Dr Niantao   Deng
Conjoint Lecturer

Dr Niantao Deng

Medicine & Health
St Vincent's Clinical School

Dr Niantao Deng obtained his bachelors degree in Applied Mathematics from Shanghai Jiao Tong University in 2006. He then completed his Masters study in statistics and his PhD study in Computation Biology at the National University of Singapore.

He has worked on multiple projects on genetic and epigenetic characterisation of Gastric Cancer using large cohorts of high-throughput microarray and sequencing data. His current interests are to extend the use of statistical methodologies to analyse/integrate large cohorts of breast cancer datasets and help to address some critical questions, such as disease stratification and drug response prediction..

Phone
+61 (0)2 9355 5890
Location
The Kinghorn Cancer Centre Garvan Institute of Medical Research 384 Victoria Street, Darlinghurst, NSW 2010

Publications

  • Journal articles | 2020
    Dr Niantao Deng
    Castillo L; Young AIJ; Mawson A; Schafranek P; Steinmann AM; Nessem D; Parkin A; Johns A; Chou A; Law AMK; Lucas MC; Murphy KJ; Deng N; Gallego-Ortega D; Caldon CE; Timpson P; Pajic M; Ormandy CJ; Oakes SR, 2020, 'MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma', Oncogene, vol. 39, pp. 1821 - 1829, http://dx.doi.org/10.1038/s41388-019-1091-0
    Journal articles | 2020
    Dr Niantao Deng
    Lee C; Fernandez KJ; Alexandrou S; Marcelo Sergio C; Deng N; Rogers S; Burgess A; Elizabeth Caldon C, 2020, 'Cyclin E2 promotes whole genome doubling in breast cancer', Cancers, vol. 12, pp. 1 - 19, http://dx.doi.org/10.3390/cancers12082268
    Journal articles | 2019
    Dr Niantao Deng
    McCabe M; Gauthier M-E; Chan C-L; Thompson T; De Sousa S; Puttick C; Grady J; Gayevskiy V; Tao J; Ying K; Cipponi A; Deng N; Swarbrick A; Thomas M; kConFab ; Lord R; Johns A; Kohonen-Corish M; O'Toole S; Clark J; Mueller S; Gupta R; McCormack A; Dinger M; Cowley M, 2019, 'Development and validation of a targeted gene sequencing panel for application to disparate cancers', Scientific Reports
    Journal articles | 2019
    Dr Niantao Deng
    Lee CS; Rogers S; Fernandez K; Alexandrou S; Deng N; Sergio CM; Kulkarni A; Gugasyan L; Musgrove EA; Deans AJ; Burgess A; Caldon CE, 2019, 'Mechanisms underlying uncontrolled genome doubling in breast cancer', Oncology Abstracts, http://dx.doi.org/10.1530/oncolabs.1.p008
    Journal articles | 2019
    Dr Niantao Deng
    Castillo L; George S; Lin H-M; Yeung N; Mawson A; Young AI; Law AM; Hastings J; Gallego-Ortega D; Deng N; Croucher D; Swarbrick A; Horvath L; Ormandy CJ; Oakes SR, 2019, 'Flicking the switch off, targeting MCL-1 in the treatment of breast and prostate cancer', Oncology Abstracts, http://dx.doi.org/10.1530/oncolabs.1.p038
    Journal articles | 2019
    Dr Niantao Deng
    Chia KM; Milioli H; Portman N; Laven-Law G; Coulson R; Yong A; Segara D; Parker A; Caldon CE; Deng N; Swarbrick A; Tilley WD; Hickey TE; Lim E, 2019, 'Non-canonical AR activity facilitates endocrine resistance in breast cancer', Endocrine-Related Cancer, vol. 26, pp. 251 - 264, http://dx.doi.org/10.1530/ERC-18-0333
    Journal articles | 2019
    Dr Niantao Deng
    Brockwell NK; Rautela J; Owen KL; Gearing LJ; Deb S; Harvey K; Spurling A; Zanker D; Chan C-L; Cumming HE; Deng N; Zakhour JM; Duivenvoorden HM; Robinson T; Harris M; White M; Fox J; Ooi C; Kumar B; Thomson J; Potasz N; Swarbrick A; Hertzog PJ; Molloy TJ; O'Toole S; Ganju V; Parker BS, 2019, 'Tumor inherent interferon regulators as biomarkers of long-term chemotherapeutic response in TNBC', NPJ PRECISION ONCOLOGY, vol. 3, http://dx.doi.org/10.1038/s41698-019-0093-2
    Journal articles | 2019
    Dr Niantao Deng
    Liu YD; Yu L; Ying L; Balic J; Gao H; Deng NT; West A; Yan F; Ji CB; Gough D; Tan P; Jenkins BJ; Li JK, 2019, 'Toll-like receptor 2 regulates metabolic reprogramming in gastric cancer via superoxide dismutase 2', International Journal of Cancer, vol. 144, pp. 3056 - 3069, http://dx.doi.org/10.1002/ijc.32060
    Journal articles | 2018
    Dr Niantao Deng
    Cazet AS; Hui MN; Elsworth BL; Wu SZ; Roden D; Chan CL; Skhinas JN; Collot R; Yang J; Harvey K; Johan MZ; Cooper C; Nair R; Herrmann D; McFarland A; Deng N; Ruiz-Borrego M; Rojo F; Trigo JM; Bezares S; Caballero R; Lim E; Timpson P; O’Toole S; Watkins DN; Cox TR; Samuel MS; Martín M; Swarbrick A, 2018, 'Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-05220-6
    Journal articles | 2018
    Dr Niantao Deng
    Rogers S; McCloy RA; Parker BL; Gallego-Ortega D; Law AMK; Chin VT; Conway JRW; Fey D; Millar EKA; O’Toole S; Deng N; Swarbrick A; Chastain PD; Cesare AJ; Timpson P; Caldon CE; Croucher DR; James DE; Watkins DN; Burgess A, 2018, 'MASTL overexpression promotes chromosome instability and metastasis in breast cancer', Oncogene, vol. 37, pp. 4518 - 4533, http://dx.doi.org/10.1038/s41388-018-0295-z
    Journal articles | 2018
    Dr Niantao Deng
    Lin HM; Nikolic I; Yang J; Castillo L; Deng N; Chan CL; Yeung NK; Dodson E; Elsworth B; Spielman C; Lee BY; Boyer Z; Simpson KJ; Daly RJ; Horvath LG; Swarbrick A, 2018, 'MicroRNAs as potential therapeutics to enhance chemosensitivity in advanced prostate cancer', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-26050-y
    Journal articles | 2018
    Dr Niantao Deng
    Shearer RF; Frikstad KAM; McKenna J; McCloy RA; Deng N; Burgess A; Stokke T; Patzke S; Saunders DN, 2018, 'The E3 ubiquitin ligase UBR5 regulates centriolar satellite stability and primary cilia', Molecular Biology of the Cell, vol. 29, pp. 1542 - 1554, http://dx.doi.org/10.1091/mbc.E17-04-0248
    Journal articles | 2018
    Dr Niantao Deng
    Silva ANS; Coffa J; Menon V; Hewitt LC; Das K; Miyagi Y; Bottomley D; Slaney H; Aoyama T; Mueller W; Arai T; Tan IB; Deng N; Chan XB; Tan P; Tsuburaya A; Sakamaki K; Hayden JD; Yoshikawa T; Zondervan I; Savola S; Grabsch HI, 2018, 'Frequent Coamplification of Receptor Tyrosine Kinase and Downstream Signaling Genes in Japanese Primary Gastric Cancer and Conversion in Matched Lymph Node Metastasis', Annals of Surgery, vol. 267, pp. 114 - 121, http://dx.doi.org/10.1097/SLA.0000000000002042
    Journal articles | 2018
    Dr Niantao Deng
    Aziz D; Etemadmoghadam D; Caldon CE; Au-Yeung G; Deng N; Hutchinson R; Bowtell D; Waring P, 2018, '19q12 amplified and non-amplified subsets of high grade serous ovarian cancer with overexpression of cyclin E1 differ in their molecular drivers and clinical outcomes', Gynecologic Oncology, vol. 151, pp. 327 - 336, http://dx.doi.org/10.1016/j.ygyno.2018.08.039
    Journal articles | 2018
    Dr Niantao Deng
    Parkin A; Steinmann A; Froio D; Drury A; Vogel N; Murphy K; Deng N; Gill A; Timpson P; Pajic M, 2018, 'PO-046 Dual inhibition of JAK and Src: a novel and promising therapeutic combination for pancreatic cancer', ESMO Open, vol. 3, pp. A245 - A245, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.579
    Journal articles | 2017
    Dr Niantao Deng
    West AC; Tang K; Tye H; Yu L; Deng N; Najdovska M; Lin SJ; Balic JJ; Okochi-Takada E; McGuirk P; Keogh B; McCormack W; Bhathal PS; Reilly M; Oshima M; Ushijima T; Tan P; Jenkins BJ, 2017, 'Identification of a TLR2-regulated gene signature associated with tumor cell growth in gastric cancer', Oncogene, vol. 36, pp. 5134 - 5144, http://dx.doi.org/10.1038/onc.2017.121
    Journal articles | 2017
    Dr Niantao Deng
    Weinberg F; Reischmann N; Fauth L; Taromi S; Mastroianni J; Köhler M; Halbach S; Becker AC; Deng N; Schmitz T; Uhl FM; Herbener N; Riedel B; Beier F; Swarbrick A; Lassmann S; Dengjel J; Zeiser R; Brummer T, 2017, 'The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior', EBioMedicine, vol. 20, pp. 79 - 97, http://dx.doi.org/10.1016/j.ebiom.2017.04.015
    Journal articles | 2016
    Dr Niantao Deng
    Van Geldermalsen M; Wang Q; Nagarajah R; Marshall AD; Thoeng A; Gao D; Ritchie W; Feng Y; Bailey CG; Deng N; Harvey K; Beith JM; Selinger CI; O'Toole SA; Rasko JEJ; Holst J, 2016, 'ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer', Oncogene, vol. 35, pp. 3201 - 3208, http://dx.doi.org/10.1038/onc.2015.381
    Journal articles | 2016
    Dr Niantao Deng
    Kurashige J; Hasegawa T; Niida A; Sugimachi K; Deng N; Mima K; Uchi R; Sawada G; Takahashi Y; Eguchi H; Inomata M; Kitano S; Fukagawa T; Sasako M; Sasaki H; Sasaki S; Mori M; Yanagihara K; Baba H; Miyano S; Tan P; Mimori K, 2016, 'Integrated Molecular Profiling of Human Gastric Cancer Identifies DDR2 as a Potential Regulator of Peritoneal Dissemination', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep22371
    Journal articles | 2016
    Dr Niantao Deng
    Cutcutache I; Wu AY; Suzuki Y; McPherson JR; Lei Z; Deng N; Zhang S; Wong WK; Soo KC; Chan WH; Ooi LL; Welsch R; Tan P; Rozen SG, 2016, 'Abundant copy-number loss of CYCLOPS and STOP genes in gastric adenocarcinoma', Gastric Cancer, vol. 19, pp. 453 - 465, http://dx.doi.org/10.1007/s10120-015-0514-z
    Journal articles | 2015
    Dr Niantao Deng
    Phua YW; Nguyen A; Roden DL; Elsworth B; Deng N; Nikolic I; Yang J; Mcfarland A; Russell R; Kaplan W; Cowley MJ; Nair R; Zotenko E; O'Toole S; Tan SX; James DE; Clark SJ; Kouros-Mehr H; Swarbrick A, 2015, 'MicroRNA profiling of the pubertal mouse mammary gland identifies miR-184 as a candidate breast tumour suppressor gene', Breast Cancer Research, vol. 17, http://dx.doi.org/10.1186/s13058-015-0593-0
    Journal articles | 2015
    Dr Niantao Deng
    Chia NY; Deng N; Das K; Huang D; Hu L; Zhu Y; Lim KH; Lee MH; Wu J; Sam XX; Tan GS; Wan WK; Yu W; Gan A; Tan ALK; Tay ST; Soo KC; Wong WK; Dominguez LTM; Ng HH; Rozen S; Goh LK; The BT; Tan P, 2015, 'Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development', Gut, vol. 64, pp. 707 - 719, http://dx.doi.org/10.1136/gutjnl-2013-306596
    Journal articles | 2015
    Dr Niantao Deng
    Qian J; Kong X; Deng N; Tan P; Chen H; Wang J; Li Z; Hu Y; Zou W; Xu J; Fang JY, 2015, 'OCT1 is a determinant of synbindin-related ERK signalling with independent prognostic significance in gastric cancer', Gut, vol. 64, pp. 37 - 48, http://dx.doi.org/10.1136/gutjnl-2013-306584
    Journal articles | 2014
    Dr Niantao Deng
    Silva ANS; Coffa J; Miyagi Y; Menon V; Bottomley D; Ward LC; Aoyama T; Hayden JD; Arai T; Tan IB; Deng N; Chan XB; Lin SJ; Tan P; Yoshikawa T; Zondervan I; Savola S; Grabsch HI, 2014, 'Coamplification of receptor tyrosine kinases and downstream targets in Japanese gastric cancers.', Journal of Clinical Oncology, vol. 32, pp. 41 - 41, http://dx.doi.org/10.1200/jco.2014.32.3_suppl.41
    Journal articles | 2014
    Dr Niantao Deng
    Das K; Gunasegaran B; Tan IB; Deng N; Lim KH; Tan P, 2014, 'Mutually exclusive FGFR2, HER2, and KRAS gene amplifications in gastric cancer revealed by multicolour FISH', Cancer Letters, vol. 353, pp. 167 - 175, http://dx.doi.org/10.1016/j.canlet.2014.07.021
    Journal articles | 2014
    Dr Niantao Deng
    Muratani M; Deng N; Ooi WF; Lin SJ; Xing M; Xu C; Qamra A; Tay ST; Malik S; Wu J; Lee MH; Zhang S; Tan LLC; Chua H; Wong WK; Ong HS; Ooi LL; Chow PKH; Chan WH; Soo KC; Goh LK; Rozen S; Teh BT; Yu Q; Ng HH; Tan P, 2014, 'Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-associated cryptic promoters and somatically acquired regulatory elements', Nature Communications, vol. 5, http://dx.doi.org/10.1038/ncomms5361
    Journal articles | 2013
    Dr Niantao Deng
    Lei Z; Tan IB; Das K; Deng N; Zouridis H; Pattison S; Chua C; Feng Z; Guan YK; Ooi CH; Ivanova T; Zhang S; Lee M; Wu J; Ngo A; Manesh S; Tan E; Teh BT; So JBY; Goh LK; Boussioutas A; Lim TKH; Flotow H; Tan P; Rozen SG, 2013, 'Identification of molecular subtypes of gastric cancer with different responses to pi3-kinase inhibitors and 5-fluorouracil', Gastroenterology, vol. 145, pp. 554 - 565, http://dx.doi.org/10.1053/j.gastro.2013.05.010
    Journal articles | 2012
    Dr Niantao Deng
    Zouridis H; Deng N; Ivanova T; Zhu Y; Wong B; Huang D; Wu YH; Wu Y; Tan IB; Liem N; Gopalakrishnan V; Luo Q; Wu J; Lee M; Yong WP; Goh LK; Teh BT; Rozen S; Tan P, 2012, 'Methylation subtypes and large-scale epigenetic alterations in gastric cancer', Science Translational Medicine, vol. 4, http://dx.doi.org/10.1126/scitranslmed.3004504
    Journal articles | 2012
    Dr Niantao Deng
    Deng N; Goh LK; Wang H; Das K; Tao J; Tan IB; Zhang S; Lee M; Wu J; Lim KH; Lei Z; Goh G; Lim QY; Tan ALK; Poh DYS; Riahi S; Bell S; Shi MM; Linnartz R; Zhu F; Yeoh KG; Toh HC; Yong WP; Cheong HC; Rha SY; Boussioutas A; Grabsch H; Rozen S; Tan P, 2012, 'A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets', Gut, vol. 61, pp. 673 - 684, http://dx.doi.org/10.1136/gutjnl-2011-301839
    Journal articles | 2012
    Dr Niantao Deng
    Nagarajan N; Bertrand D; Hillmer AM; Zang ZJI; Yao F; Jacques PÉ; Teo ASM; Cutcutache I; Zhang Z; Lee WHE; Sia YYE; Gao S; Ariyaratne PN; Ho A; Woo XYI; Veeravali L; Ong CKI; Deng N; Desai KV; Khor CCH; Hibberd ML; Shahab A; Rao J; Wu M; Teh M; Zhu F; Chin SYU; Pang B; So JBY; Bourque G; Soong R; Sung WK; Tean Teh B; Rozen S; Ruan X; Yeoh KGU; Tan PBO; Ruan Y, 2012, 'Whole-genome reconstruction and mutational signatures in gastric cancer', Genome biology, vol. 13, pp. R115, http://dx.doi.org/10.1186/gb-2012-13-12-r115
    Journal articles | 2012
    Dr Niantao Deng
    Zang ZJ; Cutcutache I; Poon SL; Zhang SL; Mcpherson JR; Tao J; Rajasegaran V; Heng HL; Deng N; Gan A; Lim KH; Ong CK; Huang DC; Chin SY; Tan IB; Ng CCY; Yu W; Wu Y; Lee M; Wu J; Poh D; Wan WK; Rha SY; So J; Salto-Tellez M; Yeoh KG; Wong WK; Zhu YJ; Futreal PA; Pang B; Ruan Y; Hillmer AM; Bertrand D; Nagarajan N; Rozen S; Teh BT; Tan P, 2012, 'Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes', Nature Genetics, vol. 44, pp. 570 - 574, http://dx.doi.org/10.1038/ng.2246
    Journal articles | 2012
    Dr Niantao Deng
    Yan B; Yau EX; Samanta S; Ong CW; Yong KJ; Ng LK; Bhattacharya B; Lim KH; Soong R; Yeoh KG; Deng N; Tan P; Lam Y; Salto-Tellez M, 2012, 'Clinical and therapeutic relevance of PIM1 kinase in gastric cancer', Gastric Cancer, vol. 15, pp. 188 - 197, http://dx.doi.org/10.1007/s10120-011-0097-2
    Journal articles | 2011
    Dr Niantao Deng
    Oh HK; Tan ALK; Das K; Ooi CH; Deng NT; Tan IBH; Beillard E; Lee J; Ramnarayanan K; Rha SY; Palanisamy N; Voorhoeve PM; Tan P, 2011, 'Genomic loss of miR-486 regulates tumor progression and the OLFM4 antiapoptotic factor in gastric cancer', Clinical Cancer Research, vol. 17, pp. 2657 - 2667, http://dx.doi.org/10.1158/1078-0432.CCR-10-3152
    Journal articles | 2011
    Dr Niantao Deng
    Tan IB; Ivanova T; Lim KH; Ong CW; Deng N; Lee J; Tan SH; Wu J; Lee MH; Ooi CH; Rha SY; Wong WK; Boussioutas A; Yeoh KG; So J; Yong WP; Tsuburaya A; Grabsch H; Toh HC; Rozen S; Cheong JH; Noh SH; Wan WK; Ajani JA; Lee J; Tellez MS; Tan P, 2011, 'Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy', Gastroenterology, vol. 141, http://dx.doi.org/10.1053/j.gastro.2011.04.042
    Journal articles | 2011
    Dr Niantao Deng
    Tao J; Deng NT; Ramnarayanan K; Huang B; Oh HK; Leong SH; Lim SS; Tan IB; Ooi CH; Wu J; Lee M; Zhang S; Rha SY; Chung HC; Smoot DT; Ashktorab H; Kon OL; Cacheux V; Yap C; Palanisamy N; Tan P, 2011, 'CD44-SLC1A2 gene fusions in gastric cancer', Science Translational Medicine, vol. 3, http://dx.doi.org/10.1126/scitranslmed.3001423
  • Conference Abstracts | 2019
    Dr Niantao Deng
    Chia KM; Milioli HH; Portman N; Laven-Law G; Coulson R; Young A; Segara D; Parker A; Caldon L; Deng N; Swarbrick A; Tilley W; Hickey T; Lim E, 2019, 'Targeting AR in endocrine-resistant breast cancer', in Oncolabs, presented at 7th PacRim Breast & Prostate Cancer Meeting, http://dx.doi.org/10.1530/oncolabs.1.P012
    Conference Abstracts | 2018
    Dr Niantao Deng
    Hui MN; Cazet A; Elsworth B; Roden D; Cox T; Yang J; McFarland A; Deng N; Chan C-L; O'Toole S; Swarbrick A, 2018, 'Targeting the Hedgehog signalling pathway in triple negative breast cancer.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, Vol. 36, http://dx.doi.org/10.1200/JCO.2018.36.15_suppl.e24216
    Conference Papers | 2015
    Dr Niantao Deng
    Das K; Gunasegaran B; Tan IB; Deng N; Lim KH; Tan P, 2015, 'Abstract 4911: Mutually exclusive FGFR2, HER2, and KRAS gene amplifications in gastric cancer revealed by multicolor FISH', in Molecular and Cellular Biology, American Association for Cancer Research, presented at Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA, http://dx.doi.org/10.1158/1538-7445.am2015-4911
    Conference Papers | 2014
    Dr Niantao Deng
    Cutcutache I; Wu AY; McPherson JR; Lei Z; Deng N; Wong WK; Soo KC; Chan WH; Ooi LL; Welsch RE; Tan P; Rozen SG, 2014, 'Abstract 5168: Gastric adenocarcinomas show pervasive loss of heterozygosity and enrichment for “STOP” genes in regions of hemizygous deletion', in Molecular and Cellular Biology, American Association for Cancer Research, presented at Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA, http://dx.doi.org/10.1158/1538-7445.am2014-5168
    Conference Papers | 2013
    Dr Niantao Deng
    Lei Z; Deng NT; Zouridis H; Tan IB; Ooi CH; Ivanova T; Zhang S; Lee M; Wu J; Ngo A; Manesh S; Boussioutas A; Teh BT; Goh LK; Flotow H; Tan P; Rozen SG, 2013, 'Abstract 1200: Molecular subtypes of gastric cancer show systematic differences in response to PI3K inhibitors and fluorouracil.', in Clinical Research, American Association for Cancer Research, presented at Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC, http://dx.doi.org/10.1158/1538-7445.am2013-1200
    Conference Papers | 2011
    Dr Niantao Deng
    Tai WMD; Ooi WS; Ngeow JY; Deng N; Wang H; Tham CK; Lim HY; Choo SP; Tan P; Toh HC; Tan IB, 2011, 'A phase I study of dovitinib in combination with capecitabine and oxaliplatin in upfront treatment of advanced colorectal and gastric cancer with a dose expansion cohort in advanced gastric cancer.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, http://dx.doi.org/10.1200/jco.2011.29.15_suppl.tps174

Awards

2016 - National Breast Cancer Foundation Postdoctoral Fellowship

Grants

Media