Ms Betty Chan

Ms Betty Chan

Head of Department

MBBS, FACEM, PhD, MDiv.

Medicine & Health
School of Clinical Medicine

Associate Professor Betty Chan is an Emergency Physician, a Clinical Toxicologist and clinical researcher.  She is head of the Clinical Toxicology Unit and an Emergency Physician at the Prince of Wales Hospital.  Her current position and roles include: head of the Discipline of Critical Care at the University of New South Wales, VMO toxicologist at the New South Wales Poisons Information Centre, editorial board member of Clinical Toxicology, member of the SES LHD Human Research and Ethics Committee.

She completed her training in Emergency Medicine in 1990.  She then completed her PhD in toxicology at the University of Sydney in 1997.  This enabled her to work in Emergency Medicine and Clinical Toxicology and conduct research in both specialties.

Research Interests:

Digoxin overdose and response to antibody, dihydropyridine toxicity, methotrexate intoxication & antidote, safe opioid use & prescription, developing & validating clinical decision rules in non-traumatic CT head, herbicide toxicity: paraquat, bromoxynil, MCPA, acute behaviour disturbance treatment, sodium channel blocker toxicity, lithium poisoning, cognitive assessment post overdose, cognitive assessment following shift work amongst medical personnel, tapentadol hospital prescription trend and poisoning, adherence to clinical guidelines for specific poisonings, enhancement of medical education, use of AI in medical education. 

Broad Research Areas:

Translational research in Clinical Toxicology, Harm Reduction, Antidotes, Medical Education, AI in medical education.

Phone
61293822911
Location
Emergency Department, Prince of Wales Hospital, Barker St, Randwick, 2031.
  • Journal articles | 2023
    Chiew AL; Chan BSH, 2023, 'Management of button battery ingestion', Clinical Toxicology, 61, pp. 1017 - 1019, http://dx.doi.org/10.1080/15563650.2023.2294622
    Journal articles | 2023
    Chiew AL; Isbister GK; Stathakis P; Isoardi KZ; Page C; Ress K; Chan BSH; Buckley NA, 2023, 'Acetaminophen Metabolites on Presentation Following an Acute Acetaminophen Overdose (ATOM-7)', Clinical Pharmacology and Therapeutics, 113, pp. 1304 - 1314, http://dx.doi.org/10.1002/cpt.2888
    Journal articles | 2023
    Chiew AL; Lin CS; Nguyen DT; Sinclair FAW; Chan BS; Solinas A, 2023, 'Home Therapies to Neutralize Button Battery Injury in a Porcine Esophageal Model', Annals of Emergency Medicine, http://dx.doi.org/10.1016/j.annemergmed.2023.08.018
    Journal articles | 2023
    Ryan B; Bhashitaa J; Chiew AL; Chan BS, 2023, 'Valacyclovir neurotoxicity and kinetics in a patient with impaired kidney function', Clinical Toxicology, 61, pp. 1062 - 1063, http://dx.doi.org/10.1080/15563650.2023.2288807
    Journal articles | 2023
    Seebaluck J; Colebatch JG; Chan BS, 2023, 'Butyrophenone-induced neuroleptic malignant syndrome in Lewy body dementia: A cautionary tale', EMA - Emergency Medicine Australasia, 35, pp. 183 - 184, http://dx.doi.org/10.1111/1742-6723.14113
    Journal articles | 2023
    Seebaluck J; Downes MA; Brown J; Harris K; Isoardi KZ; Chan BS, 2023, 'Case series profile of olanzapine post-injection delirium/sedation syndrome', British Journal of Clinical Pharmacology, 89, pp. 903 - 907, http://dx.doi.org/10.1111/bcp.15588
    Journal articles | 2022
    Black E; Monds LA; Chan B; Brett J; Hutton JE; Acheson L; Penm J; Harding S; Strumpman D; Demirkol A; Lintzeris N, 2022, 'Overdose and take-home naloxone in emergency settings: A pilot study examining feasibility of delivering brief interventions addressing overdose prevention with ‘take-home naloxone’ in emergency departments', EMA - Emergency Medicine Australasia, 34, pp. 509 - 518, http://dx.doi.org/10.1111/1742-6723.13925
    Journal articles | 2022
    Chan B; Buckley T; Tofler G, 2022, 'Analysis of Patient Perceptions of Possible Triggers of Acute Myocardial Infarction', Heart, Lung and Circulation, 31, pp. S193 - S193, http://dx.doi.org/10.1016/j.hlc.2022.06.311
    Journal articles | 2022
    Chan B; Buckley T; Tofler G, 2022, 'Circadian Variation in Acute Myocardial Infarction and Its Modifiers', Heart, Lung and Circulation, 31, pp. S198 - S199, http://dx.doi.org/10.1016/j.hlc.2022.06.323
    Journal articles | 2022
    Chan BS; Buckley NA, 2022, 'Authors’ reply to comment on: clinical experience with titrating doses of digoxin antibodies in acute digoxin poisoning', Clinical Toxicology, 60, pp. 548, http://dx.doi.org/10.1080/15563650.2021.2013497
    Journal articles | 2022
    Chan BS; Isbister GK; Chiew A; Isoardi K; Buckley NA, 2022, 'Clinical experience with titrating doses of digoxin antibodies in acute digoxin poisoning. (ATOM-6)', Clinical Toxicology, 60, pp. 433 - 439, http://dx.doi.org/10.1080/15563650.2021.1968422
    Journal articles | 2022
    Chan BS; Mirabella J; Allen K; Berling I; Chiew AL; Isoardi K; Brown J; Isbister G, 2022, 'Tapentadol exposures and poisonings in Australia', CLINICAL TOXICOLOGY, 60, pp. 1063 - 1066, http://dx.doi.org/10.1080/15563650.2022.2074857
    Journal articles | 2022
    Chan BS; Mirabella J; Allen K; Berling I; Chiew AL; Isoardi K; Brown J; Isbister G, 2022, 'Tapentadol exposures and poisonings in Australia', Clinical Toxicology, 60, pp. 1063 - 1066, http://dx.doi.org/10.1080/15563650.2022.2074857
    Journal articles | 2022
    Chan BSH; Sheppeard V; Dawson AH, 2022, 'E-cigarette or vaping product use-associated lung injury in an adolescent', Medical Journal of Australia, 216, pp. 374 - 374, http://dx.doi.org/10.5694/mja2.51473
    Journal articles | 2022
    Chiew AL; Raubenheimer JE; Berling I; Buckley NA; Becker T; Chan B; Brett J, 2022, 'Just ‘nanging’ around – harmful nitrous oxide use: a retrospective case series and review of Internet searches, social media posts and the coroner's database', Internal Medicine Journal, 52, pp. 1724 - 1732, http://dx.doi.org/10.1111/imj.15391
    Journal articles | 2022
    Mirabella J; Ravi D; Chiew AL; Buckley NA; Chan BS, 2022, 'Prescribing trend of tapentadol in a Sydney local health district', British Journal of Clinical Pharmacology, 88, pp. 3929 - 3935, http://dx.doi.org/10.1111/bcp.15448
    Journal articles | 2022
    Pai K; Buckley NA; Isoardi KZ; Isbister GK; Becker T; Chiew AL; Cairns R; Brown JA; Chan BS, 2022, 'Optimising alkalinisation and its effect on QRS narrowing in tricyclic antidepressant poisoning', British Journal of Clinical Pharmacology, 88, pp. 723 - 733, http://dx.doi.org/10.1111/bcp.15008
    Journal articles | 2022
    Seifert SA; Buckley N; Chan B; Chan TYK; Cumpston K; Kirschner RI; Megarbane B; Mullins M; Seger D; Thomas S; Vale JA; Wilks M, 2022, 'Clinical Toxicology Review Metrics and Expert Reviewers, 2021', Clinical Toxicology, 60, pp. e1 - e3, http://dx.doi.org/10.1080/15563650.2022.2038872
    Journal articles | 2021
    Chan B; Gray R; Alexopoulos C, 2021, 'Subacute Prosthetic Aortic Valve Endocarditis Causing Syncope due to Left Ventricular Outflow Tract Obstruction', Heart, Lung and Circulation, 30, pp. S206 - S206, http://dx.doi.org/10.1016/j.hlc.2021.06.246
    Journal articles | 2021
    Chan B; Gray R; French A; Alexopoulos C; Prados K, 2021, 'Management and Outcomes of STEMI in a Regional Non-24/7 Cardiac Catheterisation Lab', Heart, Lung and Circulation, 30, pp. S232 - S233, http://dx.doi.org/10.1016/j.hlc.2021.06.305
    Journal articles | 2021
    Chan BS; Buckley NA, 2021, 'Translating EXTRIP criteria to better define patients with lithium toxicity for haemodialysis', British Journal of Clinical Pharmacology, 87, pp. 2157, http://dx.doi.org/10.1111/bcp.14567
    Journal articles | 2021
    Chan BS; Kiss A; McIntosh N; Sheppeard V; Dawson AH, 2021, 'E-cigarette or vaping product use-associated lung injury in an adolescent', Medical Journal of Australia, 215, pp. 313 - 314.e1, http://dx.doi.org/10.5694/mja2.51244
    Journal articles | 2021
    Huang J; Buckley NA; Isoardi KZ; Chiew AL; Isbister GK; Cairns R; Brown JA; Chan BS, 2021, 'Angiotensin axis antagonists increase the incidence of haemodynamic instability in dihydropyridine calcium channel blocker poisoning', Clinical Toxicology, 59, pp. 464 - 471, http://dx.doi.org/10.1080/15563650.2020.1826504
    Journal articles | 2021
    Jiang E; Raubenheimer JE; Isbister GK; Chan BSH; Buckley NA, 2021, 'Machine read frontal QRS-T angle and QTc is no substitute for manual measurement of QTc in pro-arrhythmic drug overdose', Journal of Electrocardiology, 65, pp. 151 - 156, http://dx.doi.org/10.1016/j.jelectrocard.2021.02.006
    Journal articles | 2021
    Roberts DM; Premachandra KH; Chan BS; Auld R; Jiranantakan T; Ewers C; McDonald C; Shaw V; Brown JA, 2021, 'A cluster of lysergic acid diethylamide (LSD) poisonings following insufflation of a white powder sold as cocaine', Clinical Toxicology, 59, pp. 969 - 974, http://dx.doi.org/10.1080/15563650.2021.1904140
    Journal articles | 2021
    Seifert SA; Buckley N; Chan B; Chan TYK; Cumpston K; Kirschner RI; Megarbane B; Mullins M; Seger D; Thomas S; Vale JA; Wilks MF, 2021, 'Clinical Toxicology review metrics and expert reviewers, 2020', Clinical toxicology (Philadelphia, Pa.), 59, http://dx.doi.org/10.1080/15563650.2021.1874197
    Journal articles | 2021
    Sun J; Stewart P; Chiew A; Becker T; Siu W; Varndell W; Chan BS, 2021, 'Association between shift work and cognitive performance on the Trail Making Test in emergency department health officers', EMA - Emergency Medicine Australasia, 33, pp. 711 - 717, http://dx.doi.org/10.1111/1742-6723.13753
    Journal articles | 2020
    Buckley NA; Cheng S; Isoardi K; Chiew AL; Siu W; Vecellio E; Chan BS, 2020, 'Haemodialysis for lithium poisoning: Translating EXTRIP recommendations into practical guidelines', British Journal of Clinical Pharmacology, 86, pp. 999 - 1006, http://dx.doi.org/10.1111/bcp.14212
    Journal articles | 2020
    Chan BS; Cheng S; Isoardi KZ; Chiew A; Siu W; Shulruf B; Vecellio E; Buckley NA, 2020, 'Effect of age on the severity of chronic lithium poisoning', Clinical Toxicology, 58, pp. 1023 - 1027, http://dx.doi.org/10.1080/15563650.2020.1726376
    Journal articles | 2020
    Chiew AL; James LP; Isbister GK; Pickering JW; McArdle K; Chan BSH; Buckley NA, 2020, 'Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5)', Journal of Hepatology, 72, pp. 450 - 462, http://dx.doi.org/10.1016/j.jhep.2019.10.030
    Journal articles | 2020
    Seifert SA; Buckley N; Seger D; Thomas S; Chan B; Chan TYK; Kirschner RI; Megarbane B; Oakes J; Wilks M; Mullins M; Allister Vale J, 2020, 'Clinical Toxicology Expert Reviewers 2019', Clinical Toxicology, 58, pp. e1 - e3, http://dx.doi.org/10.1080/15563650.2020.1712900
    Journal articles | 2019
    Bethmont A; Harper CE; Chan BSH; Dawson AH; McAnulty J, 2019, 'Increasing illicit use of nitrous oxide in presentations to NSW emergency departments', Medical Journal of Australia, 211, pp. 429 - 429.e1, http://dx.doi.org/10.5694/mja2.50377
    Journal articles | 2019
    Bracken LM; Chan BSH; Buckley NA, 2019, 'Physiologically based pharmacokinetic modelling of acute digoxin toxicity and the effect of digoxin-specific antibody fragments', Clinical Toxicology, 57, pp. 117 - 124, http://dx.doi.org/10.1080/15563650.2018.1503288
    Journal articles | 2019
    Chan B; Aneman A, 2019, 'A prospective, observational study of cerebrovascular autoregulation and its association with delirium following cardiac surgery', Anaesthesia, 74, pp. 33 - 44, http://dx.doi.org/10.1111/anae.14457
    Journal articles | 2019
    Chan BS; Isbister GK; Page CB; Isoardi KZ; Chiew AL; Kirby KA; Buckley NA, 2019, 'Clinical outcomes from early use of digoxin-specific antibodies versus observation in chronic digoxin poisoning (ATOM-4)', Clinical Toxicology, 57, pp. 638 - 643, http://dx.doi.org/10.1080/15563650.2018.1546010
    Journal articles | 2019
    Cheng S; Buckley NA; Siu W; Chiew AL; Vecellio E; Chan BS, 2019, 'Seasonal and temperature effect on serum lithium concentrations', AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 54, pp. 282 - 287, http://dx.doi.org/10.1177/0004867419889160
    Journal articles | 2019
    Egan H; Isbister GK; Robinson J; Downes M; Chan BS; Vecellio E; Chiew AL, 2019, 'Retrospective evaluation of repeated supratherapeutic ingestion (RSTI) of paracetamol', Clinical Toxicology, 57, pp. 703 - 711, http://dx.doi.org/10.1080/15563650.2018.1547829
    Journal articles | 2019
    McLenachan CJ; Chua O; Chan BSH; Vecellio E; Chiew AL, 2019, 'Comparison of Wells and YEARS clinical decision rules with D-dimer for low-risk pulmonary embolus patients', Internal Medicine Journal, 49, pp. 739 - 744, http://dx.doi.org/10.1111/imj.14138
    Journal articles | 2019
    Scott-King JM; Tieu S; Chiew AL; Lui J; Kirby KA; Chan BS, 2019, 'Clinical decision rule for non-traumatic computed tomography of the brain', EMA - Emergency Medicine Australasia, 31, pp. 974 - 981, http://dx.doi.org/10.1111/1742-6723.13292
    Journal articles | 2018
    Chan B; Butler E; Frost SA; Chuan A; Aneman A, 2018, 'Cerebrovascular autoregulation monitoring and patient-centred outcomes after cardiac surgery: a systematic review', Acta Anaesthesiologica Scandinavica, 62, pp. 588 - 599, http://dx.doi.org/10.1111/aas.13115
    Journal articles | 2018
    Chan BS; Becker T; Chiew AL; Abdalla AM; Robertson TA; Liu X; Roberts MS; Buckley NA, 2018, 'Vasoplegic Shock Treated with Methylene Blue Complicated by Severe Serotonin Syndrome', Journal of Medical Toxicology, 14, pp. 100 - 103, http://dx.doi.org/10.1007/s13181-017-0637-1
    Journal articles | 2018
    Chan BS; Mills N; Chiew A, 2018, 'Does physician education and factsheet impact on safe opioid use in emergency patients?', Canadian Journal of Addiction, 9, pp. 26 - 33, http://dx.doi.org/10.1097/CXA.0000000000000019
    Journal articles | 2018
    Chan BSH; Chiew AL; Grainger S; Page CB; Gault A; Mostafa A; Roberts MS; Buckley NA; Isbister GK, 2018, 'Bromoxynil and 2-methyl-4-chlorophenoxyacetic acid (MCPA) poisoning could be a bad combination', Clinical Toxicology, 56, pp. 861 - 863, http://dx.doi.org/10.1080/15563650.2018.1433299
    Journal articles | 2018
    Chiew AL; Isbister GK; Page CB; Kirby KA; Chan BSH; Buckley NA, 2018, 'Modified release paracetamol overdose: a prospective observational study (ATOM-3)', Clinical Toxicology, 56, pp. 810 - 819, http://dx.doi.org/10.1080/15563650.2018.1439950
    Journal articles | 2018
    Isoardi K; Lee S; Burren JM; George J; Goggin A; Chan BS, 2018, 'Bufadienolide toxicity in a child following cane toad egg ingestion', EMERGENCY MEDICINE AUSTRALASIA, 30, pp. 728 - 729, http://dx.doi.org/10.1111/1742-6723.13150
    Journal articles | 2018
    Isoardi KZ; Harris K; Carmichael KE; Dimeski G; Chan BSH; Page CB, 2018, 'Acute bone marrow suppression and gastrointestinal toxicity following acute oral methotrexate overdose.', Clin Toxicol (Phila), 56, pp. 1204 - 1206, http://dx.doi.org/10.1080/15563650.2018.1484128
    Journal articles | 2017
    Chan BS; Chiew A; Isbister GK; O’Leary M; Buckley NA, 2017, 'Authors’ responses to letter to the editor re: “Efficacy and effectiveness of anti-digoxin antibodies in chronic digoxin poisonings from the DORA study (ATOM-1)”', Clinical Toxicology, 55, pp. 64, http://dx.doi.org/10.1080/15563650.2016.1214278
    Journal articles | 2017
    Chan BS; Dawson AH; Buckley NA, 2017, 'Response to the letter regarding “Is it really safe to withhold folinic acid when less than 1000 mg/m 2 methotrexate is ingested?”', Clinical Toxicology, 55, pp. 1020, http://dx.doi.org/10.1080/15563650.2017.1315822
    Journal articles | 2017
    Chan BS; Dawson AH; Buckley NA, 2017, 'What can clinicians learn from therapeutic studies about the treatment of acute oral methotrexate poisoning?', Clinical Toxicology, 55, pp. 88 - 96, http://dx.doi.org/10.1080/15563650.2016.1271126
    Journal articles | 2017
    Chiew AL; Isbister GK; Kirby KA; Page CB; Chan BSH; Buckley NA, 2017, 'Massive paracetamol overdose: an observational study of the effect of activated charcoal and increased acetylcysteine dose (ATOM-2)', Clinical Toxicology, 55, pp. 1055 - 1065, http://dx.doi.org/10.1080/15563650.2017.1334915
    Journal articles | 2016
    Chan BS; Isbister GK; O’Leary M; Chiew A; Buckley NA, 2016, 'Efficacy and effectiveness of anti-digoxin antibodies in chronic digoxin poisonings from the DORA study (ATOM-1)', Clinical Toxicology, 54, pp. 488 - 494, http://dx.doi.org/10.1080/15563650.2016.1175620
    Journal articles | 2016
    Corcoran G; Chan B; Chiew A, 2016, 'Use and knowledge of single dose activated charcoal: A survey of Australian doctors', EMA - Emergency Medicine Australasia, 28, pp. 578 - 585, http://dx.doi.org/10.1111/1742-6723.12659
    Journal articles | 2016
    Gupta M; Rademaker M; Sullivan JR; Foley P, 2016, 'A decade of Australian methotrexate dosing errors.', Medical Journal of Australia, 205, pp. 485 - 485.e1
    Journal articles | 2016
    Roberts DM; Gallapatthy G; Dunuwille A; Chan BS, 2016, 'Pharmacological treatment of cardiac glycoside poisoning', British Journal of Clinical Pharmacology, 81, pp. 488 - 495, http://dx.doi.org/10.1111/bcp.12814
    Journal articles | 2016
    Wong A; Mac K; Aneman A; Wong J; Chan BS, 2016, 'Modern Intermittent Haemodialysis (IHD) is an Effective Method of Removing Salicylate in Chronic Topical Salicylate Toxicity', Journal of Medical Toxicology, 12, pp. 130 - 133, http://dx.doi.org/10.1007/s13181-015-0502-z
    Journal articles | 2015
    Calver L; Page CB; Downes MA; Chan B; Kinnear F; Wheatley L; Spain D; Lsbister GK, 2015, 'The Safety and Effectiveness of Droperidol for Sedation of Acute Behavioral Disturbance in the Emergency Department', ANNALS OF EMERGENCY MEDICINE, 66, pp. 230 - 238, http://dx.doi.org/10.1016/j.annemergmed.2015.03.016
    Journal articles | 2015
    Chan BSH; Sellors K; Chiew AL; Buckley NA, 2015, 'Use of multi-dose activated charcoal in phenytoin toxicity secondary to genetic polymorphism', Clinical Toxicology, 53, pp. 131 - 133, http://dx.doi.org/10.3109/15563650.2014.998338
    Journal articles | 2014
    Chan BSH; Buckley NA, 2014, 'Authors' responses to Letter to the Editor regarding 'Early digoxin-specific antibody fragments to treat patients at risk of life-threatening toxicity'', Clinical Toxicology, 52, pp. 987, http://dx.doi.org/10.3109/15563650.2014.968253
    Journal articles | 2014
    Chan BSH; Buckley NA, 2014, 'Digoxin-specific antibody fragments in the treatment of digoxin toxicity', Clinical Toxicology, 52, pp. 824 - 836, http://dx.doi.org/10.3109/15563650.2014.943907
    Journal articles | 2014
    Chiew AL; Khamoudes D; Chan BSH, 2014, 'Use of continuous veno-venous haemodiafiltration therapy in dabigatran overdose', Clinical Toxicology, 52, pp. 283 - 287, http://dx.doi.org/10.3109/15563650.2014.900179
    Journal articles | 2014
    Sellors K; Jones A; Chan B, 2014, 'Death due to intravenous use of alpha-pyrrolidinopentiophenone', MEDICAL JOURNAL OF AUSTRALIA, 201, pp. 601 - 603, http://dx.doi.org/10.5694/mja13.00203
    Journal articles | 2011
    Bailey AR; Sathianathan VJ; Chiew AL; Paterson AD; Chan BSH; Arora S, 2011, 'Comparison of intermittent haemodialysis, prolonged intermittent renal replacement therapy and continuous renal replacement haemofiltration for lithium toxicity: A case report', Critical Care and Resuscitation, 13, pp. 120 - 122
    Journal articles | 2011
    Williams GD; Kirk EP; Wilson CJ; Meadows C; Chan BS, 2011, 'Salicylate intoxication from teething gel in infancy', MJA Open, 194, pp. 146 - 148
    Journal articles | 2010
    Graudins A; Chiew A; Chan B, 2010, 'Overdose with modified-release paracetamol results in delayed and prolonged absorption of paracetamol', Internal Medicine Journal, 40, pp. 72 - 76, http://dx.doi.org/10.1111/j.1445-5994.2009.02096.x
    Journal articles | 2009
    Graudins A; Pham H; Salonikas C; Naidoo D; Chan BS, 2009, 'Early presentation following overdose of modified-release paracetamol (Panadol Osteo) with biphasic and prolonged paracetamol absorption', New Zealand Medical Journal, 122, pp. 64 - 71
    Journal articles | 2009
    Gunja N; Roberts D; McCoubrie D; Lambert P; Jan A; Simes DC; Hackett P; Buckley NA, 2009, 'Survival after massive hydroxychloroquine overdose', Anaesthesia and Intensive Care, 37, pp. 130 - 133, http://www.ncbi.nlm.nih.gov/pubmed/19157361
    Journal articles | 2006
    Kerr JF; Dawson A; Whyte I; Buckley N; Murray L; Graudins A; Chan B; Trudinger B, 2006, 'TACTIC randomized trial of different loading infusion rates of N-acetylcysteine [7]', Annals of Emergency Medicine, 47, pp. 124 - 125, http://dx.doi.org/10.1016/j.annemergmed.2005.08.030
    Journal articles | 2005
    Chan B; Whyte I; Dawson A; Downes M, 2005, 'Use of neostigmine for the management of drug induced ileus in severe poisonings.', Journal of medical toxicology : official journal of the American College of Medical Toxicology, 1, pp. 19 - 22, http://dx.doi.org/10.1007/bf03160900
    Journal articles | 2005
    Chan B; Whyte PI; Dawson A; Downes M, 2005, 'Use of Neostigmine for the Management of Drug Induced Ileus in Severe Poisonings', JOURNAL OF MEDICAL TOXICOLOGY, 1, pp. 19 - 22, http://dx.doi.org/10.1007/BF03160900
    Journal articles | 2005
    Graudins A; Chan BS; Mallows J, 2005, 'Quality of poisoning management advice in the Monthly Index of Medical Specialities Annual', Emergency Medicine Australasia, 17, pp. 511 - 519
    Journal articles | 2005
    Graudins A; Kerr F; Dawson A; Whyte I; Buckley NA; Murray L; Chan BS; Trudinger B, 2005, 'The Australasian Clinical Toxicology investigators collaboration randomized trial of different loading infusion rates of N-Acetylcysteine', Annals of Emergency Medicine, 45, pp. 402 - 408
    Journal articles | 2002
    Chan B, 2002, 'Admission and Discharge Decisions in Emergency Medicine', Emergency Medicine, 14, pp. 330 - 330, http://dx.doi.org/10.1046/j.1442-2026.2002.00361.x
    Journal articles | 1998
    Chan BSH; Graudins A; Whyte IM; Dawson AH; Braitberg G; Duggin GG, 1998, 'Serotonin syndrome resulting from drug interactions', Medical Journal of Australia, 169, pp. 523 - 525, http://dx.doi.org/10.5694/j.1326-5377.1998.tb123399.x
    Journal articles | 1998
    Chan BSH; Lazzaro VA; Seale JP; Duggin GG, 1998, 'The renal excretory mechanisms and the role of organic cations in modulating the renal handling of paraquat', Pharmacology and Therapeutics, 79, pp. 193 - 203, http://dx.doi.org/10.1016/S0163-7258(98)00015-1
    Journal articles | 1998
    Graudins A; Stearman A; Chan B, 1998, 'Treatment of the serotonin syndrome with cyproheptadine.', J Emerg Med, 16, pp. 615 - 619, http://dx.doi.org/10.1016/s0736-4679(98)00057-2
    Journal articles | 1997
    Chan BS; Duggin GG, 1997, 'Survival after a massive hydrofluoric acid ingestion.', J Toxicol Clin Toxicol, 35, pp. 307 - 309, http://dx.doi.org/10.3109/15563659709001217
    Journal articles | 1997
    Chan BSH; Seale JP; Duggin GG, 1997, 'The mechanism of excretion of paraquat in rats', Toxicology Letters, 90, pp. 1 - 9, http://dx.doi.org/10.1016/S0378-4274(96)03820-9
    Journal articles | 1996
    Chan BSH; Lazzaro VA; Seale JP; Duggin GG, 1996, 'Transport of paraquat in a renal epithelial cell line LLC-PK1', Journal of Pharmacology and Experimental Therapeutics, 279, pp. 625 - 632
    Journal articles | 1993
    CHAN BSH; DOOHAN MM, 1993, 'Traumatic coronary artery fistula', Emergency Medicine, 5, pp. 7 - 11, http://dx.doi.org/10.1111/j.1442-2026.1993.tb00765.x
    Journal articles | 1993
    Chan B; Gaudry P; Grattan-Smith TM; McNeil R, 1993, 'The use of Glasgow Coma Scale in poisoning.', J Emerg Med, 11, pp. 579 - 582, http://dx.doi.org/10.1016/0736-4679(93)90312-u
  • Preprints | 2022
    Seebaluck J; Downes M; Brown JA; Harris K; Isoardi K; Chan B, 2022, Case Series Profile of Olanzapine Post-Injection Delitrium/Sedation Syndrome, , http://dx.doi.org/10.22541/au.166239901.18562976/v1
    Conference Papers | 2022
    Chan BS; Mirabella J; Allen K; Berling I; Chiew AL; Isoardi K; Brown J; Isbister G, 2022, 'Tapentadol exposures and poisonings in Australia', in Clinical Toxicology, pp. 1063 - 1066, http://dx.doi.org/10.1080/15563650.2022.2074857
    Conference Abstracts | 2020
    Cheng S; Buckley NA; Siu W; Chiew AL; Vecellio E; Chan BS, 2020, 'Seasonal and temperature effect on serum lithium concentrations', in Australian and New Zealand Journal of Psychiatry, Vol. 54, pp. 282 - 287, http://dx.doi.org/10.1177/0004867419889160
    Conference Presentations | 2016
    Bracken L; Chan B; Chiew A; Buckley N, 2016, 'Physiologically based pharmacokinetic modelling of digoxin for the treatment of digoxin toxicity', presented at Asia Pacific Association of Medical Toxicity, 01 December 2016 - 04 December 2016
    Conference Papers | 2008
    Chan BS; Chiew A; Graudins A, 2008, 'Intravenous hypertonic sodium bicarbonate infusion reverses flecainide-induced ventricular cardiac conduction delay', in CLINICAL TOXICOLOGY, INFORMA HEALTHCARE, pp. 369 - 369, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000256917000070&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2008
    Graudins A; Chiew A; Green D; Chan BS, 2008, 'Deliberate self-poisoning with Panadol Extend (R) results in delayed peak serum concentrations and prolonged absorption of paracetamol', in CLINICAL TOXICOLOGY, INFORMA HEALTHCARE, pp. 365 - 365, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000256917000052&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

The Inspiring Ideas Challenge for 2017 on the ONE study, "Overdose and take home Naloxone in Emergency settings." 

2016 John Gilroy Potts Award at the ACEM conference in recognition of the paper “‘The Safety and Effectiveness of Droperidol for Sedation of Acute Behavioural Disturbance in the Emergency Department’ that was published in the Annals of Emergency Medicine 2015.  (Leonie Calver; Colin B. Page, MBChB; Michael A. Downes, MBBS; Betty Chan, MBBS, PhD; Frances Kinnear, MBBS; Luke Wheatley, MBBS; David Spain, MBBS; Geoffrey Kennedy Isbister, MD, BSc)

2019 Best Scientific presentation at the 39th Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) on a paper entitled "Using EXTRIP criteria as indications for Extracorporeal Treatment in Lithium Poisoning."

I am involved as the principal investigator in a number of clinical research projects in toxicology.  In our multi-centre research project titled ‘Australian Toxicology Monitoring’ (ATOM) Study that was commenced in 2013, we looked at the pharmacokinetics and dynamics of drugs in poisoning. I was involved in the 'Translational Australian Clinical Toxicology' (TACT) program, which was a multi-disciplinary collaboration and is a recipient of the NHMRC grant.  Our research has been focused on the toxicity of drugs in overdose, efficacy and effectiveness of antidotes and harm reduction.  We studied the efficacy and effectiveness of digoxin specific antibody in acute and chronic digoxin poisoning and was able to demonstrate that patients can be managed safely with small, titrated doses of digoxin antibody.  This cost effective and saving translational study has helped to change clinical guidelines for the management of both acute and chronic digoxin poisoning.  We looked at the use of folinic acid in acute and chronic methotrexate poisoning and was able to show that acute methotrexate poisonings<1g rarely cause clinical toxicity in patients with normal renal function.  We found that in dihydropyridine calcium channel blockers poisoning, concurrent ingestion of angiotensin antagonists can cause profound vasoplegic shock.  We were able to further define the clinical indicators for haemodialysis in acute and chronic lithium poisoning.  In tricyclic antidepressant poisoning, we were able to show that hyperventilation and sodium bicarbonate have a synergistic effect in providing and maintaining alkalinisation.  We also caution the excess use of sodium bicarbonate due to its effect on sodium concentration.  Regarding harm reduction, we have shown that sedative drug overdoses can cause significant impairment on cognitive and executive function upon hospital discharge and should therefore avoid driving and other high risk activities.  We also develop education program to teach junior doctors in the safe use and prescription of opioids.

My latest research interests are in enhancement of medical education, and the use of Artificial Intelligence in medication education.

My Research Supervision

ILP Honours project - Poisons Information Centre clinical Toxicology referral Study (PICTS) and adherence of clinical guidelines for specific poisonings.

 

My Teaching

As the Head of the Discipline of Critical Care at the University of New South Wales, I am in charge of the curriculum and teaching of medical students in Emergency Medicine, Anaesthesia and Intensive Care. 

As the head of the Clinical Toxicology Unit, I am in charge of the teaching curriculum and supervision of our toxicology registrars and fellows.