Lecturer

Dr Natalie Courtney Gock Kwai

medicine-health
Exercise Physiology

My research interests cover neurodegeneration in metabolic disease, its pathogenesis, functional outcomes and protective avenues. Investigations through my PhD and postdoctoral studies have utilised cutting edge neurophysiology techniques, namely, axonal excitability techniques to delineate the underlying biophysical properties of nerves in patients with diabetes. My previous work indicated subclinical abnormalities in nerve function in patients with diabetes in the absence of neuropathy, further indicating that these abnormalities were not related to average glycaemia. Subsequent investigations revealed that these changes were related to the use of different modalities of insulin delivery, namely insulin pump therapy and further studies indicating that these alterations were related to glycaemic variability which is presently the subject of a Phase II Clinical Trial my group are undertaking in collaboration with Industry (Insulin Pump therapy for Reducing Diabetic complications ( InsPyReD ) study, ANZCRTN:12617000124336)

Publications

  • Journal articles | 2021
    Dr Natalie Courtney Gock Kwai
    Issar T; Kwai NCG; Poynten AM; Arnold R; Milner K-L; Krishnan AV, 2021, 'Effect of Exenatide on Peripheral Nerve Excitability in Type 2 Diabetes', Clinical Neurophysiology, http://dx.doi.org/10.1016/j.clinph.2021.05.033
    Journal articles | 2021
    Dr Natalie Courtney Gock Kwai
    Issar T; Tummanapalli SS; Borire AA; Kwai NCG; Poynten AM; Arnold R; Markoulli M; Krishnan AV, 2021, 'Impact of the metabolic syndrome on peripheral nerve structure and function in type 2 diabetes', European Journal of Neurology, vol. 28, pp. 2074 - 2082, http://dx.doi.org/10.1111/ene.14805
    Journal articles | 2021
    Dr Natalie Courtney Gock Kwai
    Arnold R; Pianta TJ; Issar T; Kirby A; Scales C; Kwai N; Endre Z; Krishnan AV, 2021, 'Peripheral Neuropathy: An Important Contributor To Physical Limitation And Morbidity In Stage 3-4 Chronic Kidney Disease.', Nephrol Dial Transplant, http://dx.doi.org/10.1093/ndt/gfab043
    Journal articles | 2020
    Dr Natalie Courtney Gock Kwai
    Yan A; Issar T; Tummanapalli SS; Markoulli M; Kwai NCG; Poynten AM; Krishnan AV, 2020, 'Relationship between corneal confocal microscopy and markers of peripheral nerve structure and function in Type 2 diabetes', Diabetic Medicine, vol. 37, pp. 326 - 334, http://dx.doi.org/10.1111/dme.13952
    Journal articles | 2020
    Dr Natalie Courtney Gock Kwai
    Tummanapalli SS; Issar T; Kwai N; Pisarcikova J; Poynten AM; Krishnan AV; Willcox MDP; Markoulli M, 2020, 'A Comparative Study on the Diagnostic Utility of Corneal Confocal Microscopy and Tear Neuromediator Levels in Diabetic Peripheral Neuropathy', Current Eye Research, vol. 45, pp. 921 - 930, http://dx.doi.org/10.1080/02713683.2019.1705984
    Journal articles | 2020
    Dr Natalie Courtney Gock Kwai
    Borire AA; Issar T; Kwai NC; Visser LH; Simon NG; Poynten AM; Kiernan MC; Krishnan AV, 2020, 'Sonographic assessment of nerve blood flow in diabetic neuropathy', Diabetic Medicine, vol. 37, pp. 343 - 349, http://dx.doi.org/10.1111/dme.14085
    Journal articles | 2020
    Dr Natalie Courtney Gock Kwai
    Issar T; Yan A; Kwai NCG; Poynten AM; Borire AA; Arnold R; Krishnan AV, 2020, 'Altered peripheral nerve structure and function in latent autoimmune diabetes in adults', Diabetes/Metabolism Research and Reviews, vol. 36, pp. e3260, http://dx.doi.org/10.1002/dmrr.3260
    Journal articles | 2020
    Dr Natalie Courtney Gock Kwai
    Tummanapalli SS; Willcox MDP; Issar T; Kwai N; Poynten AM; Krishnan AV; Pisarcikova J; Markoulli M, 2020, 'The Effect of Age, Gender and Body Mass Index on Tear Film Neuromediators and Corneal Nerves', Current Eye Research, vol. 45, pp. 411 - 418, http://dx.doi.org/10.1080/02713683.2019.1666998
    Journal articles | 2020
    Dr Natalie Courtney Gock Kwai
    Tummanapalli SS; Issar T; Yan A; Kwai N; Poynten AM; Krishnan AV; Willcox MDP; Markoulli M, 2020, 'Corneal nerve fiber loss in diabetes with chronic kidney disease', Ocular Surface, vol. 18, pp. 178 - 185, http://dx.doi.org/10.1016/j.jtos.2019.11.010
    Journal articles | 2020
    Dr Natalie Courtney Gock Kwai
    Tummanapalli SS; Issar T; Kwai N; Poynten A; Krishnan AV; Willcox M; Markoulli M, 2020, 'Association of corneal nerve loss with markers of axonal ion channel dysfunction in type 1 diabetes', Clinical Neurophysiology, vol. 131, pp. 145 - 154, http://dx.doi.org/10.1016/j.clinph.2019.09.029
    Journal articles | 2020
    Dr Natalie Courtney Gock Kwai
    Issar T; Tummanapalli SS; Kwai NCG; Chiang JCB; Arnold R; Poynten AM; Markoulli M; Krishnan AV, 2020, 'Associations between acute glucose control and peripheral nerve structure and function in type 1 diabetes', Diabetic Medicine, vol. 37, pp. 1553 - 1560, http://dx.doi.org/10.1111/dme.14306
    Journal articles | 2020
    Dr Natalie Courtney Gock Kwai
    Habeych ME; Trinh T; Issar T; Kwai NCG; Krishnan AV, 2020, 'Motor unit number estimation of facial muscles using the M Scan-Fit method', Muscle and Nerve, vol. 62, pp. 555 - 558, http://dx.doi.org/10.1002/mus.27010
    Journal articles | 2020
    Dr Natalie Courtney Gock Kwai
    Tummanapalli SS; Issar T; Kwai N; Poynten A; Krishnan AV; Willcox M; Markoulli M, 2020, 'Erratum to ‘Association of corneal nerve loss with markers of axonal ion channel dysfunction in type 1 diabetes’. (Clinical Neurophysiology (2020) 131(1) (145–154), (S1388245719312726), (10.1016/j.clinph.2019.09.029))', Clinical Neurophysiology, vol. 131, pp. 780, http://dx.doi.org/10.1016/j.clinph.2020.01.001
    Journal articles | 2019
    Dr Natalie Courtney Gock Kwai
    Issar T; Arnold R; Kwai NCG; Walker S; Yan A; Borire AA; Poynten AM; Pussell BA; Endre ZH; Kiernan MC; Krishnan AV, 2019, 'Relative contributions of diabetes and chronic kidney disease to neuropathy development in diabetic nephropathy patients', Clinical Neurophysiology, vol. 130, pp. 2088 - 2095, http://dx.doi.org/10.1016/j.clinph.2019.08.005
    Journal articles | 2019
    Dr Natalie Courtney Gock Kwai
    Tummanapalli SS; Willcox MDP; Issar T; Yan A; Pisarcikova J; Kwai N; Poynten AM; Krishnan AV; Markoulli M, 2019, 'Tear film substance P: A potential biomarker for diabetic peripheral neuropathy', Ocular Surface, vol. 17, pp. 690 - 698, http://dx.doi.org/10.1016/j.jtos.2019.08.010
    Journal articles | 2019
    Dr Natalie Courtney Gock Kwai
    Borire A; Issar T; Kwai N; Visser L; Poynten A; Simon N; Kiernan M; Krishnan A, 2019, '025 The utility of nerve blood flow in the assessment of peripheral neuropathy', Journal of Neurology, Neurosurgery & Psychiatry, vol. 90, pp. A9.2 - A9, http://dx.doi.org/10.1136/jnnp-2019-anzan.24
    Journal articles | 2018
    Dr Natalie Courtney Gock Kwai
    Eviston TJ; Chong LSH; Kwai NCG; Clark JR; Krishnan AV, 2018, 'Altered axonal excitability properties in facial palsy', Muscle and Nerve, vol. 57, pp. 268 - 272, http://dx.doi.org/10.1002/mus.25677
    Journal articles | 2018
    Dr Natalie Courtney Gock Kwai
    Borire AA; Arnold R; Pussell BA; Kwai NC; Visser LH; Simon NG; Kiernan MC; Krishnan AV, 2018, 'Effects of hemodialysis on intraneural blood flow in end-stage kidney disease', Muscle and Nerve, vol. 57, pp. 287 - 293, http://dx.doi.org/10.1002/mus.25704
    Journal articles | 2018
    Dr Natalie Courtney Gock Kwai
    Issar T; Arnold R; Kwai NCG; Pussell BA; Endre ZH; Poynten AM; Kiernan MC; Krishnan AV, 2018, 'The utility of the Total Neuropathy Score as an instrument to assess neuropathy severity in chronic kidney disease: A validation study', Clinical Neurophysiology, vol. 129, pp. 889 - 894, http://dx.doi.org/10.1016/j.clinph.2018.02.120
    Journal articles | 2018
    Dr Natalie Courtney Gock Kwai
    Borire AA; Issar T; Kwai NC; Visser LH; Simon NG; Poynten AM; Kiernan MC; Krishnan AV, 2018, 'Correlation between markers of peripheral nerve function and structure in type 1 diabetes', Diabetes/Metabolism Research and Reviews, vol. 34, http://dx.doi.org/10.1002/dmrr.3028
    Journal articles | 2017
    Dr Natalie Courtney Gock Kwai
    Borire AA; Arnold R; Pussell BA; Kwai NC; Visser LH; Padua L; Simon NG; Kiernan MC; Krishnan AV, 2017, 'Haemodialysis alters peripheral nerve morphology in end-stage kidney disease', Clinical Neurophysiology, vol. 128, pp. 281 - 286, http://dx.doi.org/10.1016/j.clinph.2016.09.010
    Journal articles | 2017
    Dr Natalie Courtney Gock Kwai
    Huynh W; Kwai N; Arnold R; Krishnan AV; Lin CSY; Vucic S; Kiernan MC, 2017, 'The effect of diabetes on cortical function in stroke: Implications for poststroke plasticity', Diabetes, vol. 66, pp. 1661 - 1670, http://dx.doi.org/10.2337/db16-0961
    Journal articles | 2017
    Dr Natalie Courtney Gock Kwai
    Borire A; Issar T; Kwai N; Krishnan A, 2017, 'Association between peripheral nerve function and structure in human diabetic nerves', Journal of Neurology, Neurosurgery & Psychiatry, vol. 88, pp. e1.1 - e1, http://dx.doi.org/10.1136/jnnp-2017-316074
    Journal articles | 2016
    Dr Natalie Courtney Gock Kwai
    Kwai NCG; Arnold R; Poynten AM; Howells J; Kiernan MC; Lin CSY; Krishnan AV, 2016, 'In vivo evidence of reduced nodal and paranodal conductances in type 1 diabetes', Clinical Neurophysiology, vol. 127, pp. 1700 - 1706, http://dx.doi.org/10.1016/j.clinph.2015.11.047
    Journal articles | 2016
    Dr Natalie Courtney Gock Kwai
    Kwai NCG; Arnold R; Poynten AM; Krishnan AV, 2016, 'Association between glycemic variability and peripheral nerve dysfunction in type 1 diabetes', Muscle and Nerve, vol. 54, pp. 967 - 969, http://dx.doi.org/10.1002/mus.25274
    Journal articles | 2016
    Dr Natalie Courtney Gock Kwai
    Kwai NCG; Nigole W; Poynten AM; Brown C; Krishnan AV, 2016, 'The relationship between dyslipidemia and acute axonal function in type 2 diabetes mellitus in vivo', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0153389
    Journal articles | 2015
    Dr Natalie Courtney Gock Kwai
    Kwai N; Arnold R; Poynten AM; Lin CSY; Kiernan MC; Krishnan AV, 2015, 'Continuous subcutaneous insulin infusion preserves axonal function in type 1 diabetes mellitus', Diabetes/Metabolism Research and Reviews, vol. 31, pp. 175 - 182, http://dx.doi.org/10.1002/dmrr.2583
    Journal articles | 2013
    Dr Natalie Courtney Gock Kwai
    Kwai NCG; Arnold R; Wickremaarachchi C; Lin CS-Y; Poynten AM; Kiernan MC; Krishnan AV, 2013, 'Effects of Axonal Ion-Channel Dysfunction on Quality of Life in Type 2 Diabetes.', Diabetes Care, vol. 36, pp. 1272 - 1277, http://dx.doi.org/10.2337/dc12-1310
    Journal articles | 2013
    Dr Natalie Courtney Gock Kwai
    Arnold R; Kwai NCG; Lin CS-Y; Poynten AM; Kiernan MC; Krishnan AV, 2013, 'Axonal dysfunction prior to neuropathy onset in type 1 diabetes', Diabetes - Metabolism Research and Reviews, vol. 29, pp. 53 - 59, http://dx.doi.org/10.1002/dmrr.2360
    Journal articles | 2013
    Dr Natalie Courtney Gock Kwai
    Arnold R; Kwai NCG; Krishnan AV, 2013, 'Mechanisms of axonal dysfunction in diabetic and uraemic neuropathies', Clinical Neurophysiology, vol. 124, pp. 2079 - 2090, http://dx.doi.org/10.1016/j.clinph.2013.04.012
    Journal articles | 2012
    Dr Natalie Courtney Gock Kwai
    Sung J; Park SB; Liu Y; Kwai N; Arnold R; Krishnan AV; Lin CS-Y, 2012, 'Progressive axonal dysfunction precedes development of neuropathy in type 2 Diabetes.', Diabetes, vol. 61, pp. 1592 - 1598, http://dx.doi.org/10.2337/db11-1509
    Journal articles | 2012
    Dr Natalie Courtney Gock Kwai
    Kwai N; Arnold R; Wickrema C; Poynten A; Kiernan M; Krishnan A, 2012, '20. Effects of altered axonal biophysical properties on quality of life in diabetic peripheral neuropathy', Clinical Neurophysiology, vol. 123, pp. e75 - e75, http://dx.doi.org/10.1016/j.clinph.2011.11.029
  • Conference Presentations | 2020
    Dr Natalie Courtney Gock Kwai
    Broderick C; Engel A; Hardy L; Kwai N; Van Doorn N; Ward R; Parmenter B, 2020, 'Intervention for Fundamental Motor Skills And Physical Activity In Pre-schoolers: A Cluster-randomized Controlled Trial.', presented at 2020 American College of Sports Medicine Annual Meeting, 27 May 2020 - 30 May 2020
    Conference Papers | 2013
    Dr Natalie Courtney Gock Kwai
    Arnold R; Kwai N; Pussell BA; Lin CS-Y; Kiernan MC; Krishnan AV, 2013, 'Effects of neuropathy on physical function and quality of life in moderate severity chronic kidney disease', in Clinical Neurophysiology, ANZAN Clinical Neurophysiology Workshop, Gold Coast, Queensland, pp. e4 - e4, presented at ANZAN Clinical Neurophysiology Workshop, Gold Coast, Queensland, 29 September 2013 - 02 October 2013, http://dx.doi.org/10.1016/j.clinph.2013.10.031
    Conference Papers | 2013
    Dr Natalie Courtney Gock Kwai
    Kwai N; Arnold R; Poynten A; Lin C; Kiernan MC; Krishnan A, 2013, 'Insulin pump therapy in type 1 diabetes: Potential to be neuroprotective', in Clinical Neurophysiology, Gold Coast, Queensland, pp. e1 - e2, presented at ANZAN Clinical Neurophysiology Workshop, Gold Coast, Queensland, 29 September 2013 - 02 October 2013, http://dx.doi.org/10.1016/j.clinph.2013.10.024
    Conference Papers | 2011
    Dr Natalie Courtney Gock Kwai
    Arnold R; kwai N ; Lin, C.S-Y ; Kiernan, MC ; Krishnan, AV , 2011, 'Evidence for distinct patterns of axonal excitability between type 1 and type 2 diabetic nerves', in Journal of the Peripheral Nervous System, Wiley, Potomac, Unites States of America, pp. S5 - S5, presented at Peripheral Nerve Society Meeting, Potomac, Unites States of America, 25 September 2011 - 29 September 2011, http://dx.doi.org/10.1111/j.1529-8027.2011.00335.x
    Conference Papers | 2011
    Dr Natalie Courtney Gock Kwai
    Arnold R; Kwai N; Poynten A; Lin CS-Y; Kiernan MC; Krishnan AV, 2011, 'Altered axonal excitability in asymptomatic type 1 diabetic patients', in Clinical Neurophysiology, ANZAN Clinical Neurophysiology Workshop, Gold Coast, Queensland, pp. e73 - e73, presented at ANZAN Clinical Neurophysiology Workshop, Gold Coast, Queensland, 02 October 2011 - 05 October 2011, http://dx.doi.org/10.1016/j.clinph.2011.11.023
    Conference Papers | 2011
    Dr Natalie Courtney Gock Kwai
    Lin CS-Y ; Sung JY ; Park SB ; Arnold R; Kwai N ; Krishnan AV , 2011, 'Pre-diabetic neuropathy: Axonal dysfunction evident prior to clinical neuropathy', in Journal of the Peripheral Nervous System, Wiley, Potomac, Unites States of America, presented at Peripheral Nerve Society Meeting, Potomac, Unites States of America, 25 September 2011 - 29 September 2011, http://dx.doi.org/10.1111/j.1529-8027.2011.00335.x
    Conference Papers | 2011
    Dr Natalie Courtney Gock Kwai
    Kwai N; Arnold R; Wickremaarachchi, C; Poynten AM; Lin C; Kiernan MC; Krishnan A, 2011, 'Neurophysiological parameters and impaired quality of life in diabetic peripheral neuropathy', Perth, presented at Australian Diabetes Society Scientific Meeting 2011, Perth, 31 August 2011

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