Dr Abu Sina

Dr Abu Sina

Senior Lecturer

PhD in Biomedical Engineering, The University of Queensland, Brisbane, Australia, 2017

Higher Education Teaching Certificate, Harvard University, Boston, USA, 2022

Visiting Scientist, Dana Farber Cancer Institute, Harvard University, Boston, USA, 2022

Visiting Research Fellow, Irving Cancer Research Center, Columbia University, New York, 2023

Senior Research Fellow, The University of Queensland, Brisbane, Australia, 2025

Science
School of Biotech & Biomolecular Science

Dr. Abu Sina is a Senior Lecturer and Group Leader of Sina Lab at the School of Biotechnology and Biomolecular Sciences, UNSW Sydney. Prior to this role, he served as a Senior Research Fellow at the Center for Personalized Nanomedicine and a Theme Leader at the Center for Materials Space-Tectonics (CeMaSTec), both part of the Australian Institute for Bioengineering & Nanotechnology (AIBN) at The University of Queensland (UQ), Australia. His career also includes international research appointments as a Visiting Scientist at the Dana-Farber Cancer Institute, Harvard University, and a Visiting Research Fellow at the Irving Cancer Research Center, Columbia University, NY, USA, where he spent two years collaborating with leading experts in oncology and systems biology.

At UQ, Dr. Sina worked alongside ARC Laureate Fellow and Former Federation Fellow, Professor Matt Trau, contributing to groundbreaking research in nanomedicine. During his time at Harvard, he collaborated with Professor Adam Bass, now the Global Head of Oncology Translational Research at Novartis. His tenure at Columbia University included work with Professor Andrea Califano, currently the President of the $270M Chan-Zuckerberg Biohub in New York and a Professor in the Systems Biology Department at Columbia University.

Dr. Sina earned his PhD in Biomedical Engineering in 2017 from The University of Queensland, Australia, following his Bachelor with Honours and Master's in Chemistry from Shahjalal University of Science & Technology, Bangladesh. His diverse academic and research journey reflects a commitment to advancing translational nanomedicine and molecular diagnostics on a global scale.

  • Book Chapters | 2018
    Ibn Sina AA; Koo KM; Ahmed M; Carrascosa LG; Trau M, 2018, 'Interfacial biosensing: Direct biosensing of biomolecules at the bare metal interface', in Encyclopedia of Interfacial Chemistry Surface Science and Electrochemistry, pp. 269 - 277, http://dx.doi.org/10.1016/B978-0-12-409547-2.14188-5
  • Journal articles | 2025
    Choudhury A; Linne K; Bulfone TC; Hossain T; Sina AAI; Bickler PL; Fry BG; Lewin MR, 2025, 'Electrical Cell Impedance Sensing (ECIS): Feasibility of a Novel In Vitro Approach to Studying Venom Toxicity and Potential Therapeutics', Toxins, 17, http://dx.doi.org/10.3390/toxins17040193
    Journal articles | 2025
    Sheikh MR; Mahmud HH; Hossen MS; Saha D; Uddin ME; Hossain MF; Munshi MK; Sina AAI, 2025, 'Modeling the Interactions Between Chemicals and Proteins to Predict the Health Consequences of Air Pollution', International Journal of Environmental Research and Public Health, 22, http://dx.doi.org/10.3390/ijerph22030418
    Journal articles | 2025
    Uddin ME; Sheikh MR; Asaduzzaman M; Ahmed S; Kundu SK; Sina AAI, 2025, 'Identification and Characterization of a Protease Producing Bacillus cereus Strain From Tannery Waste for Efficient Dehairing of Goat Skin', Biomed Research International, 2025, http://dx.doi.org/10.1155/bmri/7639181
    Journal articles | 2024
    Ahmed E; Masud MK; Komatineni P; Dey S; Lobb R; Hossain MSA; Möller A; Yamauchi Y; Sina AAI; Trau M, 2024, 'A mesoporous gold biosensor to investigate immune checkpoint protein heterogeneity in single lung cancer cells', Biosensors and Bioelectronics, 249, http://dx.doi.org/10.1016/j.bios.2023.115984
    Journal articles | 2024
    Jakaria Al-Mujahidy SKMD; Kryukov K; Ikeo K; Saito K; Uddin ME; Sina AAI, 2024, 'Functional genomic analysis of the isolated potential probiotic Lactobacillus delbrueckii subsp. indicus TY-11 and its comparison with other Lactobacillus delbrueckii strains', Microbiology Spectrum, 12, http://dx.doi.org/10.1128/spectrum.03470-23
    Journal articles | 2024
    Shanmugasundaram KB; Ahmed E; Miao X; Kulasinghe A; Fletcher JA; Monkman J; Mainwaring P; Masud MK; Park H; Hossain MSA; Yamauchi Y; Sina AAI; O’Byrne K; Wuethrich A; Trau M, 2024, 'A Mesoporous Gold Sensor Unveils Phospho PD-L1 in Extracellular Vesicles as a Proxy for PD-L1 Expression in Lung Cancer Tissue', ACS Sensors, 9, pp. 3009 - 3016, http://dx.doi.org/10.1021/acssensors.4c00192
    Journal articles | 2023
    Ahmed E; Shanmugasundaram KB; Li J; Behren A; Lobb R; Möller A; Wuethrich A; Dey S; Sina AAI; Trau M, 2023, 'A Microfluidic Liquid Biopsy Platform to Monitor Protein Biomarker Heterogeneity in Single Circulating Therapy‐Resistance Cancer Cell', Advanced Sensor Research, 2, http://dx.doi.org/10.1002/adsr.202300059
    Journal articles | 2023
    Ahmed M; Wuethrich A; Constantin N; Shanmugasundaram KB; Mainwaring P; Kulasinghe A; O’Leary C; O’Byrne K; Sina AAI; Carrascosa LG; Trau M, 2023, 'Liquid Biopsy Snapshots of Key Phosphoproteomic Pathways in Lung Cancer Patients for Diagnosis and Therapy Monitoring', Analytical Chemistry, 95, pp. 8522 - 8532, http://dx.doi.org/10.1021/acs.analchem.3c00519
    Journal articles | 2023
    Khamis R; Shanmugasundaram KB; Zhou Q; Lu J; Zhang Z; Hill MM; Sina AAI; Trau M; Wuethrich A, 2023, 'Multiplex SERS-Lectin-Immunoassay for Esophageal Adenocarcinoma Screening', ACS Applied Nano Materials, 6, pp. 20190 - 20197, http://dx.doi.org/10.1021/acsanm.3c03987
    Journal articles | 2023
    Li J; Sina AAI; Antaw F; Fielding D; Möller A; Lobb R; Wuethrich A; Trau M, 2023, 'Digital Decoding of Single Extracellular Vesicle Phenotype Differentiates Early Malignant and Benign Lung Lesions', Advanced Science, 10, http://dx.doi.org/10.1002/advs.202204207
    Journal articles | 2022
    Constantin N; Sina AAI; Korbie D; Trau M, 2022, 'Opportunities for Early Cancer Detection: The Rise of ctDNA Methylation-Based Pan-Cancer Screening Technologies', Epigenomes, 6, http://dx.doi.org/10.3390/epigenomes6010006
    Journal articles | 2022
    Dey S; Ahmed E; Somvanshi PS; Sina AAI; Wuethrich A; Trau M, 2022, 'An Electrochemical and Raman Scattering Dual Detection Biosensor for Rapid Screening and Biomolecular Profiling of Cancer Biomarkers', Chemosensors, 10, http://dx.doi.org/10.3390/chemosensors10030093
    Journal articles | 2022
    Shanmugasundaram KB; Li J; Sina AI; Wuethrich A; Trau M, 2022, 'Toward precision oncology: SERS microfluidic systems for multiplex biomarker analysis in liquid biopsy', Materials Advances, 3, pp. 1459 - 1471, http://dx.doi.org/10.1039/d1ma00848j
    Journal articles | 2021
    Ali MY; Sina AAI; Khandker SS; Neesa L; Tanvir EM; Kabir A; Khalil MI; Gan SH, 2021, 'Nutritional composition and bioactive compounds in tomatoes and their impact on human health and disease: A review', Foods, 10, http://dx.doi.org/10.3390/foods10010045
    Journal articles | 2021
    Li J; Wuethrich A; Sina AAI; Cheng HH; Wang Y; Behren A; Mainwaring PN; Trau M, 2021, 'A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-21431-w
    Journal articles | 2021
    Reza KK; Dey S; Wuethrich A; Jing Wang ; Behren A; Antaw F; Wang Y; Sina AAI; Trau M, 2021, 'In Situ Single Cell Proteomics Reveals Circulating Tumor Cell Heterogeneity during Treatment', ACS Nano, 15, pp. 11231 - 11243, http://dx.doi.org/10.1021/acsnano.0c10008
    Journal articles | 2021
    Wahab MA; Karim MR; Aijaz MO; Salahuddin B; Aziz S; Sina AAI, 2021, 'A study on the interfacial compatibility, microstructure and physico-chemical properties of polyimide/organically modified silica nanocomposite membrane', Polymers, 13, http://dx.doi.org/10.3390/polym13081328
    Journal articles | 2021
    Wang J; Wuethrich A; Lobb RJ; Antaw F; Sina AAI; Lane RE; Zhou Q; Zieschank C; Bell C; Bonazzi VF; Aoude LG; Everitt S; Yeo B; Barbour AP; Möller A; Trau M, 2021, 'Characterizing the Heterogeneity of Small Extracellular Vesicle Populations in Multiple Cancer Typesviaan Ultrasensitive Chip', ACS Sensors, 6, pp. 3182 - 3194, http://dx.doi.org/10.1021/acssensors.1c00358
    Journal articles | 2020
    Ahmed E; Masud MK; Hossain MSA; Na J; Sina AAI; Yamauchi Y; Trau M, 2020, 'Nanostructured mesoporous gold electrodes detect protein phosphorylation in cancer with electrochemical signal amplification', Analyst, 145, pp. 6639 - 6648, http://dx.doi.org/10.1039/d0an01096k
    Journal articles | 2020
    Khalil I; Yehye WA; Muhd Julkapli N; Sina AAI; Rahmati S; Basirun WJ; Seyfoddin A, 2020, 'Dual platform based sandwich assay surface-enhanced Raman scattering DNA biosensor for the sensitive detection of food adulteration', Analyst, 145, pp. 1414 - 1426, http://dx.doi.org/10.1039/c9an02106j
    Journal articles | 2020
    Kumar AR; Shanmugasundaram KB; Li J; Zhang Z; Ibn Sina AA; Wuethrich A; Trau M, 2020, 'Ultrasensitive melanoma biomarker detection using a microchip SERS immunoassay with anisotropic Au-Ag alloy nanoboxes', Rsc Advances, 10, pp. 28778 - 28785, http://dx.doi.org/10.1039/d0ra05032f
    Journal articles | 2020
    Sina AAI; Lin TY; Vaidyanathan R; Wang Z; Dey S; Wang J; Behren A; Wuethrich A; Carrascosa LG; Trau M, 2020, 'Methylation dependent gold adsorption behaviour identifies cancer derived extracellular vesicular DNA', Nanoscale Horizons, 5, pp. 1317 - 1323, http://dx.doi.org/10.1039/d0nh00258e
    Journal articles | 2020
    Wang J; Wuethrich A; Sina AAI; Lane RE; Lin LL; Wang Y; Cebon J; Behren A; Trau M, 2020, 'Tracking extracellular vesicle phenotypic changes enables treatment monitoring in melanoma', Science Advances, 6, http://dx.doi.org/10.1126/sciadv.aax3223
    Journal articles | 2019
    Dey S; Kamil Reza K; Wuethrich A; Korbie D; Ibn Sina AA; Trau M, 2019, 'Tracking antigen specific T-cells: Technological advancement and limitations', Biotechnology Advances, 37, pp. 145 - 153, http://dx.doi.org/10.1016/j.biotechadv.2018.11.010
    Journal articles | 2019
    Dey S; Koo KM; Wang Z; Sina AAI; Wuethrich A; Trau M, 2019, 'An integrated multi-molecular sensor for simultaneous BRAFV600E protein and DNA single point mutation detection in circulating tumour cells', Lab on A Chip, 19, pp. 738 - 748, http://dx.doi.org/10.1039/c8lc00991k
    Journal articles | 2019
    Dey S; Vaidyanathan R; Reza KK; Wang J; Wang Y; Nel HJ; Law SC; Tyler J; Rossjohn J; Reid HH; Ibn Sina AA; Thomas R; Trau M, 2019, 'A microfluidic-SERSplatform for isolation and immuno-phenotyping of antigen specific T-cells', Sensors and Actuators B Chemical, 284, pp. 281 - 288, http://dx.doi.org/10.1016/j.snb.2018.12.099
    Journal articles | 2019
    Khalil I; Yehye WA; Julkapli NM; Rahmati S; Sina AAI; Basirun WJ; Johan MR, 2019, 'Graphene oxide and gold nanoparticle based dual platform with short DNA probe for the PCR free DNA biosensing using surface-enhanced Raman scattering', Biosensors and Bioelectronics, 131, pp. 214 - 223, http://dx.doi.org/10.1016/j.bios.2019.02.028
    Journal articles | 2019
    Khondakar KR; Dey S; Wuethrich A; Sina AAI; Trau M, 2019, 'Toward Personalized Cancer Treatment: From Diagnostics to Therapy Monitoring in Miniaturized Electrohydrodynamic Systems', Accounts of Chemical Research, 52, pp. 2113 - 2123, http://dx.doi.org/10.1021/acs.accounts.9b00192
    Journal articles | 2019
    Reza KK; Sina AAI; Wuethrich A; Grewal YS; Howard CB; Korbie D; Trau M, 2019, 'A SERS microfluidic platform for targeting multiple soluble immune checkpoints', Biosensors and Bioelectronics, 126, pp. 178 - 186, http://dx.doi.org/10.1016/j.bios.2018.10.044
    Journal articles | 2019
    Sina AAI; Carrascosa LG; Trau M, 2019, 'DNA Methylation-Based Point-of-Care Cancer Detection: Challenges and Possibilities', Trends in Molecular Medicine, 25, pp. 955 - 966, http://dx.doi.org/10.1016/j.molmed.2019.05.014
    Journal articles | 2019
    Sina AAI; Vaidyanathan R; Wuethrich A; Carrascosa LG; Trau M, 2019, 'Label-free detection of exosomes using a surface plasmon resonance biosensor', Analytical and Bioanalytical Chemistry, 411, pp. 1311 - 1318, http://dx.doi.org/10.1007/s00216-019-01608-5
    Journal articles | 2019
    Wuethrich A; Rajkumar AR; Shanmugasundaram KB; Reza KK; Dey S; Howard CB; Sina AAI; Trau M, 2019, 'Single droplet detection of immune checkpoints on a multiplexed electrohydrodynamic biosensor', Analyst, 144, pp. 6914 - 6921, http://dx.doi.org/10.1039/c9an01450k
    Journal articles | 2018
    Reza KK; Dey S; Wuethrich A; Sina AAI; Korbie D; Wang Y; Trau M, 2018, 'Parallel profiling of cancer cells and proteins using a graphene oxide functionalized ac-EHD SERS immunoassay', Nanoscale, 10, pp. 18482 - 18491, http://dx.doi.org/10.1039/c8nr02886a
    Journal articles | 2018
    Sina AAI; Carrascosa LG; Liang Z; Grewal YS; Wardiana A; Shiddiky MJA; Gardiner RA; Samaratunga H; Gandhi MK; Scott RJ; Korbie D; Trau M, 2018, 'Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker', Nature Communications, 9, http://dx.doi.org/10.1038/s41467-018-07214-w
    Journal articles | 2018
    Wuethrich A; Sina AAI; Ahmed M; Lin TY; Carrascosa LG; Trau M, 2018, 'Interfacial nano-mixing in a miniaturised platform enables signal enhancement and: In situ detection of cancer biomarkers', Nanoscale, 10, pp. 10884 - 10890, http://dx.doi.org/10.1039/c7nr09496e
    Journal articles | 2017
    Ahmed M; Carrascosa LG; Ibn Sina AA; Zarate EM; Korbie D; Ru KL; Shiddiky MJA; Mainwaring P; Trau M, 2017, 'Detection of aberrant protein phosphorylation in cancer using direct gold-protein affinity interactions', Biosensors and Bioelectronics, 91, pp. 8 - 14, http://dx.doi.org/10.1016/j.bios.2016.12.012
    Journal articles | 2017
    Sina AAI; Foster MT; Korbie D; Carrascosa LG; Shiddiky MJA; Gao J; Dey S; Trau M, 2017, 'A multiplex microplatform for the detection of multiple DNA methylation events using gold-DNA affinity', Analyst, 142, pp. 3573 - 3578, http://dx.doi.org/10.1039/c7an00611j
    Journal articles | 2016
    Sina AAI; Vaidyanathan R; Dey S; Carrascosa LG; Shiddiky MJA; Trau M, 2016, 'Real time and label free profiling of clinically relevant exosomes', Scientific Reports, 6, http://dx.doi.org/10.1038/srep30460
    Journal articles | 2016
    Yadav S; Carrascosa LG; Sina AAI; Shiddiky MJA; Hill MM; Trau M, 2016, 'Electrochemical detection of protein glycosylation using lectin and protein-gold affinity interactions', Analyst, 141, pp. 2356 - 2361, http://dx.doi.org/10.1039/c6an00528d
    Journal articles | 2015
    Koo KM; Sina AAI; Carrascosa LG; Shiddiky MJA; Trau M, 2015, 'DNA-bare gold affinity interactions: Mechanism and applications in biosensing', Analytical Methods, 7, pp. 7042 - 7054, http://dx.doi.org/10.1039/c5ay01479d
    Journal articles | 2015
    Sina AAI; Al-Rafia SMI; Ahmad MF; Paul RK; Islam SMS; Younus M; Raithby PR; Ho CL; Lo YH; Liu L; Li H; Wong WY, 2015, 'Synthesis, Structures and Properties of Novel Platinum(II) Acetylide Complexes and Polymers with Tri(tolyl)phosphine as the Auxiliary Ligand', Journal of Inorganic and Organometallic Polymers and Materials, 25, pp. 427 - 436, http://dx.doi.org/10.1007/s10904-014-0071-7
    Journal articles | 2014
    Carrascosa LG; Sina AAI; Palanisamy R; Sepulveda B; Otte MA; Rauf S; Shiddiky MJA; Trau M, 2014, 'Molecular inversion probe-based SPR biosensing for specific, label-free and real-time detection of regional DNA methylation', Chemical Communications, 50, pp. 3585 - 3588, http://dx.doi.org/10.1039/c3cc49607d
    Journal articles | 2014
    Koo KM; Sina AAI; Carrascosa LG; Shiddiky MJA; Trau M, 2014, 'Emethylsorb: Rapid quantification of DNA methylation in cancer cells on screen-printed gold electrodes', Analyst, 139, pp. 6178 - 6184, http://dx.doi.org/10.1039/c4an01641f
    Journal articles | 2014
    Sina AAI; Carrascosa LG; Palanisamy R; Rauf S; Shiddiky MJA; Trau M, 2014, 'Methylsorb: A simple method for quantifying DNA methylation using DNA-gold affinity interactions', Analytical Chemistry, 86, pp. 10179 - 10185, http://dx.doi.org/10.1021/ac502214z
    Journal articles | 2014
    Sina AAI; Howell S; Carrascosa LG; Rauf S; Shiddiky MJA; Trau M, 2014, 'eMethylsorb: Electrochemical quantification of DNA methylation at CpG resolution using DNA–gold affinity interactions', Chemical Communications, 50, pp. 13153 - 13156, http://dx.doi.org/10.1039/c4cc06732k
    Journal articles | 2014
    Sultana T; Waheed CA; Islam SMS; Sina AAI; Younus M; Jabbar MA; Sabuj MRH, 2014, 'Synthesis, characterization and Electrochemical studies of Ferrocenyl-2, 4-Dinitrophenylhydrazone', Journal of Bangladesh Academy of Sciences, 38, pp. 177 - 187, http://dx.doi.org/10.3329/jbas.v38i2.21342
  • Preprints | 2023
    Mujahidy SMJ; Ikeo K; Saito K; Ibn Sina DAA; Uddin ME, 2023, A Potential Novel Probiotic Strain and its Comparative Antagonism Evaluation with a Multi-Strain Probiotic Combination along with an Innovative Approach for Quantifying the Viable Microbiota, http://dx.doi.org/10.20944/preprints202311.1374.v1
    Conference Papers | 2015
    Shiddiky MJA; Sina AAI; Carrascosa LG; Palanisamy R; Rauf S; Trau M, 2015, 'Methylsorb: A simple method for quantifying DNA methylation using DNA-gold affinity interactions', in 8th International Conference on Electrical and Computer Engineering Advancing Technology for A Better Tomorrow Icece 2014, pp. 17 - 20, http://dx.doi.org/10.1109/ICECE.2014.7027002
    Theses / Dissertations |
    Sina AAI, Detecting DNA methylation at the gold interface: a gateway towards next generation cancer diagnostics, http://dx.doi.org/10.14264/699210

NHMRC Investigator Grant (Emerging Leadership Category 1, 2020-2024)
ARC Discovery Project (2021-2024)
UQ Research Infrastucture Investment Grant (2021)
Industry Research Grant from AstraZeneca (2020)
Philanthropic Research grant from Evolution Mining (2020-2025)
UQ Early Career Researcher grant (2020-2021)

Research Excellence Award 2022 from Dana-Farber Cancer Institute, Harvard University.
Metrohm- EDRACI Young Electrochemist Award 2021 from Metrohm Australia and Electrochemistry Division of the Royal Australian Chemical Institute, Australia
Nomination for the the Journal of Materials Chemistry Lectureship 2021 and 2022
Young Scientist Award 2020 from International Association of Advanced Materials (IAAM)
Nominated for the Journal of Materials Chemistry Lectureship 2020
Queensland Health and Medical Research Award 2019 from Queenland Govt. and Australian Society for Medical Research
Nomination for University of Queensland Awards for Excellence 2019

Dr Abu Sina's research program has pioneered the development and translation of advanced nanotechnologies for the trace-level detection of biomarkers in liquid biopsies. He is internationally recognised for his groundbreaking work in early cancer detection, particularly through his invention of the Methylscape Multi-Cancer Early Detection (MCED) test (Nature Communications, 2018). Dr Sina has developed nanotechnology-based platforms for single-cell (ACS Nano, 2020, Advanced Sensor Research 2023, Biosensors and Bioelectronics, 2024), single-molecule (Nature Communications, 2021), and single extracellular vesicle (Advanced Science, 2023) analysis, enabling trace level detection of molecular alterations at the early stage of diseases. Dr Sina's research program has generated 56 peer-reviewed publications, including 4 in journals under the Nature and Science families. One of his papers ranks in the top 1% of most cited publications globally, seven in the top 5%, and thirteen in the top 10% (field-weighted; Web of Science). His publications have earned over 2,672 citations (Google Scholar), with an FWCI >2, and have been cited in 1,110 documents across 88 countries and 23 subject categories (Scopus, August 2024).

My Teaching

My identity as a teacher has been shaped by my extensive experience in research, teaching, and in the industry, within the fields of biotechnology, biomolecular sciences, molecular biology, and nano-biotechnology. As an educator, my primary objective is to excel and achieve a high standard of teaching. I strive to create a familial bond with my students while upholding a strong level of professionalism that welcomes constructive criticism and feedback. My ultimate aspiration in teaching is to equip my students with the skills and knowledge necessary to excel in the real world. I aim to nurture them into future leaders, catalysts for change, and creators of knowledge within and beyond the realms of my field, ultimately molding them into better global citizens who contribute to the advancement of the world.