Joshi S; Shen S; Pimanda JE; Dolnikov A; Cheung LC; Kotecha RS; Norris MD; Haber M; de Bock CE; Somers K; Lock RB; Thurecht KJ; Kavallaris M; Moles Meler E, 2023, 'Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia', Science translational medicine, 15, pp. eabm1262 - eabm1262, http://dx.doi.org/10.1126/scitranslmed.abm1262
    Journal articles | 2022
    Mavrodiev EV; Tursky ML; Mavrodiev NE; Schroder L; Laktionov AP; Ebach MC; Williams DM, 2022, 'On Classification and Taxonomy of Coronaviruses (Riboviria, Nidovirales, Coronaviridae) with Special Focus on Severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2)', Mathematical Biology and Bioinformatics, 17, pp. 289 - 311, http://dx.doi.org/10.17537/2022.17.289
    Journal articles | 2021
    Yeola A; Subramanian S; Oliver RA; Lucas CA; Thoms JAI; Yan F; Olivier J; Chacon D; Tursky ML; Hung T; Power C; Hardy P; D D; McCarroll J; Kavallaris M; Hesson LB; Beck D; Curtis DJ; Wong JWH; Hardeman EC; Walsh WR; Mobbs R; Chandrakanthan V; Pimanda JE; Chacon Fajardo D, 2021, 'Induction of Muscle Regenerative Multipotent Stem Cells from Human Adipocytes by PDGF-AB and 5-Azacytidine', Science Advances, pp. 2020.06.04.130872 - 2020.06.04.130872, http://dx.doi.org/10.1126/sciadv.abd1929
    Journal articles | 2021
    Yeola A; Subramanian S; Oliver RA; Lucas CA; Thoms JAI; Yan F; Olivier J; Chacon D; Tursky ML; Srivastava P; Potas JR; Hung T; Power C; Hardy P; Ma DD; Kilian KA; McCarroll J; Kavallaris M; Hesson LB; Beck D; Curtis DJ; Wong JWH; Hardeman EC; Walsh WR; Mobbs R; Chandrakanthan V; Pimanda JE; Subramanian S, 2021, 'Induction of muscle-regenerative multipotent stem cells from human adipocytes by PDGF-AB and 5-azacytidine', Science Advances, 7, pp. eabd1929, http://dx.doi.org/10.1126/sciadv.abd1929
    Journal articles | 2021
    2021, '3101 – MIR-10A AS A THERAPEUTIC TARGET AND PREDICTIVE BIOMARKER FOR MDM2 INHIBITION IN ACUTE MYELOID LEUKEMIA', Experimental Hematology, 100, pp. S91 - S91, http://dx.doi.org/10.1016/j.exphem.2021.12.318
    Journal articles | 2021
    2021, '3133 – DIRECT COMPARISON OF IMPROVED METHOD FOR HUMAN INDUCED PLURIPOTENT STEM CELL (IPSC) HAEMATOPOIETIC DIFFERENTIATION SHOWS ENHANCED EFFICIENCY AND SENSITIVITY AT REDUCED COST', Experimental Hematology, 100, pp. S107 - S107, http://dx.doi.org/10.1016/j.exphem.2021.12.350
    Journal articles | 2021
    2021, 'miR-10a as a therapeutic target and predictive biomarker for MDM2 inhibition in acute myeloid leukemia', Leukemia, 35, pp. 1933 - 1948, http://dx.doi.org/10.1038/s41375-020-01095-z
    Journal articles | 2020
    Tursky ML; Loi TH; Artuz CM; Alateeq S; Wolvetang EJ; Tao H; Ma DD; Molloy TJ, 2020, 'Direct Comparison of Four Hematopoietic Differentiation Methods from Human Induced Pluripotent Stem Cells', Stem Cell Reports, 15, pp. 735 - 748, http://dx.doi.org/10.1016/j.stemcr.2020.07.009
    Journal articles | 2019
    Murphy DJ; Ebach MC; Miller JT; Laffan SW; Cassis G; Ung V; Thornhill AH; Kerr N; Tursky ML, 2019, 'Do phytogeographic patterns reveal biomes or biotic regions?', Cladistics, 35, pp. 654 - 670, http://dx.doi.org/10.1111/cla.12381
    Journal articles | 2017
    Unnikrishnan A; Papaemmanuil E; Beck D; Deshpande NP; Verma A; Kumari A; Woll PS; Richards LA; Knezevic K; Chandrakanthan V; Thoms JAI; Tursky ML; Huang Y; Ali Z; Olivier J; Galbraith S; Kulasekararaj AG; Tobiasson M; Karimi M; Pellagatti A; Wilson SR; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen SEW; Mufti GJ; Hellstrom-Lindberg E; Wilkins MR; MacKenzie KL; Wong JWH; Campbell PJ; Pimanda JE, 2017, 'Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes', Cell Reports, 20, pp. 572 - 585, http://dx.doi.org/10.1016/j.celrep.2017.06.067
    Journal articles | 2016
    Huang Y; Thoms JAI; Tursky ML; Knezevic K; Beck D; Chandrakanthan V; Suryani S; Olivier J; Boulton A; Glaros EN; Thomas SR; Lock RB; MacKenzie KL; Bushweller JH; Wong JWH; Pimanda JE, 2016, 'MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation', Leukemia, 30, pp. 1552 - 1561, http://dx.doi.org/10.1038/leu.2016.55
    Journal articles | 2016
    Tiwari A; Tursky ML; Nekkanti LP; Jenkin G; Kirkland MA; Pande G, 2016, 'Expansion of human hematopoietic stem/progenitor cells on decellularized matrix scaffolds', Current Protocols in Stem Cell Biology, 2016, pp. 1C.15.1 - 1C.15.16, http://dx.doi.org/10.1002/9780470151808.sc01c15s36
    Journal articles | 2015
    Tursky ML; Beck D; Thoms JAI; Huang Y; Kumari A; Unnikrishnan A; Knezevic K; Evans K; Richards LA; Lee E; Morris J; Goldberg L; Izraeli S; Wong JWH; Olivier J; Lock RB; MacKenzie KL; Pimanda JE, 2015, 'Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias', Leukemia, 29, pp. 819 - 827, http://dx.doi.org/10.1038/leu.2014.299
    Journal articles | 2014
    Tiwari A; Tursky ML; Kirkland MA; Pande G, 2014, 'Expansion of human hematopoietic stem/progenitor cells on decellularized matrix scaffolds', Current Protocols in Stem Cell Biology, 1, http://dx.doi.org/10.1002/9780470151808.sc01c15s28
    Journal articles | 2013
    Tiwari A; Tursky ML; Mushahary D; Wasnik S; Collier FM; Suma K; Kirkland MA; Pande G, 2013, 'Ex vivo expansion of haematopoietic stem/progenitor cells from human umbilical cord blood on acellular scaffolds prepared from MS-5 stromal cell line', Journal of Tissue Engineering and Regenerative Medicine, 7, pp. 871 - 883, http://dx.doi.org/10.1002/term.1479
    Journal articles | 2012
    Tursky ML; Collier FM; Ward AC; Kirkland MA, 2012, 'Systematic investigation of oxygen and growth factors in clinically valid ex vivo expansion of cord blood CD34+ hematopoietic progenitor cells', Cytotherapy, 14, pp. 679 - 685, http://dx.doi.org/10.3109/14653249.2012.666851
    Journal articles | 2003
    Stenvers KL; Tursky ML; Harder KW; Kountouri N; Amatayakul-Chantler S; Grail D; Small C; Weinberg RA; Sizeland AM; Zhu HJ, 2003, 'Heart and liver defects and reduced transforming growth factor β2 sensitivity in transforming growth factor β type III receptor-deficient embryos', Molecular and Cellular Biology, 23, pp. 4371 - 4385, http://dx.doi.org/10.1128/MCB.23.12.4371-4385.2003
  • Preprints | 2021
    2021, On Classification and Taxonomy of Coronaviruses (Riboviria, Nidovirales, Coronaviridae) with Special Focus on Severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2), , http://dx.doi.org/10.21203/rs.3.rs-282371/v1
    Preprints | 2020
    Mavrodiev EV; Tursky ML; Mavrodiev NE; Ebach MC; Williams DM, 2020, On Classification and Taxonomy of Coronaviruses (Riboviria, Nidovirales, Coronaviridae) with special focus on severe acute respiratory syndrome-related coronavirus 2 (SARS-Cov-2), , http://dx.doi.org/10.1101/2020.10.17.343749
    Conference Papers | 2016
    Unnikrishnan A; Papaemmanuil E; Beck D; Verma A; Kumari A; Woll P; Richards L; Knezevic K; Chandrakanthan V; Thoms J; Tursky ML; Huang Y; Ali Z; Olivier S; Galbraith S; Kulasekararaj A; Tobiasson M; Karimi M; Pellagatti A; Wilson S; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen S; Mufti G; Hellstrom-Lindberg E; MacKenzie K; Wong J; Campbell P; Pimanda J, 2016, 'Integrative genomics identifies the molecular basis of resistance to Azacitidine therapy in Myelodysplastic Syndromes', in Integrative genomics identifies the molecular basis of resistance to Azacitidine therapy in Myelodysplastic Syndromes, Ferrata Storti Foundation, Copenhagen, Denmark, pp. 157 - 158, presented at 21st Congress Of The European Hematology Association (EHA), Copenhagen, Denmark, 09 June 2016 - 12 June 2016, https://synapse.mskcc.org/synapse/works/97032
    Conference Papers | 2015
    Unnikrishnan A; Papaemmanuil E; Beck D; Verma A; Kumari A; Richards LA; Knezevic K; Chandrakanthan V; Thoms JA I; Tursky ML; Huang Y; Galbraith S; Kulasekararaj AG; Tobiasson M; Woll PS; Pellagatti A; Wilson SR; Lindeman R; Boultwood J; Lynch K; Jacobsen SE; Mufti GJ; Hellstrom-Lindberg E; Mackenzie KL; Wong JW H; Campbell PJ; Pimanda JE, 2015, 'An Integrative Genomics Approach Uncovers the Basis of Resistance to AZA Therapy in MDS and CMML', in An Integrative Genomics Approach Uncovers the Basis of Resistance to, AMER SOC HEMATOLOGY, USA, presented at ASH Annual Meeting, USA, 05 December 2015 - 08 December 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000368019002147&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Patents | 2013
    Tursky ML; Kirkland MA, 2013, METHOD FOR THE EX VIVO EXPANSION OF HEMATOPOIETIC STEM AND PROGENITOR CELLS, Patent No. WO2013040644 A1
    Conference Papers | 2002
    Stenvers KL; Kountouri N; Tursky M; Amatayakul-Chantler S; Grail D; Small C; Weinberg RA; Sizeland A, 2002, 'Defective heart and liver development in type III TGF beta-receptor-deficient embryos.', in DEVELOPMENTAL BIOLOGY, ACADEMIC PRESS INC ELSEVIER SCIENCE, pp. 510 - 510, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000176830700304&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Professor David Ma and Associate Professor John Moore conduct several clinical and laboratory based research projects at St Vincent's Centre for Applied Medical Research. Contact us for more information. We are available for supervision of Biomed, ILP, Honours, Masters and PhD students who are Australian permanent residents or citizens. Competitive full and top-up scholarships available.

Current projects of our group include:

  • Testing novel targeted therapeutic approaches for acute leukaemia
  • Using CRISPR-based gene editing for the study of putative leukaemia oncogenes

 

  • Assessing cytokines levels in the plasma of autoimmune patients following autologous stem cell transplantation
  • Clinical correlation of gene expression in T-cells of patients following transplantation for autoimmune diseases

 

  • Using haematopoietic stem cells to model disease and aging processes
  • Study of myeloid gene mutations in individuals over the age of 65 by Next Generation Sequencing

 

  • Study of the prevalence & causes of anaemia & cytopenia and its disease association in routine clinical laboratory testing
  • Investigation of the clinical incidence and surgical management of acute bowel obstruction in patients with haematological malignancies

 

  • Telehealth improving the quality of life in bone marrow transplant patients
  • Advancing healthcare in emerging countries in the Asia Pacific