Dr Akanksha Bhargava

Dr Akanksha Bhargava

Lecturer
Engineering
Biomedical Engineering

Dr Akanksha Bhargava is a Lecturer and Early Career Academic Fellow in the School of Biomedical Engineering at UNSW Sydney. Her research investigates how imaging across scales and modalities can be integrated to understand biological structure and function in disease. She develops multimodal biomedical imaging and imaging data science approaches spanning micro-computed tomography, light-sheet microscopy, magnetic resonance imaging and hyperspectral imaging, with a focus on vascular and cellular dysfunction in cancer and neuroscience.

Her PhD and postdoctoral research at Johns Hopkins University and Johns Hopkins Medicine, USA established her expertise in multiscale vascular imaging and image-based computational hemodynamic modeling, leading to the development of VascuViz (Nature Methods, 2022), a multimodal vascular imaging framework for 3D mapping of vascular structure and function. This work also enabled the development of a three-dimensional in-silico angiogenesis atlas for breast cancer. At UNSW, she is extending this work through multimodal data integration and AI-enabled approaches to disease phenotyping and biomarker discovery. Her research has been recognised through the 2020 North American Microcirculatory Society Emerging Leaders Award and a 2025 UNSW Founders Early Career Academic Startup Fellowship supporting research translation biomedical imaging research.

  • Journal articles | 2026
    Knab A; Handley S; Xu X; Mackevicius M; Anwer AG; Campbell JM; Tian Y; Goldys EM; Bhargava A, 2026, 'Multidimensional data analysis and classification using SMIAL', Communications Biology, 9, http://dx.doi.org/10.1038/s42003-026-09630-x
    Journal articles | 2026
    Lei Z; Xu X; Tilia L; Toit-Thompson SD; Horta F; Gilchrist RB; Walls ML; Bhargava A; Goldys EM, 2026, 'Deep learning-based segmentation of human oocytes with cross-dataset evaluation', Computer Methods and Programs in Biomedicine, 285, http://dx.doi.org/10.1016/j.cmpb.2026.109507
    Journal articles | 2025
    Lowe AL; Issa M; Johnson JA; Chen D; Brown E; Orsini AA; Quinn KN; Bhargava A; Pathak A; Tuffaha S; Thakor NV, 2025, '3D Vascular Analysis of Regenerative Peripheral Nerve Interfaces Shows Neovasculature in Muscle Core by Day 5 Post Surgery', Muscle and Nerve, 72, pp. 662 - 671, http://dx.doi.org/10.1002/mus.70001
    Journal articles | 2025
    Wu HHL; Handley S; Knab A; Bhargava A; Goldys EM; Pollock CA; Saad S, 2025, 'WCN25-79 NON-INVASIVE DIAGNOSIS OF CHRONIC KIDNEY DISEASE BY MACHINE-LEARNING BASED EVALUATION OF URINARY EXFOLIATED PROXIMAL TUBULE CELL MULTISPECTRAL AUTOFLUORESCENCE', Kidney International Reports, 10, pp. S60 - S61, http://dx.doi.org/10.1016/j.ekir.2024.11.168
    Journal articles | 2025
    Wu HHL; Lang Y; Handley S; Knab A; Agha A; Tian Y; Bhargava A; Goldys EM; Pollock CA; Saad S, 2025, 'Noninvasive Assessment of Urinary Exfoliated Proximal Tubule Cell Multispectral Autofluorescence May Differentiate between Causes of Kidney Transplant Dysfunction', Kidney360, 6, pp. 1853 - 1862, http://dx.doi.org/10.34067/KID.0000000879
    Journal articles | 2024
    Campbell JM; Gosnell M; Agha A; Handley S; Knab A; Anwer AG; Bhargava A; Goldys EM, 2024, 'Label-Free Assessment of Key Biological Autofluorophores: Material Characteristics and Opportunities for Clinical Applications', Advanced Materials, 36, http://dx.doi.org/10.1002/adma.202403761
    Journal articles | 2024
    Campbell JM; Habibalahi A; Agha A; Handley S; Knab A; Xu X; Bhargava A; Lei Z; Mackevicius M; Tian Y; Mahbub SB; Anwer AG; Gronthos S; Paton S; Grey ST; Wu L; Gilchrist RB; Goldys EM, 2024, 'Single cell, Label free Characterisation of Human Mesenchymal Stromal cell Stemness and Future Growth Potential by Autofluorescence Multispectral Imaging', Stem Cell Reviews and Reports, 20, pp. 2283 - 2292, http://dx.doi.org/10.1007/s12015-024-10778-4
    Journal articles | 2024
    Gowda PC; Weinstein RM; Bhargava A; Senarathna J; Stewart RQ; Ekbote PV; Singh M; Guan E; Banghar S; Pathak AP; Weiss CR, 2024, 'Development of a High-Fidelity Benchtop Model for Simultaneous Flow, Pressure, and Imaging Assessment of Transarterial Embolization Procedures', Cardiovascular Engineering and Technology, 15, pp. 738 - 748, http://dx.doi.org/10.1007/s13239-024-00749-8
    Journal articles | 2024
    Handley S; Anwer AG; Knab A; Bhargava A; Goldys EM, 2024, 'AutoMitoNetwork: Software for analyzing mitochondrial networks in autofluorescence images to enable label-free cell classification', Cytometry Part A, 105, pp. 688 - 703, http://dx.doi.org/10.1002/cyto.a.24889
    Journal articles | 2024
    Ren Y; Chu X; Senarathna J; Bhargava A; Grayson WL; Pathak AP, 2024, 'Multimodality imaging reveals angiogenic evolution in vivo during calvarial bone defect healing', Angiogenesis, 27, pp. 105 - 119, http://dx.doi.org/10.1007/s10456-023-09899-0
    Journal articles | 2023
    Bhargava A; Popel AS; Pathak AP, 2023, 'Vascular phenotyping of the invasive front in breast cancer using a 3D angiogenesis atlas', Microvascular Research, 149, http://dx.doi.org/10.1016/j.mvr.2023.104555
    Journal articles | 2022
    Bhargava A; Monteagudo B; Kushwaha P; Senarathna J; Ren Y; Riddle RC; Aggarwal M; Pathak AP, 2022, 'VascuViz: a multimodality and multiscale imaging and visualization pipeline for vascular systems biology', Nature Methods, 19, pp. 242 - 254, http://dx.doi.org/10.1038/s41592-021-01363-5
    Journal articles | 2022
    Gowda P; Weinstein R; Bhargava A; Senarathna J; Amlani L; Gong A; Khalil A; Garg T; Yuan F; Pathak A; Weiss C, 2022, 'Abstract No. 298 Intravascular pressure changes during transarterial embolization therapy in a benchtop hepatic vascular model', Journal of Vascular and Interventional Radiology, 33, pp. S137 - S137, http://dx.doi.org/10.1016/j.jvir.2022.03.379
    Journal articles | 2022
    Gowda P; Weinstein R; Senarathna J; Bhargava A; Stewart R; Pond S; Mehta T; Garg T; Gong A; Khalil A; Pathak A; Weiss C, 2022, 'Abstract No. 293 EmboMetrix: a novel multiparametric benchtop model for real-time and simultaneous flow, pressure, and imaging assessment of transarterial embolization procedures', Journal of Vascular and Interventional Radiology, 33, pp. S134 - S135, http://dx.doi.org/10.1016/j.jvir.2022.03.374
    Journal articles | 2022
    Ren Y; Bhargava A; Senarathna J; Chu X; Grayson W; Pathak A, 2022, 'Characterizing the Correlation Between Angiogenesis and Osteogenesis In Vivo Using Multicontrast Functional Imaging in a Calvarial Defect Model', The FASEB Journal, 36, http://dx.doi.org/10.1096/fasebj.2022.36.s1.r2091
    Journal articles | 2022
    Senarathna J; Kovler M; Prasad A; Bhargava A; Thakor NV; Sodhi CP; Hackam DJ; Pathak AP, 2022, 'In vivo phenotyping of the microvasculature in necrotizing enterocolitis with multicontrast optical imaging', Microcirculation, 29, pp. e12768 - e12768, http://dx.doi.org/10.1111/micc.12768
    Journal articles | 2021
    Bhargava A; Popel A; Pathak A, 2021, 'Image-Based Modeling of the Invasive Vascular Front in Breast Cancer', FASEB JOURNAL, 35, http://dx.doi.org/10.1096/fasebj.2021.35.S1.04594
    Journal articles | 2021
    Guerraty M; Bhargava A; Senarathna J; Mendelson AA; Pathak AP, 2021, 'Advances in translational imaging of the microcirculation', Microcirculation, 28, http://dx.doi.org/10.1111/micc.12683
    Journal articles | 2020
    Bhargava A; Monteagudo B; Aggarwal M; Pathak A, 2020, 'A Novel Vascular Fiducials‐based Approach (VASFID) for Co‐registering Multiscale Imaging Data for Microcirculation Systems Biology', The FASEB Journal, 34, pp. 1 - 1, http://dx.doi.org/10.1096/fasebj.2020.34.s1.06756
    Journal articles | 2020
    Senarathna J; Prasad A; Bhargava A; Gil S; Thakor NV; Pathak AP, 2020, 'HemoSYS: A Toolkit for Image-based Systems Biology of Tumor Hemodynamics', Scientific Reports, 10, pp. 2372 - 2372, http://dx.doi.org/10.1038/s41598-020-58918-3
    Journal articles | 2020
    Senarathna J; Prasad A; Bhargava A; Pathak A, 2020, 'HemoSYS: An Image-based Toolkit for Quantifying Hemodynamics in the Microcirculation', FASEB JOURNAL, 34, http://dx.doi.org/10.1096/fasebj.2020.34.s1.05910
    Journal articles | 2019
    Stamatelos SK; Bhargava A; Kim E; Popel AS; Pathak AP, 2019, 'Tumor Ensemble-Based Modeling and Visualization of Emergent Angiogenic Heterogeneity in Breast Cancer', Scientific Reports, 9, pp. 5276 - 5276, http://dx.doi.org/10.1038/s41598-019-40888-w
    Journal articles | 2014
    Bhargava A; Chanmugam A; Herman C, 2014, 'Heat transfer model for deep tissue injury: A step towards an early thermographic diagnostic capability', Diagnostic Pathology, 9, http://dx.doi.org/10.1186/1746-1596-9-36
    Journal articles | 2011
    Bakshi SR; Bhargava A; Mohammadizadeh S; Agarwal A; Tsukanov I, 2011, 'Computational estimation of elastic properties of spark plasma sintered TaC by meshfree and finite element methods', Computational Materials Science, 50, pp. 2615 - 2620, http://dx.doi.org/10.1016/j.commatsci.2011.04.003
  • Conference Papers | 2025
    Campbell J; Habibalahi A; Agha A; Handley S; Knab A; Xu X; Bhargava A; Lei Z; Mackevicius M; Tian Y; Mahbub S; Anwer A; Gronthos S; Grey S; Wu L; Gilchrist R; Goldys E, 2025, 'Non-invasive characterization of hBM-MSCs using autofluorescence multispectral imaging: future growth and pluripotency', SPIE, the international society for optics and photonics, pp. 30, presented at Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXIII, http://dx.doi.org/10.1117/12.3041463
    Conference Papers | 2025
    Handley S; Anwer A; Knab A; Bhargava A; Goldys E, 2025, 'AutoMitoNetwork: software for quantitative mitochondrial network analysis using label-free autofluorescence images for cell classification', in Tarnok A; Houston JP; Su X (eds.), Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXIII, SPIE, pp. 20 - 20, presented at Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXIII, 25 January 2025 - 31 January 2025, http://dx.doi.org/10.1117/12.3041459
    Conference Papers | 2025
    Wu HHL; Knab A; Handley S; Bhargava A; Tian Y; Agha A; Pollock C; Saad S; Goldys EM, 2025, 'Non-invasive evaluation of urinary exfoliated proximal tubule cells for chronic kidney disease diagnosis using machine-learning and multispectral autofluorescence', in Kang HW; Sroka R; Zhang JJ (eds.), Advanced Photonics in Urology 2025, SPIE, pp. 16 - 16, presented at Advanced Photonics in Urology 2025, 25 January 2025 - 31 January 2025, http://dx.doi.org/10.1117/12.3041568
    Conference Papers | 2012
    Chanmugam A; Bhargava A; Herman C, 2012, 'Heat transfer model and quantitative analysis of deep tissue injury', in ASME International Mechanical Engineering Congress and Exposition Proceedings Imece, pp. 717 - 723, http://dx.doi.org/10.1115/IMECE2012-88405

  • Early Career Academic Fellowship, School of Biomedical Engineering, 2025
  • Early Carrer Academic Startup Fellowship, UNSW Founders, 2025
  • Sidney Kimmel Comprehensive Cancer Center Quantitative Sciences Grant, Johns Hopkins Medicine "Modeling drug delivery in breast cancer using real microvascular networks”, USD15k, 2019
  • School of Biomedical Engineering Mini-education grant, UNSW "Enhancing student learning through interactive video lessons", 5k, 2023

 

  • 2026 Winner of the Ambassador-Australia recognition for the highest-scoring abstract from Australia at the World Molecular Imaging Congress.
  • 2026 NSW Cardiovascular Research Network Rising Star Seminar Series participant, Sydney
  • 2020 Emerging Leaders Award, North American Microcirculatory Society, USA
  • 2019 Winner of the Biomedical Picture of the Day for beautiful imagery in biomedical science by the MRC London Institute of Medical Sciences (LMS), UK: https://bpod.org.uk/archive/2019/4/17?domain_redirected=true
  • 2018 Image-Based Biomedical Modeling Fellowship, Scientific Computing and Imaging Institute, University of Utah, USA
  • 2013 Creel Family Teaching Assistant Award for excellence in undergraduate teaching, Mechanical Engineering, Johns Hopkins University, USA
  • 2010 PhD scholarship, Mechanical Engineering, Johns Hopkins University (USD 402k)
  • 2010 Undergraduate research scholarship, Mechanical and Material Science Engineering, Florida International University, USA (USD 4k)

 

 

  • Biomedical engineering academic lead, 2026 Young Women in Engineering Pathway Program (Imaging). 
  • Engineering representative, 2026 UNSW Indonesia Open Days in Jakarta and Surabaya
  • ECR lead 2025 UNSW-India Research Sympsium, IIT Delhi, IIT Madras and IISc Bangalore
  • Member, World Molecular Imaging Society (WMIS) and the Imaging Data Science group
  • Host, 2025 biweekly seminar series at the former ARC Center of Excellence for Nanoscale Biophotonics.
  • Co-chair, 2025 Co-chair Current Students Committee, Biomedical Engineering, UNSW

My Research Supervision

  • Hyperspectral imaging of mitochondria function
  • AI applications of hyperspectral imaging
  • AI based assessment of oocyte quality
  • Assessment of oocyte quality using polarized light microscopy
  • Image-based biomarker development for clinical applications

My Teaching

  • Course coordination and development of new lab modules: Applications of Light in Engineering, Technology and the Life Sciences, BIOM9811, Biomedical Engineering. 
  • Co-teaching: Introduction to Engineering Design and Innovation, DESN1000.
  • Course design and development: Biomedical data analysis, BIOM2700 (a part of the Course Design Institute). 
  • Course innovation: Computer Aided Fluid Mechanics and Heat Transfer, Mechanical Engineering, Johns Hopkins University