Dr Brenna Osborne

Dr Brenna Osborne

Postdoctoral Fellow
Science
School of Biotech & Biomolecular Science

Dr Brenna Osborne is a Postdoctoral Fellow in the Hoehn Lab in the School of Biotechnology and Biomolecular Sciences. Brenna completed her PhD at the Garvan Institute, Sydney in 2015 investigating the role of post-translational modifications in mitochondria that are mediated by the sirtuin protein, SIRT3, in models of insulin resistance and diet-induced obesity. 

 

Research Focus

Brenna’s current primary research interests include exploring the role of NAD+ metabolism in skeletal muscle and liver in in vivo animal models in the context of obesity, type 2 diabetes and longevity, and investigating novel therapeutics to prevent or treat the pathophysiology associated with ageing, excess dietary fat and insulin resistance.

 

Qualifications

PhD, Garvan Institute of Medical Research, 2015

 

Professional Experience

  • 2024- current: Postdoctoral Fellow, School of Biotechnology and Biomolecular Sciences, UNSW
  • 2018 - 2023: Assistant Professor, Center for Healthy Ageing, Faculty of Health, University of Copenhagen, Denmark
  • 2018 - 2020: Postdoc, Center for Healthy Ageing, Faculty of Health, University of Copenhagen, Denmark
  • 2015 - 2018: Research Associate, School of Medical Sciences, UNSW
  • 2011-2014: PhD student, Garvan Institute of Medical Research
  • 2005 - 2010: Research Assistant, Centenary Institute of Medical Research

 

Awards

  • Ian Potter Travel Award 2017
  • Australian Diabetes Society Pincus Taft Young Investigator Award, 2016
  • Travel Awards: Australian Diabetes Society 2014 ; International Diabetes Federation 2013; Seahorse Bioscience 2013; European Association for the Study of Diabetes 2012
  • NHMRC Dora Lush  Biomedical Postgraduate Scholarship, 2011 - 2014
  • Book Chapters | 2019
    Osborne B; Brandon A; Smith GC; Turner N, 2019, 'Impact of Lifestyle and Clinical Interventions on Mitochondrial Function in Obesity and Type 2 Diabetes', in Morio B; Pénicaud L; Rigoulet M (ed.), Mitochondria in Obesity and Type 2 Diabetes, Elsevier, pp. 367 - 397, http://dx.doi.org/10.1016/C2016-0-01694-7
    Book Chapters | 2019
    Osborne B; Brandon AE; Smith GC; Turner N, 2019, 'Chapter 16 Impact of Lifestyle and Clinical Interventions on Mitochondrial Function in Obesity and Type 2 Diabetes', in Mitochondria in Obesity and Type 2 Diabetes, Elsevier, pp. 367 - 397, http://dx.doi.org/10.1016/b978-0-12-811752-1.00016-x
    Book Chapters | 2019
    Osborne B; Brandon AE; Smith GC; Turner N, 2019, 'Impact of lifestyle and clinical interventions on mitochondrial function in obesity and type 2 diabetes', in Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases, pp. 367 - 397, http://dx.doi.org/10.1016/B978-0-12-811752-1.00016-X
    Book Chapters | 2011
    Keane FM; Chowdhury S; Yao T-W; Nadvi NA; Gall MG; Chen Y; Osborne B; Ribeiro AJV; Church WB; McCaughan GW; Gorrell MD; Yu DMT, 2011, 'Targeting Dipeptidyl Peptidase-4 (DPP-4) and Fibroblast Activation Protein (FAP) for Diabetes and Cancer Therapy', in Proteinases as Drug Targets, The Royal Society of Chemistry, pp. 118 - 144, http://dx.doi.org/10.1039/9781849733151-00118
    Book Chapters | 2011
    Osborne B; Keane FM; Chowdhury S; Yao TW; Nadvi NA; Gall MG; Chen Y; Ribeiro AJV; Church WB; McCaughan GW; Gorrell MD; Yu DMT, 2011, 'Targeting Dipeptidyl Peptidase-4 (DPP-4) and Fibroblast Activation Protein (FAP) for Diabetes and Cancer Therapy', in Dunn B (ed.), Proteinases as Drug Targets, Royal Society of Chemistry, Cambridge, UK, pp. 118 - 144, http://dx.doi.org/10.1039/9781849733151
  • Journal articles | 2024
    Petr MA; Matiyevskaya F; Osborne B; Berglind M; Reves S; Zhang B; Ezra MB; Carmona-Marin LM; Syadzha MF; Mediavilla MC; Keijzers G; Bakula D; Mkrtchyan GV; Scheibye-Knudsen M, 2024, 'Pharmacological interventions in human aging', Ageing Research Reviews, 95, http://dx.doi.org/10.1016/j.arr.2024.102213
    Journal articles | 2023
    Osborne B; Wright LE; Brandon AE; Stuart E; Small L; Hoeks J; Schrauwen P; Sinclair DA; Montgomery MK; Cooney GJ; Turner N, 2023, 'SIRT3 overexpression in rat muscle does not ameliorate peripheral insulin resistance', The Journal of endocrinology, 258, http://dx.doi.org/10.1530/JOE-22-0101
    Journal articles | 2022
    Heckenbach I; Mkrtchyan GV; Ezra MB; Bakula D; Madsen JS; Nielsen MH; Oró D; Osborne B; Covarrubias AJ; Idda ML; Gorospe M; Mortensen L; Verdin E; Westendorp R; Scheibye-Knudsen M, 2022, 'Nuclear morphology is a deep learning biomarker of cellular senescence', Nature Aging, 2, pp. 742 - 755, http://dx.doi.org/10.1038/s43587-022-00263-3
    Journal articles | 2022
    Osborne B; Reznick J; Wright LE; Sinclair DA; Cooney GJ; Turner N, 2022, 'Liver-specific overexpression of SIRT3 enhances oxidative metabolism, but does not impact metabolic defects induced by high fat feeding in mice', Biochemical and Biophysical Research Communications, 607, pp. 131 - 137, http://dx.doi.org/10.1016/j.bbrc.2022.03.088
    Journal articles | 2020
    Du X; Zhou L; Aw YC; Mak HY; Xu Y; Rae J; Wang W; Zadoorian A; Hancock SE; Osborne B; Chen X; Wu JW; Turner N; Parton RG; Li P; Yang H, 2020, 'ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets', Journal of Cell Biology, 219, http://dx.doi.org/10.1083/jcb.201905162
    Journal articles | 2020
    Mkrtchyan GV; Abdelmohsen K; Andreux P; Bagdonaite I; Barzilai N; Brunak S; Cabreiro F; Cabo RD; Campisi J; Cuervo AM; Demaria M; Ewald CY; Fang EF; Faragher R; Ferrucci L; Freund A; Silva-García CG; Georgievskaya A; Gladyshev VN; Glass DJ; Gorbunova V; Grey AD; He WW; Hoeijmakers J; Hoffmann E; Horvath S; Houtkooper RH; Jensen MK; Jensen MB; Kane A; Kassem M; Keizer PD; Kennedy B; Karsenty G; Lamming DW; Lee KF; MacAulay N; Mamoshina P; Mellon J; Molenaars M; Moskalev A; Mund A; Niedernhofer L; Osborne B; Pak HH; Parkhitko A; Raimundo N; Rando TA; Rasmussen LJ; Reis C; Riedel CG; Franco-Romero A; Schumacher B; Sinclair DA; Suh Y; Taub PR; Toiber D; Treebak JT; Valenzano DR; Verdin E; Vijg J; Young S; Zhang L; Bakula D; Zhavoronkov A; Scheibye-Knudsen M, 2020, 'ARDD 2020: from aging mechanisms to interventions', Aging, 12, pp. 24486 - 24503, http://dx.doi.org/10.18632/aging.202454
    Journal articles | 2020
    Osborne B; Bakula D; Ben Ezra M; Dresen C; Hartmann E; Kristensen SM; Mkrtchyan GV; Nielsen MH; Petr MA; Scheibye-Knudsen M, 2020, 'New methodologies in ageing research', Ageing Research Reviews, 62, http://dx.doi.org/10.1016/j.arr.2020.101094
    Journal articles | 2020
    Xi CR; Di Fazio A; Nadvi NA; Patel K; Xiang MSW; Zhang HE; Deshpande C; Low JKK; Wang XT; Chen Y; McMillan CLD; Isaacs A; Osborne B; de Ribeiro AJV; McCaughan GW; Mackay JP; Church WB; Gorrell MD, 2020, 'A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2', Molecules, 25, http://dx.doi.org/10.3390/MOLECULES25225392
    Journal articles | 2020
    2020, 'Next generation diabetes scientists shape global research culture: A reflective proposal from postdoctoral researchers in diabetes research', Acta Physiologica, 229, http://dx.doi.org/10.1111/apha.13455
    Journal articles | 2019
    Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y; Treviño-Villarreal JH; Kang MJ; Hung TT; Lee B; Williams EO; Igarashi M; Mitchell JR; Wu LE; Turner N; Arany Z; Guarente L; Sinclair DA, 2019, 'Erratum: Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging (Cell (2018) 173(1) (74–89.e20), (S0092867418301521) (10.1016/j.cell.2018.02.008))', Cell, 176, pp. 944 - 945, http://dx.doi.org/10.1016/j.cell.2019.01.026
    Journal articles | 2019
    Keijzers G; Bakula D; Petr MA; Madsen NGK; Teklu A; Mkrtchyan G; Osborne B; Scheibye-Knudsen M, 2019, 'Human exonuclease 1 (EXO1) regulatory functions in DNA replication with putative roles in cancer', International Journal of Molecular Sciences, 20, http://dx.doi.org/10.3390/ijms20010074
    Journal articles | 2019
    Liu M; Hancock SE; Sultani G; Wilkins BP; Ding E; Osborne B; Quek LE; Turner N, 2019, 'Snail-overexpression induces epithelialmesenchymal transition and metabolic reprogramming in human pancreatic ductal adenocarcinoma and non-tumorigenic ductal cells', Journal of Clinical Medicine, 8, http://dx.doi.org/10.3390/jcm8060822
    Journal articles | 2019
    Montgomery MK; Osborne B; Brandon AE; O'Reilly L; Fiveash CE; Brown SHJ; Wilkins BP; Samsudeen A; Yu J; Devanapalli B; Hertzog A; Tolun AA; Kavanagh T; Cooper AA; Mitchell TW; Biden TJ; Smith NJ; Cooney GJ; Turner N, 2019, 'Regulation of mitochondrial metabolism in murine skeletal muscle by the medium-chain fatty acid receptor Gpr84', FASEB Journal, 33, pp. 12264 - 12276, http://dx.doi.org/10.1096/fj.201900234R
    Journal articles | 2019
    2019, 'A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction', , http://dx.doi.org/10.1038/s41388-018-0666-5
    Journal articles | 2018
    Bentley NL; Fiveash CE; Osborne B; Quek LE; Ogura M; Inagaki N; Cooney GJ; Polly P; Montgomery MK; Turner N, 2018, 'Protein hypoacylation induced by Sirt5 overexpression has minimal metabolic effect in mice', Biochemical and Biophysical Research Communications, 503, pp. 1349 - 1355, http://dx.doi.org/10.1016/j.bbrc.2018.07.047
    Journal articles | 2018
    Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y; Treviño-Villarreal JH; Kang MJ; Hung TT; Lee B; Williams EO; Igarashi M; Mitchell JR; Wu LE; Turner N; Arany Z; Guarente L; Sinclair DA, 2018, 'Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging', Cell, 173, pp. 74 - 89.e20, http://dx.doi.org/10.1016/j.cell.2018.02.008
    Journal articles | 2018
    Sultani G; Bentley N; Osborne B; Joshi S; Araki T; Montgomery M; Polly P; Byrne F; Wu L; Turner N, 2018, 'PO-011 Impact of compartment-specific changes in NAD biosynthesis on diethylnitrosamine-induced liver cancer', ESMO Open, 3, pp. A25 - A25, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.56
    Journal articles | 2018
    Turner N; Lim XY; Toop HD; Osborne B; Brandon AE; Taylor EN; Fiveash CE; Govindaraju H; Teo JD; McEwen HP; Couttas TA; Butler SM; Das A; Kowalski GM; Bruce CR; Hoehn KL; Fath T; Schmitz-Peiffer C; Cooney GJ; Montgomery MK; Morris JC; Don AS; Brandon A, 2018, 'A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism', Nature Communications, 9, pp. 3165, http://dx.doi.org/10.1038/s41467-018-05613-7
    Journal articles | 2017
    Sultani G; Samsudeen AF; Osborne B; Turner N, 2017, 'NAD+: A key metabolic regulator with great therapeutic potential', Journal of Neuroendocrinology, 29, http://dx.doi.org/10.1111/jne.12508
    Journal articles | 2016
    Hayward B; Molero JC; Windmill K; Sanigorski A; Weir J; McRae NL; Aston-Mourney K; Osborne B; Liao B; Walder KR; Meikle PJ; Konstantopoulos N; Schmitz-Peiffer C, 2016, 'Pathways of Acetyl-CoA Metabolism Involved in the Reversal of Palmitate-Induced Glucose Production by Metformin and Salicylate', Experimental and Clinical Endocrinology and Diabetes, 124, pp. 602 - 612, http://dx.doi.org/10.1055/s-0042-111516
    Journal articles | 2016
    Montgomery MK; Brown SHJ; Lim XY; Fiveash CE; Osborne B; Bentley NL; Braude JP; Mitchell TW; Coster ACF; Don AS; Cooney GJ; Schmitz-Peiffer C; Turner N, 2016, 'Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1861, pp. 1828 - 1839, http://dx.doi.org/10.1016/j.bbalip.2016.08.016
    Journal articles | 2016
    Osborne B; Bentley NL; Montgomery MK; Turner N, 2016, 'The role of mitochondrial sirtuins in health and disease', Free Radical Biology and Medicine, 100, pp. 164 - 174, http://dx.doi.org/10.1016/j.freeradbiomed.2016.04.197
    Journal articles | 2016
    Turner N; Zeng XY; Osborne B; Rogers S; Ye JM, 2016, 'Repurposing Drugs to Target the Diabetes Epidemic', Trends in Pharmacological Sciences, 37, pp. 379 - 389, http://dx.doi.org/10.1016/j.tips.2016.01.007
    Journal articles | 2015
    Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, 471, pp. 243 - 253, http://dx.doi.org/10.1042/BJ20150602
    Journal articles | 2015
    Montgomery MK; Fiveash CE; Braude JP; Osborne B; Brown SHJ; Mitchell TW; Turner N, 2015, 'Disparate metabolic response to fructose feeding between different mouse strains', Scientific Reports, 5, http://dx.doi.org/10.1038/srep18474
    Journal articles | 2014
    Liu M; Montgomery MK; Fiveash CE; Osborne B; Cooney GJ; Bell-Anderson K; Turner N, 2014, 'PPARα -independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis', Scientific Reports, 4, http://dx.doi.org/10.1038/srep05538
    Journal articles | 2014
    Osborne B; Cooney GJ; Turner N, 2014, 'Are sirtuin deacylase enzymes important modulators of mitochondrial energy metabolism?', Biochimica et Biophysica Acta - General Subjects, 1840, pp. 1295 - 1302, http://dx.doi.org/10.1016/j.bbagen.2013.08.016
    Journal articles | 2014
    Osborne B; Yao TW; Wang XM; Chen Y; Kotan LD; Nadvi NA; Herdem M; McCaughan GW; Allen JD; Yu DMT; Topaloglu AK; Gorrell MD, 2014, 'A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation', Biochimica et Biophysica Acta - Proteins and Proteomics, 1844, pp. 1248 - 1259, http://dx.doi.org/10.1016/j.bbapap.2014.03.015
    Journal articles | 2013
    Keane FM; Yao TW; Seelk S; Gall MG; Chowdhury S; Poplawski SE; Lai JH; Li Y; Wu W; Farrell P; Vieira de Ribeiro AJ; Osborne B; Yu DM; Seth D; Rahman K; Haber P; Topaloglu AK; Wang C; Thomson S; Hennessy A; Prins J; Twigg SM; McLennan SV; McCaughan GW; Bachovchin WW; Gorrell MD, 2013, 'Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs.', FEBS Open Bio, 4, pp. 43 - 54, http://dx.doi.org/10.1016/j.fob.2013.12.001
    Journal articles | 2013
    Montgomery MK; Osborne B; Brown SHJ; Small L; Mitchell TW; Cooney GJ; Turner N, 2013, 'Contrasting metabolic effects of medium-versus long-chain fatty acids in skeletal muscle', Journal of Lipid Research, 54, pp. 3322 - 3333, http://dx.doi.org/10.1194/jlr.M040451
    Journal articles | 2012
    Hoeks J; Wright L; Jörgensen JA; Osborne B; Montgomery M; Cooney G; Schrauwen P; Turner N, 2012, 'PS - 46. SIRT3 overexpression in rat skeletal muscle does not alleviate high-fat diet-induced insulin resistance', Nederlands Tijdschrift voor Diabetologie, 10, pp. 130 - 130, http://dx.doi.org/10.1007/s12467-012-0080-5
    Journal articles | 2012
    Osborne B; Montgomery M; Reznick J; Cooney GJ; Turner N, 2012, 'Effect of acute hepatic overexpression of SIRT3 on metabolic parameters in short-term high fat fed mice', DIABETOLOGIA, 55, pp. S263 - S263, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208826501385&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2010
    Yu DMT; Yao TW; Chowdhury S; Nadvi NA; Osborne B; Church WB; McCaughan GW; Gorrell MD, 2010, 'The dipeptidyl peptidase IV family in cancer and cell biology', FEBS Journal, 277, pp. 1126 - 1144, http://dx.doi.org/10.1111/j.1742-4658.2009.07526.x
    Journal articles | 2008
    Xin MW; Yao TW; Nadvi NA; Osborne B; McCaughan GW; Gorrell MD, 2008, 'Fibroblast activation protein and chronic liver disease', Frontiers in Bioscience, 13, pp. 3168 - 3180, http://dx.doi.org/10.2741/2918
  • Preprints | 2022
    Amanda Tan RP; Kozlova I; Su F; Sah S; Keable R; Hagan W; Bustamante S; Du X; Osborne B; Turner N; Clemens K; Begg D; Phelps E; Yang H; Leshchyns’ka I; Sytnyk V, 2022, Neuronal growth regulator 1 (NEGR1) promotes synaptic targeting of glutamic acid decarboxylase 65 (GAD65), , http://dx.doi.org/10.1101/2022.02.08.479601
    Preprints | 2022
    Petr MA; Carmona-Marin L; Tulika T; Kristensen S; Reves S; Bakula D; Keijzers G; Osborne B; Mitchell S; Hamilton S; Kato J; Alfaras I; Teklu A; Heckenbach I; Madsen J; Ezra MB; Mkrtchyan G; Varner E; Fink B; Krusenstiern EV; Snyder N; Herranz H; Cabo RD; Scheibye-Knudsen M, 2022, Ketones facilitate transcriptional resolution of secondary DNA structures in premature aging, , http://dx.doi.org/10.1101/2022.03.08.483430
    Preprints | 2020
    Xi C; Arianna Di Fazio A; Nadvi N; Patel K; Xiang M; Zhang HE; Deshpande C; Low J; Wang XT; Chen Y; McMillan C; Isaacs A; Osborne B; Vieira de Ribeiro AJ; McCaughan G; Mackay J; Church B; Gorrell M, 2020, A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2, , http://dx.doi.org/10.20944/preprints202009.0390.v2
    Preprints | 2020
    Xi C; Arianna Di Fazio A; Nadvi N; Patel K; Xiang M; Zhang HE; Deshpande C; Low J; Wang XT; Chen Y; Osborne B; Vieira de Ribeiro AJ; McCaughan G; Church B; Mackay J; Gorrell M, 2020, A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2, , http://dx.doi.org/10.20944/preprints202009.0390.v1
    Conference Abstracts | 2016
    Montgomery MK; Brandon AE; O'Reilly L; Osborne B; Fiveash CE; Brown SH; Smith NJ; Mitchell TW; Biden TJ; Cooney GJ; Turner N, 2016, 'The free fatty acid receptor GPR84: A new player in glucose tolerance and mitochondrial function?', in DIABETOLOGIA, SPRINGER, GERMANY, Munich, Vol. 59, pp. S322 - S322, presented at 52nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), GERMANY, Munich, 12 September 2016 - 16 September 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000398373702048&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Theses / Dissertations | 2015
    Osborne B, 2015, An investigation of the mitochondrial sirtuin enzyme SIRT3 and its influence on the response of skeletal muscle and liver to lipid oversupply

My Research Supervision

Honours