Dr Ze Yu

Fields of research: Foetal and adult Cardiac Physiology and heart disease models in both large and small animals.

Research Interests: My research centres on heart disease development, including producing left ventricular hypertrophy in response to pressure overload and hypertension in rat or mice. How to treating those disease and understanding the molecular mechanisms are the two major research areas of my work. I am expanding my training in large and small animaly surgery and physiological monitoring to include the use of the isolated heart cell and immunocytochemistry to better understand normal development of heart cells and the effect of left ventricular hypertrophy on heart cell development form an early stage of the development until to adult life.

Qualifications: PhD, School of Physiology & Pharmacology UNSW, MB BS, China

Member of Australia Medical Council, American Heart Assocciation, Cardiac Society of Australia & New Zealand

Supervise Honours, Master and PhD Students

Phone

02 9295 8756

E-mail

j.yu@victorchang.edu.au

Location

Victor Chang Cardiac Research Institute 405 Liverpool Street DARLINGHURST NSW 2010

Journal articles | 2022

Yu ZY; Gong H; Kesteven S; Guo Y; Wu J; Li JV; Cheng D; Zhou Z; Iismaa SE; Kaidonis X; Graham RM; Cox CD; Feneley MP; Martinac B, 2022, 'Piezo1 is the cardiac mechanosensor that initiates the cardiomyocyte hypertrophic response to pressure overload in adult mice', Nature Cardiovascular Research, 1, pp. 577 - 591, http://dx.doi.org/10.1038/s44161-022-00082-0

Journal articles | 2021

Guo Y; Merten AL; Schöler U; Yu ZY; Cvetkovska J; Fatkin D; Feneley MP; Martinac B; Friedrich O, 2021, 'In vitro cell stretching technology (IsoStretcher) as an approach to unravel Piezo1-mediated cardiac mechanotransduction', Progress in Biophysics and Molecular Biology, 159, pp. 22 - 33, http://dx.doi.org/10.1016/j.pbiomolbio.2020.07.003

Journal articles | 2021

Guo Y; Yu ZY; Wu J; Gong H; Kesteven S; Iismaa SE; Chan AY; Holman S; Pinto S; Pironet A; Cox CD; Graham RM; Vennekens R; Feneley MP; Martinac B, 2021, 'The ca²⁺-activated cation channel trpm4 is a positive regulator of pressure overload-induced cardiac hypertrophy', eLife, 10, http://dx.doi.org/10.7554/eLife.66582

Journal articles | 2021

Li JV; Ng CA; Cheng D; Zhou Z; Yao M; Guo Y; Yu ZY; Ramaswamy Y; Ju LA; Kuchel PW; Feneley MP; Fatkin D; Cox CD, 2021, 'Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations', Communications Biology, 4, pp. 1038, http://dx.doi.org/10.1038/s42003-021-02528-w

Journal articles | 2021

Yu ZY; Gong H; Wu J; Dai Y; Kesteven SH; Fatkin D; Martinac B; Graham RM; Feneley MP, 2021, 'Cardiac Gq Receptors and Calcineurin Activation Are Not Required for the Hypertrophic Response to Mechanical Left Ventricular Pressure Overload', Frontiers in Cell and Developmental Biology, 9, pp. 639509, http://dx.doi.org/10.3389/fcell.2021.639509

Journal articles | 2017

Nikolova-Krstevski V; Wagner S; Yu ZY; Cox CD; Cvetkovska J; Hill AP; Huttner IG; Benson V; Werdich AA; MacRae C; Feneley MP; Friedrich O; Martinac B; Fatkin D, 2017, 'Endocardial TRPC-6 Channels Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk', JACC: Basic to Translational Science, 2, pp. 575 - 590, http://dx.doi.org/10.1016/j.jacbts.2017.05.006

Journal articles | 2017

Wang LW; Huttner IG; Santiago CF; Kesteven SH; Yu ZY; Feneley MP; Fatkin D; Martin I, 2017, 'Standardized echocardiographic assessment of cardiac function in normal adult zebrafish and heart disease models', DMM Disease Models and Mechanisms, 10, pp. 63 - 76, http://dx.doi.org/10.1242/dmm.026989

Journal articles | 2016

Wang L; Huttner I; Santiago C; Yu Z; Kesteven S; Feneley M; Fatkin D, 2016, 'Development and Validation of a Novel Technique for High Frequency Echocardiography in Zebrafish Models of Health and Disease Provide Key Insights into Cardiac Physiology and Applications for Studying Heart Failure', Heart, Lung and Circulation, 25, pp. S106 - S106, http://dx.doi.org/10.1016/j.hlc.2016.06.251

Journal articles | 2015

Cannon L; Yu ZY; Marciniec T; Waardenberg AJ; Iismaa SE; Nikolova-Krstevski V; Neist E; Ohanian M; Qiu MR; Rainer S; Harvey RP; Feneley MP; Graham RM; Fatkin D, 2015, 'Irreversible triggers for hypertrophic cardiomyopathy are established in the early postnatal period', Journal of the American College of Cardiology, 65, pp. 560 - 569, http://dx.doi.org/10.1016/j.jacc.2014.10.069

Journal articles | 2014

Yu ZY; Tan JC; McMahon AC; Iismaa SE; Xiao H; Kesteven SH; Reichelt ME; Mohl MC; Smith NJ; Fatkin D; Allen D; Head SI; Graham RM; Feneley MP, 2014, 'RhoA/ROCK signaling and pleiotropic α1A-adrenergic receptor regulation of cardiac contractility', PLoS ONE, 9, http://dx.doi.org/10.1371/journal.pone.0099024

Journal articles | 2013

Yu Z; Tan J; McMahon A; Iismaa S; Xiao X; Kesteven S; Reichelt M; Mohl M; Dai Y; Sketchley A; Yang L; Gong H; Fatkin D; Allen D; Head S; Graham R; Feneley M, 2013, 'Studies of a Mouse Model of Cardiac α1A-Adrenergic Receptor Overexpression Provide Evidence For a Critical Role of RhoA/ROCK Signalling in Cardiac Contractility', Heart, Lung and Circulation, 22, pp. S59 - S59, http://dx.doi.org/10.1016/j.hlc.2013.05.143

Journal articles | 2011

Fatkin D; Mohl M; Iismaa SE; Xiao XH; Friedrich O; Wagner ; Nikolova-Krstevski ; Wu J; Yu ZY; Feneley MP; Allen ; Graham RM, 2011, 'Regulation of murine cardiac contractility by activation of alpha(1A)-adrenergic receptor-operated Ca(2+) entry', Cardiovascular Research, 91, pp. 310 - 319, http://dx.doi.org/10.1093/cvr/cvr081

Journal articles | 2011

Nikolova V; Leimena C; Xiao X; Kesteven SH; Tan J; Yeo LS; Yu ZY; Zhang Q; Carlton A; Head SI; Shanahan C; Feneley MP; Fatkin D, 2011, 'Nesprin-1 and actin contribute to nuclear and cytoskeletal defects in lamin A/C-deficient cardiomyopathy', Journal of Molecular and Cellular Cardiology, 50, pp. 479 - 486, http://dx.doi.org/10.1016/j.yjmcc.2010.12.001

Journal articles | 2007

Yu ZY; McKay K; van Asperen P; Zheng M; Fleming J; Ginn S; Kizana E; Latham M; Feneley MP; Kirkland P; Rowe PB; Lumbers ER; Alexander I, 2007, 'Lentivirus vector-mediated gene transfer to the developing bronchiolar airway epithelium in the fetal lamb', Journal of Gene Medicine, 9, pp. 429 - 439, http://dx.doi.org/10.1002/jgm.1039

Journal articles | 2003

Lumbers ER; Yu ZY; Crawford EN, 2003, 'Effects of fetal behavioral states on renal sympathetic nerve activity and arterial pressure of unanesthetized fetal sheep', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 285, http://dx.doi.org/10.1152/ajpregu.00252.2003

Journal articles | 2002

Yu Z; Lumbers ER; Simonetta G, 2002, 'The cardiovascular and renal effects of acute and chronic inhibition of nitric oxide production in fetal sheep', Experimental Physiology, 87, pp. 343 - 351, http://dx.doi.org/10.1113/eph8702339

Journal articles | 2002

Yu Z; Lumbers ER, 2002, 'Effects of Birth of Barorecptor-Mediated Changes in Heart Rate Variability in Lambs and Fetal Sheep', Clinical and Experimental Pharmacology and Physiology, 29, pp. 455 - 463, http://dx.doi.org/10.1046/j.1440-1681.2002.03678.x

Journal articles | 2001

Lumbers ER; Yu Z; Gibson KJ, 2001, 'The Selfish Brain and the Barker Hypothesis', Clinical and Experimental Pharmacology and Physiology, 28, pp. 942 - 947, http://dx.doi.org/10.1046/j.1440-1681.2001.03554.x

Journal articles | 2000

Scott JF; Chen Y; Yu Z; Loidl A; Guo R; Bhalla AS; Crostella L, 2000, 'Dielectric polarization process in Bi:SrTiO3', Journal of Physics and Chemistry of Solids, 61, pp. 191 - 196, http://dx.doi.org/10.1016/S0022-3697(99)00281-4

Journal articles | 2000

Yu Z; Lumbers ER, 2000, 'Effect of cold on fetal heart rate and its variability', Clinical and Experimental Pharmacology and Physiology, 27, pp. 607 - 611, http://dx.doi.org/10.1046/j.1440-1681.2000.03305.x

Journal articles | 2000

Yu Z; Lumbers ER, 2000, 'Measurement of baroreceptor mediated effects on heart rate variability in fetal sheep', Pediatric Research, 47, pp. 233 - 239

Journal articles | 1999

Dodic M; Peers A; Coghlan JP; May CN; Lumbers ER; Yu Z; Wintour EM, 1999, 'Altered cardiovascular haemodynamics and baroreceptor-heart rate reflex in adult sheep after prenatal exposure to dexamethasone', Clinical Science, 97, pp. 103 - 109, http://dx.doi.org/10.1042/CS19980356

Journal articles | 1999

Lumbers ER; Yu Z, 1999, 'A method for determining baroreflex mediated sympathetic and parasympathetic control of the heart in pregnant and non-pregnant sheep', The Journal of Physiology, pp. 555 - 566

Journal articles | 1999

Scott JF; Ang CH; Yu Z; Ledbetter H; Baptista JL, 1999, 'Dielectric and ultrasonic anomalies at 16, 37, and 65K in SrTiO3', Physical Review - Section B - Condensed Matter, 59, pp. 6661 - 6664, http://dx.doi.org/10.1103/PhysRevB.59.6661

Journal articles | 1998

Yu Z; Lumbers ER; Gibson KJ; Stevens AD, 1998, 'Effects of hypoxaemia on foetal heart rate, variability and cardiac rhythm', Clinical and Experimental Pharmacology and Physiology, 25, pp. 577 - 584, http://dx.doi.org/10.1111/j.1440-1681.1998.tb02255.x
Conference Papers | 2007

Yu Z; Lismaa S; Tan JC; Marcininec T; McMahon AC; Sharp D; Kesteven SH; Xiao X; Reichelt M; Wang ZM; Williamson DJ; Graham RM; Fenely M, 2007, 'Cardiac restricted alpha 1A-Adrenergic receptor overexpression in the adult rodent heart induces a hypersensitive contractile response to adrenergic stimulation with reduced baseline contractility but no hypertrophy', in Circulation, Lippincott Williams & Wilkins, Philadelphia, PA, USA, pp. 195 - 195, presented at 80th Annual Scientific Session of the American-Heart-Association, Orlando, Florida, USA, 04 November 2007 - 07 November 2007, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000250394300864&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Conference Papers | 2000

Lumbers ER; Yu Z, 2000, 'A method of determining baroreflex-mediated sympathetic and parasympathetic control of heart in pregnant and non-pregnant ewes', in Proceedings of Aust Neuroscience Society, 20th annual meeting Australian Neuroscience Society, Melbourne Convention Centre, pp. 180, presented at 20th annual meeting Australian Neuroscience Society, Melbourne Convention Centre, 30 January 2000 - 02 February 2000

Conference Papers | 2000

Lumbers ER; Yu Z, 2000, 'Effects of arterial pressure on renal sympathetic nerve activity of conscious unanaesthetised fetal sheep', in Proceedings of Aust Neuroscience Society, 20th annual meeting Australian Neuroscience Society, Melbourne Convention Centre, pp. 88, presented at 20th annual meeting Australian Neuroscience Society, Melbourne Convention Centre, 30 January 2000 - 02 February 2000

Conference Papers | 2000

Lumbers ER; Yu Z, 2000, 'Effects of birth on baroreceptor mediated changes in heart rate variability in chronically catheterised fetal sheep', in Chinese Perinatal Society Annual Meeting, Chinese Perinatal Society Annual Meeting, Harbin, China, presented at Chinese Perinatal Society Annual Meeting, Harbin, China, 25 April 2000 - 27 April 2000

Conference Papers | 2000

Simonetta G; Yu Z; Lumbers ER, 2000, 'Long-term nitric oxide synthase inhibition enhances the pressor responses to angiotensin II and noradrenaline in the fetal sheep', in Federation of American Societies for Experimantal Biology Journal, Federation American Society Exp Biol, Bethesda, MD, USA, pp. 17, presented at FASEB Summer Research Conference, Copper Mt, Colorado, USA, 04 June 2000 - 09 June 2000

Conference Papers | 2000

Yu Z; Lumbers ER; Garlick DG, 2000, 'Relationships between resting heart rate, baroreflex gain and the time to onset of heart rate and blood pressure responses to the valsalva maneuvre', in Proceedings of the High Blood Pressure Research Council of Australia, 22nd Annual Scientific Meet. of High Blood Pressure Research Council of Aust, University of Sydney, pp. 29, presented at 22nd Annual Scientific Meet. of High Blood Pressure Research Council of Aust, University of Sydney, 07 December 2000 - 09 December 2000

Conference Papers | 2000

Yu Z; Lumbers ER, 2000, 'Effects of fetal hypertension and hypotension on fetal behavioural states and on renal sympathetic nerve activity', in Endocrincology and Development (Wyeth Meeting), Endocrincology and Development (Wyeth Meeting), McLaren Vale, SA, presented at Endocrincology and Development (Wyeth Meeting), McLaren Vale, SA, 03 November 2000 - 04 November 2000

Conference Papers | 2000

Yu Z; Lumbers ER, 2000, 'Effects of nitric oxide synthase inhibition on cardiovascular and renal function of fetal sheep', in Proceedings of the High Blood Pressure Research Council of Australia, 22nd Annual Scientific Meet. of High Blood Pressure Research Council of Aust, University of Sydney, pp. 63, presented at 22nd Annual Scientific Meet. of High Blood Pressure Research Council of Aust, University of Sydney, 07 December 2000 - 09 December 2000

Conference Papers | 1999

Simonetta G; Yu Z; Lumbers ER, 1999, 'Impact of long-term NOS inhibition on pressor responses in the fetal sheep', in Proceedings for the Australian Society for Medical Research, 38th National Scientific Conference Of the Aust. Society for medical research, Leura, NSW, pp. 4-3, presented at 38th National Scientific Conference Of the Aust. Society for medical research, Leura, NSW, 27 November 1999 - 29 November 1999

Conference Papers | 1999

Yu Z; Lumbers ER; Simonetta G, 1999, 'Does nitric oxide deficiency in late gestation alter programming of the cardiovascular system?', in Perinatal Society of Aust and New Zealand, Perinatal Society of Aust. and New Zealand Congress, Melbourne, pp. 261, presented at Perinatal Society of Aust. and New Zealand Congress, Melbourne, 21 March 1999 - 24 March 1999

Conference Papers | 1999

Yu Z; Simonetta G; Lumbers ER, 1999, 'The effect of netric oxide deficiency on the pressor reponses to angiotensin II and noradrenaline in fetal sheep?', in 13th Nat. Workshop on Fetal and Neonatal Physiol, 13th Nat. Workshop on Fetal and Neonatal Physiol, Melbourne, pp. A38, presented at 13th Nat. Workshop on Fetal and Neonatal Physiol, Melbourne, 20 March 1999 - 21 March 1999

Conference Papers | 1998

Dodic M; Wintour EM; Lumbers ER; Yu Z; Coghlan JP, 1998, 'Programming of hypertension in sheep by short exposure to dexamethasone early in gestation', in 4th Congress of the Federation of Asian and Oceanian Physiological Societies, 4th Congress of FAOPS, Brisbane, Qld, presented at 4th Congress of FAOPS, Brisbane, Qld, 27 September 1998 - 01 October 1998

Conference Papers | 1998

Dodic M; Wintour EM; Lumbers ER; Yu Z; Coghlan JP, 1998, 'Programming of hypertension in sheep by short exposure to dexamethasone early in gestation', in Australian Physiol. Pharmacol Society, Australian Physiol. Pharmacol Society, pp. 346, presented at Australian Physiol. Pharmacol Society

Conference Papers | 1998

Lumbers ER; Yu Z, 1998, 'A comparison of baroreceptor mediated effects on heart rate and on heart, rate variability in fetal, lamb and adult sheep', in Cardiovascular function in Health and Disease, Cardiovascular function in Health and Disease, Sydney, presented at Cardiovascular function in Health and Disease, Sydney, 25 June 1998 - 26 June 1998

Conference Papers | 1998

Yu Z; Lumbers ER, 1998, 'A method of determining baroreflex mediated sympathetic and parasympathetic control of the heart in pregnant and non-pregnant sheep.', in Cardiovascular function in Health and Disease, Sydney, pp. 555 - 566, presented at Cardiovascular function in Health and Disease, Sydney, 25 June 1998 - 26 June 1998, http://dx.doi.org/10.1111/j.1469-7793.1999.555ac.x

Conference Papers | 1998

Yu Z; Lumbers ER, 1998, 'A new method of measuring baroreflex mediated sympathetic and parasympathetic regulation of the heart rates of adult and fetal sheep', in 4th Congress of the Federation of Asian and Oceanian Physiological Societies, 4th Congress of FAOPS, Brisbane, Qld, presented at 4th Congress of FAOPS, Brisbane, Qld, 27 September 1998 - 01 October 1998

Conference Papers | 1998

Yu Z; Lumbers ER, 1998, 'A new method of measuring baroreflex mediated sympathetic and parasympathetic regulation of the heart rates of adult and fetal sheep', in Australian Physiol. Pharmacol Society, Australian Physiol. Pharmacol Society, pp. 338, presented at Australian Physiol. Pharmacol Society

Conference Papers | 1997

Lumbers ER; Yu Z, 1997, 'Assessment of the neural components of baroreflex mediated control of the heart using heart rate variability in the chronically catheterised pregnant sheep.', in 33rd International Union Physiological society, 33rd International Union Physiological society, St Petersberg, presented at 33rd International Union Physiological society, St Petersberg, 30 June 1997 - 05 July 1997

Conference Papers | 1997

Yu Z; Lumbers ER, 1997, 'Comparison of the effect of change in arterial pressure on heart rate variability in fetal sheep, non-pregnant and pregnant ewes.', in FASEB Summer Research Conference, Perinatal Regulation of the Cardiovascular System, FASEB Summer Research Conference, Perinatal Regulation of the Cardiovascular System, Colorado, USA, presented at FASEB Summer Research Conference, Perinatal Regulation of the Cardiovascular System, Colorado, USA, 17 August 1997 - 20 August 1997

Conference Papers | 1997

Yu Z; Lumbers ER, 1997, 'The fetal heart rate response to changes in arterial pressure.', in Hagan R (ed.), 1st Annual Congress of the Perinatal Society of Australia and New Zealand, 1st Annual Congress of the Perinatal Society of Australia and New Zealand, Fremantle, WA, presented at 1st Annual Congress of the Perinatal Society of Australia and New Zealand, Fremantle, WA, 16 March 1997 - 20 March 1997

Conference Papers | 1997

Zhang DY; Lumbers ER; Yu Z, 1997, 'Developmental changes in angiotensinogen gene expression and its protein content in fetal sheep.', in FASEB Summer Research Conference, Perinatal Regulation of the Cardiovascular System, FASEB Summer Research Conference, Perinatal Regulation of the Cardiovascular System, Colorado, USA, presented at FASEB Summer Research Conference, Perinatal Regulation of the Cardiovascular System, Colorado, USA, 17 August 1997 - 20 August 1997

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