The role of Runx1t1 in the childhood cancer neuroblastoma and other embryonal tumours

Neuroblastoma is a type of cancer that occurs in children and those tumours with increased copies or amplification of the cancer-causing gene MYCN, frequently have a poor outcome. Finding alternative treatments for these children is the overall goal of our research.

Using a mouse model of MYCN-driven neuroblastoma, we have undertaken an in vivo mutagenesis screen and identified a gene, Runx1t1, with a loss-of-function mutation that abolishes tumorigenesis in this model.

This is the first time that Runx1t1 has been shown to have a role in any paediatric solid tumour and this project with use a range of molecular techniques and models to elucidate its mechanism of action as well as its role in other high-risk embryonal tumours.

How to Apply

Express your interest in this project by emailing Professor Murray Norris. Include a copy of your CV and your academic transcript(s).