Dr Antony   Cooper
Conjoint Associate Professor

Dr Antony Cooper

medicine-health
St Vincent's Clinical School

Associate Professor Antony Cooper is Head of both the Neurodegeneration & Neurogenomics Program and Neuroscience Division at the Garvan Institute of Medical Research. 

Research Interests

Our main focus is to identify the underlying disease mechanism(s) of Parkinson’s Disease so as to identify and develop Neuroprotective therapies, especially those to slow/stop disease progression.  Intensive Neurogenomic approaches are also being employed to identify peripheral biomarkers for both presymptomatic diagnosis and efficacy assessment of new disease-modifying therapies. Whole Genome Sequencing and transcriptional analysis of Bipolar Disorder pedigrees are being conducted to provide insights into the basis of this disease.

Phone
9295 8238

Publications

  • Journal articles | 2021
    Dr Antony Cooper
    Guennewig B; Lim J; Marshall L; McCorkindale AN; Paasila PJ; Patrick E; Kril JJ; Halliday GM; Cooper AA; Sutherland GT, 2021, 'Defining early changes in Alzheimer’s disease from RNA sequencing of brain regions differentially affected by pathology', Scientific Reports, vol. 11, pp. 4865, http://dx.doi.org/10.1038/s41598-021-83872-z
    Journal articles | 2021
    Dr Antony Cooper
    O'Sullivan JM; den Heijer JM; Groeneveld GJ; Cooper AA, 2021, 'Intronic Haplotypes in GBA Modify Age at Diagnosis of Parkinson's: Replication in a Subgroup', Movement Disorders, vol. 36, pp. 1468 - 1470, http://dx.doi.org/10.1002/mds.28620
    Journal articles | 2020
    Dr Antony Cooper
    Toma C; Shaw AD; Overs BJ; Mitchell PB; Schofield PR; Cooper AA; Fullerton JM, 2020, 'De Novo Gene Variants and Familial Bipolar Disorder', JAMA network open, vol. 3, pp. e203382, http://dx.doi.org/10.1001/jamanetworkopen.2020.3382
    Journal articles | 2020
    Dr Antony Cooper
    Schierding W; Farrow S; Fadason T; Graham OEE; Pitcher TL; Qubisi S; Davidson AJ; Perry JK; Anderson TJ; Kennedy MA; Cooper A; O'Sullivan JM, 2020, 'Common Variants Coregulate Expression of GBA and Modifier Genes to Delay Parkinson's Disease Onset', Movement Disorders, vol. 35, pp. 1346 - 1356, http://dx.doi.org/10.1002/mds.28144
    Journal articles | 2019
    Dr Antony Cooper
    Montgomery MK; Osborne B; Brandon AE; O'Reilly L; Fiveash CE; Brown SHJ; Wilkins BP; Samsudeen A; Yu J; Devanapalli B; Hertzog A; Tolun AA; Kavanagh T; Cooper AA; Mitchell TW; Biden TJ; Smith NJ; Cooney GJ; Turner N, 2019, 'Regulation of mitochondrial metabolism in murine skeletal muscle by the medium-chain fatty acid receptor Gpr84', FASEB Journal, vol. 33, pp. 12264 - 12276, http://dx.doi.org/10.1096/fj.201900234R
    Journal articles | 2018
    Dr Antony Cooper
    Dong X; Liao Z; Gritsch D; Hadzhiev Y; Bai Y; Locascio JJ; Guennewig B; Liu G; Blauwendraat C; Wang T; Adler CH; Hedreen JC; Faull RLM; Frosch MP; Nelson PT; Rizzu P; Cooper AA; Heutink P; Beach TG; Mattick JS; Müller F; Scherzer CR, 2018, 'Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease', Nature Neuroscience, vol. 21, pp. 1482 - 1492, http://dx.doi.org/10.1038/s41593-018-0223-0
    Journal articles | 2015
    Dr Antony Cooper
    Murphy KE; Gysbers AM; Abbott SK; Spiro AS; Furuta A; Cooper A; Garner B; Kabuta T; Halliday GM, 2015, 'Lysosomal-associated membrane protein 2 isoforms are differentially affected in early Parkinson's disease', Movement Disorders, vol. 30, pp. 1639 - 1647, http://dx.doi.org/10.1002/mds.26141
    Journal articles | 2014
    Dr Antony Cooper
    Guennewig B; Cooper AA, 2014, 'The central role of noncoding RNA in the brain', International Review of Neurobiology, vol. 116, pp. 153 - 194, http://dx.doi.org/10.1016/B978-0-12-801105-8.00007-2
    Journal articles | 2014
    Dr Antony Cooper
    Murphy KE; Cottle L; Gysbers AM; Cooper AA; Halliday GM, 2014, 'ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies', Acta Neuropathologica Communications, vol. 2, pp. 11, http://dx.doi.org/10.1186/2051-5960-1-11
    Journal articles | 2014
    Dr Antony Cooper
    Kong SMY; Chan BKK; Park JS; Hill KJ; Aitken JB; Cottle L; Farghaian H; Cole AR; Lay PA; Sue CM; Cooper AA, 2014, 'Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes', Human Molecular Genetics, vol. 23, pp. 2816 - 2833, http://dx.doi.org/10.1093/hmg/ddu099
    Journal articles | 2014
    Dr Antony Cooper
    Murphy KE; Gysbers AM; Abbott SK; Tayebi N; Kim WS; Sidransky E; Cooper A; Garner B; Halliday GM, 2014, 'Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease', Brain, vol. 137, pp. 834 - 848, http://dx.doi.org/10.1093/brain/awt367
    Journal articles | 2012
    Dr Antony Cooper
    Protter D; Lang C; Cooper A; Lang C, 2012, 'alphaSynuclein and mitochondrial dysfunction: A pathogenic partnership in Parkinson's Disease?', Parkinson's Disease, vol. 2012, pp. 829207, http://dx.doi.org/10.1155/2012/829207
    Journal articles | 2012
    Dr Antony Cooper
    Chesi A; Kilaru A; Fang X; Cooper A, 2012, 'The role of the Parkinson's disease gene PARK9 in essential cellular pathways and the manganese homeostasis network in yeast', PLoS One, vol. 7, pp. e34178, http://dx.doi.org/10.1371/journal.pone.0034178
    Journal articles | 2011
    Dr Antony Cooper
    Park JS; Mehta P; Cooper A; Veivers D; Heimbach A; Stiller B; Kubisch C; Fung VS; Krainc D; Mackay-Sim A; Sue CM, 2011, 'Pathogenic effects of novel mutations in the P-type ATPase ATP13A2 (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset parkinsonism', Human Mutation, vol. 32, pp. 956 - 964, http://dx.doi.org/10.1002/humu.21527
    Journal articles | 2011
    Dr Antony Cooper
    Webber K; Cooper A; Kleiven H; Yip D; Goldstein D, 2011, 'Management of metastatic renal cell carcinoma in the era of targeted therapies', Internal Medicine Journal, vol. 41, pp. 594 - 605, http://dx.doi.org/10.1111/j.1445-5994.2011.02540.x
    Journal articles | 2010
    Dr Antony Cooper
    McConoughey S; Basso SJ; Nietsetskaya Z; Sleiman SF; Smirnova T; Langley B; Mahishi L; Cooper AJ; Antonyak MA; Cerione RA; Li B; Starkov A; Chaturvedi R; Beale M; Coppola G; Geschwind D; Ryu H; Li XR; Iismaa SE; Pallos J; Pasternack R; Hils M; Fan J; Raymond LA; Marsh JL; Thompson LM; Ratan R, 2010, 'Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease', EMBO Journal, vol. 2, pp. 349 - 370, http://dx.doi.org/10.1002/emmm.201000084
    Journal articles | 2010
    Dr Antony Cooper
    Su LJ; Auluck PK; Outeiro TF; Yeger-Lotem E; Kritzer J; Tardiff D; Strathearn K; Liu F; Cao S; Hamamichi S; Hill KJ; Caldwell K; Bell GW; Fraenkel E; Cooper A; Caldwell G; McCaffery J; Rochet J-C; Lindquist S, 2010, 'Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models', Disease Models and Mechanisms, vol. 3, pp. 194-208, http://dx.doi.org/10.1242/dmm.004267
    Journal articles | 2009
    Dr Antony Cooper
    Bunce M; Worthy T; Phillips M; Holdaway RN; Willerslev E; Haile J; Shapiro RP; Scofield RP; Drummond A; Kamp PJJ; Cooper A, 2009, 'The evolutionary history of the extinct ratite moa and New Zealand Neogene paleogeography.', Proceedings of the National Academy of Sciences of the United States of America, vol. 106, pp. 20646 - 20651, http://dx.doi.org/10.1073/pnas.0906660106
    Journal articles | 2009
    Dr Antony Cooper
    Gitler A; Chesi A; Geddie M; Strathearn K; Hamamichi S; Caldwell K; Hill KJ; Caldwell G; Cooper A; Rochet J; Lindquist S, 2009, 'Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity', Nature Genetics, vol. 41, pp. 308 - 315, http://dx.doi.org/10.1038/ng.300
    Journal articles | 2009
    Dr Antony Cooper
    Zhao JT; Hill A; Varghese A; Cooper A; Swan H; Laitinen-Forsblom P; Rees M; Skinner J; Campbell TJ; Vandenberg JI, 2009, 'Not all hERG pore domain mutations have a severe phenotype: G584S has an inactivation gating defect with mild phenotype compared to G572S, which has a dominant negative trafficking defect and a severe phenotype', Journal of Cardiovascular Electrophysiology, vol. 20, pp. 923 - 930, http://dx.doi.org/10.1111/j.1540-8167.2009.01468.x
    Journal articles | 2009
    Dr Antony Cooper
    Gitler AD; Chesi A; Geddie ML; Strathearn KE; Hamamichi S; Hill KJ; Caldwell KA; Caldwell GA; Cooper AA; Rochet JC; Lindquist S, 2009, 'α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity', Nature Genetics, vol. 41, pp. 308 - 315, http://dx.doi.org/10.1038/ng.300
    Journal articles | 2008
    Dr Antony Cooper
    Jackson CJ; Cooper A; Smillie L, 2008, 'A trait conceptualization of reward-reactivity: psychometric properties of the appetitive motivation scale (AMS)', Journal of Individual Differences, vol. 29, pp. 168 - 180, http://dx.doi.org/10.1027/1614-0001.29.3.168
    Journal articles | 2007
    Dr Antony Cooper
    Kincaid M; Cooper A, 2007, 'ERADicate ER stress or die trying', Antioxidants and Redox Signaling, vol. 9, pp. 2373 - 2387, http://dx.doi.org/10.1089/ars.2007.1817
    Journal articles | 2007
    Dr Antony Cooper
    Kincaid M; Cooper A, 2007, 'Misfolded proteins traffic from the endoplasmic reticulum (ER) due to ER export signals', Molecular Biology of the Cell, vol. 18, pp. 455 - 463, http://dx.doi.org/10.1091/mbc.E06-08-0696
    Journal articles | 2006
    Dr Antony Cooper
    Cooper AA; Gitler AD; Cashikar A; Haynes CM; Hill KJ; Bhullar B; Liu K; Xu K; Strathearn KE; Liu F; Cao S; Caldwell KA; Caldwell GA; Marsischky G; Kolodner RD; LaBaer J; Rochet JC; Bonini NM; Lindquist S, 2006, 'α-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models', Science, vol. 313, pp. 324 - 328, http://dx.doi.org/10.1126/science.1129462
    Journal articles | 2006
    Dr Antony Cooper
    Molero JC; Waring S; Cooper A; Turner N; Laybutt DR; Cooney GJ; James DE, 2006, 'Casitas b-lineage lymphoma-deficient mice are protected against high-fat died-induced obesity and insulin resistance', Diabetes, vol. 55, pp. 708 - 715, http://dx.doi.org/10.2337/diabetes.55.03.06.db05-0312
    Journal articles | 2004
    Dr Antony Cooper
    Haynes CM; Titus EA; Cooper AA, 2004, 'Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death', Molecular Cell, vol. 15, pp. 767 - 776, http://dx.doi.org/10.1016/j.molcel.2004.08.025
    Journal articles | 2002
    Dr Antony Cooper
    Haynes CM; Caldwell S; Cooper AA, 2002, 'An HRD/DER-independent er quality control mechanism involves Rsp5p-dependent ubiquitination and ER-Golgi transport', Journal of Cell Biology, vol. 158, pp. 91 - 101, http://dx.doi.org/10.1083/jcb.200201053
    Journal articles | 2001
    Dr Antony Cooper
    Caldwell SR; Hill KJ; Cooper AA, 2001, 'Degradation of Endoplasmic Reticulum (ER) Quality Control Substrates Requires Transport between the ER and Golgi', Journal of Biological Chemistry, vol. 276, pp. 23296 - 23303, http://dx.doi.org/10.1074/jbc.M102962200
    Journal articles | 2000
    Dr Antony Cooper
    Hill K; Cooper AA, 2000, 'Degradation of unassembled Vph1p reveals novel aspects of the yeast ER quality control system', EMBO Journal, vol. 19, pp. 550 - 561, http://dx.doi.org/10.1093/emboj/19.4.550
    Journal articles | 1996
    Dr Antony Cooper
    Cooper AA; Stevens TH, 1996, 'Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases', Journal of Cell Biology, vol. 133, pp. 529 - 541, http://dx.doi.org/10.1083/jcb.133.3.529
    Journal articles | 1995
    Dr Antony Cooper
    Piper RC; Cooper AA; Yang H; Stevens TH, 1995, 'VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae', Journal of Cell Biology, vol. 131, pp. 603 - 617, http://dx.doi.org/10.1083/jcb.131.3.603
    Journal articles | 1995
    Dr Antony Cooper
    Cooper AA; Stevens TH, 1995, 'Protein splicing: self-splicing of genetically mobile elements at the protein level', Trends in Biochemical Sciences, vol. 20, pp. 351 - 356, http://dx.doi.org/10.1016/S0968-0004(00)89075-1
    Journal articles | 1993
    Dr Antony Cooper
    Cooper AA; Chen YJ; Lindorfer MA; Stevens TH, 1993, 'Protein splicing of the yeast TFP1 intervening protein sequence: A model for self-excision', EMBO Journal, vol. 12, pp. 2575 - 2583, http://dx.doi.org/10.1002/j.1460-2075.1993.tb05913.x
    Journal articles | 1993
    Dr Antony Cooper
    Cooper AA; Stevens TMH, 1993, 'Protein splicing: Excision of intervening sequences at the protein level', BioEssays, vol. 15, pp. 667 - 674, http://dx.doi.org/10.1002/bies.950151006
    Journal articles | 1992
    Dr Antony Cooper
    Cooper A; Bussey H, 1992, 'Yeast Kex1p is a Golgi-associated membrane protein: Deletions in a cytoplasmic targeting domain result in mislocalization to the vacuolar membrane', Journal of Cell Biology, vol. 119, pp. 1459 - 1468, http://dx.doi.org/10.1083/jcb.119.6.1459
    Journal articles | 1990
    Dr Antony Cooper
    Thomas L; Cooper A; Bussey H; Thomas G, 1990, 'Yeast KEX1 protease cleaves a prohormone processing intermediate in mammalian cells', Journal of Biological Chemistry, vol. 265, pp. 10821 - 10824
    Journal articles | 1989
    Dr Antony Cooper
    Cooper A; Bussey H, 1989, 'Characterization of the yeast KEX1 gene product: a carboxypeptidase involved in processing secreted precursor proteins.', Molecular and cellular biology, vol. 9, pp. 2706 - 2714, http://dx.doi.org/10.1128/MCB.9.6.2706
    Journal articles | 1965
    Dr Antony Cooper
    Barclay GA; Cooper A, 1965, '685. The crystal structure of copper(II) ethyl acetoacetate', Journal of the Chemical Society (Resumed), pp. 3746 - 3751, http://dx.doi.org/10.1039/JR9650003746
  • Reports | 2019
    Dr Antony Cooper
    Dong X; Liao Z; Gritsch D; Hadzhiev Y; Bai Y; Locascio JJ; Guennewig B; Liu G; Blauwendraat C; Wang T; Adler CH; Hedreen JC; Faull RLM; Frosch MP; Nelson PT; Rizzu P; Cooper AA; Heutink P; Beach TG; Mattick JS; Müller F; Scherzer CR, 2019, Erratum to: Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease (Nature Neuroscience, (2018), 21, 10, (1482-1492), 10.1038/s41593-018-0223-0), United States, http://dx.doi.org/10.1038/s41593-018-0277-z

Awards

Grants

Media