Dr Mingzi Zhang
Research Associate

Dr Mingzi Zhang

Dr Mingzi Zhang holds two PhD degress respectively in Engineering (Tohoku University, Japan) and Biomedical Scienecs (Macquarie University, Australia).

Engineering
Mechanical and Manufacturing Engineering

Dr. Mingzi Zhang is currently a research associate with Dr. Susann Beier in the Faulty of Engineering at the University of New South Wales. He gained a PhD degree in Engineering from Tohoku University (Japan), for his work on the structural optimisation and manufacturing of neurovascular stents. He then obtained a second PhD degree in Biomedical Sciences from Macquarie University, with a thesis into the virtual stenting and simulation-based treatment individualisation for patients with cerebral aneurysms. Prior to switching his research focus onto cerebrovascular diseases, Dr. Zhang had developed a lumped parameter model of human circulatory system over his master’s study, applicable for modelling of various structural and coronary heart diseases.

Throughout his study and research, Dr. Zhang has published over 25 scientific articles in prestigious peer-reviewed academic journals and co-authored 2 book chapters. He has presented in over 20 esteemed academic conferences (including invited talks). Meanwhile, he has been serving as the external peer reviewer for many academic journals. Dr. Zhang’s areas of expertise lie in the computational modelling of cardiovascular and cerebrovascular diseases, structural optimisation and virtual deployment of endovascular stents and surgical implants, and image-based non-invasive estimation of in vivo haemodynamic parameters.

Alongside his effort in unravelling the link between haemodynamics and vascular diseases, Dr. Zhang has been enthusiastic about translating his research outcomes to diagnostic-assisting or treatment-planning tools applicable in clinical settings to improve the quality of patient care. A representative example of such is a virtual stenting platform that can be used by neuro-interventionists to individualise the treatment strategy for intracranial aneurysms. This platform allows the treating clinicians to assess feasibility and examine the deployed stent structures prior to the real treatments. The embedded blood flow evaluation module would meanwhile suggest the optimal treatment plan with the best efficacy in diverting blood flow away from entering the aneurysm sac. The core technologies developed, together with a 3D printing method for fabricating in vitro vascular models, are being commercialised in Japan for neuro-interventionists to rehearse and standardise the care for patients with cerebrovascular diseases.

Location
Ainsworth Building J17 Level 4, Room 401 UNSW, Kensington Campus Sydney NSW 2052 AUSTRALIA
  • Journal articles | 2022
    Hongbiao S; Shaochun X; Xiang W; YuRun T; Yang L; Mingzi Z; Hua Y; Keyang Z; Chi-Cheng F; Qu F; Pengchen G; Yi X; Shiyuan L, 2022, 'Comparison and verification of two deep learning models for the detection of chest CT rib fractures', Acta Radiologica, http://dx.doi.org/10.1177/02841851221083519
    Journal articles | 2022
    Li B; Liu T; Liu J; Liu Y; Cao B; Zhao X; Wang W; Shi M; Zhang L; Xu K; Chen M; Wen C; Zhang M, 2022, 'Reliability of using generic flow conditions to quantify aneurysmal haemodynamics: A comparison against simulations incorporating boundary conditions measured in vivo', Computer Methods and Programs in Biomedicine, vol. 225, http://dx.doi.org/10.1016/j.cmpb.2022.107034
    Journal articles | 2022
    Liu J; Wang X; Li B; Huang S; Sun H; Zhang L; Sun Y; Liu Z; Liu J; Wang L; Zhao X; Wang W; Zhang M; Liu Y, 2022, 'Non-Invasive Quantification of Fraction Flow Reserve Based on Steady-State Geometric Multiscale Models', Frontiers in Physiology, vol. 13, http://dx.doi.org/10.3389/fphys.2022.881826
    Journal articles | 2022
    Mitsuzuka K; Li Y; Nakayama T; Anzai H; Goanno D; Tupin S; Zhang M; Wang H; Horie K; Ohta M, 2022, 'A Parametric Study of Flushing Conditions for Improvement of Angioscopy Visibility', Journal of Functional Biomaterials, vol. 13, http://dx.doi.org/10.3390/jfb13020069
    Journal articles | 2022
    Ou C; Qian Y; Chong W; Hou X; Zhang M; Zhang X; Si W; Duan CZ, 2022, 'A deep learning–based automatic system for intracranial aneurysms diagnosis on three-dimensional digital subtraction angiographic images', Medical Physics, http://dx.doi.org/10.1002/mp.15846
    Journal articles | 2022
    Wang X; Gao M; Xie J; Deng Y; Tu W; Yang H; Liang S; Xu P; Zhang M; Lu Y; Fu C; Li Q; Fan L; Liu S, 2022, 'Development, Validation, and Comparison of Image-Based, Clinical Feature-Based and Fusion Artificial Intelligence Diagnostic Models in Differentiating Benign and Malignant Pulmonary Ground-Glass Nodules', FRONTIERS IN ONCOLOGY, vol. 12, http://dx.doi.org/10.3389/fonc.2022.892890
    Journal articles | 2022
    Zhang M; Hou X; Qian Y; Chong W; Zhang X; Duan CZ; Ou C, 2022, 'Evaluation of aneurysm rupture risk based upon flowrate-independent hemodynamic parameters: A multi-center pilot study', Journal of NeuroInterventional Surgery, http://dx.doi.org/10.1136/neurintsurg-2022-018691
    Journal articles | 2022
    Zhao K; Zhang M; Xie Z; Yan X; Wu S; Liao P; Lu H; Shen W; Fu C; Cui H; Fang Q; Mei J, 2022, 'Deep Learning Assisted Diagnosis of Musculoskeletal Tumors Based on Contrast-Enhanced Magnetic Resonance Imaging', Journal of Magnetic Resonance Imaging, vol. 56, pp. 99 - 107, http://dx.doi.org/10.1002/jmri.28025
    Journal articles | 2021
    Li G; Wang H; Zhang M; Tupin S; Qiao A; Liu Y; Ohta M; Anzai H, 2021, 'Prediction of 3D Cardiovascular hemodynamics before and after coronary artery bypass surgery via deep learning', Communications Biology, vol. 4, http://dx.doi.org/10.1038/s42003-020-01638-1
    Journal articles | 2021
    Li Y; Yoneyama Y; Isoda H; Terada M; Kosugi T; Kosugi T; Zhang M; Ohta M, 2021, 'Haemodynamics in a patient-specific intracranial aneurysm according to experimental and numerical approaches: A comparison of PIV, CFD and PC-MRI', Technology and Health Care, vol. 29, pp. 253 - 267, http://dx.doi.org/10.3233/THC-202252
    Journal articles | 2021
    Li Y; Zhang M; Tupin S; Mitsuzuka K; Nakayama T; Anzai H; Ohta M, 2021, 'Flush Flow Behaviour Affected by the Morphology of Intravascular Endoscope: A Numerical Simulation and Experimental Study', Frontiers in Physiology, vol. 12, http://dx.doi.org/10.3389/fphys.2021.733767
    Journal articles | 2021
    Zhang M; Li Y; Sugiyama SI; Verrelli DI; Matsumoto Y; Tominaga T; Qian Y; Tupin S; Anzai H; Ohta M, 2021, 'Incomplete stent expansion in flow-diversion treatment affects aneurysmal haemodynamics: a quantitative comparison of treatments affected by different severities of malapposition occurring in different segments of the parent artery', International Journal for Numerical Methods in Biomedical Engineering, vol. 37, http://dx.doi.org/10.1002/cnm.3465
    Journal articles | 2021
    Zhang M; Liu J; Zhang H; Verrelli DI; Wang Q; Hu L; Li Y; Ohta M; Liu J; Zhao X, 2021, 'CTA-Based Non-invasive Estimation of Pressure Gradients Across a CoA: a Validation Against Cardiac Catheterisation', Journal of Cardiovascular Translational Research, vol. 14, pp. 873 - 882, http://dx.doi.org/10.1007/s12265-020-10092-7
    Journal articles | 2021
    Zhang M; Tupin S; Anzai H; Kohata Y; Shojima M; Suzuki K; Okamoto Y; Tanaka K; Yagi T; Fujimura S; Ohta M, 2021, 'Implementation of computer simulation to assess flow diversion treatment outcomes: Systematic review and meta-analysis', Journal of NeuroInterventional Surgery, vol. 13, pp. 164 - 170, http://dx.doi.org/10.1136/neurintsurg-2020-016724
    Journal articles | 2021
    Zhang M; Tupin S; Li Y; Ohta M, 2021, 'Association Between Aneurysmal Haemodynamics and Device Microstructural Characteristics After Flow-Diversion Treatments With Dual Stents of Different Sizes: A Numerical Study', Frontiers in Physiology, vol. 12, http://dx.doi.org/10.3389/fphys.2021.663668
    Journal articles | 2019
    Dai Y; Qian Y; Zhang M; Li Y; Lv P; Tang X; Javadzadegan A; Lin J, 2019, 'Associations between local haemodynamics and carotid intraplaque haemorrhage with different stenosis severities: A preliminary study based on MRI and CFD', Journal of Clinical Neuroscience, vol. 66, pp. 220 - 225, http://dx.doi.org/10.1016/j.jocn.2019.05.041
    Journal articles | 2018
    Li Y; Zhang M; Verrelli DI; Chong W; Ohta M; Qian Y, 2018, 'Numerical simulation of aneurysmal haemodynamics with calibrated porous-medium models of flow-diverting stents', Journal of Biomechanics, vol. 80, pp. 88 - 94, http://dx.doi.org/10.1016/j.jbiomech.2018.08.026
    Journal articles | 2017
    LI Y; ZHANG M; SEN I; OHTA M, 2017, 'Haemodynamic simulation of flow-diverting stent efficacy using porous medium method', The Proceedings of Mechanical Engineering Congress, Japan, vol. 2017, pp. J0230205 - J0230205, http://dx.doi.org/10.1299/jsmemecj.2017.j0230205
    Journal articles | 2017
    ZHANG M; LI Y; ANZAI H; SEN I; OHTA M, 2017, 'Introduction of numerical simulation being applied to the study of aneurysm treatment with flow-diverting stent', The Proceedings of Mechanical Engineering Congress, Japan, vol. 2017, pp. J0230204 - J0230204, http://dx.doi.org/10.1299/jsmemecj.2017.j0230204
    Journal articles | 2017
    Zhang M; Li Y; Zhao X; Verrelli DI; Chong W; Ohta M; Qian Y, 2017, 'Haemodynamic effects of stent diameter and compaction ratio on flow-diversion treatment of intracranial aneurysms: A numerical study of a successful and an unsuccessful case', Journal of Biomechanics, vol. 58, pp. 179 - 186, http://dx.doi.org/10.1016/j.jbiomech.2017.05.001
    Journal articles | 2016
    Zhang M; Anzai H; Chopard B; Ohta M, 2016, 'Towards the patient-specific design of flow diverters made from helix-like wires: An optimization study', BioMedical Engineering Online, vol. 15, http://dx.doi.org/10.1186/s12938-016-0257-z
    Journal articles | 2015
    Zhao X; Liu Y; Ding J; Ren X; Bai F; Zhang M; Ma L; Wang W; Xie J; Qiao A, 2015, 'Hemodynamic effects of the anastomoses in the modified blalock-taussig shunt: A numerical study using a 0D/3D coupling method', Journal of Mechanics in Medicine and Biology, vol. 15, http://dx.doi.org/10.1142/S0219519415500177
    Journal articles | 2014
    Ma L; Liu Y; Zhao X; Ren X; Bai F; Ding J; Zhang M; Wang W; Xie J; Zhang H; Zhao Z; Han H, 2014, 'Hemodynamic Influence of Different Pulmonary Stenosis Degree in Glenn Procedure: A Numerical Study', Advances in Mechanical Engineering, vol. 2014, http://dx.doi.org/10.1155/2014/472370
    Journal articles | 2014
    Ren XC; Liu YJ; Bai F; Zhao X; Zhang MZ; Ding JL; Ma LC; Xie JS, 2014, 'Hemodynamics-based numerical comparison between two options of modified B-T shunt', Yiyong Shengwu Lixue/Journal of Medical Biomechanics, vol. 29, pp. 146 - 153
    Journal articles | 2013
    Zhang MZ; Liu YJ; Xie JS; Zhao X; Ren XC; Bai F; Ding JL, 2013, 'Numerical study on multiscale simulation for hemodynamics of systemic-pulmonary shunt procedure based on lattice Boltzmann method', Yiyong Shengwu Lixue/Journal of Medical Biomechanics, vol. 28, pp. 642 - 647
  • Conference Papers | 2017
    Li Y; Zhang M; Verrelli DI; Yang W; Chong W; Ohta M; Qian Y, 2017, 'Sensitivity study on modelling a flow-diverting stent as a porous medium using computational fluid dynamics', in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, pp. 3389 - 3392, http://dx.doi.org/10.1109/EMBC.2017.8037583
    Conference Papers | 2017
    Zhang M; Li Y; Verrelli DI; Chong W; Ohta M; Qian Y, 2017, 'Applying computer simulation to the design of flow-diversion treatment for intracranial aneurysms', in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, pp. 3385 - 3388, http://dx.doi.org/10.1109/EMBC.2017.8037582
    Conference Papers | 2014
    Zhao X; Liu Y; Ding J; Zhang M; Fu W; Bai F; Ren X; Qiao A, 2014, 'Multiscale study on hemodynamics in patient-specific thoracic aortic coarctation', in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), pp. 57 - 64, http://dx.doi.org/10.1007/978-3-642-54268-8_7

University Affiliations

Honorary Research Fellow at Macquarie Medical School, Macquarie University, Australia
Collaborative Researcher at the Biofluid Dynamics Lab, Institute of Fluid Science, Tohoku University, Japan

Professional Memberships

The Japanese Society of Mechanical Engineers (JSME)
Institute of Electrical and Electronics Engineers (IEEE)
Institution of Engineers Australia (EA)

Peer Reviewer of Academic Journals

Computers in Biology and Medicine
Computer Methods and Programs in Biomedicine
Technology and Health Care
Journal of Vascular and Interventional Radiology
Frontiers in Physiology/Neuroscience
......

2021-2023, Principle Investigator, Collaborative Research Projects (J21I074 & J22I075), IFS, Tohoku University, Japan.