Dr Zhihong Xu

Dr Zhihong Xu

PhD thesis title: Stromal-tumour interaction in pancreatic cancer. Faculty of Medicine, UNSW Sydney.

Medicine & Health
School of Clinical Medicine

I obtained my PhD degree at UNSW Sydney. My research interests focus on pancreatic cancer, chronic pancreatitis and pancreatic stellate cells. I have published more than 20 peer-reviewed publications with total citations over 1500 and one book chapter, 10 publications and over 1200 citations in the past five years, and an H-index of 17. I'm a co-investigator of an Ideas Grant (2020-2023) funded by Australian National Health and Medical Research Council, the chief investigator of a project founded by Tour de Cure in 2019 and a co-investigator of a 3-year project (2018-2020) funded by Avner Pancreatic Cancer Foundation. 

02 8738 9197
Level 4, Ingham Institute, No. 1 Campbell Street, Liverpool, NSW 2170 Australia
  • Journal articles | 2020
    Pothula SP; Xu Z; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2020, 'Targeting hgf/c-met axis in pancreatic cancer', International Journal of Molecular Sciences, vol. 21, pp. 1 - 18, http://dx.doi.org/10.3390/ijms21239170
    Journal articles | 2017
    Lugea A; Gerloff A; Su HY; Xu Z; Go A; Hu C; French SW; Wilson JS; Apte MV; Waldron RT; Pandol SJ, 2017, 'The Combination of Alcohol and Cigarette Smoke Induces Endoplasmic Reticulum Stress and Cell Death in Pancreatic Acinar Cells', Gastroenterology, vol. 153, pp. 1674 - 1686, http://dx.doi.org/10.1053/j.gastro.2017.08.036
    Journal articles | 2017
    Pang TCY; Xu Z; Pothula S; Becker T; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2017, 'Circulating pancreatic stellate (stromal) cells in pancreatic cancer-a fertile area for novel research', Carcinogenesis, vol. 38, pp. 588 - 591, http://dx.doi.org/10.1093/carcin/bgx030
    Journal articles | 2016
    Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Arozena AA; Adachi H; Adams CM; Adams PD; Adeli K; Adhihetty PJ; Adler SG; Agam G; Agarwal R; Aghi MK; Agnello M; Agostinis P; Aguilar PV; Aguirre-Ghiso J; Airoldi EM; Ait-Si-Ali S; Akematsu T; Akporiaye ET; Al-Rubeai M; Albaiceta GM; Albanese C; Albani D; Albert ML; Aldudo J; Algül H; Alirezaei M; Alloza I; Almasan A; Almonte-Beceril M; Alnemri ES; Alonso C; Altan-Bonnet N; Altieri DC; Alvarez S; Alvarez-Erviti L; Alves S; Amadoro G; Amano A; Amantini C; Ambrosio S; Amelio I; Amer AO; Amessou M; Amon A; An Z; Anania FA; Andersen SU; Andley UP; Andreadi CK; Andrieu-Abadie N; Anel A; Ann DK; Anoopkumar-Dukie S; Antonioli M; Aoki H; Apostolova N; Aquila S; Aquilano K; Araki K; Arama E; Aranda A; Araya J; Arcaro A; Arias E; Arimoto H; Ariosa AR; Armstrong JL; Arnould T; Arsov I; Asanuma K; Askanas V; Asselin E; Atarashi R; Atherton SS; Atkin JD; Attardi LD; Auberger P; Auburger G; Aurelian L; Autelli R; Avagliano L; Avantaggiati ML; Avrahami L; Azad N; Awale S; Bachetti T; Backer JM; Bae DH; Bae JS; Bae ON; Bae SH; Baehrecke EH; Baek SH; Baghdiguian S; Bagniewska-Zadworna A, 2016, 'Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)', Autophagy, vol. 12, pp. 1 - 222, http://dx.doi.org/10.1080/15548627.2015.1100356
    Journal articles | 2015
    Ali S; Suresh R; Banerjee S; Bao B; Xu Z; Wilson J; Philip PA; Apte M; Sarkar FH, 2015, 'Contribution of microRNAs in understanding the pancreatic tumor microenvironment involving cancer associated stellate and fibroblast cells', AMERICAN JOURNAL OF CANCER RESEARCH, vol. 5, pp. 1251 - 1264, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000354772800030&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2015
    Apte MV; Xu Z; Pothula S; Goldstein D; Pirola RC; Wilson JS, 2015, 'Pancreatic cancer: The microenvironment needs attention too!', Pancreatology, vol. 15, pp. S32 - S38, http://dx.doi.org/10.1016/j.pan.2015.02.013
    Journal articles | 2014
    Patel MB; Pothula SP; Xu Z; Lee AK; Goldstein D; Pirola RC; Apte MV; Wilson JS, 2014, 'The role of the hepatocyte growth factor/c-MET pathway in pancreatic stellate cell-endothelial cell interactions: Anti-angiogenic implications in pancreatic cancer', Carcinogenesis, vol. 35, http://dx.doi.org/10.1093/carcin/bgu122
    Journal articles | 2014
    Xu Z; Pothula SP; Wilson JS; Apte MV, 2014, 'Pancreatic cancer and its stroma: A conspiracy theory', World Journal of Gastroenterology, vol. 20, pp. 11216 - 11229, http://dx.doi.org/10.3748/wjg.v20.i32.11216
  • Conference Papers | 2015
    Pothula S; Xu Z; Goldstein D; Pirola R; Wilson JS; Apte M, 2015, 'Pancreatic cancer: stromal reprogramming offers a novel therapeutic approach', in PANCREAS, LIPPINCOTT WILLIAMS & WILKINS, San Diego, Pancreas 44(8):1407, pp. 1407 - 1408, presented at American Pancreatic Association, San Diego, Pancreas 44(8):1407, - , http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000363324000233&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Conference Papers | 2015
    Xu Z; Pothula S; Pandol S; Pirola R; Wilson JS; Apte M, 2015, 'Smoking worsens the fibrosis of alcoholic chronic pancreatitis via activation of pancreatic stellate cells', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY, San Diego, Pancreas 44(8):1426, pp. 13 - 14, presented at American Pancreatic Association, San Diego, Pancreas 44(8):1426, - , http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000363324000306&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Conference Papers | 2006
    Vonlaufen A; Xu Z; Daniel B; Joshi SB; Kumar RK; Pirola RC; Wilson JS; Apte MV, 2006, 'Bacterial endotoxin: a trigger factor for alcoholic pancreatitis? Evidence from a novel, physiologically relevant animal model', in Pancreas, Lippincott Williams & Wilkins, pp. 506 - 507, http://dx.doi.org/10.1053/j.gastro.2007.06.062

1.    Co-investigator of National Health and Medical Research Council Ideas Grant. Pancreatic Cancer-Related Diabetes: Novel Role of Pancreatic Stellate Cells (2020 2023; $486,210).

2.     Lead Researcher of Tour de Cure of pancreatic cancer: Capture, investigate and target circulating stromal cells and cancer cells (2019; $80,000). Funded by Tour de Cure.

3.     Co-investigator of Avner Pancreatic Cancer Foundation Accelerator Grant. Pathway to a Novel Treatment for Pancreatic Cancer – Targeting the Microenvironment (Stroma) (2018 – 2020; $735,815)

  • Basic Research Paper of the Year by the South West Sydney Clinical Campuses. Xu et al., Targeting the HGF/c-MET pathway in advanced pancreatic cancer: A key element of treatment that limits primary tumour growth and eliminates metastasis. Br J Cancer 2020 May; 122(10): 1486–1495.
  • Finalist of Young Investigator Award, Australian Gastroenterology Week 2019. Xu Z., et al. Inhibition of Hepatocyte Growth Factor (HGF) Signalling Pathway in Combination with Chemotherapy Reduces Tumour Burden in an Orthotopic Model of Advanced Pancreatic Cancer. 8-10 Sep 2019, Adelaide Convention Centre, Australia. ​
  • Young Investigator Travel Award for the 2018 the annual meeting of the American Pancreatic Association (APA), 31 Oct - 3 November 2018, Miami, Florida, USA.  
  • Travel Award from International Association of Pancreatology (IAP) for the 2017 IAP and LAPSG Joint Meeting. 28-30 September 2017, Buenos Aires, Argentina.  
  • Papers of the Year Biomedical Research (South Western Sydney Clinical School, Faculty of Medicine, UNSW Sydney). Lee*, Xu* et al (*Equal first authors). Alcohol and cigarette smoke components activate human pancreatic stellate cells: Implications for the progression of chronic pancreatitis.Alcoholism: Clinical and Experimental Research. Vol 39(11):2123-33.  
  • Young Investigator Travel Award from IAP for the joint annual meeting of the Pancreatic Cancer Committee of Chinese Anti-Cancer Association and IAP, 27-29 August 2015, Shanghai, China.  Paper of the Month Awards (School of Medical Sciences, Faculty of Medicine, UNSW Sydney): Xu et al, Role of pancreatic stellate cells in pancreatic cancer metastasis. Am J Patho, Vol 177 (5):2585-96. 

My research interests focus on pancreatic cancer, chronic pancreatitis and the biology of pancreatic exocrine function. 

My Research Supervision