Senior Lecturer

Dr Angelica Marie Merlot

medicine-health
Childhood Cancer Research
Location
Level 1, Lowy Cancer Research Centre The University of New South Wales, Sydney, NSW 2052, Australia

Publications

  • Journal articles | 2019
    Dr Angelica Marie Merlot
    Seebacher NA; Stacy AE; Porter GM; Merlot AM, 2019, 'Clinical development of targeted and immune based anti-cancer therapies', Journal of Experimental and Clinical Cancer Research, vol. 38, http://dx.doi.org/10.1186/s13046-019-1094-2
    Journal articles | 2019
    Dr Angelica Marie Merlot
    Merlot AM; Porter GM; Sahni S; Lim EG; Peres P; Richardson DR, 2019, 'The metastasis suppressor, NDRG1, differentially modulates the endoplasmic reticulum stress response', Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1865, pp. 2094 - 2110, http://dx.doi.org/10.1016/j.bbadis.2019.04.007
    Journal articles | 2019
    Dr Angelica Marie Merlot
    Merlot AM; Kalinowski DS; Kovacevic Z; Jansson PJ; Sahni S; Huang MLH; Lane DJR; Lok H; Richardson DR, 2019, 'Exploiting cancer metal metabolism using anti-cancer metal- binding agents', Current Medicinal Chemistry, vol. 26, pp. 302 - 322, http://dx.doi.org/10.2174/0929867324666170705120809
    Journal articles | 2018
    Dr Angelica Marie Merlot
    Merlot A; Shafie N; Lim E; Chen A; Sahni S; Yu Y; Richardson D, 2018, 'Cellular metal sequestration and redox stress by thiosemicarbazones induces endoplasmic reticulum stress in tumors to suppress cancer progression', Free Radical Biology and Medicine, vol. 120, pp. S37 - S37, http://dx.doi.org/10.1016/j.freeradbiomed.2018.04.126
    Journal articles | 2016
    Dr Angelica Marie Merlot
    Gutierrez EM; Seebacher NA; Arzuman L; Kovacevic Z; Lane DJR; Richardson V; Merlot AM; Lok H; Kalinowski DS; Sahni S; Jansson PJ; Richardson DR, 2016, 'Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT)', Biochimica et Biophysica Acta - Molecular Cell Research, vol. 1863, pp. 1665 - 1681, http://dx.doi.org/10.1016/j.bbamcr.2016.04.017
    Journal articles | 2016
    Dr Angelica Marie Merlot
    Merlot AM; Sahni S; Lane DJR; Richardsons V; Huang MLH; Kalinowski DS; Richardson DR, 2016, 'Letter to the editor: “Analysis of the interaction of Dp44mt with human serum albumin and calf thymus dna using molecular docking and spectroscopic techniques”', International Journal of Molecular Sciences, vol. 17, http://dx.doi.org/10.3390/ijms17111916
    Journal articles | 2016
    Dr Angelica Marie Merlot
    Merlot AM; Shafie NH; Yu Y; Richardson V; Jansson PJ; Sahni S; Lane DJR; Kovacevic Z; Kalinowski DS; Richardson DR, 2016, 'Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase', Biochemical Pharmacology, vol. 109, pp. 27 - 47, http://dx.doi.org/10.1016/j.bcp.2016.04.001
    Journal articles | 2016
    Dr Angelica Marie Merlot
    Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Arozena AA; Adachi H; Adams CM; Adams PD; Adeli K; Adhihetty PJ; Adler SG; Agam G; Agarwal R; Aghi MK; Agnello M; Agostinis P; Aguilar PV; Aguirre-Ghiso J; Airoldi EM; Ait-Si-Ali S; Akematsu T; Akporiaye ET; Al-Rubeai M; Albaiceta GM; Albanese C; Albani D; Albert ML; Aldudo J; Algül H; Alirezaei M; Alloza I; Almasan A; Almonte-Beceril M; Alnemri ES; Alonso C; Altan-Bonnet N; Altieri DC; Alvarez S; Alvarez-Erviti L; Alves S; Amadoro G; Amano A; Amantini C; Ambrosio S; Amelio I; Amer AO; Amessou M; Amon A; An Z; Anania FA; Andersen SU; Andley UP; Andreadi CK; Andrieu-Abadie N; Anel A; Ann DK; Anoopkumar-Dukie S; Antonioli M; Aoki H; Apostolova N; Aquila S; Aquilano K; Araki K; Arama E; Aranda A; Araya J; Arcaro A; Arias E; Arimoto H; Ariosa AR; Armstrong JL; Arnould T; Arsov I; Asanuma K; Askanas V; Asselin E; Atarashi R; Atherton SS; Atkin JD; Attardi LD; Auberger P; Auburger G; Aurelian L; Autelli R; Avagliano L; Avantaggiati ML; Avrahami L; Azad N; Awale S; Bachetti T; Backer JM; Bae DH; Bae JS; Bae ON; Bae SH; Baehrecke EH; Baek SH; Baghdiguian S; Bagniewska-Zadworna A, 2016, 'Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)', Autophagy, vol. 12, pp. 1 - 222, http://dx.doi.org/10.1080/15548627.2015.1100356
    Journal articles | 2016
    Dr Angelica Marie Merlot
    Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Arozena AA; Adachi H; Adams CM; Adams PD; Adeli K; Adhihetty PJ; Adler SG; Agam G; Agarwal R; Aghi MK; Agnello M; Agostinis P; Aguilar PV; Aguirre-Ghiso J; Airoldi EM; Ait-Si-Ali S; Akematsu T; Akporiaye ET; Al-Rubeai M; Albaiceta GM; Albanese C; Albani D; Albert ML; Aldudo J; Algül H; Alirezaei M; Alloza I; Almasan A; Almonte-Beceril M; Alnemri ES; Alonso C; Altan-Bonnet N; Altieri DC; Alvarez S; Alvarez-Erviti L; Alves S; Amadoro G; Amano A; Amantini C; Ambrosio S; Amelio I; Amer AO; Amessou M; Amon A; An Z; Anania FA; Andersen SU; Andley UP; Andreadi CK; Andrieu-Abadie N; Anel A; Ann DK; Anoopkumar-Dukie S; Antonioli M; Aoki H; Apostolova N; Aquila S; Aquilano K; Araki K; Arama E; Aranda A; Araya J; Arcaro A; Arias E; Arimoto H; Ariosa AR; Armstrong JL; Arnould T; Arsov I; Asanuma K; Askanas V; Asselin E; Atarashi R; Atherton SS; Atkin JD; Attardi LD; Auberger P; Auburger G; Aurelian L; Autelli R; Avagliano L; Avantaggiati ML; Avrahami L; Azad N; Awale S; Bachetti T; Backer JM; Bae DH; Bae JS; Bae ON; Bae SH; Baehrecke EH; Baek SH; Baghdiguian S; Bagniewska-Zadworna A, 2016, 'Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356', Autophagy, vol. 12, pp. 443, http://dx.doi.org/10.1080/15548627.2016.1147886
    Journal articles | 2016
    Dr Angelica Marie Merlot
    Paluncic J; Kovacevic Z; Jansson PJ; Kalinowski D; Merlot AM; Huang MLH; Lok HC; Sahni S; Lane DJR; Richardson DR, 2016, 'Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling', Biochimica et Biophysica Acta - Molecular Cell Research, vol. 1863, pp. 770 - 784, http://dx.doi.org/10.1016/j.bbamcr.2016.01.025
    Journal articles | 2016
    Dr Angelica Marie Merlot
    Kalinowski DS; Stefani C; Toyokuni S; Ganz T; Anderson GJ; Subramaniam NV; Trinder D; Olynyk JK; Chua A; Jansson PJ; Sahni S; Lane DJR; Merlot AM; Kovacevic Z; Huang MLH; Lee CS; Richardson DR, 2016, 'Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics', Biochimica et Biophysica Acta - Molecular Cell Research, vol. 1863, pp. 727 - 748, http://dx.doi.org/10.1016/j.bbamcr.2016.01.026
    Journal articles | 2016
    Dr Angelica Marie Merlot
    Chiang S; Kovacevic Z; Sahni S; Lane DJR; Merlot AM; Kalinowski DS; Huang MLH; Richardson DR, 2016, 'Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia', Clinical Science, vol. 130, pp. 853 - 870, http://dx.doi.org/10.1042/CS20160072
    Journal articles | 2015
    Dr Angelica Marie Merlot
    Lane DJR; Bae DH; Merlot AM; Sahni S; Richardson DR, 2015, 'Duodenal cytochrome b (DCYTB) in Iron metabolism: An update on function and regulation', Nutrients, vol. 7, pp. 2274 - 2296, http://dx.doi.org/10.3390/nu7042274
    Journal articles | 2015
    Dr Angelica Marie Merlot
    Merlot AM; Kalinowski DS; Kovacevic Z; Jansson PJ; Lane DJ; Huang MLH; Sahni S; Richardson DR, 2015, 'Making a case for albumin - A highly promising drug-delivery system', Future Medicinal Chemistry, vol. 7, pp. 553 - 556, http://dx.doi.org/10.4155/fmc.15.15
    Journal articles | 2015
    Dr Angelica Marie Merlot
    Liu W; Kovacevic Z; Peng Z; Jin R; Wang P; Yue F; Zheng M; Huang MLH; Jansson PJ; Richardson V; Kalinowski DS; Lane DJR; Merlot AM; Sahni S; Richardson DR, 2015, 'The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: New therapeutic targets', Oncotarget, vol. 6, pp. 35522 - 35541, http://dx.doi.org/10.18632/oncotarget.5849
    Journal articles | 2015
    Dr Angelica Marie Merlot
    Lui GYL; Kovacevic Z; Richardson V; Merlot AM; Kalinowski DS; Richardson DR, 2015, 'Targeting cancer by binding iron: Dissecting cellular signaling pathways', Oncotarget, vol. 6, pp. 18748 - 18779, http://dx.doi.org/10.18632/oncotarget.4349
    Journal articles | 2015
    Dr Angelica Marie Merlot
    Journal articles | 2015
    Dr Angelica Marie Merlot
    Liu W; Yue F; Zheng M; Merlot A; Bae D-H; Huang M; Lane D; Jansson P; Lui GYL; Richardson V; Sahni S; Kalinowski D; Kovacevic Z; Richardson DR, 2015, 'The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1.', Oncotarget, vol. 6, pp. 8851 - 8874, http://dx.doi.org/10.18632/oncotarget.3316
    Journal articles | 2015
    Dr Angelica Marie Merlot
    Jansson PJ; Kalinowski DS; Lane DJR; Kovacevic Z; Seebacher NA; Fouani L; Sahni S; Merlot AM; Richardson DR, 2015, 'The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones', Pharmacological Research, vol. 100, pp. 255 - 260, http://dx.doi.org/10.1016/j.phrs.2015.08.013
    Journal articles | 2015
    Dr Angelica Marie Merlot
    Lane DJR; Merlot AM; Huang MLH; Bae DH; Jansson PJ; Sahni S; Kalinowski DS; Richardson DR, 2015, 'Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease', Biochimica et Biophysica Acta - Molecular Cell Research, vol. 1853, pp. 1130 - 1144, http://dx.doi.org/10.1016/j.bbamcr.2015.01.021
    Journal articles | 2015
    Dr Angelica Marie Merlot
    Lui GYL; Kovacevic Z; Menezes SV; Kalinowski DS; Merlot AM; Sahni S; Richardson DR, 2015, 'Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (stat3) pathway: Inhibition of constitutive and interleukin 6-induced activation by iron depletion', Molecular Pharmacology, vol. 87, pp. 543 - 560, http://dx.doi.org/10.1124/mol.114.096529
    Journal articles | 2015
    Dr Angelica Marie Merlot
    Merlot AM; Sahni S; Lane DJR; Fordham AM; Pantarat N; Hibbs DE; Richardson V; Doddareddy MR; Ong JA; Huang MLH; Richardson DR; Kalinowski DS, 2015, 'Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: Two saturable mechanisms of Dp44mT uptake by cells', Oncotarget, vol. 6, pp. 10374 - 10398, http://dx.doi.org/10.18632/oncotarget.3606
    Journal articles | 2014
    Dr Angelica Marie Merlot
    Lane DJR; Mills TM; Shafie NH; Merlot AM; Saleh Moussa R; Kalinowski DS; Kovacevic Z; Richardson DR, 2014, 'Expanding horizons in iron chelation and the treatment of cancer: Role of iron in the regulation of ER stress and the epithelial-mesenchymal transition', Biochimica et Biophysica Acta - Reviews on Cancer, vol. 1845, pp. 166 - 181, http://dx.doi.org/10.1016/j.bbcan.2014.01.005
    Journal articles | 2014
    Dr Angelica Marie Merlot
    Merlot AM; Kalinowski DS; Richardson DR, 2014, 'Unraveling the mysteries of serum albumin-more than just a serum protein', Frontiers in Physiology, vol. 5 AUG, http://dx.doi.org/10.3389/fphys.2014.00299
    Journal articles | 2014
    Dr Angelica Marie Merlot
    Sahni S; Merlot AM; Krishan S; Jansson PJ; Richardson DR, 2014, 'Gene of the month: BECN1', Journal of Clinical Pathology, vol. 67, pp. 656 - 660, http://dx.doi.org/10.1136/jclinpath-2014-202356
    Journal articles | 2014
    Dr Angelica Marie Merlot
    Lane DJR; Merlot AM; Richardson DR, 2014, 'The lure of a LYR: The logistics of iron sulfur cluster delivery', Cell Metabolism, vol. 19, pp. 348 - 350, http://dx.doi.org/10.1016/j.cmet.2014.02.011
    Journal articles | 2013
    Dr Angelica Marie Merlot
    Merlot AM; Kalinowski DS; Richardson DR, 2013, 'Novel chelators for cancer treatment: Where are we now?', Antioxidants and Redox Signaling, vol. 18, pp. 973 - 1006, http://dx.doi.org/10.1089/ars.2012.4540
    Journal articles | 2013
    Dr Angelica Marie Merlot
    Merlot AM; Pantarat N; Menezes SV; Sahni S; Richardson DR; Kalinowski DS, 2013, 'Cellular uptake of the antitumor agent Dp44mT occurs via a carrier/receptor-mediated mechanisms', Molecular Pharmacology, vol. 84, pp. 911 - 924, http://dx.doi.org/10.1124/mol.113.088393
    Journal articles | 2012
    Dr Angelica Marie Merlot
    Serda M; Kalinowski DS; Mrozek-Wilczkiewicz A; Musiol R; Szurko A; Ratuszna A; Pantarat N; Kovacevic Z; Merlot AM; Richardson DR; Polanski J, 2012, 'Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy', Bioorganic and Medicinal Chemistry Letters, vol. 22, pp. 5527 - 5531, http://dx.doi.org/10.1016/j.bmcl.2012.07.030
    Journal articles | 2010
    Dr Angelica Marie Merlot
    Merlot AM; Pantarat N; Lovejoy DB; Kalinowski DS; Richardson DR, 2010, 'Membrane transport and intracellular sequestration of novel thiosemicarbazone chelators for the treatment of cancer', Molecular Pharmacology, vol. 78, pp. 675 - 684, http://dx.doi.org/10.1124/mol.110.066126
    Journal articles | 1983
    Dr Angelica Marie Merlot
    Bachelet M; Bader C; Merlot A; Laborde K; Snarska J; Ulmann A, 1983, 'Cellular utilization of cytosolic NADPH in kidney and liver cells from rats fed a normal or a vitamin D‐deficient diet', Cell Biochemistry and Function, vol. 1, pp. 25 - 29, http://dx.doi.org/10.1002/cbf.290010105
  • Conference Abstracts | 2019
    Dr Angelica Marie Merlot
    Merlot AM; Porter G; Sahni S; Lim E; Peres P; Richardson DR, 2019, 'The interactions between the metastasis suppressor, NDRG1, and the endoplasmic reticulum response in cancer cells', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, Ferrara, ITALY, Vol. 139, pp. S37 - S37, presented at Annual Meeting of the Society-for-Free-Radical-Research- Europe (SFRRE) on Redox Homeostasis - From Signaling to Damage, Ferrara, ITALY, 19 June 2019 - 21 June 2019, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000471646000141&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    Dr Angelica Marie Merlot
    Merlot AM; Shafie NH; Porter G; Lim E; Sahni S; Yu Y; Richardson DR, 2019, 'Thiosemicarbazone-induced redox stress stimulates endoplasmic reticulum stress to inhibit cancer proliferation and migration', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, Ferrara, ITALY, Vol. 139, pp. S37 - S38, presented at Annual Meeting of the Society-for-Free-Radical-Research- Europe (SFRRE) on Redox Homeostasis - From Signaling to Damage, Ferrara, ITALY, 19 June 2019 - 21 June 2019, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000471646000142&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2018
    Dr Angelica Marie Merlot
    Merlot A; Shafie N; Porter G; Sahni S; Richardson D, 2018, 'Abstract B143: The formation of redox active complexes is important for the induction of the UPR by Dp44mT', in Therapeutic Agents: Other Topics, American Association for Cancer Research, presented at Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; October 26-30, 2017; Philadelphia, PA, http://dx.doi.org/10.1158/1535-7163.targ-17-b143
    Conference Papers | 2016
    Dr Angelica Marie Merlot
    Merlot AM; Shafie N; Yu Y; Kalinowski DS; Richardson DR, 2016, 'The Redox Active Anti-Cancer Drug, Dp44mT, Induces Endoplasmic Reticulum Stress Activating Pro-Apoptotic Pathways of the Unfolded Protein Response in Cancer Cells', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, pp. S126 - S126, http://dx.doi.org/10.1016/j.freeradbiomed.2016.10.328
    Conference Papers | 2016
    Dr Angelica Marie Merlot
    Merlot AM; Peres P; Sahni S; Richardson DR, 2016, 'Dissecting the Role of the Iron-Regulated Metastasis Suppressor NDRG1 in Regulating Endoplasmic Reticulum Stress and Cancer Cell Survival', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, pp. S126 - S126, http://dx.doi.org/10.1016/j.freeradbiomed.2016.10.329
    Conference Papers | 2014
    Dr Angelica Marie Merlot
    Merlot AM; Fordham AM; Sahni S; Pantarat N; Kalinowski DS; Richardson DR, 2014, 'EXPLOITING HSA TO STIMULATE THE DELIVERY AND ANTI-TUMOUR ACTIVITY OF THE ANTI-CANCER THIOSEMICARBAZONE, DP44MT, TO CANCER CELLS', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, pp. 19 - 19, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000344745100040&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2012
    Dr Angelica Marie Merlot
    Merlot AM; Kalinowski DS; Pantarat N; Menezes S; Doddareddy M; Hibbs D; Richardson DR, 2012, 'Transport of the Anticancer Agent, Dp44mT, via a Receptor-mediated Process', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, European Org Res & Treatment Canc (EORTC), Dublin, IRELAND, pp. 36 - 36, presented at 24th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, European Org Res & Treatment Canc (EORTC), Dublin, IRELAND, 06 November 2012 - 09 November 2012, http://dx.doi.org/10.1016/S0959-8049(12)71914-7
    Conference Papers | 2011
    Dr Angelica Marie Merlot
    Merlot AM; Kalinowski DS; Pantarat N; Doddareddy M; Hibbs DE; Richardson DR, 2011, 'Abstract A112: Enhanced accumulation of anticancer drug in tumor cells through albumin interactions: A novel drug delivery mechanism.', in Drug Delivery, American Association for Cancer Research, presented at Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 12-16, 2011; San Francisco, CA, http://dx.doi.org/10.1158/1535-7163.targ-11-a112

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