Dr Anouschka Akerman

Dr Anouschka Akerman

Postdoctoral Fellow

Bachelor of Science, First Class Honours (2014), UNSW

PhD in cancer therapeutics and stromal cell metabolism (2019), UNSW

Medicine & Health
The Kirby Institute

Nush completed her PhD at UNSW in 2019 which focused on understanding and therapeutically targeting tumour-stromal interactions in pancreatic cancer. She then worked as part of the Medicine Research Infrastructure and Operational Services team across the Upper Campus Biomedical Precinct between 2020 and 2021. She was recruited to the Viral Pathogenesis and Vector Laboratory as part of the Immunovirology and Pathogenesis Program within The Kirby Institute in 2021, where she has been managing several projects on SARS-CoV-2 and Mpox. 

Phone
+61-2-9348 0687
  • Journal articles | 2024
    Phetsouphanh C; Jacka B; Ballouz S; Jackson KJL; Wilson DB; Manandhar B; Klemm V; Tan HX; Wheatley A; Aggarwal A; Akerman A; Milogiannakis V; Starr M; Cunningham P; Turville SG; Kent SJ; Byrne A; Brew BJ; Darley DR; Dore GJ; Kelleher AD; Matthews GV, 2024, 'Improvement of immune dysregulation in individuals with long COVID at 24-months following SARS-CoV-2 infection', Nature Communications, 15, http://dx.doi.org/10.1038/s41467-024-47720-8
    Journal articles | 2024
    Singer J; Tunbridge MJ; Shi B; Perkins GB; Chai CS; Salehi T; Sim BZ; Kireta S; Johnston JK; Akerman A; Milogiannakis V; Aggarwal A; Turville S; Hissaria P; Ying T; Wu H; Grubor-Bauk B; Coates PT; Chadban SJ, 2024, 'Dietary Inulin to Improve SARS-CoV-2 Vaccine Response in Kidney Transplant Recipients: The RIVASTIM-Inulin Randomised Controlled Trial', Vaccines, 12, http://dx.doi.org/10.3390/vaccines12060608
    Journal articles | 2023
    Akerman A; Milogiannakis V; Jean T; Esneau C; Silva MR; Ison T; Fichter C; Lopez JA; Chandra D; Naing Z; Caguicla J; Li D; Walker G; Amatayakul-Chantler S; Roth N; Manni S; Hauser T; Barnes T; Condylios A; Yeang M; Wong M; Foster CSP; Sato K; Lee S; Song Y; Mao L; Sigmund A; Phu A; Vande More AM; Hunt S; Douglas M; Caterson I; Britton W; Sandgren K; Bull R; Lloyd A; Triccas J; Tangye S; Bartlett NW; Darley D; Matthews G; Stark DJ; Petoumenos K; Rawlinson WD; Murrell B; Brilot F; Cunningham AL; Kelleher AD; Aggarwal A; Turville SG, 2023, 'Emergence and antibody evasion of BQ, BA.2.75 and SARS-CoV-2 recombinant sub-lineages in the face of maturing antibody breadth at the population level', eBioMedicine, 90, http://dx.doi.org/10.1016/j.ebiom.2023.104545
    Journal articles | 2023
    Alcheikh A; Perkins GB; Pucar PA; Cecchin A; Chai CS; Tunbridge M; Akerman A; Aggarwal A; Milogiannakis V; Turville S; Allen S; Hissaria P; Banovic T; Coates PT; Ross DM, 2023, 'Humoral and cellular immunity to SARS-CoV-2 Ancestral and Omicron BA.5 variants following vaccination in myelofibrosis patients', Blood Cancer Journal, 13, http://dx.doi.org/10.1038/s41408-023-00824-8
    Journal articles | 2023
    Bowden-Reid E; Ledger S; Zhang Y; Di Giallonardo F; Aggarwal A; Stella AO; Akerman A; Milogiannakis V; Walker G; Rawlinson W; Turville S; Kelleher AD; Ahlenstiel C, 2023, 'Novel siRNA therapeutics demonstrate multi-variant efficacy against SARS-CoV-2', Antiviral Research, 217, http://dx.doi.org/10.1016/j.antiviral.2023.105677
    Journal articles | 2023
    Poumbourios P; Langer C; Boo I; Zakir T; Center RJ; Akerman A; Milogiannakis V; Aggarwal A; Johnstone BA; Ha J; Coulibaly F; Turville SG; Drummer HE, 2023, 'Enhanced stability of the SARS CoV-2 spike glycoprotein following modification of an alanine cavity in the protein core', PLoS Pathogens, 19, http://dx.doi.org/10.1371/journal.ppat.1010981
    Journal articles | 2023
    Troelnikov A; Armour B; Putty T; Aggarwal A; Akerman A; Milogiannakis V; Chataway T; King J; Turville S; Gordon TP; Wang JJ, 2023, 'Imprinted repertoire restriction in immunodeficiency', Pathology, 55, pp. S28 - S28, http://dx.doi.org/10.1016/j.pathol.2022.12.093
    Journal articles | 2023
    Troelnikov A; Armour B; Putty T; Aggarwal A; Akerman A; Milogiannakis V; Chataway T; King J; Turville SG; Gordon TP; Wang JJ, 2023, 'Immunoglobulin repertoire restriction characterizes the serological responses of patients with predominantly antibody deficiency', Journal of Allergy and Clinical Immunology, 152, pp. 290 - 301.e7, http://dx.doi.org/10.1016/j.jaci.2023.02.033
    Journal articles | 2022
    Aggarwal A; Akerman A; Milogiannakis V; Silva MR; Walker G; Stella AO; Kindinger A; Angelovich T; Waring E; Amatayakul-Chantler S; Roth N; Manni S; Hauser T; Barnes T; Condylios A; Yeang M; Wong M; Jean T; Foster CSP; Christ D; Hoppe AC; Munier ML; Darley D; Churchill M; Stark DJ; Matthews G; Rawlinson WD; Kelleher AD; Turville SG, 2022, 'SARS-CoV-2 Omicron BA.5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern', eBioMedicine, 84, http://dx.doi.org/10.1016/j.ebiom.2022.104270
    Journal articles | 2022
    Aggarwal A; Stella A; Walker G; Akerman A; Milogiannakis V; Brilot F; Amatayakul-Chantler S; Roth N; Coppola G; Schofield P; Jackson J; Lenthall H; Mazigi O; Langley D; Lu Y; Forster C; McAllery S; Mathivanan V; Fitcher C; Hoppe AC; Munier ML; Jack H-M; Cromer D; Darley D; Matthews G; Christ D; Khoury D; Davenport M; Rawlinson W; Kelleher A; Turville S, 2022, 'SARS-CoV-2 Omicron: evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern', , http://dx.doi.org/10.21203/rs.3.rs-1207364/v1
    Journal articles | 2022
    Aggarwal A; Stella AO; Walker G; Akerman A; Esneau C; Milogiannakis V; Burnett DL; McAllery S; Silva MR; Lu Y; Foster CSP; Brilot F; Pillay A; Van Hal S; Mathivanan V; Fichter C; Kindinger A; Hoppe AC; Munier ML; Amatayakul-Chantler S; Roth N; Coppola G; Symonds GP; Schofield P; Jackson J; Lenthall H; Henry JY; Mazigi O; Jäck HM; Davenport MP; Darley DR; Matthews GV; Khoury DS; Cromer D; Goodnow CC; Christ D; Robosa R; Starck DJ; Bartlett NW; Rawlinson WD; Kelleher AD; Turville SG, 2022, 'Platform for isolation and characterization of SARS-CoV-2 variants enables rapid characterization of Omicron in Australia', Nature Microbiology, 7, pp. 896 - 908, http://dx.doi.org/10.1038/s41564-022-01135-7
    Journal articles | 2022
    Akerman A; Pessoa JP; Weller L, 2022, 'The West’s Teeth: IMF conditionality during the Cold War', World Economy, 45, pp. 2034 - 2051, http://dx.doi.org/10.1111/twec.13264
    Journal articles | 2022
    Phetsouphanh C; Khoo WH; Jackson K; Klemm V; Howe A; Aggarwal A; Akerman A; Milogiannakis V; Stella AO; Rouet R; Schofield P; Faulks ML; Law H; Danwilai T; Starr M; Munier CML; Christ D; Singh M; Croucher PI; Brilot-Turville F; Turville S; Phan TG; Dore GJ; Darley D; Cunningham P; Matthews GV; Kelleher AD; Zaunders JJ, 2022, 'High titre neutralizing antibodies in response to SARS–CoV–2 infection require RBD–specific CD4 T cells that include proliferative memory cells', Frontiers in Immunology, 13, http://dx.doi.org/10.3389/fimmu.2022.1032911
    Journal articles | 2022
    Shen Y; Freeman JA; Holland J; Naidu K; Solterbeck A; Van Bilsen N; Downe P; Kerridge I; Wallman L; Akerman A; Aggarwal A; Milogiannakis V; Martins Costa Gomes G; Doyle CM; Sandgren KJ; Turville S; Cunningham AL; Mulligan SP, 2022, 'Multiple COVID-19 vaccine doses in CLL and MBL improve immune responses with progressive and high seroconversion', Blood, 140, pp. 2709 - 2721, http://dx.doi.org/10.1182/blood.2022017814
    Journal articles | 2022
    Shen Y; Freeman JA; Holland J; Solterbeck A; Naidu K; Soosapilla A; Downe P; Tang C; Kerridge I; Wallman L; Van Bilsen N; Milogiannakis V; Akerman A; Martins Costa Gomes G; Sandgren K; Cunningham A; Turville S; Mulligan SP, 2022, 'COVID-19 vaccine failure in chronic lymphocytic leukaemia and monoclonal B-lymphocytosis; humoural and cellular immunity', British Journal of Haematology, 197, pp. 41 - 51, http://dx.doi.org/10.1111/bjh.18014
    Journal articles | 2018
    Akerman A; Sharbeen G; Holst J; Youkhana J; McCarroll J; Goldstein D; Erkan M; Phillips P, 2018, 'Targeting a solute carrier to metabolically reprogram tumour-promoting stromal cells in pancreatic cancer', Pancreatology, 18, pp. S156 - S156, http://dx.doi.org/10.1016/j.pan.2018.05.419
    Journal articles | 2016
    Akerman A; Vennin C; Sharbeen G; Warren SC; Timpson P; Phillips PA, 2016, 'Novel therapeutics and preclinical imaging for pancreatic cancer - View from the lab', Cancer Forum, 40, pp. 16 - 22
    Journal articles | 2016
    Sharbeen G; Youkhana J; McCarroll J; Akerman A; Goldstein D; Phillips P, 2016, 'MutY-Homolog modulates pancreatic cancer cell survival and chemoresistance', Pancreatology, 16, pp. S5 - S5, http://dx.doi.org/10.1016/j.pan.2016.05.024
  • Preprints | 2023
    Aggarwal A; Fichter C; Milogiannakis V; Akerman A; Ison T; Ruiz Silva M; Esneau C; Bartlett N; Burrell L; Patel S; Churchill M; Angelovich T; Parry R; Sng J; Neely G; Moreno C; Loo L; Kelleher A; Brilot F; Khromykh A; Turville SG, 2023, TMPRSS2 activation of Omicron lineage Spike glycoproteins is regulated by TMPRSS2 cleavage of ACE2, , http://dx.doi.org/10.1101/2023.09.22.558930
    Preprints | 2023
    Perkins G; Hope C; Chai CS; Tunbridge M; Sterling S; Webb K; Yap J; Yeow AEL; Masavuli M; Kireta S; Zuiani J; Akerman A; Aggarwal A; Milogiannakis V; Roberts M; Wilson W; Hurtado P; Turville S; Grubor-Bauk B; Barry S; Coates T; Ravindran J; Hissaria P, 2023, Immune profiling of COVID-19 vaccine responses in people with multiple sclerosis on B cell-depleting therapy, , http://dx.doi.org/10.1101/2023.12.04.23299409
    Preprints | 2023
    Perkins G; Tunbridge M; Chai CS; Hope C; Yeow AEL; Salehi T; Singer J; Shi B; Masavuli M; Mekonnen ZA; Garcia-Valtanen P; Kireta S; Johnston J; Drogemuller C; Sim B; Spencer S; Sallustio B; Comerford I; Bouras G; Weiskopf D; Sette A; Aggarwal A; Milogiannakis V; Akerman A; Turville S; Hurtado P; Ying T; Hissaria P; Barry S; Chadban S; Grubor-Bauk B; Coates T, 2023, mTOR inhibition improves the formation of functional T cell memory following COVID-19 vaccination of kidney transplant recipients, , http://dx.doi.org/10.1101/2023.03.27.23287773
    Preprints | 2023
    Phetsouphanh C; Jacka B; Ballouz S; Jackson KJL; Wilson D; Manandhar B; Klemm V; Tan H-X; Wheatley A; Aggarwal A; Akerman A; Milogiannakis V; Starr M; Cunningham P; Turville S; Kent S; Byrne A; Brew B; Darley D; Dore G; Kelleher A; Matthews G, 2023, Improvement of immune dysregulation and health-related quality of life in individuals with long COVID at 24-months following SARS-CoV-2 infection, , http://dx.doi.org/10.1101/2023.08.27.23294704
    Preprints | 2022
    Aggarwal A; Akerman A; Milogiannakis V; Silva MR; Walker G; Kidinger A; Angelovich T; Waring E; Amatayakul-Chantler S; Roth N; Coppola G; Yeang M; Jean T; Foster C; Hoppe AC; Ling Munier M; Darley D; Churchill M; Starck D; Christ D; Matthews G; Rawlinson W; Kelleher A; Turville S, 2022, SARS-CoV-2 Omicron BA.5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern, , http://dx.doi.org/10.1101/2022.07.07.22277128
    Preprints | 2022
    Aggarwal A; Stella A; Akerman A; Walker G; Milogiannakis V; McAllery S; Esneau C; Silva MR; Lu Y; Forster C; Hal SV; Mathivanan V; Fitcher C; Hoppe AC; Munier ML; Darley D; Matthews G; Starck D; Robosa R; Bartlett N; Rawlinson W; Kelleher A; Turville S, 2022, Rapid isolation and resolution immune evasion and viral fitness across contemporary SARS-CoV-2 variants, , http://dx.doi.org/10.21203/rs.3.rs-1210846/v1
    Preprints | 2022
    Akerman A; Milogiannakis V; Jean T; Esneau C; Silva MR; Ison T; Fitcher C; Lopez JA; Chandra D; Naing Z; Caguicla J; Li D; Walker G; Amatayakul-Chantler S; Roth N; Manni S; Hauser T; Barnes T; Condylios A; Yeang M; Wong M; Foster CSP; Sato K; Lee S; Song Y; Mao L; Sigmund A; Phu A; Vande More AM; Hunt S; Douglas M; Caterson I; Sandgren K; Bull R; Lloyd A; Triccas J; Tangye S; Bartlett NW; Darley D; Matthews G; Stark DJ; Rawlinson WD; Murrell B; Brilot F; Cunningham AL; Kelleher AD; Aggarwal A; Turville SG, 2022, Emergence and antibody evasion of BQ, BA.2.75 and SARS-CoV-2 recombinant sublineages in the face of maturing antibody breadth at the population level, , http://dx.doi.org/10.1101/2022.12.06.22283000
    Preprints | 2022
    Phetsouphanh C; Khoo WH; Jackson K; Klemm V; Howe A; Aggarwal A; Akerman A; Milogiannakis V; Stella AO; Rouet R; Schofield P; Faulks M; Law H; Danwilai T; Starr M; Munier ML; Christ D; Singh M; Croucher P; Brilot-Turville F; Turville S; Phan TG; Dore G; Darley D; Cunningham P; Matthews G; Kelleher A; Zaunders J, 2022, High titre neutralizing antibodies in response to SARS-CoV-2 infection require RBD-specific CD4 T cells that include proliferative memory cells, , http://dx.doi.org/10.1101/2022.07.22.22277947
    Preprints | 2022
    Poumbourios P; Langer C; Boo I; Zakir T; Center RJ; Akerman A; Milogiannakis V; Aggarwal A; Turville S; Drummer. HE, 2022, Enhanced stability of the SARS CoV-2 spike glycoprotein trimer following modification of an alanine cavity in the protein core, , http://dx.doi.org/10.1101/2022.11.08.515567
    Conference Abstracts | 2022
    Troelnikov A; Wang JJ; Armour B; Putty T; Aggarwal A; Akerman A; Milogiannakis V; Smith A; Hughes T; Turville S; Chataway T; King J; Gordon TP, 2022, 'MOLECULAR PROFILING UNCOVERS RESTRICTED ANTIBODY REPERTOIRES FOLLOWING COVID-19 VACCINATION IN PREDOMINANT ANTIBODY DEFICIENCIES', in INTERNAL MEDICINE JOURNAL, WILEY, Vol. 52, pp. 31 - 31, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000862654200083&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Preprints | 2021
    Aggarwal A; Stella AO; Walker G; Akerman A; Milogiannakis V; Brilot F; Amatayakul-Chantler S; Roth N; Coppola G; Schofield P; Jackson J; Henry J; Mazigi O; Langley D; Lu Y; Forster C; McAllery S; Mathivanan V; Fichter C; Hoppe AC; Munier ML; Jack H-M; Cromer D; Darley D; Matthews G; Christ D; Khoury D; Davenport M; Rawlinson W; Kelleher A; Turville S, 2021, SARS-CoV-2 Omicron: evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern, , http://dx.doi.org/10.1101/2021.12.14.21267772
    Preprints | 2021
    Shen Y; Freeman JA; Holland J; Solterbeck A; Naidu K; Soosapilla A; Downe P; Tang C; Kerridge I; Wallman L; Van Bilsen N; Milogiannakis V; Akerman A; Martins Costa Gomes G; Sandgren K; Cunningham AL; Turville S; Mulligan SP, 2021, COVID-19 Vaccine Failure in Chronic Lymphocytic Leukemia and Monoclonal B-Lymphocytosis; Humoral and Cellular Immunity, , http://dx.doi.org/10.1101/2021.10.28.21265549
    Conference Abstracts | 2018
    Kokkinos J; Sharbeen G; McCarroll J; Boyer C; Akerman A; Youkhana J; Davis TP; Goldstein D; Phillips PA, 2018, 'beta III-Tubulin is a Brake for External Cell-Death Signaling and Regulates TRAIL Sensitivity in Pancreatic Cancer', in PANCREAS, LIPPINCOTT WILLIAMS & WILKINS, Miami Beach, Florida, Vol. 47, pp. 1401 - 1401, presented at 49th Annual Meeting of the American Pancreatic Association, Miami Beach, Florida, 31 October 2018 - 03 November 2018, http://dx.doi.org/10.1097/MPA.0000000000001177
    Conference Papers | 2018
    Kokkinos J; Sharbeen G; Mccarroll J; Akerman A; Youkhana J; Goldstein D; Phillips P, 2018, 'beta III-Tubulin is a brake for external cell-death signaling and chemosensitivity in pancreatic cancer', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY, pp. 19 - 19, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000530647800030&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2018
    Sharbeen G; Akerman A; McCarroll J; Boyer C; Holst J; Youkhana J; Davis TP; Goldstein D; Erkan M; Phillips PA, 2018, 'Metabolically Reprograming Pancreatic Stellate Cells Using a Novel Nanomedicine for the Treatment of Pancreatic Cancer', in PANCREAS, LIPPINCOTT WILLIAMS & WILKINS, Vol. 47, pp. 1422 - 1422, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000449304600230&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2016
    Phillips P; Sharbeen G; Youkhana J; Mawson A; McCarroll J; Akerman A; Goldstein D, 2016, 'MutY-Homolog Modulates Pancreatic Cancer Cell Survival and Chemoresistance', in PANCREAS, LIPPINCOTT WILLIAMS & WILKINS, Vol. 45, pp. 1534 - 1534, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000386978400183&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Preprints |
    Aggarwal A; Akerman A; Milogiannakis V; Silva MR; Walker G; Kidinger A; Angelovich T; Waring E; Amatayakul-Chantler S; Roth N; Yeang M; Jean T; Foster C; Hoppe AC; Munier ML; Darley DR; Churchill M; Starck D; Christ D; Matthews G; Rawlinson W; Kelleher A; Turville S, SARS-CoV-2 Omicron BA.5: Evolving Tropism and Evasion of Potent Humoral Responses and Resistance to Clinical Immunotherapeutics Relative to Viral Variants of Concern, , http://dx.doi.org/10.2139/ssrn.4157473
    Preprints |
    Akerman A; Milogiannakis V; Jean T; Esneu C; Silva MR; Ison T; Fitcher C; Lopez JA; Chandra D; Naing Z; Caguicla J; Li D; Walker G; Amatayakul-Chantler S; Roth N; Manni S; Hauser T; Barnes T; Condylios A; Yeang M; Wong M; Foster C; Lee S; Song Y; Mao L; Sigmund A; Phu A; Vande More AM; Hunt S; Douglas M; Caterson I; Sandgren KJ; Bull RA; Lloyd AR; Triccas J; Tangye SG; Bartlett NW; Darley DR; Matthews G; Starck D; Rawlinson W; Brilot F; Cunningham AL; Kelleher A; Aggarwal A; Turville S, Emergence and Antibody Evasion of BQ and BA.2.75 SARS-CoV-2 Sublineages in the Face of Maturing Antibody Breadth at the Population Level, , http://dx.doi.org/10.2139/ssrn.4295993

Laboratory Efficiency Assessment Framework (LEAF) grant (2023)

This grant was awarded to the Kirby Institute LEAF team to establish a soft plastics recycling stream within the PC2 laboratory.

School of Medical Science (SoMS) Award for Safety Culture (MEDRIOS Team) (2020)

Nomination for UNSW Dean’s Award for Outstanding PhD Theses (2019)

Translational Cancer Research Network, PhD Scholarship Top-up Award (2018 – 2019)

European Pancreas Club Jubilee Meeting Travel Scholarship (2018)

Postgraduate Research Student Support Scheme (2018)

Prince of Wales Clinical School Travel Award (2018)

Campion-Ma-Playoust Memorial Award (Best Oral Presentation) Australian Society for Medical Research National Scientific Conference (2017)

Australian Postgraduate Award (APA) Scholarship (2015 – 2018)

The focus of Nush's PhD (2015-2019) was understanding the metabolic changes that occur in pancreatic tumour cells and tumour-associated stromal cells, as these changes represent vulnerabilities that can be therapeutically targeted. Her PhD focused specifically on inhibiting various nutrient transporters, that are over-expressed in both cell types, using pharmacological inhibitors or gene therapy (nanoparticles coupled with siRNA). 

In 2021, Nush joined the Viral Pathogenesis and Vector Lab (VPVL) within the Immunovirology and Pathogenesis Program (IVPP) where she is involved in:

  • Collaborative testing of sera samples from convalescent or vaccinated donors
  • Screening of new antiviral SARS-CoV-2 drugs
  • Investigating SARS-CoV-2 viral tropism
  • Establishing platforms for testing Mpox