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Conjoint Senior Lecturer

Dr Andrew Gifford

BSc (Med) Hons, MBBS UNSW

PhD, UNSW

FRCPA

 

Medicine & Health
School of Clinical Medicine

I work as a diagnostic Paediatric Pathologist for children at the Randwick Campus and as a Clinical Research Fellow at Children's Cancer Institute. My undergraduate medical studies and PhD, characterising methotrexate resistance in childhood acute lymphoblastic leukaemia, were undertaken at UNSW. This was followed by formal training in Anatomical Pathology leading to Fellowship of the Royal College of Pathologists of Australasia. My areas of interest comprise paediatric tumour pathology, including both extracranial solid tumours and brain tumours; general paediatric surgical pathology including Hirschsprung disease; and paediatric gastroenterology.
E-mail
agifford@ccia.org.au
Location
Anatomical Pathology, NSW Health Pathology, L4 Campus Centre, Prince of Wales Hospital, Barker Street, Randwick NSW 2031
  • Book Chapters | 2022
    2022, 'The Alimentary Tract and Exocrine Pancreas', in Keeling's Fetal and Neonatal Pathology, pp. 551 - 595, http://dx.doi.org/10.1007/978-3-030-84168-3_22
  • Journal articles | 2023
    2023, 'A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer', Genome Medicine, 15, pp. 20, http://dx.doi.org/10.1186/s13073-023-01170-x
    Journal articles | 2023
    2023, 'Fetal Lung Interstitial Tumor (FLIT): A case series', Journal of Neonatal Surgery, 12, pp. 4 - 4, http://dx.doi.org/10.47338/jns.v12.1141
    Journal articles | 2023
    2023, 'Histone H3-wild type diffuse midline gliomas with H3K27me3 loss are a distinct entity with exclusive EGFR or ACVR1 mutation and differential methylation of homeobox genes', Scientific Reports, 13, pp. 3775, http://dx.doi.org/10.1038/s41598-023-30395-4
    Journal articles | 2023
    2023, 'Improved local diagnosis of focal hyperinsulinism in the COVID-19 era by interstate radiopharmaceutical transport', Journal of Paediatrics and Child Health, 59, pp. 398 - 400, http://dx.doi.org/10.1111/jpc.16307
    Journal articles | 2022
    2022, 'In vitro and in vivo drug screens of tumor cells identify novel therapies for high-risk child cancer', EMBO Molecular Medicine, 14, http://dx.doi.org/10.15252/emmm.202114608
    Journal articles | 2022
    2022, 'Inhibition of mitochondrial translocase SLC25A5 and histone deacetylation is an effective combination therapy in neuroblastoma', International Journal of Cancer, http://dx.doi.org/10.1002/ijc.34349
    Journal articles | 2021
    2021, 'A Primer for Assessing the Pathology in Mouse Models of Neuroblastoma', Current Protocols, 1, pp. e310, http://dx.doi.org/10.1002/cpz1.310
    Journal articles | 2021
    2021, 'Dual targeting of chromatin stability by the curaxin CBL0137 and histone deacetylase inhibitor panobinostat shows significant preclinical efficacy in neuroblastoma', Clinical Cancer Research, 27, pp. 4338 - 4352, http://dx.doi.org/10.1158/1078-0432.CCR-20-2357
    Journal articles | 2021
    2021, 'Exploiting the reactive oxygen species imbalance in high-risk paediatric acute lymphoblastic leukaemia through auranofin', British Journal of Cancer, 125, pp. 55 - 64, http://dx.doi.org/10.1038/s41416-021-01332-x
    Journal articles | 2021
    2021, 'Parents' experiences of postmortem tumor donation for high-grade gliomas: Benefits and suggested improvements', Neuro-Oncology Advances, 3, pp. vdab087, http://dx.doi.org/10.1093/noajnl/vdab087
    Journal articles | 2021
    2021, 'The important role of routine cytopathology in pediatric precision oncology', Cancer Cytopathology, http://dx.doi.org/10.1002/cncy.22448
    Journal articles | 2020
    2020, 'ABCC4/MRP4 contributes to the aggressiveness of Myc-associated epithelial ovarian cancer', International Journal of Cancer, 147, pp. 2225 - 2238, http://dx.doi.org/10.1002/ijc.33005
    Journal articles | 2020
    2020, 'Accelerating development of high-risk neuroblastoma patient-derived xenograft models for preclinical testing and personalised therapy', British Journal of Cancer, http://dx.doi.org/10.1038/s41416-019-0682-4
    Journal articles | 2020
    2020, 'CD30 and ALK combination therapy has high therapeutic potency in RANBP2-ALK-rearranged epithelioid inflammatory myofibroblastic sarcoma', British Journal of Cancer, 123, pp. 1101 - 1113, http://dx.doi.org/10.1038/s41416-020-0996-2
    Journal articles | 2020
    2020, 'Fatty acid synthase and adenosine monophosphate-activated protein kinase regulate cell survival and drug sensitivity in diffuse large B-cell lymphoma', Leukemia and Lymphoma, 61, pp. 1810 - 1822, http://dx.doi.org/10.1080/10428194.2020.1742899
    Journal articles | 2020
    2020, 'Recurrent SPECC1L–NTRK fusions in pediatric sarcoma and brain tumors', Cold Spring Harbor Molecular Case Studies, 6, http://dx.doi.org/10.1101/MCS.A005710
    Journal articles | 2020
    2020, 'Stathmin levels alter PTPN14 expression and impact neuroblastoma cell migration', British Journal of Cancer, 122, pp. 434 - 444, http://dx.doi.org/10.1038/s41416-019-0669-1
    Journal articles | 2020
    2020, 'Suppression of ABCE1-mediated mRNA translation limits N-MYC-driven cancer progression', Cancer Research, 80, pp. 3706 - 3718, http://dx.doi.org/10.1158/0008-5472.CAN-19-3914
    Journal articles | 2020
    2020, 'Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer', Nature Medicine, 26, pp. 1742 - 1753, http://dx.doi.org/10.1038/s41591-020-1072-4
    Journal articles | 2019
    2019, 'A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia', Cancer Cell, 36, pp. 660 - 673.e11, http://dx.doi.org/10.1016/j.ccell.2019.11.001
    Journal articles | 2019
    2019, 'Complex Compound Inheritance of Lethal Lung Developmental Disorders Due to Disruption of the TBX-FGF Pathway', American Journal of Human Genetics, 104, pp. 213 - 228, http://dx.doi.org/10.1016/j.ajhg.2018.12.010
    Journal articles | 2019
    2019, 'Crizotinib and surgery for long-term disease control in children and adolescents with ALK-positive inflammatory myofibroblastic tumors', JCO Precision Oncology, 3, pp. 1 - 11, http://dx.doi.org/10.1200/PO.18.00297
    Journal articles | 2019
    2019, 'Drugging MYCN oncogenic signaling through the MYCN-PA2G4 binding interface', Cancer Research, 79, pp. 5652 - 5667, http://dx.doi.org/10.1158/0008-5472.CAN-19-1112
    Journal articles | 2019
    2019, 'Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma', Science Translational Medicine, 11, http://dx.doi.org/10.1126/scitranslmed.aau1099
    Journal articles | 2019
    2019, 'Rare case of cervical thymic cyst diagnosed on pre-operative imaging', ANZ Journal of Surgery, 89, pp. 1504 - 1505, http://dx.doi.org/10.1111/ans.14923
    Journal articles | 2018
    Kabalan P; Gifford AJ; Ziegler DS, 2018, 'Unresectable VIP-secreting neuroblastoma: Efficacy of debulking and steroids for symptom control', Pediatric Blood and Cancer, 65, http://dx.doi.org/10.1002/pbc.27358
    Journal articles | 2018
    Matsuno R; Gifford AJ; Fang J; Warren M; Lukeis RE; Trahair T; Sugimoto T; Marachelian A; Asgharzadeh S; Maris JM; Ikegaki N; Shimada H, 2018, 'Rare MYC-amplified Neuroblastoma With Large Cell Histology', Pediatric and Developmental Pathology, 21, pp. 461 - 466, http://dx.doi.org/10.1177/1093526617749670
    Journal articles | 2018
    Sagnella SM; Trieu J; Brahmbhatt H; MacDiarmid JA; MacMillan A; Whan RM; Fife CM; McCarroll JA; Gifford AJ; Ziegler DS; Kavallaris M, 2018, 'Targeted doxorubicin-loaded bacterially derived nano-cells for the treatment of neuroblastoma', Molecular Cancer Therapeutics, 17, pp. 1012 - 1023, http://dx.doi.org/10.1158/1535-7163.MCT-17-0738
    Journal articles | 2018
    Tsoli M; Wadham C; Pinese M; Failes T; Joshi S; Mould E; Yin JX; Gayevskiy V; Kumar A; Kaplan W; Ekert PG; Saletta F; Franshaw L; Liu J; Gifford A; Weber MA; Rodriguez M; Cohn RJ; Arndt G; Tyrrell V; Haber M; Trahair T; Marshall GM; McDonald K; Cowley MJ; Ziegler DS, 2018, 'Integration of genomics, high throughput drug screening, and personalized xenograft models as a novel precision medicine paradigm for high risk pediatric cancer', Cancer Biology and Therapy, 19, pp. 1078 - 1087, http://dx.doi.org/10.1080/15384047.2018.1491498
    Journal articles | 2018
    Ziegler DS; Wong M; Mayoh C; Kumar A; Tsoli M; Mould E; Tyrrell V; Khuong-Quang DA; Pinese M; Gayevskiy V; Cohn RJ; Lau LM S; Reynolds M; Cox MC; Gifford A; Rodriguez M; Cowley MJ; Ekert PG; Marshall GM; Haber M, 2018, 'Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma', British Journal of Cancer, 119, pp. 693 - 696, http://dx.doi.org/10.1038/s41416-018-0251-2
    Journal articles | 2018
    2018, 'Analysis of eosinophilic esophagitis in children with repaired congenital esophageal atresia', Journal of Allergy and Clinical Immunology, http://dx.doi.org/10.1016/j.jaci.2018.08.040
    Journal articles | 2018
    2018, 'Clinical Importance of Myc Family Oncogene Aberrations in Epithelial Ovarian Cancer', JNCI: Cancer Spectrum, 2, http://dx.doi.org/10.1093/jncics/pky047
    Journal articles | 2017
    Hennika T; Hu G; Olaciregui NG; Barton KL; Ehteda A; Chitranjan A; Chang C; Gifford AJ; Tsoli M; Ziegler DS; Carcaboso AM; Becher OJ, 2017, 'Pre-clinical study of panobinostat in xenograft and genetically engineered murine diffuse intrinsic pontine glioma models', PLoS ONE, 12, http://dx.doi.org/10.1371/journal.pone.0169485
    Journal articles | 2017
    2017, 'Antenatal gastrointestinal anomalies in neonates subsequently found to have alveolar capillary dysplasia', CLINICAL CASE REPORTS, 5, pp. 559 - 566, http://dx.doi.org/10.1002/ccr3.888
    Journal articles | 2017
    2017, 'Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumour growth and sensitises to irinotecan in vivo', European Journal of Cancer, 83, pp. 132 - 141, http://dx.doi.org/10.1016/j.ejca.2017.06.024
    Journal articles | 2016
    2016, 'Resolution of intestinal histopathology changes in cystic fibrosis after treatment with ivacaftor', Annals of the American Thoracic Society, 13, pp. 297 - 298, http://www.atsjournals.org/doi/abs/10.1513/AnnalsATS.201510-669LE?journalCode=annalsats
    Journal articles | 2015
    Carter DR; Murray J; Cheung BB; Gamble L; Koach J; Tsang J; Sutton S; Kalla H; Syed S; Gifford AJ; Issaeva N; Biktasova A; Atmadibrata B; Sun Y; Sokolowski N; Ling D; Kim PY; Webber H; Clark A; Ruhle M; Liu B; Oberthuer A; Fischer M; Byrne J; Saletta F; Thwe LM; Purmal A; Haderski G; Burkhart C; Speleman F; De Preter K; Beckers A; Ziegler DS; Liu T; Gurova KV; Gudkov AV; Norris MD; Haber M; Marshall GM, 2015, 'Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma', Science Translational Medicine, 7, http://dx.doi.org/10.1126/scitranslmed.aab1803
    Journal articles | 2015
    Tan LZ; Gifford AJ; Clarkson CM; Henry GM; Krishnan U, 2015, 'Barrett's esophagus and eosinophilic esophagitis in a young pediatric patient with esophageal atresia', Journal of Pediatric Surgery Case Reports, 3, pp. 272 - 275, http://dx.doi.org/10.1016/j.epsc.2015.05.004
    Journal articles | 2013
    Pasquier E; Street J; Pouchy C; Carre M; Gifford AJ; Murray J; Norris MD; Trahair T; Andre N; Kavallaris M, 2013, 'B-blockers increase response to chemotherapy via direct antitumour and anti-angiogenic mechanisms in neuroblastoma', British Journal of Cancer, 108, pp. 2485 - 2494, http://dx.doi.org/10.1038/bjc.2013.205
    Journal articles | 2012
    Gifford AJ; Colebatch AJ; Litkouhi S; Hersch F; Warzecha W; Snook K; Sywak M; Gill AJ, 2012, 'Remote frozen section examination of breast sentinel lymph nodes by telepathology', ANZ Journal of Surgery, 82, pp. 803 - 808, http://dx.doi.org/10.1111/j.1445-2197.2012.06191.x
    Journal articles | 2009
    Schwartz TL; Sterkel BB; Meyer-Rochow GY; Gifford AJ; Samara JS; Sywak MS; Johnson FE, 2009, 'Accessory spleen masquerading as a pancreatic neoplasm', American Journal of Surgery, 197, http://dx.doi.org/10.1016/j.amjsurg.2008.07.063
    Journal articles | 2009
    2009, 'Reduced folate carrier and methylenetetrahydrofolate reductase gene polymorphisms: associations with clinical outcome in childhood acute lymphoblastic leukemia', Leukemia, 23, pp. 1348 - 1351, http://dx.doi.org/10.1038/leu.2009.67
    Journal articles | 2007
    Meyer-Rochow GY; Gifford AJ; Samra JS; Sywak MS, 2007, 'Intrapancreatic splenunculus', American Journal of Surgery, 194, pp. 75 - 76, http://dx.doi.org/10.1016/j.amjsurg.2006.11.022
    Journal articles | 2002
    2002, 'Role of E45K reduced folate carrier gene mutation in methotrexate resistance in human leukaemia cells', Leukemia, 16, pp. 2379 - 2387, http://dx.doi.org/10.1038/sj.leu.2402655
    Journal articles | 2001
    2001, 'Single nucleotide polymorphisms in the human reduced folate carrier: characterization of a high-frequency G.A variant at position 80 and transport properties of the his27 And Arg27 carriers', Clinical Cancer Research, 7, pp. 3416 - 3422, https://aacrjournals.org/clincancerres/article/7/11/3416/288667/Single-Nucleotide-Polymorphisms-in-the-Human
    Journal articles | 1998
    1998, 'P-glycoprotein-mediated methotrexate resistance in CCRF-CEM sublines deficient in Methotrexate accumulation due to a point mutation in the reduced folate carrier gene', International Journal of Cancer, 78, pp. 176 - 181, http://dx.doi.org/10.1002/(SICI)1097-0215(19981005)78:2<176::AID-IJC10>3.0.CO;2-9
  • Other | 2023
    2023, Data from Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma, , http://dx.doi.org/10.1158/1078-0432.c.6530664
    Other | 2023
    2023, Data from Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma, , http://dx.doi.org/10.1158/1078-0432.c.6530664.v1
    Other | 2023
    2023, Data from Suppression of ABCE1-Mediated mRNA Translation Limits N-MYC–Driven Cancer Progression, , http://dx.doi.org/10.1158/0008-5472.c.6511953.v1
    Other | 2023
    2023, Supplementary Figure Legends from Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma, , http://dx.doi.org/10.1158/1078-0432.22481343
    Other | 2023
    2023, Supplementary Figure Legends from Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma, , http://dx.doi.org/10.1158/1078-0432.22481343.v1
    Other | 2023
    2023, Supplementary Figures from Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma, , http://dx.doi.org/10.1158/1078-0432.22481337
    Other | 2023
    2023, Supplementary Figures from Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma, , http://dx.doi.org/10.1158/1078-0432.22481337.v1
    Other | 2023
    2023, Supplementary Materials from Suppression of ABCE1-Mediated mRNA Translation Limits N-MYC–Driven Cancer Progression, , http://dx.doi.org/10.1158/0008-5472.22425135
    Other | 2023
    2023, Supplementary Materials from Suppression of ABCE1-Mediated mRNA Translation Limits N-MYC–Driven Cancer Progression, , http://dx.doi.org/10.1158/0008-5472.22425135.v1
    Other | 2023
    2023, Supplementary Tables 1-5 from Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma, , http://dx.doi.org/10.1158/1078-0432.22481334
    Other | 2023
    2023, Supplementary Tables 1-5 from Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma, , http://dx.doi.org/10.1158/1078-0432.22481334.v1
    Other | 2023
    2023, Supplementary Video S1 from Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma, , http://dx.doi.org/10.1158/1078-0432.22481331
    Other | 2023
    2023, Supplementary Video S1 from Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma, , http://dx.doi.org/10.1158/1078-0432.22481331.v1
    Other | 2023
    2023, Supplementary Video S2 from Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma, , http://dx.doi.org/10.1158/1078-0432.22481328
    Other | 2023
    2023, Supplementary Video S2 from Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma, , http://dx.doi.org/10.1158/1078-0432.22481328.v1
    Other | 2023
    2023, Supplementary Video S3 from Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma, , http://dx.doi.org/10.1158/1078-0432.22481325
    Other | 2023
    2023, Supplementary Video S3 from Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma, , http://dx.doi.org/10.1158/1078-0432.22481325.v1
    Other | 2023
    2023, Supplementary Video S4 from Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma, , http://dx.doi.org/10.1158/1078-0432.22481322
    Other | 2023
    2023, Supplementary Video S4 from Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma, , http://dx.doi.org/10.1158/1078-0432.22481322.v1
    Conference Abstracts | 2022
    2022, 'Expanding the molecular spectrum of congenital mesoblastic nephroma: A rarely described KIAA1549::BRAF fusion in a classic variant', in Pathology, Elsevier BV, Vol. 54, pp. S51 - S51, http://dx.doi.org/10.1016/j.pathol.2021.12.166
    Preprints | 2022
    2022, A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer, , http://dx.doi.org/10.1101/2022.09.16.508179
    Conference Abstracts | 2020
    2020, 'Abstract A35: P-Glycoprotein is a resistance mechanism for conventional induction chemotherapy but not ALK inhibitors in high-risk neuroblastoma', in Cancer Research, American Association for Cancer Research (AACR), Vol. 80, pp. A35 - A35, presented at Abstracts: AACR Special Conference on the Advances in Pediatric Cancer Research; September 17-20, 2019; Montreal, QC, Canada, http://dx.doi.org/10.1158/1538-7445.pedca19-a35
    Conference Abstracts | 2020
    2020, 'DIPG-75. PRECISION MEDICINE FOR PAEDIATRIC HIGH-GRADE DIFFUSE MIDLINE GLIOMAS - RESULTS FROM THE ZERO CHILDHOOD CANCER COMPREHENSIVE PRECISION MEDICINE PROGRAM', in Neuro-oncology, Vol. 22, pp. iii302 - iii302
    Conference Abstracts | 2020
    2020, 'Embryonal rhabdomyosarcoma – A case series', in Pathology, Elsevier BV, Vol. 52, pp. S92 - S92, http://dx.doi.org/10.1016/j.pathol.2020.01.313
    Conference Abstracts | 2020
    2020, 'PRECISION MEDICINE FOR PAEDIATRIC HIGH-GRADE DIFFUSE MIDLINE GLIOMAS - RESULTS FROM THE ZERO CHILDHOOD CANCER COMPREHENSIVE PRECISION MEDICINE PROGRAM', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, Vol. 22, pp. 302 - 302, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000606080100118&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2020
    2020, 'Zero Childhood Cancer: A comprehensive precision medicine platform for children with high-risk cancer in Australia', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, ELECTR NETWORK, Vol. 80, presented at AACR Annual Meeting, ELECTR NETWORK, 22 June 2020 - 24 June 2020, http://dx.doi.org/10.1158/1538-7445.AM2020-SY09-02
    Conference Abstracts | 2019
    2019, 'Abstract 2884: Establishment of patient-derived xenograft models for high-risk neuroblastoma', in Tumor Biology, American Association for Cancer Research, presented at Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA, http://dx.doi.org/10.1158/1538-7445.sabcs18-2884
    Conference Abstracts | 2019
    2019, 'Abstract 4741: Re-evaluating the role of P-glycoprotein in the resistance of high-risk neuroblastoma to standard-of-care chemotherapies', in Cancer Research, American Association for Cancer Research (AACR), Vol. 79, pp. 4741 - 4741, presented at Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA, http://dx.doi.org/10.1158/1538-7445.am2019-4741
    Conference Abstracts | 2019
    2019, 'Abstract 4824: Targeting CD30 as a novel treatment strategy inRANBP2-ALK-rearranged inflammatory myofibroblastic tumor', in Experimental and Molecular Therapeutics, American Association for Cancer Research, presented at Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA, http://dx.doi.org/10.1158/1538-7445.sabcs18-4824
    Conference Abstracts | 2019
    2019, 'Complex compound inheritance of lethal lung developmental disorders due to disruption of the TBX-FGF pathway', in EUROPEAN JOURNAL OF HUMAN GENETICS, NATURE PUBLISHING GROUP, SWEDEN, Gothenburg, Vol. 27, pp. 1148 - 1149, presented at 52nd Conference of the European-Society-of-Human-Genetics (ESHG), SWEDEN, Gothenburg, 15 June 2019 - 18 June 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000489313900198&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    2019, 'Establishment of patient-derived xenograft models for high-risk neuroblastoma', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, GA, Atlanta, Vol. 79, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), GA, Atlanta, 29 March 2019 - 03 April 2019, http://dx.doi.org/10.1158/1538-7445.AM2019-2884
    Conference Abstracts | 2019
    2019, 'Molecular targeted therapies and precision medicine for children with neuroblastoma and other refractory malignancies', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CANADA, Montreal, Vol. 80, pp. 23 - 24, presented at AACR Special Conference on the Advances in Pediatric Cancer Research, CANADA, Montreal, 17 September 2019 - 20 September 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000551367400013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    2019, 'P-Glycoprotein is a resistance mechanism for conventional induction chemotherapy but not ALK inhibitors in high-risk neuroblastoma', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CANADA, Montreal, Vol. 80, pp. 61 - 61, presented at AACR Special Conference on the Advances in Pediatric Cancer Research, CANADA, Montreal, 17 September 2019 - 20 September 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000551367400079&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    2019, 'RESULTS OF THE ZERO CHILDHOOD CANCER INTEGRA-TM PRECISION MEDICINE PLATFORM FOR PAEDIATRIC HIGH-RISK BRAIN TUMOURS', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, CA, San Francisco, Vol. 21, pp. 118 - 118, presented at 5th Biennial Conference of the Society-for-Neuro-Oncology on Pediatric Neuro-Oncology Basic and Translational Research, CA, San Francisco, 03 May 2019 - 04 May 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000473243700229&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    2019, 'Re-evaluating the role of P-glycoprotein in the resistance of high-risk neuroblastoma to standard-of-care chemotherapies', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, GA, Atlanta, Vol. 79, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), GA, Atlanta, 29 March 2019 - 03 April 2019, http://dx.doi.org/10.1158/1538-7445.SABCS18-4741
    Conference Abstracts | 2019
    2019, 'THER-23. RESULTS OF THE ZERO CHILDHOOD CANCER INTEGRATED PRECISION MEDICINE PLATFORM FOR PAEDIATRIC HIGH-RISK BRAIN TUMOURS', in Neuro-Oncology, Oxford University Press (OUP), Vol. 21, pp. ii118 - ii118, http://dx.doi.org/10.1093/neuonc/noz036.228
    Conference Abstracts | 2019
    2019, 'THER-23. RESULTS OF THE ZERO CHILDHOOD CANCER INTEGRATED PRECISION MEDICINE PLATFORM FOR PAEDIATRIC HIGH-RISK BRAIN TUMOURS', in Neuro-oncology, Vol. 21, pp. ii118 - ii118
    Conference Abstracts | 2019
    2019, 'Targeting CD30 as a novel treatment strategy in RANBP2-ALK-rearranged inflammatory myofibroblastic tumor', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, GA, Atlanta, Vol. 79, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), GA, Atlanta, 29 March 2019 - 03 April 2019, http://dx.doi.org/10.1158/1538-7445.AM2019-4824
    Conference Abstracts | 2019
    2019, 'Zero Childhood Cancer: A Comprehensive Precision Medicine Platform for Children and Adolescents with High-Risk Cancer', in PEDIATRIC BLOOD & CANCER, WILEY, Vol. 66, pp. S504 - S505, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000488458005162&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    2019, 'Zero Childhood Cancer: A comprehensive precision medicine platform for children with high-risk cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Atlanta, GA, Vol. 79, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), Atlanta, GA, 29 March 2019 - 03 April 2019, http://dx.doi.org/10.1158/1538-7445.AM2019-3111
    Conference Abstracts | 2018
    Ekert P; Wong M; Mould E; Gifford A; Norris M; Warby M; Trahair T; Tucker K; Ziegler D; Marshall G; O'Brien T; Haber M; Vanessa T; Cowley M, 2018, 'Zero Childhood Cancer: A Comprehensive Precision Medicine Platform for Children with High-Risk Cancer', in PEDIATRIC BLOOD & CANCER, WILEY, Vol. 65, pp. S643 - S644, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000445195005221&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2018
    Johnson A; Bye A; Ziegler D; Gifford A; Jacobsen E; Cohn R, 2018, 'PAEDIATRIC EXTRAVENTRICULAR NEUROCYTOMA: A SERIES AND A RARE COMPLICATION', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, CO, Denver, Vol. 20, pp. 42 - 42, presented at 18th International Symposium on Pediatric Neuro-Oncology (ISPNO), CO, Denver, 30 June 2018 - 03 July 2018, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000438339000065&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2018
    2018, 'A rare case of langerhans cell histiocytosis presenting in the gastrointestinal tract', in Pathology, Elsevier BV, Vol. 50, pp. S144 - S144, http://dx.doi.org/10.1016/j.pathol.2017.11.061
    Conference Abstracts | 2018
    2018, 'Abstract A19: Establishment of in vitro and in vivo models of inflammatory myofibroblastic tumor', in Clinical Cancer Research, American Association for Cancer Research (AACR), Vol. 24, pp. A19 - A19, presented at Abstracts: Advances in Sarcomas: From Basic Science to Clinical Translation; May 16-19, 2017; Philadelphia, PA, http://dx.doi.org/10.1158/1557-3265.sarcomas17-a19
    Conference Abstracts | 2018
    2018, 'CRAN-27. PAEDIATRIC EXTRAVENTRICULAR NEUROCYTOMA: A SERIES AND A RARE COMPLICATION', in Neuro-Oncology, Oxford University Press (OUP), Vol. 20, pp. i42 - i42, http://dx.doi.org/10.1093/neuonc/noy059.063
    Conference Abstracts | 2018
    2018, 'CRAN-27. PAEDIATRIC EXTRAVENTRICULAR NEUROCYTOMA: A SERIES AND A RARE COMPLICATION', in Neuro-oncology, Vol. 20, pp. i42 - i42
    Conference Abstracts | 2018
    2018, 'Integrated genomics: drug screening and personalized xenograft development approach to identify precision treatments for aggressive pediatric brain tumors', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, IL, Chicago, Vol. 78, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), IL, Chicago, 14 April 2018 - 18 April 2018, http://dx.doi.org/10.1158/1538-7445.AM2018-LB-137
    Conference Abstracts | 2018
    2018, 'Pleuropulmonary blastoma – Case report of a rare tumour harbouring a DICER1 mutation', in Pathology, Elsevier BV, Vol. 50, pp. S144 - S144, http://dx.doi.org/10.1016/j.pathol.2017.11.062
    Conference Abstracts | 2018
    2018, 'Zero Childhood Cancer: A comprehensive precision medicine platform for children with high-risk cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, IL, Chicago, Vol. 78, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), IL, Chicago, 14 April 2018 - 18 April 2018, http://dx.doi.org/10.1158/1538-7445.AM2018-LB-138
    Conference Abstracts | 2018
    2018, 'Zero childhood cancer – Accelerating translation of experimental oncology: Better matching drug to target', in Pathology, Elsevier BV, Vol. 50, pp. S31 - S31, http://dx.doi.org/10.1016/j.pathol.2017.12.072
    Conference Papers | 2017
    2017, 'Establishment of in vitro and in vivo models of inflammatory myofibroblastic tumor', in CLINICAL CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, PA, Philadelphia, pp. 45 - 46, presented at AACR Special Conference on Advances in Sarcomas - From Basic Science to Clinical Translation, PA, Philadelphia, 16 May 2017 - 19 May 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000422882000054&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2017
    2017, 'Pilot study of a comprehensive precision medicine platform for children with high-risk cancer.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, IL, Chicago, Vol. 35, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 02 June 2017 - 06 June 2017, http://dx.doi.org/10.1200/JCO.2017.35.15_suppl.10539
    Conference Papers | 2015
    2015, 'MYCN and is a therapeutic target in neuroblastoma', in MOLECULAR CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CA, La Jolla, presented at AACR Special Conference on Myc - From Biology to Therapy, CA, La Jolla, 07 January 2015 - 10 January 2015, http://dx.doi.org/10.1158/1557-3125,MYC15-PRO9
    Conference Abstracts | 2014
    Vedi A; Tucker K; Gifford AJ; Suter M; Shimada H; Henry G; Pereira J; Anazodo A, 2014, 'Pleomorphic anaplastic neuroblastoma in a child exposed to in utero chemotherapy for maternal carcinoma of the breast: A case report and a review of the literature', in Pathology, Elsevier BV, Vol. 46, pp. S96 - S96, http://dx.doi.org/10.1097/01.pat.0000443671.34425.0b
    Conference Abstracts | 2014
    2014, '36. Giant cell fibroblastoma: A soft tissue tumour on a spectrum with dermatofibrosarcoma protuberans. report of a case', in Pathology, Elsevier BV, Vol. 46, pp. S118 - S118, http://dx.doi.org/10.1097/01.pat.0000443726.39370.f4
    Conference Abstracts | 2010
    2010, '16. Primary choriocarcinoma of the colon – a case report', in Pathology, Elsevier BV, Vol. 42, pp. S85 - S86, http://dx.doi.org/10.1097/01268031-201042001-00187
    Conference Abstracts | 2010
    2010, '25. Peliosis of the spleen presenting as spontaneous splenic rupture – report of two cases', in Pathology, Elsevier BV, Vol. 42, pp. S88 - S89, http://dx.doi.org/10.1097/01268031-201042001-00196

1. Histopathological assessment of genetically engineered mouse models of paediatric cancer, in particular the TH-MYCN mouse model of neuroblastoma.

2. Application of Anatomical Pathology to Paediatric Precision Oncology.

(i) Histopathological assessment of patient derived tumour xenografts in immunodeficient mice prior to utilising the xenografts for clinical decision making. Accurate morphologic assessment ensures the xenografts resemble the child's original tumour. This permits exclusion of growths in mice which mimic a tumour such as proliferation of EBV-infected cells.

(ii) Cytopathological assessment of patient-derived or xenograft-derived tumour cells prior to submitting the cells to a high throughput drug screen assay. This ensure the cells examined in the drug screening assay are the patient's tumour cells. This permits exclusion of non-neoplastic cells, such as fibroblasts, which mimic tumour cells.   

3. Establishment of a series of tissue microarrays from archived formalin-fixed paraffin embedded samples from a range of paediatric solid tumours. This will facilitate assessment of expression of protein biomarkers in a range of paediatric tumours.