Dr Arunasingam Abayasingam

Back to

Arun completed his Bachelor’s Degree in Science with Honours at the University of New South Wales in 2016. During his studies, he focused on pathology and pharmacology, undertaking a project investigate the effects of epidermal growth factor receptor targeted and metabolic inhibitor combination therapy in osteosarcomas.

In 2017, Arun joined the Viral Immunology Systems Program as a Postgraduate Student under the supervision of Dr Rowena Bull and Dr Chaturaka Rodrigo. His current project includes characterising Hepatitis C (HCV) Transmitted/Founder virus, understanding the host-viral interaction during acute HCV infection, and investigating the host-viral interactions in HCV re-infection. Findings of this project will potentially contribute towards designing an effective protective vaccine against HCV.

Phone

+61 (2) 9348 1583

E-mail

aabayasingam@kirby.unsw.edu.au

Journal articles | 2024

Adhikari A; Abayasingam A; Brasher NA; Kim HN; Lord M; Agapiou D; Maher L; Rodrigo C; Lloyd AR; Bull RA; Tedla N, 2024, 'Characterization of antibody-dependent cellular phagocytosis in patients infected with hepatitis C virus with different clinical outcomes', Journal of Medical Virology, 96, http://dx.doi.org/10.1002/jmv.29381

Journal articles | 2024

Underwood AP; Gupta M; Wu B-R; Eltahla AA; Boo I; Wang JJ; Agapiou D; Abayasingam A; Reynaldi A; Keoshkerian E; Zhao Y; Brasher N; Walker MR; Bukh J; Maher L; Gordon T; Davenport MP; Luciani F; Drummer HE; Lloyd AR; Bull RA, 2024, 'B cell characteristics define HCV reinfection outcome.', J Hepatol, http://dx.doi.org/10.1016/j.jhep.2024.04.004

Journal articles | 2023

Norton T; Lynn MA; Rossouw C; Abayasingam A; Perkins G; Hissaria P; Bull RA; Lynn DJ, 2023, 'B and T cell responses to the BNT162b2 COVID-19 mRNA vaccine are not impaired in germ-free or antibiotic-treated mice.', Gut, http://dx.doi.org/10.1136/gutjnl-2023-329810

Journal articles | 2023

Ryan FJ; Norton TS; McCafferty C; Blake SJ; Stevens NE; James J; Eden GL; Tee YC; Benson SC; Masavuli MG; Yeow AEL; Abayasingam A; Agapiou D; Stevens H; Zecha J; Messina NL; Curtis N; Ignjatovic V; Monagle P; Tran H; McFadyen JD; Bull RA; Grubor-Bauk B; Lynn MA; Botten R; Barry SE; Lynn DJ, 2023, 'A systems immunology study comparing innate and adaptive immune responses in adults to COVID-19 mRNA and adenovirus vectored vaccines', Cell Reports Medicine, 4, http://dx.doi.org/10.1016/j.xcrm.2023.100971

Journal articles | 2023

Underwood AP; Gupta M; Wu B-R; Eltahla AA; Boo I; Wang JJ; Agapiou D; Abayasingam A; Reynaldi A; Keoshkerian E; Zhao Y; Brasher N; Walker MR; Bukh J; Maher L; Gordon T; Davenport M; Luciani F; Drummer HE; Lloyd AR; Bull RA, 2023, 'B Cell Signatures and Antibody Imprinting Define HCV Reinfection Outcome', , http://dx.doi.org/10.2139/ssrn.4418620

Journal articles | 2022

Adhikari A; Abayasingam A; Rodrigo C; Agapiou D; Pandzic E; Brasher NA; Fernando BSM; Keoshkerian E; Li H; Kim HN; Lord M; Popovic G; Rawlinson W; Mina M; Post JJ; Hudson B; Gilroy N; Dwyer D; Sasson SC; Grubor-Bauk B; Lloyd AR; Martinello M; Bull RA; Tedla N; Lloyd AR; Kaldor J; Dore G; Sorrell T; Hudson B; Bartlett A; Lemberg D; Di Girolamo N; Byrne M; Hammoud M; Lloyd AR; Sultan R; Hudson B; Konecny P; Matthews G; Shek D; Holdaway S; Mitsa-Kos K; How-Chow D; Lagunday R; Robinson S; Terrill L; Joshi N; Li Y; Gill S; Sevehon A, 2022, 'Longitudinal Characterization of Phagocytic and Neutralization Functions of Anti-Spike Antibodies in Plasma of Patients after Severe Acute Respiratory Syndrome Coronavirus 2 Infection', Journal of Immunology, 209, pp. 1499 - 1512, http://dx.doi.org/10.4049/jimmunol.2200272

Journal articles | 2022

Garcia-Valtanen P; Hope CM; Masavuli MG; Yeow AEL; Balachandran H; Mekonnen ZA; Al-Delfi Z; Abayasingam A; Agapiou D; Stella AO; Aggarwal A; Bouras G; Gummow J; Ferguson C; O'Connor S; McCartney EM; Lynn DJ; Maddern G; Gowans EJ; Reddi BAJ; Shaw D; Kok-Lim C; Beard MR; Weiskopf D; Sette A; Turville SG; Bull RA; Barry SC; Grubor-Bauk B, 2022, 'SARS-CoV-2 Omicron variant escapes neutralizing antibodies and T cell responses more efficiently than other variants in mild COVID-19 convalescents', Cell Reports Medicine, 3, http://dx.doi.org/10.1016/j.xcrm.2022.100651

Journal articles | 2021

Abayasingam A; Balachandran H; Agapiou D; Hammoud M; Rodrigo C; Keoshkerian E; Li H; Brasher NA; Christ D; Rouet R; Burnet D; Grubor-Bauk B; Rawlinson W; Turville S; Aggarwal A; Stella AO; Fichter C; Brilot F; Mina M; Post JJ; Hudson B; Gilroy N; Dwyer D; Sasson SC; Tea F; Pilli D; Kelleher A; Tedla N; Lloyd AR; Martinello M; Bull RA; Burnett D, 2021, 'Long-term persistence of RBD⁺ memory B cells encoding neutralizing antibodies in SARS-CoV-2 infection', Cell Reports Medicine, 2, pp. 100228, http://dx.doi.org/10.1016/j.xcrm.2021.100228

Journal articles | 2021

Rouet R; Mazigi O; Walker GJ; Langley DB; Sobti M; Schofield P; Lenthall H; Jackson J; Ubiparipovic S; Henry JY; Abayasingam A; Burnett D; Kelleher A; Brink R; Bull RA; Turville S; Stewart AG; Goodnow CC; Rawlinson WD; Christ D, 2021, 'Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies', mAbs, 13, http://dx.doi.org/10.1080/19420862.2021.1922134

Journal articles | 2020

Rouet R; Mazigi O; Walker G; Langley D; Sobti M; Schofield P; Lenthall H; Jackson J; Ubiparipovic S; Henry J; Abayasingam A; Burnett D; Kelleher A; Brink R; Bull R; Turville S; Stewart A; Goodnow C; Rawlinson W; Christ D, 2020, 'Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies', , http://dx.doi.org/10.1101/2020.12.14.422791

Journal articles | 2019

Abayasingam A; Leung P; Eltahla A; Bull RA; Luciani F; Grebely J; Dore GJ; Applegate T; Page K; Bruneau J; Cox AL; Kim AY; Schinkel J; Shoukry NH; Lauer GM; Maher L; Hellard M; Prins M; Lloyd A; Rodrigo C, 2019, 'Genomic characterization of hepatitis C virus transmitted founder variants with deep sequencing', Infection, Genetics and Evolution, 71, pp. 36 - 41, http://dx.doi.org/10.1016/j.meegid.2019.02.032

Journal articles | 2019

Walker MR; Leung P; Eltahla AA; Underwood A; Abayasingam A; Brasher NA; Li H; Wu BR; Maher L; Luciani F; Lloyd AR; Bull RA, 2019, 'Clearance of hepatitis C virus is associated with early and potent but narrowly-directed, Envelope-specific antibodies', Scientific Reports, 9, pp. 13300, http://dx.doi.org/10.1038/s41598-019-49454-w
Preprints | 2023

Adhikari A; Abayasingam A; A NB; Kim HN; Lord M; Agapiou D; Maher L; Rodrigo C; Lloyd A; Bull R; Tedla N, 2023, Characterisation of antibody dependent cellular phagocytosis in patients infected with Hepatitis C virus with different clinical outcomes, , http://dx.doi.org/10.22541/au.168992839.95818489/v1

Preprints | 2022

Ryan FJ; Norton TS; McCafferty C; Blake SJ; Stevens NE; James J; Eden GL; Tee YC; Benson SC; Masavuli MG; Yeow AEL; Abayasingam A; Agapiou D; Stevens H; Zecha J; Messina NL; Curtis N; Ignjatovic V; Monagle P; Tran H; McFadyen JD; Bull RA; Grubor-Bauk B; Lynn MA; Botten R; Barry SE; Lynn DJ, 2022, A systems immunology study comparing innate and adaptive immune responses in adults to COVID-19 mRNA (BNT162b2/mRNA-1273) and adenovirus vectored vaccines (ChAdOx1-S) after the first, second and third doses, , http://dx.doi.org/10.1101/2022.09.22.22280180

Preprints | 2021

Adhikari A; Abayasingam A; Rodrigo C; Agapiou D; Pandzic E; Brasher N; Madushan Fernando BS; Keoshkerian E; Li H; Kim HN; Lord M; Popovic G; Rawlinson W; Mina M; Post J; Hudson B; Gilroy N; Bartlett A; Ahlenstiel G; Grubor-Bauk B; Dwyer D; Konecny P; Lloyd A; Martinello M; Bull R; Tedla N, 2021, Longitudinal characterisation of phagocytic and neutralisation functions of anti-Spike antibodies in plasma of patients after SARS-CoV-2 infection, , http://dx.doi.org/10.1101/2021.12.21.473774

Preprints | 2021

Garcia-Valtanen P; Hope C; Masavuli M; Lip Yeow AE; Balachandran H; Mekonnen Z; Al-Delfi Z; Abayasingam A; Agapiou D; Stella AO; Aggarwal A; Gummow J; Ferguson C; O’Connor S; McCartney E; Lynn D; Maddern G; Gowans E; Reddi BAJ; Shaw D; Kok-Lim C; Turville S; Beard M; Weiskopf D; Sette A; Bull R; Barry S; Grubor-Bauk B, 2021, COVID-19 convalescents exhibit deficient humoral and T cell responses to variant of concern Spike antigens at 12 month post-infection, , http://dx.doi.org/10.1101/2021.11.08.21266035

Preprints | 2020

Bull R; Abayasingam A; Balachandran H; Agapiou D; Rodrigo C; Keoshkerian E; Li H; Brasher N; Christ D; Rouet R; Burnett D; Grubor-Bauk B; Rawlinson W; Turville S; Aggarwal A; Brilot F; Mina M; Post J; Hudson B; Gilroy N; Dwyer D; Sasson S; Tea F; Pilli D; Tedla N; Lloyd A; Martinello M, 2020, Long-term persistence of neutralizing memory B cells in SARS-CoV-2, , http://dx.doi.org/10.21203/rs.3.rs-92527/v1

Preprints |

Abayasingam A; Balachandran H; Agapiou D; Rodrigo C; Keoshkerian E; Li H; Brasher N; Christ D; Rouet R; Burnett D; Grubor-Bauk B; Rawlinson W; Turville S; Aggarwal A; Brilot F; Mina M; Post JJ; Hudson B; Gilroy N; Dwyer D; Sasson S; Tea F; Pilli D; Tedla N; Lloyd AR; Martinello M; Bull RA; Group COSINS, Long-Term Persistence of Neutralizing Memory B Cells in SARS-CoV-2, , http://dx.doi.org/10.2139/ssrn.3732365

Preprints |

Garcia Valtanen P; Hope CM; Masavuli MG; Yeow AEL; Balachandran H; Mekonnen ZA; Al-Delfi Z; Abayasingam A; Agapiou D; Gummow J; Ferguson C; O’Connor S; McCartney EM; Lynn DJ; Maddern G; Gowans EJ; Reddi BAJ; Shaw D; Chuan K-L; Beard M; Weiskopf D; Sette A; Bull RA; Barry SC; Grubor-Bauk B, 'One Year Later' - SARS-CoV-2-Specific Immunity in Mild Cases of COVID-19, , http://dx.doi.org/10.2139/ssrn.3859298

Development of a human tonsil organoid model to study human disease. CI Abayasingam. Triple I Clinical Academic Group Seed. 2023. $75,000.

Follow

Dr Arunasingam Abayasingam