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Dr Biyao Yang

Senior Research Associate
  • PhD in Biomedical Engineering, UNSW, Australia
Engineering
Biomedical Engineering

I obtained my PhD degree in Biomedical Engineering at UNSW in 2023. I am currently a research associate at the Graduate School of Biomedical Engineering, UNSW, working in the fields of cancer diagnosis and therapy, CRISPR technology, and triggerable liposome delivery platforms. My current research interest is focused on developing ultra-sensitive CRISPR-based biosensors for cancer diagnosis.
E-mail
biyao.yang@unsw.edu.au
  • Journal articles | 2025
    Deng F; Sang R; Li Y; Yang B; Zhai X; Xue R; Zhang C; Deng W; Goldys EM, 2025, 'Hairpin-locker mediated CRISPR/Cas tandem system for ultrasensitive detection of DNA without pre-amplification', Microchemical Journal, 210, pp. 113025, http://dx.doi.org/10.1016/j.microc.2025.113025
    Journal articles | 2024
    Deng F; Li Y; Yang B; Sang R; Deng W; Kansara M; Lin F; Thavaneswaran S; Thomas DM; Goldys EM, 2024, 'Topological barrier to Cas12a activation by circular DNA nanostructures facilitates autocatalysis and transforms DNA/RNA sensing', Nature Communications, 15, pp. 1818, http://dx.doi.org/10.1038/s41467-024-46001-8
    Journal articles | 2024
    Yang B; Sang R; Li Y; Goldys E; Deng W, 2024, 'Liposome platform enables X-ray induced photodynamic therapy treatment against human triple negative breast cancer cells', CANCER RESEARCH, 84, http://dx.doi.org/10.1158/1538-7445.AM2024-5743
    Journal articles | 2024
    Yang B; Sang R; Li Y; Goldys EM; Deng W, 2024, 'Improved effectiveness of X-PDT against human triple-negative breast cancer cells through the use of liposomes co-loaded with protoporphyrin IX and perfluorooctyl bromide', Journal of Materials Chemistry B, 12, pp. 3764 - 3773, http://dx.doi.org/10.1039/d4tb00011k
    Journal articles | 2022
    Zhang C; Yang B; Biazik J; Webster RF; Xie W; Tang J; Allioux F-M; Abbasi R; Mousavi M; Goldys EM; Killian KA; Chandrawati R; Esrafilzadeh D; Kalantar-Zadeh K, 2022, 'Gallium Nanodroplets are Anti-Inflammatory without Interfering with Iron Homeostasis', ACS Nano, http://dx.doi.org/10.1021/acsnano.1c10981
    Journal articles | 2021
    Yang B; Song BP; Shankar S; Guller A; Deng W, 2021, 'Recent advances in liposome formulations for breast cancer therapeutics', Cellular and Molecular Life Sciences, 78, pp. 5225 - 5243, http://dx.doi.org/10.1007/s00018-021-03850-6
    Journal articles | 2020
    Aksoy YA; Yang B; Chen W; Hung T; Kuchel RP; Zammit NW; Grey ST; Goldys EM; Deng W, 2020, 'Spatial and Temporal Control of CRISPR-Cas9-Mediated Gene Editing Delivered via a Light-Triggered Liposome System', ACS Applied Materials and Interfaces, 12, pp. 52433 - 52444, http://dx.doi.org/10.1021/acsami.0c16380
  • Preprints | 2024
    Deng F; Sang R; Li Y; Yang B; Zhai X; Xue R; Zhang C; Deng W; Goldys E, 2024, Hairpin-locker mediated CRISPR/Cas tandem system for ultrasensitive detection of DNA without pre-amplification, http://dx.doi.org/10.1101/2024.03.05.583466
    Preprints | 2023
    Li Y; Yang B; Deng F; Goldys E, 2023, Topological barrier to Cas12a activation by circular DNA nanostructures facilitates autocatalysis, http://dx.doi.org/10.21203/rs.3.rs-2586294/v1

  • Sydney Vital Research Scholar Award, 05/2020

  • Translational Cancer Research Network PhD Scholarship Top-up Award, 04/2021
  • Sydney Vital Research Scholar Award, 05/2020

I am currently undertaking a project titled "Low cost biosensors for liquid biopsies: towards practical implementation of precision oncology". The aim of this project is to make ctDNA testing significantly more affordable and much simpler. We will develop a biosensor for ctDNA test in cancer clinical samples based on CRISPR technology, with high sensitivity and selectivity, low cost, and simplificity.

Served as a peer reviewer for Journal of Nanobiotechnology, Frontiers in Medical Technology, ACS Omega et al.