Dr Caroline   Atkinson
Conjoint Associate Lecturer

Dr Caroline Atkinson

  • Doctorate of philosophy, Griffith University, 2016.
  • Master of Medical research, Griffith University, 2011.
  • Bachelor of Biomedical Science, Griffith University, 2008
Medicine & Health
Sch Women's&Children's Health

Originally from Queensland, I am an early career, post-doctoral researcher at the Children's Cancer Institute. My PhD, completed at Griffith University and QIMR Berghofer, focused on delineating a role for cellular prion protein in colorectal and breast cancer chemotherapeutic resistance. After completing my PhD in 2016, I joined Mater Research Institute where I assessed the functional consequences of a variant in ATM on DNA damage response signalling in melanoma. In 2017, I moved to Sydney to take a position at Children's Cancer Institute where I am currently involved in several projects aimed at improving the outcome of patients with high-risk neuroblastoma.  

Sample Publications:

  • Kamili, A., Atkinson, C., Trahair, T., Fletcher, J. Mouse Models of High-Risk Neuroblastoma (2020) Cancer and Metastasis Reviews. Doi: 10.1007/s10555-020-9855-0
  • Atkinson, C., Kawamata, F., Liu, C., Ham, S., Gyorffy, B., Munn, AL., Wei, M.Q., Moller A., Whitehall, V., Wiegmans, AP. EGFR and Prion protein (PrP) promote signalling via FOXO3a-KLF5 resulting in clinical resistance to platinum agents in colorectal cancer. (2018) Molecular Oncology. DOI: 10.1002/1878-0261.12411
  • Wiegmans, A.P., Saunas, J., Ham, S., Lobb, R., Kutasovic, J., Dalley A., Miranda, M., Atkinson, C., Foliak S., Ferguson, k., Niland, C., Johnstone, C., Lewis, V., Collins, S., Lakhani, S., Al-Ejeh, F., Moller, A. Chelation by the octorepeart domain of Prion protein induces anthracycline resistance. (2019) JCI insight. 10.1172/jci.insight.124092
  • Atkinson, C., Zhang, K., Wiegmans, A., Munn, A., Wei, MQ. Prion protein scrapie and the normal cellular prion protein. (2015) Prion. 0. doi: 10.1080/19336896.2015.1110293
Location
Lvl 1- Lowy Cancer Research Centre UNSW

Publications

  • Journal articles | 2020
    Dr Caroline Atkinson
    Kamili A; Atkinson C; Trahair TN; Fletcher JI, 2020, 'Mouse models of high-risk neuroblastoma', Cancer and Metastasis Reviews, http://dx.doi.org/10.1007/s10555-020-09855-0
    Journal articles | 2019
    Dr Caroline Atkinson
    Atkinson CJ; Kawamata F; Liu C; Ham S; Gyorffy B; Munn AL; Wei MQ; Moeller A; Whitehall V; Wiegmans AP, 2019, 'EGFR and Prion protein promote signaling via FOXO3a-KLF5 resulting in clinical resistance to platinum agents in colorectal cancer', MOLECULAR ONCOLOGY, vol. 13, pp. 725 - 737, http://dx.doi.org/10.1002/1878-0261.12411
    Journal articles | 2019
    Dr Caroline Atkinson
    Wiegmans AP; Saunus JM; Ham S; Lobb R; Kutasovic JR; Dalley AJ; Miranda M; Atkinson C; Foliaki ST; Ferguson K; Niland C; Johnstone CN; Lewis V; Collins SJ; Lakhani SR; Al-Ejeh F; Möller A, 2019, 'Secreted cellular prion protein binds doxorubicin and correlates with anthracycline resistance in breast cancer', JCI Insight, vol. 4, http://dx.doi.org/10.1172/jci.insight.124092
    Journal articles | 2016
    Dr Caroline Atkinson
    Atkinson CJ; Zhang K; Munn AL; Wiegmans A; Wei MQ, 2016, 'Prion protein scrapie and the normal cellular prion protein', PRION, vol. 10, pp. 63 - 82, http://dx.doi.org/10.1080/19336896.2015.1110293
    Journal articles | 2013
    Dr Caroline Atkinson
    Hinton C; Antony H; Hashimi SM; Munn A; Wei MQ, 2013, 'Significance of Prion and Prion-Like Proteins in Cancer Development, Progression and Multi-Drug Resistance', CURRENT CANCER DRUG TARGETS, vol. 13, pp. 895 - 904, http://dx.doi.org/10.2174/156800961131300092
  • Conference Papers | 2021
    Dr Caroline Atkinson
    Vijayasubhash V, 2021, 'Analysis of DNA minimal residual disease markers in pediatric solid cancers using quantitative real time PCR and droplet digital PCR', in Analysis of DNA minimal residual disease markers in pediatric solid cancers using quantitative real time PCR and droplet digital PCR, presented at AACR 2021, http://dx.doi.org/10.1158/1538-7445.AM2021-639
    Conference Abstracts | 2020
    Dr Caroline Atkinson
    Atkinson C; Tactacan C; Kamili A; Saletta F; Gana C; Eden G; Mayoh C; Lock R; Norris M; Haber M; Gifford A; Trahair T; Fletcher J, 2020, 'Abstract A35: P-Glycoprotein is a resistance mechanism for conventional induction chemotherapy but not ALK inhibitors in high-risk neuroblastoma', in Poster Presentations - Proffered Abstracts, American Association for Cancer Research, presented at Abstracts: AACR Special Conference on the Advances in Pediatric Cancer Research; September 17-20, 2019; Montreal, QC, Canada, http://dx.doi.org/10.1158/1538-7445.pedca19-a35
    Conference Abstracts | 2019
    Dr Caroline Atkinson
    Atkinson C; Tactacan CM; Kamili A; Saletta F; Gana C; Eden GL; Mayoh C; Lock RB; Norris MD; Haber M; Gifford AJ; Trahair TN; Fletcher JI, 2019, 'Abstract 4741: Re-evaluating the role of P-glycoprotein in the resistance of high-risk neuroblastoma to standard-of-care chemotherapies', in Experimental and Molecular Therapeutics, American Association for Cancer Research, presented at Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA, http://dx.doi.org/10.1158/1538-7445.am2019-4741
    Conference Abstracts | 2019
    Dr Caroline Atkinson
    Atkinson C; Tactacan C; Kamili A; Saletta F; Gana C; Eden G; Mayoh C; Lock R; Norris M; Haber M; Gifford A; Trahair T; Fletcher J, 2019, 'P-Glycoprotein is a resistance mechanism for conventional induction chemotherapy but not ALK inhibitors in high-risk neuroblastoma', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Montreal, CANADA, Vol. 80, pp. 61 - 61, presented at AACR Special Conference on the Advances in Pediatric Cancer Research, Montreal, CANADA, 17 September 2019 - 20 September 2019, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000551367400079&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    Dr Caroline Atkinson
    Atkinson C; Tactacan CM; Kamili A; Saletta F; Gana C; Eden GL; Mayoh C; Lock RB; Norris MD; Haber M; Gifford AJ; Trahair TN; Fletcher JI, 2019, 'Re-evaluating the role of P-glycoprotein in the resistance of high-risk neuroblastoma to standard-of-care chemotherapies', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Atlanta, GA, Vol. 79, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), Atlanta, GA, 29 March 2019 - 03 April 2019, http://dx.doi.org/10.1158/1538-7445.SABCS18-4741

Awards

Grants

CIB - NHMRC New Ideas Grant “Improving induction therapy for high-risk neuroblastoma through bypass or inhibition of P-glycoprotein”, 2020-2021 (CIA Dr Jamie Fletcher, CIC Dr Alvin Kamili). 

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