Blake Cochran

Blake Cochran

Lecturer

The objective of my research is to characterise the role of cholesterol in the mechanisms of disease development and progression. Whilst cholesterol is a fundamental constituent of animal cells, impaired cholesterol homeostasis plays a critical role in the development and pathogenesis of diabetes, atherosclerosis and obesity. My research utilises novel animal models, in vitro systems and translational research approaches to answer important medical questions

Accepting applications to supervise Honours, PhD, ILP and Undergraduate Internship (eg SOMS3001) students. 

Current Students

Bikash Manandhar - PhD 
Thomas King - BMedSci Honours
Veronica Turong - BMedSci Honours
Shivam Patel - BMedSci Honours
Angela Li - BMedSci Honours
Wei Jack Ang - Medicine ILP
Bradley Tucker - Medicine ILP

Previous Students

2015 - Praween Senenyake - BMedSci Honours. Currently studying Medicine at Western Sydney University, Masters of Clinical Epidemiology at University of Sydney
2016 - Sumaya Mozumder - B MedSci Honours 
2017 - Alexander Dupuy - BMedSci Honours. Currently Research Assistant at Heart Research Institute, Sydney
2017 - Maybelle Ling Hoon - Medicine ILP
2018 - Yong Chang Lai - BMed(Hons)
2018 - Wei Ting Tan - Medicine ILP
2018 - Rebecca Metzger - Medicine ILP
2018 - Ishbel Henderson - Exchange student SOMS3001
Phone

(02) 9385 2910

Email

b.cochran@unsw.edu.au

Location

Room 415, Level 4 East, Wallace Wurth Building, School of Medical Sciences, UNSW Australia 2052

Publications

  • Manandhar B; Cochran BJ; Rye KA, 2020, 'Role of High-Density Lipoproteins in Cholesterol Homeostasis and Glycemic Control', Journal of the American Heart Association, vol. 9, pp. e013531, http://dx.doi.org/10.1161/JAHA.119.013531
  • 2020
  • Lai YC; Woollard KJ; McClelland RL; Allison MA; Rye KA; Ong KL; Cochran BJ, 2019, 'The association of plasma lipids with white blood cell counts: Results from the Multi-Ethnic Study of Atherosclerosis', Journal of Clinical Lipidology, vol. 13, pp. 812 - 820, http://dx.doi.org/10.1016/j.jacl.2019.07.003
  • 2019
  • Hackett MJ; Hollings A; Majimbi M; Brook E; Cochran B; Giles C; Lam V; Nesbit M; Rye KA; Mamo JCL; Takechi R, 2019, 'Multimodal Imaging Analyses of Brain Hippocampal Formation Reveal Reduced Cu and Lipid Content and Increased Lactate Content in Non-Insulin-Dependent Diabetic Mice', ACS Chemical Neuroscience, vol. 10, pp. 2533 - 2540, http://dx.doi.org/10.1021/acschemneuro.9b00039 2019
  • Kopecky C; Pandzic E; Parmar A; Szajer J; Lee V; Dupuy A; Arthur A; Fok S; Whan R; Ryder WJ; Rye KA; Cochran BJ, 2019, 'Translocator protein localises to CD11b + macrophages in atherosclerosis', Atherosclerosis, vol. 284, pp. 153 - 159, http://dx.doi.org/10.1016/j.atherosclerosis.2019.03.011 2019
  • Cochran B; Tang S; Tabet F; Cuesta Torres L; Wu B; Barter P; Rye K-A, 2019, 'Apolipoprotein A-I enhances insulin-dependent and insulinindependent glucose uptake by skeletal muscle', Scientific Reports, vol. 9, http://dx.doi.org/10.1038/s41598-018-38014-3 2019
  • Hou L; Tang S; Wu BJ; Ong KL; Westerterp M; Barter PJ; Cochran BJ; Tabet F; Rye KA, 2019, 'Apolipoprotein A-l improves pancreatic β-cell function independent of the ATP-binding cassette transporters ABCA1 and ABCG1', FASEB Journal, vol. 33, pp. 8479 - 8489, http://dx.doi.org/10.1096/fj.201802512RR 2019
  • Aleidi SM; Yang A; Sharpe LJ; Rao G; Cochran BJ; Rye KA; Kockx M; Brown AJ; Gelissen IC, 2018, 'The E3 ubiquitin ligase, HECTD1, is involved in ABCA1-mediated cholesterol export from macrophages', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1863, pp. 359 - 368, http://dx.doi.org/10.1016/j.bbalip.2017.12.011 2018
  • Barter PJ; Cochran BJ; Rye KA, 2018, 'CETP inhibition, statins and diabetes', Atherosclerosis, vol. 278, pp. 143 - 146, http://dx.doi.org/10.1016/j.atherosclerosis.2018.09.033 2018
  • Jones B; Buenaventura T; Kanda N; Chabosseau P; Owen BM; Scott R; Goldin R; Angkathunyakul N; Corrêa IR; Bosco D; Johnson PR; Piemonti L; Marchetti P; Shapiro AMJ; Cochran BJ; Hanyaloglu AC; Inoue A; Tan T; Rutter GA; Tomas A; Bloom SR, 2018, 'Targeting GLP-1 receptor trafficking to improve agonist efficacy', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-03941-2 2018
  • Pandzic E; Gelissen IC; Whan R; Barter PJ; Sviridov D; Gaus K; Rye KA; Cochran BJ, 2017, 'The ATP binding cassette transporter, ABCG1, localizes to cortical actin filaments', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/srep42025
  • Cochran BJ; Hou L; Manavalan APC; Moore BM; Tabet F; Sultana A; Torres LC; Tang S; Shrestha S; Senanayake P; Patel M; Ryder WJ; Bongers A; Maraninchi M; Wasinger VC; Westerterp M; Tall AR; Barter PJ; Rye K-A, 2017, 'Impact of Perturbed Pancreatic beta-Cell Cholesterol Homeostasis on Adipose Tissue and Skeletal Muscle Metabolism (vol 65, pg 3610, 2016)', DIABETES, vol. 66, pp. 560 - 560, http://dx.doi.org/10.2337/db17-er02b
  • 2017
  • Cochran BJ; Ryder W; parmar A; Meikle S; Barter P; Rye K, 2017, 'Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT', Journal of Visualized Experiments, vol. 2017, http://dx.doi.org/10.3791/55184
  • Cochran BJ; Ryder WJ; Parmar A; Tang S; Reilhac A; Arthur A; Charil A; Hamze H; Barter PJ; Kritharides L; Meikle SR; Gregoire MC; Rye KA, 2016, 'In vivo PET imaging with [18F]FDG to explain improved glucose uptake in an apolipoprotein A-I treated mouse model of diabetes', Diabetologia, vol. 59, pp. 1977 - 1984, http://dx.doi.org/10.1007/s00125-016-3993-5 2016
  • Cochran BJ; Hou L; Manavalan APC; Moore BM; Tabet F; Sultana A; Torres LC; Tang S; Shrestha S; Senanayake P; Patel M; Ryder WJ; Bongers A; Maraninchi M; Wasinger VC; Westerterp M; Tall AR; Barter PJ; Rye KA, 2016, 'Impact of perturbed pancreatic β-cell cholesterol homeostasis on adipose tissue and skeletal muscle metabolism', Diabetes, vol. 65, pp. 3610 - 3620, http://dx.doi.org/10.2337/db16-0668 2016
  • Rye KA; Barter PJ; Cochran BJ, 2016, 'Apolipoprotein A-I interactions with insulin secretion and production', Current Opinion in Lipidology, vol. 27, pp. 8 - 13, http://dx.doi.org/10.1097/MOL.0000000000000253 2016
  • Sultana A; Cochran BJ; Tabet F; Patel M; Cuesta Torres L; Barter PJ; Rye K, 2016, 'Inhibition of inflammatory signaling pathways in 3T3-L1 adipocytes by apolipoprotein A-I', The FASEB Journal, vol. 30, pp. 2324 - 2335, http://dx.doi.org/10.1096/fj.201500026R 2016
  • Cochran BJ; Bisoendial RJ; Hou L; Glaros E; Rossy J; Thomas SR; Barter PJ; Rye KA, 2014, 'Apolipoprotein a-I increases insulin secretion and production from pancreatic β-cells via a g-protein-camp-PKA-FOXO1-dependent mechanism', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 34, pp. 2261 - 2267, http://dx.doi.org/10.1161/ATVBAHA.114.304131 2014
  • Lee JA; Cochran BJ; Lobov S; Ranson M, 2011, 'Forty years later and the role of plasminogen activator inhibitor type 2/SERPINB2 is still an enigma', Seminars in Thrombosis and Hemostasis, vol. 37, pp. 395 - 407, http://dx.doi.org/10.1055/s-0031-1276589 2011
  • Cochran BJ; Saunders D; Croucher DR; Lobov S; Ranson M, 2011, 'Dependence on endocytic receptor binding via a minimal binding motif underlies the differential prognostic profiles of serpinE1 and serpinB2 in cancer', The Journal of Biological Chemistry, vol. 286, pp. 24467 - 24475, http://dx.doi.org/10.1074/jbc.M111.225706 2011
  • Cochran BJ; Gunawardhana LP; Vine KL; Lee JA; Lobov S; Ranson M, 2009, 'The CD-loop of PAI-2 (SERPINB2) is redundant in the targeting, inhibition and clearance of cell surface uPA activity', BMC Biotechnology, vol. 9, http://dx.doi.org/10.1186/1472-6750-9-43 2009

Haeusler M; Dunn K; Cochran B; Cheng T, 2019, 'Design in Paediatric Healthcare: Rethinking 3D models of paediatric orthopaedic data using Design approaches.', in Real / Material / Etheral, Monash University Melbourne, presented at 2nd Annual Design Research Conference, Monash University Melbourne, 03 October 2019 - 04 October 2019

Kopecky CM; Ryder WJ; Szajer J; Parmar A; Pandzic E; Rye KA; Cochran BJ, 2018, 'Translocator Protein as Novel Marker for Early Atherosclerosis', in ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, San Francisco, CA, presented at Scientific Sessions of the American-Heart-Association on Vascular Discovery - From Genes to Medicine, San Francisco, CA, 10 May 2018 - 12 May 2018, http://dx.doi.org/10.1161/atvb.38.suppl_1.222

Cochran BJ; Trajanovska S; Sunn N; Rye KA; Ryder WJ, 2018, 'Development of 3D printing filaments for bespoke X-Ray phantoms', in 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018 - Proceedings, IEEE, presented at 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 10 November 2018 - 17 November 2018, http://dx.doi.org/10.1109/NSSMIC.2018.8824621

Kopecky C; Ryder WJ; Szajer J; Parmar A; Pandzic E; Rye K-A; Cochran BJ, 2018, 'THE TSPO RADIOLIGAND 18F-PBR111 AS A PRE-ATHEROSCLEROTIC LESION DETECTION AGENT', in ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, Toronto, CANADA, Vol. 32, pp. 145 - 146, presented at International Symposium on Atherosclerosis (ISA), Toronto, CANADA, 09 June 2018 - 12 June 2018, http://dx.doi.org/10.1016/j.atherosclerosissup.2018.04.446

2018

Cochran BJ; Pinheiro D; Prendecki M; Jones B; Cegla J; Lee V; Barter PJ; Murphy AJ; Rye K-A; Woollard KJ, 2018, 'PRO-ATHEROSCLEROTIC LOW-DENSITY NEUTROPHILS ARE PRESENT IN HYPERCHOLESTEROLEMIA', in ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, Toronto, CANADA, Vol. 32, pp. 39 - 40, presented at International Symposium on Atherosclerosis (ISA), Toronto, CANADA, 09 June 2018 - 12 June 2018, http://dx.doi.org/10.1016/j.atherosclerosissup.2018.04.115

2018

Polly P; Jones G; Cochran B, 2017, 'EMENTORING TO SUPPORT AND ENABLE RESEARCH INTEGRATED LEARNING USING AUTHENTIC ASSESSMENT IN A THIRD YEAR UNDERGRADUATE SCIENCE COURSE IN PATHOLOGY AT A RESEARCH INTENSIVE UNIVERSITY', in EDULEARN17 Proceedings, 9th International Conference on Education and New Learning Technologies, presented at 9th International Conference on Education and New Learning Technologies

2017

Cochran BJ; Hou L; Manavalan APC; Sultana A; Moore BM; Patel M; Tall A; Barter PJ; Rye KA, 2015, 'PANCREATIC BETA-CELL SPECIFIC DELETION OF ABCA1 AND ABCG1 PERTURBS GLUCOSE METABOLISM AND INCREASES ADIPOSITY IN MICE DUE TO SUBOPTIMAL PLASMA INSULIN LEVELS', in ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, Glasgow, SCOTLAND, Vol. 241, pp. E3 - E3, presented at 83rd Congress of the European-Atherosclerosis-Society (EAS), Glasgow, SCOTLAND, 22 March 2015 - 25 March 2015, http://dx.doi.org/10.1016/j.atherosclerosis.2015.04.028

Tan WT; Kopecky C; Manandhar B; Rye K-A; Cochran B, 'Skeletal Muscle Specific Deletion Of Abca1 And Abcg1 Impacts Body Composition And Metabolism And Is Age Dependent', presented at 87th European Atherosclerosis Society Congress, http://dx.doi.org/10.1016/j.atherosclerosis.2019.06.122

Tucker B; Rehan R; Vaidya K; Rye K; Cochran B; Patel S, 'Colchicine inhibits neutrophil extracellular trap formation in acute coronary syndrome patients', presented at Australian Atherosclerosis Society Annual Scientific Meeting, Melbourne, 16 October 2019 - 19 October 2019

Manandhar B; Cochran BJ; Rye K, 'APOLIPOPROTEIN A-I LOCALISES TO MITOCHONDRIA AND INHIBITS ROS GENERATION IN INSULIN PRODUCING CELLS.', presented at AAS 2019 Annual Scientific meeting, Victoria University City Convention Centre, Melbourne, 16 October 2019 - 19 October 2019