Dr Brooke Anne Pereira
Conjoint Associate Lecturer

Dr Brooke Anne Pereira

PhD - 2019 - Monash University Australia
BS/BEng (Hons) - 2013 - Monash University Australia

medicine-health
St Vincent's Clinical School

Brooke completed her PhD at Monash University within the Biomedicine Discovery Institute (BDI) under the supervision of Professor Gail Risbridger in early 2019. During her candidature she studied tumour-stroma interactions in localised prostate cancer using tissue engineering and quantitative mass spectrometry (MS)-based proteomics. Brooke is now a post-doctoral Research Officer at the Garvan Institute of Medical Research, where she is investigating novel stromal targets in pancreatic cancer under the supervision of Professor Paul Timpson. She is using a range of cutting-edge techniques such as patient-derived xenografting (PDX), LC-MS/MS, MALDI imaging and advanced microscopy to study the stroma of both murine and human pancreatic tumours. Brooke is a Conjoint Associate Lecturer in the Faulty of Medicine at UNSW.

Publications

  • Book Chapters | 2017
    Dr Brooke Anne Pereira
    Pereira BA; Lister NL; De-Juan-Pardo EM; Risbridger GP; Ellem SJ, 2017, 'Three-Dimensional Bioengineered Cancer Models', in Comprehensive Biomaterials II, pp. 303 - 328, http://dx.doi.org/10.1016/b978-0-12-803581-8.09297-3
    Book Chapters | 2017
    Dr Brooke Anne Pereira
    Pereira BA; Lister NL; De-Juan-Pardo EM; Risbridger GP; Ellem SJ, 2017, '5.17 Three-dimensional bioengineered cancer models', in Comprehensive Biomaterials II, pp. 303 - 328, http://dx.doi.org/10.1016/B978-0-12-803581-8.09297-3
  • Journal articles | 2021
    Dr Brooke Anne Pereira
    Lakis V; Lawlor RT; Newell F; Patch AM; Mafficini A; Sadanandam A; Koufariotis LT; Johnston RL; Leonard C; Wood S; Rusev B; Corbo V; Luchini C; Cingarlini S; Landoni L; Salvia R; Milella M; Chang D; Bailey P; Jamieson NB; Duthie F; Gingras MC; Muzny DM; Wheeler DA; Gibbs RA; Milione M; Chantrill LA; Timpson P; Chou A; Pajic M; Murphy A; Dwarte T; Hermann D; Vennin C; Cox TR; Pereira B; Ritchie S; Reed DA; Chambers CR; Metcalf X; Nobis M; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Xu Q; Hofmann O; Samra JS; Pavlakis N; Arena J; High HA; Asghari R; Merrett ND; Pavey D; Das A; Cosman PH; Ismail K; O’Connnor C; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forest C; Ballal M; Fletcher DR; Zeps N; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Dixon J; Scardoni M; Bassi C; Grimaldi S; Cantù C; Bonizzato G; Bersani S, 2021, 'DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association', Communications Biology, vol. 4, http://dx.doi.org/10.1038/s42003-020-01469-0
    Journal articles | 2021
    Dr Brooke Anne Pereira
    Sharbeen G; McCarroll JA; Akerman A; Kopecky C; Youkhana J; Kokkinos J; Holst J; Boyer C; Erkan M; Goldstein D; Timpson P; Cox TR; Pereira BA; Chitty JL; Fey SK; Najumudeen AK; Campbell AD; Sansom OJ; Ignacio RMC; Naim S; Liu J; Russia N; Lee J; Chou A; Johns A; Gill AJ; Gonzales-Aloy E; Gebski V; Guan YF; Pajic M; Turner N; Apte MV; Davis TP; Morton JP; Haghighi KS; Kasparian J; McLean BJ; Setargew YF; Phillips PA, 2021, 'Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to slc7a11 inhibition', Cancer Research, vol. 81, pp. 3461 - 3479, http://dx.doi.org/10.1158/0008-5472.CAN-20-2496
    Journal articles | 2021
    Dr Brooke Anne Pereira
    Teng LKH; Pereira BA; Keerthikumar S; Huang C; Niranjan B; Lee SN; Richards M; Schittenhelm RB; Furic L; Goode DL; Lawrence MG; Taylor RA; Ellem SJ; Risbridger GP; Lister NL, 2021, 'Mast cell‐derived samd14 is a novel regulator of the human prostate tumor microenvironment', Cancers, vol. 13, pp. 1 - 25, http://dx.doi.org/10.3390/cancers13061237
    Journal articles | 2021
    Dr Brooke Anne Pereira
    Kokkinos J; Sharbeen G; Haghighi KS; Ignacio RMC; Kopecky C; Gonzales-Aloy E; Youkhana J; Timpson P; Pereira BA; Ritchie S; Pandzic E; Boyer C; Davis TP; Butler LM; Goldstein D; McCarroll JA; Phillips PA, 2021, 'Ex vivo culture of intact human patient derived pancreatic tumour tissue', Scientific Reports, vol. 11, pp. 1944, http://dx.doi.org/10.1038/s41598-021-81299-0
    Journal articles | 2021
    Dr Brooke Anne Pereira
    Murphy KJ; Chambers CR; Herrmann D; Timpson P; Pereira BA, 2021, 'Dynamic stromal alterations influence tumor-stroma crosstalk to promote pancreatic cancer and treatment resistance', Cancers, vol. 13, http://dx.doi.org/10.3390/cancers13143481
    Journal articles | 2021
    Dr Brooke Anne Pereira
    Chambers CR; Ritchie S; Pereira BA; Timpson P, 2021, 'Overcoming the senescence-associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer', Molecular Oncology, http://dx.doi.org/10.1002/1878-0261.13042
    Journal articles | 2021
    Dr Brooke Anne Pereira
    Ritchie S; Reed DA; Pereira BA; Timpson P, 2021, 'The cancer cell secretome drives cooperative manipulation of the tumour microenvironment to accelerate tumourigenesis.', Fac Rev, vol. 10, pp. 4, http://dx.doi.org/10.12703/r/10-4
    Journal articles | 2020
    Dr Brooke Anne Pereira
    Wu SZ; Roden DL; Wang C; Holliday H; Harvey K; Cazet AS; Murphy KJ; Pereira B; Al-Eryani G; Bartonicek N; Hou R; Torpy JR; Junankar S; Chan CL; Lam CE; Hui MN; Gluch L; Beith J; Parker A; Robbins E; Segara D; Mak C; Cooper C; Warrier S; Forrest A; Powell J; O'Toole S; Cox TR; Timpson P; Lim E; Liu XS; Swarbrick A, 2020, 'Stromal cell diversity associated with immune evasion in human triple-negative breast cancer', EMBO Journal, vol. 39, http://dx.doi.org/10.15252/embj.2019104063
    Journal articles | 2020
    Dr Brooke Anne Pereira
    Kokkinos J; Ignacio RMC; Sharbeen G; Boyer C; Gonzales-Aloy E; Goldstein D; McCarroll JA; Phillips PA, 2020, 'Targeting the undruggable in pancreatic cancer using nano-based gene silencing drugs', Biomaterials, vol. 240, pp. 119742, http://dx.doi.org/10.1016/j.biomaterials.2019.119742
    Journal articles | 2020
    Dr Brooke Anne Pereira
    Lawrence MG; Pidsley R; Niranjan B; Papargiris M; Pereira BA; Richards M; Teng L; Norden S; Ryan A; Frydenberg M; Stirzaker C; Taylor RA; Risbridger GP; Clark SJ, 2020, 'Alterations in the methylome of the stromal tumour microenvironment signal the presence and severity of prostate cancer', Clinical Epigenetics, vol. 12, pp. 48, http://dx.doi.org/10.1186/s13148-020-00836-2
    Journal articles | 2020
    Dr Brooke Anne Pereira
    Wu S; Roden D; Wang C; Holliday H; Harvey K; Cazet A; Murphy K; Pereira B; Al-Eryani G; Bartonicek N; Hou R; Torpy J; Junankar S; Chan C-L; Lam E; Hui M; Gluch L; Beith J; Parker A; Robbins E; Segara D; Mak C; Cooper C; Warrier S; Forrest A; Powell J; O’Toole S; Cox T; Timpson P; Lim E; Liu S; Swarbrick A, 2020, 'Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer', bioRxiv, http://dx.doi.org/10.1101/2020.06.04.135327
    Journal articles | 2020
    Dr Brooke Anne Pereira
    Ritchie S; Pereira BA; Vennin C; Timpson P, 2020, 'Targeting genetically-tuned CAFs in pancreatic cancer via perlecan manipulation', Expert Opinion on Therapeutic Targets, vol. 24, pp. 171 - 174, http://dx.doi.org/10.1080/14728222.2020.1727887
    Journal articles | 2019
    Dr Brooke Anne Pereira
    Nguyen EV; Pereira BA; Lawrence MG; Ma X; Rebello RJ; Chan H; Niranjan B; Wu Y; Ellem S; Guan X; Wu J; Skhinas JN; Cox TR; Risbridger GP; Taylor RA; Lister NL; Daly RJ, 2019, 'Proteomic profiling of human prostate cancer-associated fibroblasts (CAF) reveals LOXL2-dependent regulation of the tumor microenvironment', Molecular and Cellular Proteomics, vol. 18, pp. 1410 - 1427, http://dx.doi.org/10.1074/mcp.RA119.001496
    Journal articles | 2019
    Dr Brooke Anne Pereira
    Pereira BA; Vennin C; Papanicolaou M; Chambers CR; Herrmann D; Morton JP; Cox TR; Timpson P, 2019, 'CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer', Trends in Cancer, vol. 5, pp. 724 - 741, http://dx.doi.org/10.1016/j.trecan.2019.09.010
    Journal articles | 2019
    Dr Brooke Anne Pereira
    Pereira BA; Lister NL; Hashimoto K; Teng L; Flandes-Iparraguirre M; Eder A; Sanchez-Herrero A; Niranjan B; Frydenberg M; Papargiris MM; Lawrence MG; Taylor RA; Hutmacher DW; Ellem SJ; Risbridger GP; De-Juan-Pardo EM, 2019, 'Tissue engineered human prostate microtissues reveal key role of mast cell-derived tryptase in potentiating cancer-associated fibroblast (CAF)-induced morphometric transition in vitro', Biomaterials, vol. 197, pp. 72 - 85, http://dx.doi.org/10.1016/j.biomaterials.2018.12.030
    Journal articles | 2015
    Dr Brooke Anne Pereira
    Hutmacher DW; Holzapfel BM; De-Juan-Pardo EM; Pereira BA; Ellem SJ; Loessner D; Risbridger GP, 2015, 'Convergence of regenerative medicine and synthetic biology to develop standardized and validated models of human diseases with clinical relevance', Current Opinion in Biotechnology, vol. 35, pp. 127 - 132, http://dx.doi.org/10.1016/j.copbio.2015.06.001
    Journal articles | 2015
    Dr Brooke Anne Pereira
    Kolodziejczyk B; Winther-Jensen O; Pereira BA; Nair SS; Winther-Jensen B, 2015, 'Patterning of conducting layers on breathable substrates using laser engraving for gas sensors', Journal of Applied Polymer Science, vol. 132, http://dx.doi.org/10.1002/app.42359

Awards

Awards/Honours

  • 2018 Lorne Cancer Conference Poster Prize – 1 of 6 awarded
  • 2017 EACR Image of the Month – “3D melt electrospun scaffold model of the human prostate tumour microenvironment” http://magazine.eacr.org/eacr-image-of-the-month-october-2016-2017/4/
  • 2016 World Biomaterials Congress (WBC) Trainee Award – 1 of 45 recipients worldwide
  • 2014 ASMR Campion-Ma-Playoust Memorial Award – Best Presentation at the Australian Health and Medical Research Congress
  • 2014 Department of Education Research Training Program (RTP) PhD Stipend
  • 2013 Monash Summer Research Scholarship – Australian Centre of Blood Diseases (ACBD)


Travel Grants

  • 2020 Matrix Biology & Matrix Biology Plus Award
  • 2017 ESA Postgraduate Student Travel Grant
  • 2017 ASBTE Postgraduate Student Travel Grant
  • 2016 Monash University Postgraduate Travel Grant Award
  • 2016 ASBTE Postgraduate Student Travel Grant
  • 2015 Monash Institute for Medical Engineering (MIME) Travel Grant
  • 2014 Justus Liebig University (JLU) Postgraduate Student Travel Grant

Grants

2020 – 2021    Sydney Catalyst Seed Funding Grant - CIA Brooke Pereira. Dual targeting of stromal and immunological aberrations in pancreatic cancer by combining perlecan inhibition with immunotherapy. ($50,000 AUD)

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