Radiochemistry Laboratory

Flexlab is a vessel-based synthesis module that has the following key features and capabilities: 

• Most commonly used in F-18 synthesis
• Dual reactors for multi-steps synthesis
• 4x HPLC Eluents
• Dual prep-HPLC injector and column switchers for two independent purifications
• Dual HPLC product solid phase extraction (SPE) reformulation for concentrating purified intermediate or product formulation.
• User-friendly editable Excel step list for automation development
• 19 reagent vessels available

Filter Integrity Tester (FIT) is a compact standalone bench-top unit capable of fully automating the process of bubble-point testing commonly used vented & non-vented sterilizing filters used in radiopharmaceutical quality control. It provides results to verify the sterilising filter used in the production of radiopharmaceuticals is integral, thereby providing sterility assurance.

Multisyn is a cassette-based synthesis module that has the following key features and capabilities: 

• Most commonly used in radiometals (e.g. Ga-68, Lu-177, Ac-225, Tb-161, Pb-212 etc.)
• User-friendly editable Excel step list for automation development
• Disposable cassettes to avoid cross contamination between synthesis and method transfer for clinical productions
• 12 valves cassette manifolds available

We have two Shimadzu HPLC systems and one UPLC system with LabLogic radio-detectors. The systems include the following key features and capabilities: 

• 1'' NaI(TI) PMT Detector for PET (e.g. F-18, Ga-68, Zr-89) and SPECT (e.g. Tc-99m, Lu-177) radionuclide detection
• User friendly Laura software - Single Point of Control of both the radio-detector and HPLC/UPLC system. The ideal radiochromatography system for analyses and publications.
• PDA Detectors capable of capturing the full UV-vis spectrum of your sample to help assessing purity and quantitative analyses.
• Autosampler to streamline analysis, improve precision and reduce radiation dose to the operator. 
• A Posi-RAM radio-detector that is ultra-sensitive for detecting PET radionuclide. It can be used for analysis of radiometabolites. 
• Column oven to provide precise and stable temperature control of the mobile phase, column, and sample. 
• Quaternary pump (low-pressure gradient pump) capable for mixing up to four solvents.

Our Radio-TLC scanner is capable of analysing the radiochemical purities (or radiochemical impurities) of PET/SPECT radiotracers. 

Lead shielded radiochemistry workbench is a 50 mm lead shielded box that can be used for manual radiolabelling work. It is typically used for radiochemistry development work prior to the translation of automated method on synthesis modules. 

Our hot cells have the following key features and capabilities

• Radiation shielding: Protects personnel from harmful ionizing radiation emitted (all α, β, γ) by radioactive materials.
• Safe handling: Allows manipulation of high-activity radionuclides via the use of automated synthesis module and dispenser.
• Controlled environment: Maintains cleanroom standards (e.g., ISO Class 5 or better) for sterile radiopharmaceutical production.
• Monitoring and safety systems: Equipped with dose rate monitors, alarms, and interlocks to ensure worker and environmental safety.
• Production and synthesis: Used for automated or manual synthesis of PET and SPECT radiopharmaceuticals. 

Our Capintec CRC-55tR dose calibrator has the following key features and capabilities: 

• On-screen display of Nuclide Name, Number, Activity, Unit of Measure and Calibration Number.
• Automated QC including constancy and linearity programs.
• Automated Geometry and Linearity Testing.
• Automated Half-life determination.

Radiation area monitors have the following key features and capabilities: 

• Detect and alert personnel to elevated radiation levels in real-time.
• Provide alarm once the pre-determined safety threshold is reached. 

Trasis AllInOne is a cassette-based synthesis module that has the following key features and capabilities:

• 36 valves cassette manifolds available
• 2 reactors and 1 cartridge heater
• Semi-preparative HPLC for purification
• Various commercially available cassette and reagent kits available.
• Suitable for the synthesis of both radio-metals (e.g. Ga-68, Lu-177, Zr-89) and non-radiometal (e.g. F-18, C-11) radiotracers.

User-friendly interface for the design of synthesis, purification and formulation methods.