Dr Chantal Kopecky
Postdoctoral Fellow

Dr Chantal Kopecky

2018: Promotion to Lecturer, UNSW Sydney

2015: PhD in Immunology, Medical University of Vienna, Austria

2009: MSc in Nutrition Science, University of Vienna, Austria

Science
School of Chemistry

I obtained my PhD in Immunology at the Medical University of Vienna, Austria in the field of cardiovascular and lipoprotein biology in chronic kidney disease. Extending my work in Austria as junior Post-doctoral Fellow my research was further focused on linking molecular changes in lipid quality with clinical outcomes in cardiovascular high-risk patient populations.

After moving to Sydney in 2016, I was investigating metabolic and inflammatory complications in diabetes and cardiovascular disease at UNSW. Specifically, I utilised 3D lightsheet fluorescence imaging to visualise pathologic processes, immune cell involvement and disease progression in atherosclerosis and I was working on characterising impairments of skeletal muscle metabolism in the context of diabetes.

Working in the Pancreatic Cancer Translational Research Group at UNSW from 2018 - 2020, my research was focused on efficacy of drug delivery and novel therapeutic approaches in pancreatic cancer. Specific projects were aimed to investigate therapeutic targets to metabolically reprogramm the stroma in pancreatic cancer and the development of novel nanomedicines to deliver gene therapeutics to pancreatic tumours.

Currently, I am working in the field of Biomaterials and Tissue Engineering (Kilian Lab UNSW) with a specific focus on cancer mechanobiology and the development of novel 3D tumour micorenvironments.

Location
Hilmer Building Level 7 Sydney NSW 2052
  • Journal articles | 2022
    Srivastava P; Romanazzo S; Kopecky C; Nemec S; Ireland J; Molley TG; Lin K; Jayathilaka PB; Pandzic E; Yeola A; Chandrakanthan V; Pimanda J; Kilian K, 2022, 'Defined Microenvironments Trigger In Vitro Gastrulation in Human Pluripotent Stem Cells', Advanced Science, pp. e2203614, http://dx.doi.org/10.1002/advs.202203614

2020 – 2021: Innovative nanomedicines to improve drug delivery and metabolic reprogramming in pancreatic cancer; Cancer Clinical Academic Group E/MCR Seed grant scheme (Primary Investigator)

2019 - 2021: MyoRobot automated Biomechatronics Technology for Higher Education and Teaching Using Virtual Skills Lab; Australia-Germany Joint Research Cooperation Scheme (Secondary Investigator)

2016 - 2020: Effect of empagliflozin on the renin-angiotensin system in patients with chronic kidney disease with and without type 2 diabetes (NCT03078101); Boehringer-Ingelheim Investigator-Initiated Study (Applicant and Secondary Investigator)

  1. UNSW Sydney School of Medical Sciences Paper of the Month award (2019)
  2. Travel grant of the Australian Atherosclerosis Society (2018)
  3. Abstract Prize of the Austrian Diabetes Society (2017)
  4. Young Investigator Fellowship of the European Society of Atherosclerosis (2016)
  5. Clinical Science award of the Austrian Society of Transplantation, Transfusion and Genetics (2015)
  6. Hans-Krister-Stummvoll prize of the Austrian Society of Nephrology (2014)

  1. Evaluation of nanomedicine therapeutics in vitro and in vivo to demonstrate the functional impact of metabolic reprogramming in pancreatic cancer
  2. Utilisation of state-of-the-art methodologies such as 3D lightsheet fluorescence microscopy to identify and characterise:

a. human pancreatic tumour morphology

b. different stages of atherosclerosis progression and the associated immune cell profile

  1. Identification of key molecular pathways and structural features of impaired skeletal muscle metabolism in diabetes
  2. Characterisation of molecular effects of anti-diabetic and antihypertensive therapies on renin-angiotensin system (RAS) regulation in diabetic kidney disease
  3. Comprehensive profiling of the protein composition and cardioprotective properties of high-density lipoproteins in chronic inflammatory diseases with high cardiovascular risk