In a groundbreaking analysis of the Perindopril Protection Against Recurrent Stroke Study (PROGRESS), researchers have delved into the effects of fluctuating kidney function on cardiovascular outcomes.
Over a span of two years, researchers investigated the relationship between kidney function changes and stroke risk, dementia, and mortality in patients with a history of stroke. The study, published in The Journal of Hypertension, focused on individuals with atrial fibrillation, hypertension, and newly initiated oral anticoagulants (OACs). It revealed several key findings.
Patients with baseline systolic blood pressure (SBP) in the 145–180 mmHg range (before starting OACs) faced more than double the risk of haemorrhagic stroke compared to those with an SBP of 130 mmHg. Lowering SBP to below 145 mmHg before initiating oral anticoagulants emerged as a crucial strategy to mitigate this risk.
The study explored how changes in kidney function impact the risk of recurrent stroke and dementia. Patients experiencing declining kidney function were found to be at a higher risk of these adverse outcomes. Monitoring kidney health, therefore, becomes essential not only for stroke prevention but also for overall well-being.
Researchers investigated whether incorporating kidney-related parameters (such as glomerular filtration rate) alongside conventional cardiovascular risk factors improves predictive models. This innovative approach could enhance our ability to identify individuals at higher risk of stroke and dementia.
The study cohort included patients with a history of stroke, hypertension, and atrial fibrillation. Optimizing blood pressure control, especially before initiating oral anticoagulants, remains pivotal in reducing the risk of haemorrhagic stroke.
Understanding the interplay between kidney function and cardiovascular outcomes can guide better preventive strategies. Maintaining optimal blood pressure levels remains crucial, particularly for patients with hypertension and atrial fibrillation. By lowering blood pressure, we can significantly reduce the risk of haemorrhagic stroke and enhance overall health.