Dr Abhirup Das
Adjunct Lecturer

Dr Abhirup Das

Education

  • PhD, Stanford University, USA (2010)
  • MSc, IIT Kanpur, India (2004)
  • BSc, University of Kalyani, India (2002)
Medicine & Health
School of Clinical Medicine
Phone
(+61) 2 9385 1621
Location
4-10 South Street Research and Education Centre St. George Hospital Campus Kogarah, NSW 2217
  • Journal articles | 2022
    He B; Sheldrick K; Das A; Diwan A, 2022, 'Clinical and Research MRI Techniques for Assessing Spinal Cord Integrity in Degenerative Cervical Myelopathy—A Scoping Review', Biomedicines, vol. 10, pp. 2621 - 2621, http://dx.doi.org/10.3390/biomedicines10102621
    Journal articles | 2022
    Li W; Lai K; Chopra N; Zheng Z; Das A; Diwan AD, 2022, 'Gut-disc axis: A cause of intervertebral disc degeneration and low back pain?', European Spine Journal, vol. 31, pp. 917 - 925, http://dx.doi.org/10.1007/s00586-022-07152-8
    Journal articles | 2021
    Chopra N; Menounos S; Choi JP; Hansbro PM; Diwan AD; Das A, 2021, 'Blood-Spinal Cord Barrier: Its Role in Spinal Disorders and Emerging Therapeutic Strategies', NeuroSci, vol. 3, pp. 1 - 27, http://dx.doi.org/10.3390/neurosci3010001
    Journal articles | 2021
    Koremans FW; Chen X; Das A; Diwan AD, 2021, 'Changes in back pain scores after bariatric surgery in obese patients: A systematic review and meta-analysis', Journal of Clinical Medicine, vol. 10, http://dx.doi.org/10.3390/jcm10071443
    Journal articles | 2021
    Menounos S; Hansbro PM; Diwan AD; Das A, 2021, 'Pathophysiological Correlation between Cigarette Smoking and Amyotrophic Lateral Sclerosis', NeuroSci, vol. 2, pp. 120 - 134, http://dx.doi.org/10.3390/neurosci2020008
    Journal articles | 2021
    Shariev A; Menounos S; Laos AJ; Laxman P; Lai D; Hua S; Zinger A; McRae CR; Casbolt LS; Combes V; Smith G; Hung TT; Dixon KM; Thordarson P; Mason RS; Das A, 2021, 'Skin protective and regenerative effects of RM191A, a novel superoxide dismutase mimetic', Redox Biology, vol. 38, http://dx.doi.org/10.1016/j.redox.2020.101790
    Journal articles | 2021
    Tu J; Castillo JV; Das A; Diwan AD, 2021, 'Degenerative cervical myelopathy: Insights into its pathobiology and molecular mechanisms', Journal of Clinical Medicine, vol. 10, pp. 1 - 28, http://dx.doi.org/10.3390/jcm10061214
    Journal articles | 2021
    Yin H; Wang K; Das A; Li G; Song Y; Luo R; Cheung JPY; Zhang T; Li S; Yang C, 2021, 'The REDD1/TXNIP Complex Accelerates Oxidative Stress-Induced Apoptosis of Nucleus Pulposus Cells through the Mitochondrial Pathway', Oxidative Medicine and Cellular Longevity, vol. 2021, pp. 7397516, http://dx.doi.org/10.1155/2021/7397516
    Journal articles | 2021
    Zhao K; An R; Xiang Q; Li G; Wang K; Song Y; Liao Z; Li S; Hua W; Feng X; Wu X; Zhang Y; Das A; Yang C, 2021, 'Acid-sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration', Cell Proliferation, vol. 54, http://dx.doi.org/10.1111/cpr.12941
    Journal articles | 2020
    Kim L-J; Chalmers TJ; Madawala R; Smith GC; Li C; Das A; Keung Poon EW; Wang J; Tucker SP; Sinclair DA; Quek L-E; Wu LE, 2020, 'Nicotinamide mononucleotide (NMN) deamidation by host-microbiome interactions', , http://dx.doi.org/10.1101/2020.09.10.289561
    Journal articles | 2020
    Koremans FW; Chen X; Das A; Diwan AD, 2020, 'Changes in back pain scores after bariatric surgery in obese patients: A systematic review and meta-analysis', , http://dx.doi.org/10.1101/2020.08.25.20182022
    Journal articles | 2019
    Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y; Treviño-Villarreal JH; Kang MJ; Hung TT; Lee B; Williams EO; Igarashi M; Mitchell JR; Wu LE; Turner N; Arany Z; Guarente L; Sinclair DA, 2019, 'Erratum: Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging (Cell (2018) 173(1) (74–89.e20), (S0092867418301521) (10.1016/j.cell.2018.02.008))', Cell, vol. 176, pp. 944 - 945, http://dx.doi.org/10.1016/j.cell.2019.01.026
    Journal articles | 2019
    Youngson NA; Mezbah Uddin G; Das A; Martinez C; Connaughton HS; Whiting S; Yu J; Sinclair DA; John Aitken R; Morris MJ, 2019, 'Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice', Reproduction, vol. 158, pp. 169 - 179, http://dx.doi.org/10.1530/REP-18-0574
    Journal articles | 2018
    Bonkowski MS; Das A; Schultz M; Lu Y; Mitchell J; Wu L; Guarente L; Sinclair D, 2018, 'IMPAIRMENT OF AN ENDOTHELIAL NAD+-H2S SIGNALING NETWORK IS A REVERSIBLE CAUSE OF VASCULAR AGING', Innovation in aging, vol. 2, pp. 388 - 388, http://dx.doi.org/10.1093/geroni/igy023.1446
    Journal articles | 2018
    Bonkowski MS; Das A; Schultz MB; Lu Y; Mitchell J; Wu L; Guarente L; Sinclair DA, 2018, 'IMPAIRMENT OF AN ENDOTHELIAL NAD+-H2S SIGNALING NETWORK IS A REVERSIBLE CAUSE OF VASCULAR AGING', Innovation in aging, vol. 2, pp. 799 - 799, http://dx.doi.org/10.1093/geroni/igy023.2966
    Journal articles | 2018
    Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y; Treviño-Villarreal JH; Kang MJ; Hung TT; Lee B; Williams EO; Igarashi M; Mitchell JR; Wu LE; Turner N; Arany Z; Guarente L; Sinclair DA, 2018, 'Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging', Cell, vol. 173, pp. 74 - 89.e20, http://dx.doi.org/10.1016/j.cell.2018.02.008
    Journal articles | 2018
    Longchamp A; Mirabella T; Arduini A; MacArthur MR; Das A; Treviño-Villarreal JH; Hine C; Ben-Sahra I; Knudsen NH; Brace LE; Reynolds J; Mejia P; Tao M; Sharma G; Wang R; Corpataux JM; Haefliger JA; Ahn KH; Lee CH; Manning BD; Sinclair DA; Chen CS; Ozaki CK; Mitchell JR, 2018, 'Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production', Cell, vol. 173, pp. 117 - 129.e14, http://dx.doi.org/10.1016/j.cell.2018.03.001
    Journal articles | 2018
    Turner N; Lim XY; Toop HD; Osborne B; Brandon AE; Taylor EN; Fiveash CE; Govindaraju H; Teo JD; McEwen HP; Couttas TA; Butler SM; Das A; Kowalski GM; Bruce CR; Hoehn KL; Fath T; Schmitz-Peiffer C; Cooney GJ; Montgomery MK; Morris JC; Don AS, 2018, 'A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-05613-7
    Journal articles | 2017
    Chowdhury MKH; Turner N; Bentley NL; Das A; Wu LE; Richani D; Bustamante S; Gilchrist RB; Morris MJ; Shepherd PR; Smith GC, 2017, 'Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/srep40159
    Journal articles | 2017
    Das A; Sinclair D; Bonkowski M; Johnston I; Wu L, 2017, 'Extension of physical endurance and protection against physical, chemical and radiological trauma by NAD + precursors', Journal of Science and Medicine in Sport, vol. 20, pp. S165 - S166, http://dx.doi.org/10.1016/j.jsams.2017.09.564
    Journal articles | 2016
    Mohamad M; Mitchell SJ; Wu LE; White MY; Cordwell SJ; Mach J; Solon-Biet SM; Boyer D; Nines D; Das A; Catherine Li SY; Warren A; Hilmer SN; Fraser R; Sinclair DA; Simpson SJ; de Cabo R; Le Couteur DG; Cogger VC, 2016, 'Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance', Aging Cell, vol. 15, pp. 706 - 715, http://dx.doi.org/10.1111/acel.12481
    Journal articles | 2011
    Javidpour P; Das A; Khosla C; Tsai SC, 2011, 'Structural and biochemical studies of the hedamycin type II polyketide ketoreductase (Hed KR): Molecular basis of stereo- and regiospecificities', Biochemistry, vol. 50, pp. 7426 - 7439, http://dx.doi.org/10.1021/bi2006866
    Journal articles | 2011
    Libert S; Pointer K; Bell EL; Das A; Cohen DE; Asara JM; Kapur K; Bergmann S; Preisig M; Otowa T; Kendler KS; Chen X; Hettema JM; Van Den Oord EJ; Rubio JP; Guarente L, 2011, 'SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive', Cell, vol. 147, pp. 1459 - 1472, http://dx.doi.org/10.1016/j.cell.2011.10.054
    Journal articles | 2011
    Szu PH; Govindarajan S; Meehan MJ; Das A; Nguyen DD; Dorrestein PC; Minshull J; Khosla C, 2011, 'Analysis of the ketosynthase-chain length factor heterodimer from the fredericamycin polyketide synthase', Chemistry and Biology, vol. 18, pp. 1021 - 1031, http://dx.doi.org/10.1016/j.chembiol.2011.07.015
    Journal articles | 2010
    Das A; Szu PH; Fitzgerald JT; Khosla C, 2010, 'Mechanism and engineering of polyketide chain initiation in fredericamycin biosynthesis', Journal of the American Chemical Society, vol. 132, pp. 8831 - 8833, http://dx.doi.org/10.1021/ja102517q
    Journal articles | 2010
    Tahanian E; Lord-Dufour S; Das A; Khosla C; Roy R; Annabi B, 2010, 'Inhibition of tubulogenesis and of carcinogen-mediated signaling in brain endothelial cells highlight the antiangiogenic properties of a mumbaistatin analog', Chemical Biology and Drug Design, vol. 75, pp. 481 - 488, http://dx.doi.org/10.1111/j.1747-0285.2010.00961.x
    Journal articles | 2009
    Das A; Khosla C, 2009, 'Biosynthesis of Aromatic Polyketides in Bacteria', Accounts of Chemical Research, vol. 42, pp. 631 - 639, http://dx.doi.org/10.1021/ar8002249
    Journal articles | 2009
    Das A; Khosla C, 2009, 'ChemInform Abstract: Biosynthesis of Aromatic Polyketides in Bacteria', ChemInform, vol. 40, http://dx.doi.org/10.1002/chin.200932273
    Journal articles | 2009
    Das A; Khosla C, 2009, 'In Vivo and In Vitro Analysis of the Hedamycin Polyketide Synthase', Chemistry and Biology, vol. 16, pp. 1197 - 1207, http://dx.doi.org/10.1016/j.chembiol.2009.11.005
    Journal articles | 2009
    Lord-Dufour S; Copland IB; Levros LC; Post M; Das A; Khosla C; Galipeau J; Rassart E; Annabi B, 2009, 'Evidence for transcriptional regulation of the glucose-6-phosphate transporter by HIF-1α: Targeting G6PT with mumbaistatin analogs in hypoxic mesenchymal stromal cells', Stem Cells, vol. 27, pp. 489 - 497, http://dx.doi.org/10.1634/stemcells.2008-0855
    Journal articles | 2007
    Lee TS; Das A; Khosla C, 2007, 'Structure-activity relationships of semisynthetic mumbaistatin analogs', Bioorganic and Medicinal Chemistry, vol. 15, pp. 5207 - 5218, http://dx.doi.org/10.1016/j.bmc.2007.05.019
  • Preprints | 2020
    Kim L-J; Chalmers T; Smith G; Li C; Das A; Poon WKE; Wang J; Tucker S; Sinclair D; Quek L-E; Wu L, 2020, Nicotinamide mononucleotide (NMN) deamidation and indirect regulation of the NAD metabolome, http://dx.doi.org/10.21203/rs.3.rs-87047/v1
    Conference Abstracts | 2020
    Murphy T; Wu L; Sandow S; Das A; Naim H, 2020, 'Effect of Dietary Nicotinamide Mononucleotide (NMN) on Function and Mechanics of Skeletal Muscle Arteries from Aged Mice', in FASEB JOURNAL, WILEY, CA, San Diego, Vol. 34, presented at Annual Meeting on Experimental Biology, CA, San Diego, 04 April 2020 - 07 April 2020, http://dx.doi.org/10.1096/fasebj.2020.34.s1.04752
    Preprints | 2020
    Shariev A; Laos AJ; Lai D; Hua S; Zinger A; McRae CR; Casbolt LS; Combes V; Hung T-T; Dixon KM; Thordarson P; Mason RS; Das A, 2020, Skin protective effects of RM191A, a novel superoxide dismutase mimetic, http://dx.doi.org/10.1101/2020.05.10.086694
    Preprints | 2019
    Hayano M; Yang J-H; Bonkowski MS; Amorim JA; Ross JM; Coppotelli G; Griffin PT; Chew YC; Guo W; Yang X; Vera DL; Salfati EL; Das A; Thakur S; Kane AE; Mitchell SJ; Mohri Y; Nishimura EK; Schaevitz L; Garg N; Balta A-M; Rego MA; Gregory-Ksander M; Jakobs TC; Zhong L; Wakimoto H; Mostoslavsky R; Wagers AJ; Tsubota K; Bonasera SJ; Palmeira CM; Seidman JG; Seidman CE; Wolf NS; Kreiling JA; Sedivy JM; Murphy GF; Oberdoerffer P; Ksander BR; Rajman LA; Sinclair DA, 2019, DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging, http://dx.doi.org/10.1101/808659

  • CRO MetroBiotech International: Testing the efficacy of NAD precursors in wound healing using mouse models (2018 - present)

  • UNSW RIS_LSCI_MWAC (Associate Investigator): Laser Speckle Imaging Equipment Grant (2017)

  • NHMRC APP1093643 (Associate Investigator): New drugs to prevent premature ageing and side effects of chemotherapy (2015 - 2018)

  • Paul F. Glenn Postdoctoral Fellowship, Massachusetts Institute of Technology: Molecular dynamics of Sirtuin enzymes (2010 - 2014)

  • National Institute of Health Quantitative Chemical Biology Fellowship, Stanford University: Polyketide biosynthesis (2005 - 2008)

Patents

  • Methods for enhancing vascular density (Application No. PCT/AU2017/051435

My Research Supervision

PhDs

ILPs

 

My Teaching

  • Animal Care and Ethics Course (14/129A), UNSW Sydney (2015 - present)
  • Invited Lecture (PHAR3251): Targeting PI3-kinase(s) in cancer, UNSW Sydney (2015)
  • Session 1 Practical (PHAR3251): PI3K Inhibition and Cancer Cell Growth, University of New South Wales, Australia (2015)
  • Session 2 Practical (PHAR3251): PI3  Inhibition and Cancer Cell Metastasis, University of New South Wales, Australia (2015)
  • Massachusetts Institute of Technology Teaching Certificate (2014)
  • Advanced Undergraduate Seminar Course (7.341): Unraveling the Molecular Mechanisms of Aging and Age-related Diseases, Massachusetts Institute of Technology, USA (2013)
  • General Chemistry (CHEM 31A/B), Stanford University, USA (2004)