Project

Randomised clinical trials (RCTs) are the key gold standard in pre-market evaluation of the safety and efficacy of therapies, however they do not always represent real-world populations or settings. The results identified in an RCT for the “average” patient could also miss substantial benefits of harms for particular sub-groups. This project aims to develop an analytic framework and methodology for measuring and reporting on the use and effectiveness of interventions in heterogeneous populations as used in routine care. This will be developed and evaluated using exemplar interventional procedures, including the use of electroconvulsive therapy (ECT) for treating depression, schizophrenia, and manic or psychotic symptoms.