Sophia Gu

Senior Lecturer

Dr Zi (Sophia) Gu is a Senior Lecturer, Principle Investigator, and Head of NanoBiotechnology Research Laboratory at School of Chemical Engineering of UNSW. After PhD training at The University of Queensland and Cornell University (US), she was engaged in a commercialisation project of drug-delivered nanotechnologies which led to 5 successful Clinical Trials. She was awarded a NHMRC Peter Doherty Biomedical Early Career Fellowship in 2014, prior to joining UNSW in 2016. She was promoted to Senior Lecturer in 2019. Currently, she leads a NanoBiotechnology Research Group working on multidisciplinary research projects that combine the knowledge and skills across material chemistry, biomedical engineering and nanotechnology, and developed several nanoparticle platforms for disease diagnosis and treatment. She has published >60 research papers and filed a provisional patent. Most of these publications are in top tier journals in the fields of Material Science (Advanced Materials, Advanced Functional Materials, Materials Horizons), Nanotechnology (Advanced Science, Small, Small Methods), Chemistry (Chemistry of Materials), Biomaterials (Biomaterials), and Pharmaceutical Science (Journal of Controlled Release, Pharmaceutics). She has been awarded several grants and awards and has several academic leadership roles such as international conference chair, and an Associate Editor for Journal of Nanobiotechnology (Springer Nature).

Research Appointments
Senior Lecturer, University of New South Wales, 2019-present
Lecturer (Tenure), University of New South Wales, 2018
Lecturer (Tenure Track), University of New South Wales, 2016-2018
NHMR EC Fellow, University of New South Wales, 2016-2019
NHMRC EC Fellow, University of Queensland, 2014-2016
Postdoctoral Researcher, University of Queensland, 2011-2013
Research Fellow, Cornell University, US, 2010


Course Teaching
CEIC6712 Pharmaceutical Design and Engineering
GSOE9111 Energy Storage
CEIC Thesis A, B, C (project supervision)

 

Journal articles
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Wang X; Yan M; Zhou J; Song W; Xiao Y; Cui C; Gao W; Ke F; Zhu J; Gu Z; Hou R, 2021, 'Delivery of acetamiprid to tea leaves enabled by porous silica nanoparticles: efficiency, distribution and metabolism of acetamiprid in tea plants', BMC Plant Biology, vol. 21, http://dx.doi.org/10.1186/s12870-021-03120-4
2021
Guo Z; Xie W; Lu J; Guo X; Chi Y; Wang D; Takuya N; Xu W; Ye J; Liu X; Gu Z; Xu B; Wu H; Zhao L, 2021, 'Ferrous ions doped layered double hydroxide: Smart 2D nanotheranostic platform with imaging-guided synergistic chemo/photothermal therapy for breast cancer', Biomaterials Science, vol. 9, pp. 5928 - 5938, http://dx.doi.org/10.1039/d1bm00765c
2021
Peguda HK; Mahbub SB; Sherpa TD; Subedi D; Habibalahi A; Anwer AG; Gu Z; Willcox MDP; Goldys EM; Carnt NA, 2021, 'The autofluorescence patterns of acanthamoeba castellanii, pseudomonas aeruginosa and staphylococcus aureus: Effects of antibiotics and tetracaine', Pathogens, vol. 10, http://dx.doi.org/10.3390/pathogens10070894
2021
Han J; Cui Y; Li F; Gu Z; Yang D, 2021, 'Responsive disassembly of nucleic acid nanocomplex in cells for precision medicine', Nano Today, vol. 39, http://dx.doi.org/10.1016/j.nantod.2021.101160
2021
Han J; Cui Y; Gu Z; Yang D, 2021, 'Controllable assembly/disassembly of polyphenol-DNA nanocomplex for cascade-responsive drug release in cancer cells', Biomaterials, vol. 273, pp. 120846, http://dx.doi.org/10.1016/j.biomaterials.2021.120846
2021
Li F; Yu W; Zhang J; Dong Y; Ding X; Ruan X; Gu Z; Yang D, 2021, 'Spatiotemporally programmable cascade hybridization of hairpin DNA in polymeric nanoframework for precise siRNA delivery', Nature Communications, vol. 12, pp. 1138, http://dx.doi.org/10.1038/s41467-021-21442-7
2021
Zhao H; Li T; Yao C; Gu Z; Liu C; Li J; Yang D, 2021, 'Dual Roles of Metal-Organic Frameworks as Nanocarriers for miRNA Delivery and Adjuvants for Chemodynamic Therapy', ACS Applied Materials and Interfaces, vol. 13, pp. 6034 - 6042, http://dx.doi.org/10.1021/acsami.0c21006
2021
Zhao H; Lv J; Li F; Zhang Z; Zhang C; Gu Z; Yang D, 2021, 'Enzymatical biomineralization of DNA nanoflowers mediated by manganese ions for tumor site activated magnetic resonance imaging', Biomaterials, vol. 268, http://dx.doi.org/10.1016/j.biomaterials.2020.120591
2021
Zhao H; Liu C; Gu Z; Dong L; Li F; Yao C; Yang D, 2020, 'Persistent Luminescent Nanoparticles Containing Hydrogels for Targeted, Sustained, and Autofluorescence-Free Tumor Metastasis Imaging', Nano Letters, vol. 20, pp. 252 - 260, http://dx.doi.org/10.1021/acs.nanolett.9b03755
2020
Ge J; Zhang Q; Zeng J; Gu Z; Gao M, 2020, 'Radiolabeling nanomaterials for multimodality imaging: New insights into nuclear medicine and cancer diagnosis', Biomaterials, vol. 228, http://dx.doi.org/10.1016/j.biomaterials.2019.119553
2020
Tang J; Yao C; Gu Z; Jung S; Luo D; Yang D, 2020, 'Super-Soft and Super-Elastic DNA Robot with Magnetically Driven Navigational Locomotion for Cell Delivery in Confined Space', Angewandte Chemie - International Edition, vol. 59, pp. 2490 - 2495, http://dx.doi.org/10.1002/anie.201913549
2020
Cao Z; Li B; Sun L; Li L; Xu ZP; Gu Z, 2020, '2D Layered Double Hydroxide Nanoparticles: Recent Progress toward Preclinical/Clinical Nanomedicine', Small Methods, vol. 4, http://dx.doi.org/10.1002/smtd.201900343
2020
Zhang Q; Liang J; Yun SLJ; Liang K; Yang D; Gu Z, 2020, 'Recent advances in improving tumor-targeted delivery of imaging nanoprobes', Biomaterials Science, vol. 8, pp. 4108 - 4125, http://dx.doi.org/10.1039/d0bm00761g
2020
Zhao H; Zhao H; Jiao Y; Zhu Y; Liu C; Li F; Wang Y; Gu Z; Yang D, 2020, 'Biosynthetic molecular imaging probe for tumor-targeted dual-modal fluorescence/magnetic resonance imaging', Biomaterials, vol. 256, http://dx.doi.org/10.1016/j.biomaterials.2020.120220
2020
Guo X; Li F; Liu C; Zhu Y; Xiao N; Gu Z; Luo D; Jiang J; Yang D, 2020, 'Construction of Organelle-Like Architecture by Dynamic DNA Assembly in Living Cells', Angewandte Chemie - International Edition, vol. 59, pp. 20651 - 20658, http://dx.doi.org/10.1002/anie.202009387
2020
Xie W; Guo Z; Gao Q; Wang D; Liang K; Gu Z; Zhao LY, 2020, 'Manganese-Doped Layered Double Hydroxide: A Biodegradable Theranostic Nanoplatform with Tumor Microenvironment Response for Magnetic Resonance Imaging-Guided Photothermal Therapy', ACS Applied Bio Materials, vol. 3, pp. 5845 - 5855, http://dx.doi.org/10.1021/acsabm.0c00564
2020
Guo X; Li F; Liu C; Zhu Y; Xiao N; Gu Z; Luo D; Jiang J; Yang D, 2020, 'Construction of Organelle-Like Architecture by Dynamic DNA Assembly in Living Cells', Angewandte Chemie, http://dx.doi.org/10.1002/ange.202009387
2020
Lv J; Dong Y; Gu Z; Yang D, 2020, 'Programmable DNA Nanoflowers for Biosensing, Bioimaging, and Therapeutics', Chemistry - A European Journal, vol. 26, pp. 14512 - 14524, http://dx.doi.org/10.1002/chem.202002242
2020
Zhang H; Cao Z; Zhang Q; Xu J; Yun SLJ; Liang K; Gu Z, 2020, 'Chemotaxis-Driven 2D Nanosheet for Directional Drug Delivery toward the Tumor Microenvironment', Small, vol. 16, pp. e2002732, http://dx.doi.org/10.1002/smll.202002732
2020
Guo Z; Liu J; Li Y; McDonald JA; Bin Zulkifli MY; Khan SJ; Xie L; Gu Z; Kong B; Liang K, 2020, 'Biocatalytic metal-organic framework nanomotors for active water decontamination', Chemical Communications, vol. 56, pp. 14837 - 14840, http://dx.doi.org/10.1039/d0cc06429g
2020
Lu J; Guo Z; Che S; Gao F; Gu Z; Xu J; Chi Y; Xu W; Zhang J; Takuya N; Yu J; Zhao L, 2020, 'Dihydroartemisinin loaded layered double hydroxide nanocomposites for tumor specific photothermal-chemodynamic therapy', Journal of Materials Chemistry B, vol. 8, pp. 11082 - 11089, http://dx.doi.org/10.1039/d0tb01964j
2020
Liu J; Guo Z; Kordanovski M; Kaltbeitzel J; Zhang H; Cao Z; Gu Z; Wich PR; Lord M; Liang K, 2020, 'Metal-organic frameworks as protective matrices for peptide therapeutics', Journal of Colloid and Interface Science, vol. 576, pp. 356 - 363, http://dx.doi.org/10.1016/j.jcis.2020.05.057
2020
Li B; Hao G; Sun B; Gu Z; Xu ZP, 2020, 'Engineering a Therapy-Induced “Immunogenic Cancer Cell Death” Amplifier to Boost Systemic Tumor Elimination', Advanced Functional Materials, vol. 30, http://dx.doi.org/10.1002/adfm.201909745
2020
Qian X; Zhang J; Gu Z; Chen Y, 2019, 'Nanocatalysts-augmented Fenton chemical reaction for nanocatalytic tumor therapy', Biomaterials, vol. 211, pp. 1 - 13, http://dx.doi.org/10.1016/j.biomaterials.2019.04.023
2019
Yuan Y; Gu Z; Yao C; Luo D; Yang D, 2019, 'Nucleic Acid–Based Functional Nanomaterials as Advanced Cancer Therapeutics', Small, vol. 15, pp. e1900172, http://dx.doi.org/10.1002/smll.201900172
2019
Zhang P; Zeng X; Wen X; Yang C; Ouyang S; Li P; Gu Z; Wu D; Frost RL, 2019, 'Insights into efficient removal and mechanism for ammonium from aqueous solution on tricalcium aluminate', Chemical Engineering Journal, vol. 366, pp. 11 - 20, http://dx.doi.org/10.1016/j.cej.2019.02.010
2019
Xie W; Guo Z; Cao Z; Gao Q; Wang D; Boyer C; Kavallaris M; Sun X; Wang X; Zhao L; Gu Z, 2019, 'Manganese-Based Magnetic Layered Double Hydroxide Nanoparticle: A pH-Sensitive and Concurrently Enhanced T1/ T2-Weighted Dual-Mode Magnetic Resonance Imaging Contrast Agent', ACS Biomaterials Science and Engineering, vol. 5, pp. 2555 - 2562, http://dx.doi.org/10.1021/acsbiomaterials.8b01618
2019
Zhang P; Ouyang S; Li P; Gu Z; Huang Y; Deng S, 2019, 'Effect of anion co-existence on ionic organic pollutants removal over Ca based layered double hydroxide', Journal of Colloid and Interface Science, vol. 534, pp. 440 - 446, http://dx.doi.org/10.1016/j.jcis.2018.09.019
2019
Zhao H; Shu G; Zhu J; Fu Y; Gu Z; Yang D, 2019, 'Persistent luminescent metal-organic frameworks with long-lasting near infrared emission for tumor site activated imaging and drug delivery', Biomaterials, vol. 217, http://dx.doi.org/10.1016/j.biomaterials.2019.119332
2019
Gao S; Hou J; Zeng J; Richardson JJ; Gu Z; Gao X; Li D; Gao M; Wang DW; Chen P; Chen V; Liang K; Zhao D; Kong B, 2019, 'Superassembled Biocatalytic Porous Framework Micromotors with Reversible and Sensitive pH-Speed Regulation at Ultralow Physiological H 2 O 2 Concentration', Advanced Functional Materials, vol. 29, pp. 1808900 - 1808900, http://dx.doi.org/10.1002/adfm.201808900
2019
Guo Z; Wang T; Rawal A; Hou J; Cao Z; Zhang H; Xu J; Gu Z; Chen V; Liang K, 2019, 'Biocatalytic self-propelled submarine-like metal-organic framework microparticles with pH-triggered buoyancy control for directional vertical motion', Materials Today, vol. 28, pp. 10 - 16, http://dx.doi.org/10.1016/j.mattod.2019.04.022
2019
Li B; Tang J; Chen W; Hao G; Kurniawan N; Gu Z; Xu ZP, 2018, 'Novel theranostic nanoplatform for complete mice tumor elimination via MR imaging-guided acid-enhanced photothermo-/chemo-therapy', Biomaterials, vol. 177, pp. 40 - 51, http://dx.doi.org/10.1016/j.biomaterials.2018.05.055
2018
Cao Z; Adnan NNM; Wang G; Rawal A; Shi B; Liu R; Liang K; Zhao L; Gooding JJ; Boyer C; Gu Z, 2018, 'Enhanced colloidal stability and protein resistance of layered double hydroxide nanoparticles with phosphonic acid-terminated PEG coating for drug delivery', Journal of Colloid and Interface Science, vol. 521, pp. 242 - 251, http://dx.doi.org/10.1016/j.jcis.2018.03.006
2018
Gu Z; Yan S; Cheong S; Cao Z; Zuo H; Thomas AC; Rolfe BE; Xu ZP, 2018, 'Layered double hydroxide nanoparticles: Impact on vascular cells, blood cells and the complement system', Journal of Colloid and Interface Science, vol. 512, pp. 404 - 410, http://dx.doi.org/10.1016/j.jcis.2017.10.069
2018
Chua S; Fang R; Sun Z; Wu M; Gu Z; Wang Y; Hart JN; Sharma N; Li F; Wang DW, 2018, 'Hybrid Solid Polymer Electrolytes with Two-Dimensional Inorganic Nanofillers', Chemistry - A European Journal, vol. 24, pp. 18180 - 18203, http://dx.doi.org/10.1002/chem.201804781
2018
Cao Z; Zhang L; Liang K; Cheong S; Boyer C; Gooding JJ; Chen Y; Gu Z, 2018, 'Biodegradable 2D Fe–Al Hydroxide for Nanocatalytic Tumor-Dynamic Therapy with Tumor Specificity', Advanced Science, vol. 5, http://dx.doi.org/10.1002/advs.201801155
2018
Harrison R; Li L; Gu Z; Xu ZP, 2017, 'Controlling mesoporous silica-coating of layered double hydroxide nanoparticles for drug control release', Microporous and Mesoporous Materials, vol. 238, pp. 97 - 104, http://dx.doi.org/10.1016/j.micromeso.2016.04.031
2017
Zuo H; Chen W; Li B; Xu K; Cooper H; Gu Z; Xu ZP, 2017, 'MnAl Layered Double Hydroxide Nanoparticles as a Dual-Functional Platform for Magnetic Resonance Imaging and siRNA Delivery', Chemistry - A European Journal, vol. 23, pp. 14299 - 14306, http://dx.doi.org/10.1002/chem.201702835
2017
Gu Z; Yang B; Yu C, 2017, 'Nanomedicine-Augmented Cancer-Localized Treatment by 3D Theranostic Implants', Journal of Biomedical Nanotechnology, vol. 13, pp. 871 - 890, http://dx.doi.org/10.1166/jbn.2017.2401
2017
Li B; Gu Z; Kurniawan N; Chen W; Xu ZP, 2017, 'Manganese-Based Layered Double Hydroxide Nanoparticles as a T1-MRI Contrast Agent with Ultrasensitive pH Response and High Relaxivity', Advanced Materials, vol. 29, http://dx.doi.org/10.1002/adma.201700373
2017
Qian X; Gu Z; Chen Y, 2017, 'Two-dimensional black phosphorus nanosheets for theranostic nanomedicine', Materials Horizons, vol. 4, pp. 800 - 816, http://dx.doi.org/10.1039/c7mh00305f
2017
Pavlovic M; Li L; Dits F; Gu Z; Adok-Sipiczki M; Szilagyi I, 2016, 'Aggregation of layered double hydroxide nanoparticles in the presence of heparin: towards highly stable delivery systems', RSC ADVANCES, vol. 6, pp. 16159 - 16167, http://dx.doi.org/10.1039/c5ra26072h
2016
Li L; Gu Z; Gu WY; Xu ZP, 2016, 'Direct synthesis of layered double hydroxide nanosheets for efficient siRNA delivery', RSC Advances, vol. 6, pp. 95518 - 95526, http://dx.doi.org/10.1039/c6ra19225d
2016
Li L; Gu Z; Gu W; Liu J; Xu ZP, 2016, 'Efficient drug delivery using SiO2-layered double hydroxide nanocomposites', Journal of Colloid and Interface Science, vol. 470, pp. 47 - 55, http://dx.doi.org/10.1016/j.jcis.2016.02.042
2016
Gu Z; Zuo H; Li L; Wu A; Xu ZP, 2015, 'Pre-coating layered double hydroxide nanoparticles with albumin to improve colloidal stability and cellular uptake', JOURNAL OF MATERIALS CHEMISTRY B, vol. 3, pp. 3331 - 3339, http://dx.doi.org/10.1039/c5tb00248f
2015
Gu Z; Atherton JJ; Xu ZP, 2015, 'Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications', CHEMICAL COMMUNICATIONS, vol. 51, pp. 3024 - 3036, http://dx.doi.org/10.1039/c4cc07715f
2015
Gu Z; Zuo H; Wu A; Xu ZP, 2015, 'Stabilization of layered double hydroxide nanoparticles by bovine serum albumin pre-coating for drug/gene delivery', JOURNAL OF CONTROLLED RELEASE, vol. 213, pp. E150 - E151, http://dx.doi.org/10.1016/j.jconrel.2015.05.255
2015
Zuo H; Gu Z; Cooper H; Xu ZP, 2015, 'Crosslinking to enhance colloidal stability and redispersity of layered double hydroxide nanoparticles', Journal of Colloid and Interface Science, vol. 459, pp. 10 - 16, http://dx.doi.org/10.1016/j.jcis.2015.07.063
2015
Shi S; Fliss BC; Gu Z; Zhu Y; Hong H; Valdovinos HF; Hernandez R; Goel S; Luo H; Chen F; Barnhart TE; Nickles RJ; Xu ZP; Cai W, 2015, 'Chelator-Free Labeling of Layered Double Hydroxide Nanoparticles for in Vivo PET Imaging', SCIENTIFIC REPORTS, vol. 5, http://dx.doi.org/10.1038/srep16930
2015
Gu Z; Wu A; Li L; Xu ZP, 2014, 'Influence of hydrothermal treatment on physicochemical properties and drug release of anti-inflammatory drugs of intercalated layered double hydroxide nanoparticles', Pharmaceutics, vol. 6, pp. 235 - 248, http://dx.doi.org/10.3390/pharmaceutics6020235
2014
Gu Z; Rolfe BE; Thomas AC; Xu ZP, 2013, 'Restenosis treatments using nanoparticle-based drug delivery systems', Current Pharmaceutical Design, vol. 19, pp. 6330 - 6339, http://dx.doi.org/10.2174/1381612811319350009
2013
Yang D; Peng S; Hartman MR; Gupton-Campolongo T; Rice EJ; Chang AK; Gu Z; Lu GQM; Luo D, 2013, 'Enhanced transcription and translation in clay hydrogel and implications for early life evolution', SCIENTIFIC REPORTS, vol. 3, http://dx.doi.org/10.1038/srep03165
2013
Gu Z; Rolfe BE; Xu ZP; Campbell JH; Lu GQM; Thomas AC, 2012, 'Antibody-targeted drug delivery to injured arteries using layered double hydroxide nanoparticles', Advanced Healthcare Materials, vol. 1, pp. 669 - 673, http://dx.doi.org/10.1002/adhm.201200069
2012
Xu ZP; Gu Z; Cheng X; Rasoul F; Whittaker AK; Lu GQM, 2011, 'Controlled release of ketorolac through nanocomposite films of hydrogel and LDH nanoparticles', JOURNAL OF NANOPARTICLE RESEARCH, vol. 13, pp. 1253 - 1264, http://dx.doi.org/10.1007/s11051-010-0118-9
2011
Gu Z; Rolfe BE; Thomas AC; Campbell JH; Lu GQM; Xu ZP, 2011, 'Cellular trafficking of low molecular weight heparin incorporated in layered double hydroxide nanoparticles in rat vascular smooth muscle cells', Biomaterials, vol. 32, pp. 7234 - 7240, http://dx.doi.org/10.1016/j.biomaterials.2011.05.083
2011
Gu Z; Rolfe BE; Xu ZP; Thomas AC; Campbell JH; Lu GQM, 2010, 'Enhanced effects of low molecular weight heparin intercalated with layered double hydroxide nanoparticles on rat vascular smooth muscle cells', Biomaterials, vol. 31, pp. 5455 - 5462, http://dx.doi.org/10.1016/j.biomaterials.2010.03.050
2010
Pang Z; Tan X; Ding R; Gu Z; Liu S, 2008, 'Preparation, characterization and catalytic performance of SrTi0.9Li0.1O3 ultrafine powders', Ceramics International, vol. 34, pp. 1805 - 1810, http://dx.doi.org/10.1016/j.ceramint.2007.06.012
2008
Gu Z; Thomas AC; Xu ZP; Campbell JH; Lu GQ, 2008, 'In vitro sustained release of LMWH from MgAl-layered double hydroxide nanohybrids', CHEMISTRY OF MATERIALS, vol. 20, pp. 3715 - 3722, http://dx.doi.org/10.1021/cm703602t
2008
TAN X; PANG Z; GU Z; LIU S, 2007, 'Catalytic perovskite hollow fibre membrane reactors for methane oxidative coupling', Journal of Membrane Science, vol. 302, pp. 109 - 114, http://dx.doi.org/10.1016/j.memsci.2007.06.033
2007
Conference Papers
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Li L; Gu Z; Gu W; Xu ZP, 2015, 'Efficient drug delivery for cancer treatment using SiO2-LDH nanocomposites', in Efficient drug delivery for cancer treatment using SiO2-LDH nanocomposites, Washington D.C., presented at 10th Annual TechConnect World Innovation Conference and Expo, Washington D.C., 25 June 2015 - 27 June 2015
2015
Book Chapters
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Gu Z; Rolfe BE; Thomas AC; Campbell JH; Lu GQ; Xu ZP, 2012, 'Heparin-related Nanomaterials', in Piyathilake DE; Liang R (ed.), Heparin, Properties, Uses and Side Effects, Nova Publisher, pp. 159 - 178
2012

2019, Academic & Professional Women in Leadership Program, UNSW

2018, Research Excellence Award, Australian Association of Chinese Biomedical Scientists

2018, Rising Star Award, Australian Association of Chinese Biomedical Scientists

2017, Monash Engineering Women's Leadership Award

2014-2018, NHMRC Early Career Fellowship (Peter Doherty Biomedical Early Career Fellowship)

2014, Ian Potter Foundation Travel Award

2013, Deputy Vice-Chancellor (Academic) Award, The University of Queensland

2010, Graduate School International Travel Award, The University of Queensland

2008-2010, Endeavour International Postgraduate Research Scholarship

2008, Chinese Government Award for Outstanding Student Abroad, China Scholarship Council

2007, Best Student Poster Award at 4th ARC Centre of Excellence for Functional Nanomaterials Annual Conference

2020-2022, Australian Research Council Discovery Project Grant

2019-2021, UNSW-CAS Joint Research Fund

2019-2022, Industrial Contract Research Fund

2016-2017, UNSW-Tsinghua Joint Research Fund

2017, Australian Centre for NanoMedicine Seed Research Fund

2014-2019, NHMRC EC Fellowship (Peter Doherty Biomedical EC Fellowship)

2014, Ian Potter Foundation Travel Award