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Mr Ali Jaafar

Mr Ali Jaafar

Postdoctoral Fellow
Medicine & Health
School of Biomedical Sciences

My research focuses on how lipid species and apolipoproteins influence α-synuclein aggregation and toxicity in the context of neurodegenerative diseases. I earned my PhD from the Université de La Réunion, France where I studied lipid-related mechanisms of neuropathology. I use a combination of in vitro, in vivo, and imaging approaches to explore the molecular links between metabolic dysfunction and neurodegenerative diseases such as Parkinson’s disease.

 

 

 
E-mail
ali.jaafar@unsw.edu.au
Location
School of Biomedical Sciences, UNSW Medicine & Health Level 3, Lowy Building UNSW SYDNEY 2052
  • Book Chapters | 2023
    Jaafar A, 2023, 'Role of Proprotein Convertase Subtilisin Kexin Type 9 in Lipoprotein(a) Metabolism', in Lipoprotein(a)
  • Journal articles | 2025
    Chemello K; Guedon AF; Techer R; Jaafar AK; Guilhen S; Swietek MJ; Lambert G; Gallo A, 2025, 'Apolipoprotein E Plasma Concentrations Are Predictive of Recurrent Strokes: Insights From the SPARCL Trial.', Journal of the American Heart Association, 14, pp. e036630, http://dx.doi.org/10.1161/JAHA.124.036630
    Journal articles | 2025
    Graves NJ; Jaafar AK; Gambin Y; Sierecki E, 2025, 'Divalent and Trivalent Metallic Ions Differentially Affect Alpha-Synuclein Aggregation', ACS Chemical Neuroscience, 16, pp. 3497 - 3512, http://dx.doi.org/10.1021/acschemneuro.5c00160
    Journal articles | 2025
    Jaafar AK; Paulo-Ramos A; Rastoldo G; Veeren B; Planesse C; Bringart M; Rondeau P; Chemello K; Meilhac O; Lambert GC; Bourane S, 2025, 'PCSK9 deficiency promotes the development of peripheral neuropathy.', JCI insight, pp. e183786, http://dx.doi.org/10.1172/jci.insight.183786
    Journal articles | 2023
    Jaafar AK; Techer R; Chemello K; Lambert G; Bourane S, 2023, 'PCSK9 and the nervous system: a no-brainer?', Journal of lipid research, 64, pp. 100426, http://dx.doi.org/10.1016/j.jlr.2023.100426
    Journal articles | 2022
    Jaafar AK; Paulo-Ramos A; Lambert G; Meilhac O; Bourane S, 2022, 'Impact of dyslipidemia on peripheral neuropathy', Atherosclerosis, 355, pp. 31 - 32, http://dx.doi.org/10.1016/j.atherosclerosis.2022.06.178
    Journal articles | 2022
    Rastoldo G; Jaafar AK; Paulo-Ramos A; Bourane S, 2022, 'Development of a neuropathy model in pre-diabetic mice', Atherosclerosis, 355, pp. 127 - 128, http://dx.doi.org/10.1016/j.atherosclerosis.2022.06.596
    Journal articles | 2022
    Suchowerska AK; Stokman G; Palmer JT; Coghlan PA; Pieterman EJ; Keijzer N; Lambert G; Chemello K; Jaafar AK; Parmar J; Yan L; Tong Y; Mu L; Princen HMG; Bonnar J; Evison BJ, 2022, 'A Novel, Orally Bioavailable, Small-Molecule Inhibitor of PCSK9 With Significant Cholesterol-Lowering Properties In Vivo', Journal of Lipid Research, 63, http://dx.doi.org/10.1016/J.JLR.2022.100293
    Journal articles | 2021
    Chemello K; Jaafar AK; Lambert G, 2021, 'Heart to heart with PCSK9.', European heart journal, 42, pp. 3091 - 3093, http://dx.doi.org/10.1093/eurheartj/ehab480
    Journal articles | 2021
    Uribe KB; Chemello K; Larrea-Sebal A; Benito-Vicente A; Galicia-Garcia U; Bourane S; Jaafar AK; Lambert G; Martín C, 2021, 'A Systematic Approach to Assess the Activity and Classification of PCSK9 Variants.', International journal of molecular sciences, 22, http://dx.doi.org/10.3390/ijms222413602
  • Preprints | 2024
    Jaafar A; Paulo-Ramos A; Rastoldo G; Veeren B; Planesse C; Bringart M; Rondeau P; Meilhac O; Lambert G; Bourane S, 2024, PCSK9 deficiency promotes the development of peripheral neuropathy, http://dx.doi.org/10.1101/2024.03.03.583154
    Preprints | 2024
    Rastoldo G; Jaafar A; Aurélie-Paulo-Ramos ; Thouvenot K; Planesse C; Bringart M; Gonthier M-P; Lambert G; Bourane S, 2024, Alteration of nociceptive Schwann cells in a mouse model of high-fat diet induced diabetic peripheral neuropathy, http://dx.doi.org/10.1101/2024.03.12.584541