Dr Charles Cox

Martinac B; Nikolaev YA; Silvani G; Bavi N; Romanov V; Nakayama Y; Martinac AD; Rohde P; Bavi O; Cox CD, 2020, 'Cell membrane mechanics and mechanosensory transduction', in Current Topics in Membranes, pp. 83 - 141, http://dx.doi.org/10.1016/bs.ctm.2020.08.002

Cranfield CG; Kloda A; Nikolaev YA; Martinac AD; Ridone P; Bavi N; Bavi O; Petrov E; Battle AR; Nomura T; Rohde PR; Nakayama Y; Rosholm KR; Cox CD; Baker MA; Martinac B, 2019, 'Mechanosensitivity of Ion Channels', in Encyclopedia of Biophysics, Springer Berlin Heidelberg, pp. 1 - 11, http://dx.doi.org/10.1007/978-3-642-35943-9_376-2

Cranfield CG; Kloda A; Nikolaev YA; Martinac AD; Ridone P; Bavi N; Bavi O; Petrov E; Battle AR; Nomura T; Rohde PR; Nakayama Y; Rosholm KR; Cox CD; Baker MA; Martinac B, 2018, 'Mechanosensitivity of Ion Channels', in Encyclopedia of Biophysics, Springer Berlin Heidelberg, pp. 1 - 11, http://dx.doi.org/10.1007/978-3-642-35943-9_376-1

Martinac B; Cox CD, 2017, 'Mechanosensory Transduction: Focus on Ion Channels ☆', in Reference Module in Life Sciences, Elsevier, http://dx.doi.org/10.1016/b978-0-12-809633-8.08094-8

Bavi N; Nikolaev YA; Bavi O; Ridone P; Martinac AD; Nakayama Y; Cox CD; Martinac B, 2017, 'Principles of Mechanosensing at the Membrane Interface', in Springer Series in Biophysics, Springer Singapore, pp. 85 - 119, http://dx.doi.org/10.1007/978-981-10-6244-5_4

Cranfield CG; Kloda A; Petrov E; Battle A; Nomura T; Rohde PR; Cox C; Martinac B, 2013, 'Mechanosensitivity of Ion Channels', in Encyclopedia of Biophysics, Springer Berlin Heidelberg, pp. 1433 - 1440, http://dx.doi.org/10.1007/978-3-642-16712-6_376

Pineda S; Nikolova-Krstevski V; Leimena C; Atkinson AJ; Altekoester AK; Cox CD; Jacoby A; Huttner IG; Ju YK; Soka M; Ohanian M; Trivedi G; Kalvakuri S; Birker K; Johnson R; Molenaar P; Kuchar D; Allen DG; Van Helden DF; Harvey RP; Hill AP; Bodmer R; Vogler G; Dobrzynski H; Ocorr K; Fatkin D, 2021, 'Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, KCa1.1, in Sinus Node Function and Arrhythmia Risk', Circulation: Genomic and Precision Medicine, pp. 230 - 242, http://dx.doi.org/10.1161/CIRCGEN.120.003144

Guo Y; Yu ZY; Wu J; Gong H; Kesteven S; Iismaa SE; Chan AY; Holman S; Pinto S; Pironet A; Cox CD; Graham RM; Vennekens R; Feneley MP; Martinac B, 2021, 'The ca²⁺-activated cation channel trpm4 is a positive regulator of pressure overload-induced cardiac hypertrophy', eLife, vol. 10, http://dx.doi.org/10.7554/eLife.66582

Zhang Y; Daday C; Gu RX; Cox CD; Martinac B; de Groot BL; Walz T, 2021, 'Visualization of the mechanosensitive ion channel MscS under membrane tension', Nature, vol. 590, pp. 509 - 514, http://dx.doi.org/10.1038/s41586-021-03196-w

Lai A; Chen YC; Cox CD; Jaworowski A; Peter K; Baratchi S, 2021, 'Analyzing the shear-induced sensitization of mechanosensitive ion channel Piezo-1 in human aortic endothelial cells', Journal of Cellular Physiology, vol. 236, pp. 2976 - 2987, http://dx.doi.org/10.1002/jcp.30056

Kuchel PW; Cox CD; Daners D; Shishmarev D; Galvosas P, 2021, 'Surface model of the human red blood cell simulating changes in membrane curvature under strain', Scientific Reports, vol. 11, http://dx.doi.org/10.1038/s41598-021-92699-7

Silvani G; Romanov V; Cox CD; Martinac B, 2021, 'Biomechanical Characterization of Endothelial Cells Exposed to Shear Stress Using Acoustic Force Spectroscopy', Frontiers in Bioengineering and Biotechnology, vol. 9, http://dx.doi.org/10.3389/fbioe.2021.612151

Kuchel PW; Romanenko K; Shishmarev D; Galvosas P; Cox CD, 2021, 'Enhanced Ca²⁺ influx in mechanically distorted erythrocytes measured with ¹⁹F nuclear magnetic resonance spectroscopy', Scientific Reports, vol. 11, http://dx.doi.org/10.1038/s41598-021-83044-z

Romanov V; Silvani G; Zhu H; Cox CD; Martinac B, 2021, 'An Acoustic Platform for Single-Cell, High-Throughput Measurements of the Viscoelastic Properties of Cells', Small, vol. 17, http://dx.doi.org/10.1002/smll.202005759

Vero Li J; D Cox C; Martinac B, 2021, 'The anchor domain is critical for Piezo1 channel mechanosensitivity', Channels, vol. 15, pp. 438 - 446, http://dx.doi.org/10.1080/19336950.2021.1923199

Li J; Ann Ng C; Cheng D; Cox CD, 2021, 'Modified N-Linked Glycosylation Status Predicts Trafficking Defective Piezo1 Channel Mutations', Biophysical Journal, vol. 120, pp. 236a - 237a, http://dx.doi.org/10.1016/j.bpj.2020.11.1562

Patkunarajah A; Stear JH; Moroni M; Schroeter L; Blaszkiewicz J; Tearle JLE; Cox CD; Fuerst C; Sánchez-Carranza O; Fernández MDÁO; Fleischer R; Eravci M; Weise C; Martinac B; Biro M; Lewin GR; Poole K, 2020, 'TMEM87a/Elkin1, a component of a novel mechanoelectrical transduction pathway, modulates melanoma adhesion and migration.', eLife, vol. 9, http://dx.doi.org/10.7554/eLife.53308

Ridone P; Pandzic E; Vassalli M; Cox CD; Macmillan A; Gottlieb PA; Martinac B, 2020, 'Disruption of membrane cholesterol organization impairs the activity of PIEZO1 channel clusters', Journal of General Physiology, vol. 152, http://dx.doi.org/10.1085/jgp.201912515

Buyan A; Cox CD; Barnoud J; Li J; Chan HSM; Martinac B; Marrink SJ; Corry B, 2020, 'Piezo1 Forms Specific, Functionally Important Interactions with Phosphoinositides and Cholesterol', Biophysical Journal, vol. 119, pp. 1683 - 1697, http://dx.doi.org/10.1016/j.bpj.2020.07.043

Xue F; Cox CD; Bavi N; Rohde PR; Nakayama Y; Martinac B, 2020, 'Membrane stiffness is one of the key determinants of E. coli MscS channel mechanosensitivity', Biochimica et Biophysica Acta - Biomembranes, vol. 1862, pp. 183203, http://dx.doi.org/10.1016/j.bbamem.2020.183203

Baratchi S; Khoshmanesh K; Cox CD; Gomez GA, 2020, 'Editorial: Mechanobiology: Emerging Tools and Methods', Frontiers in Bioengineering and Biotechnology, vol. 8, http://dx.doi.org/10.3389/fbioe.2020.00289

Nikolaev YA; Cox CD; Ridone P; Rohde PR; Cordero-Morales JF; Vásquez V; Laver DR; Martinac B, 2019, 'Mammalian TRP ion channels are insensitive to membrane stretch', Journal of Cell Science, vol. 132, http://dx.doi.org/10.1242/jcs.238360

Cox CD; Gottlieb PA, 2019, 'Amphipathic molecules modulate PIEZO1 activity', Biochemical Society Transactions, vol. 47, pp. 1833 - 1842, http://dx.doi.org/10.1042/BST20190372

Cox CD; Bavi N; Martinac B, 2019, 'Biophysical Principles of Ion-Channel-Mediated Mechanosensory Transduction', Cell Reports, vol. 29, pp. 1 - 12, http://dx.doi.org/10.1016/j.celrep.2019.08.075

Fatkin D; Cox CD; Huttner IG; Martinac B, 2018, 'Is There a Role for Genes in Exercise-Induced Atrial Cardiomyopathy?', Heart Lung and Circulation, vol. 27, pp. 1093 - 1098, http://dx.doi.org/10.1016/j.hlc.2018.03.028

Cox CD; Bavi N; Martinac B, 2018, 'Bacterial Mechanosensors', Annual Review of Physiology, vol. 80, pp. 71 - 93, http://dx.doi.org/10.1146/annurev-physiol-021317-121351

Nikolova-Krstevski V; Wagner S; Yu ZY; Cox CD; Cvetkovska J; Hill AP; Huttner IG; Benson V; Werdich AA; MacRae C; Feneley MP; Friedrich O; Martinac B; Fatkin D, 2017, 'Endocardial TRPC-6 Channels Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk', JACC: Basic to Translational Science, vol. 2, pp. 575 - 590, http://dx.doi.org/10.1016/j.jacbts.2017.05.006

Cox CD; Bavi N; Martinac B, 2017, 'Origin of the Force: The Force-From-Lipids Principle Applied to Piezo Channels', Current Topics in Membranes, vol. 79, pp. 59 - 96, http://dx.doi.org/10.1016/bs.ctm.2016.09.001

Bavi N; Cox CD; Perozo E; Martinac B, 2017, 'Toward a structural blueprint for bilayer-mediated channel mechanosensitivity', Channels, vol. 11, pp. 91 - 93, http://dx.doi.org/10.1080/19336950.2016.1224624

Sharifian Gh M; Cox CD; Wilhelm MJ; Dai H-L, 2017, 'In Vivo Nonlinear Light Scattering Probe of Drug-Induced Activation of Bacterial Mechanosensitive Channels', Biophysical Journal, vol. 112, pp. 580a - 580a, http://dx.doi.org/10.1016/j.bpj.2016.11.3125

Bavi O; Cox CD; Vossoughi M; Naghdabadi R; Jamali Y; Martinac B, 2016, 'Influence of Global and Local Membrane Curvature on Mechanosensitive Ion Channels: A Finite Element Approach', MEMBRANES, vol. 6, http://dx.doi.org/10.3390/membranes6010014

Abdulkareem ZA; Gee JMW; Cox CD; Wann KT, 2016, 'Knockdown of the small conductance Ca²⁺-activated K⁺ channels is potently cytotoxic in breast cancer cell lines', British Journal of Pharmacology, vol. 173, pp. 177 - 190, http://dx.doi.org/10.1111/bph.13357

Syeda R; Florendo MN; Cox CD; Kefauver JM; Santos JS; Martinac B; Patapoutian A, 2016, 'Piezo1 Channels Are Inherently Mechanosensitive', Cell Reports, vol. 17, pp. 1739 - 1746, http://dx.doi.org/10.1016/j.celrep.2016.10.033

Bavi N; Cortes DM; Cox CD; Rohde PR; Liu W; Deitmer JW; Bavi O; Strop P; Hill AP; Rees D; Corry B; Perozo E; Martinac B, 2016, 'The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels', Nature Communications, vol. 7, http://dx.doi.org/10.1038/ncomms11984

Cox CD; Bae C; Ziegler L; Hartley S; Nikolova-Krstevski V; Rohde PR; Ng CA; Sachs F; Gottlieb PA; Martinac B, 2016, 'Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension', Nature Communications, vol. 7, http://dx.doi.org/10.1038/ncomms10366

Sharifian Gh M; Cox CD; Wilhelm MJ; Sheffield JB; Dai H-L, 2016, 'Cell Membrane Integrity Examined by Nonlinear Light Scattering', Biophysical Journal, vol. 110, pp. 160a - 160a, http://dx.doi.org/10.1016/j.bpj.2015.11.898

Nomura T; Cox CD; Bavi N; Sokabe M; Martinac B, 2015, 'Unidirectional incorporation of a bacterial mechanosensitive channel into liposomal membranes', FASEB Journal, vol. 29, pp. 4334 - 4345, http://dx.doi.org/10.1096/fj.15-275198

Cox CD; Nakayama Y; Nomura T; Martinac B, 2015, 'The evolutionary ‘tinkering’ of MscS-like channels: generation of structural and functional diversity', Pflugers Archiv European Journal of Physiology, vol. 467, pp. 3 - 13, http://dx.doi.org/10.1007/s00424-014-1522-2

Burley DS; Cox CD; Zhang J; Wann KT; Baxter GF, 2014, 'Natriuretic peptides modulate ATP-sensitive K⁺ channels in rat ventricular cardiomyocytes', Basic Research in Cardiology, vol. 109, http://dx.doi.org/10.1007/s00395-014-0402-4

Bavi N; Nakayama Y; Bavi O; Cox CD; Qin QH; Martinac B, 2014, 'Biophysical implications of lipid bilayer rheometry for mechanosensitive channels', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, pp. 13864 - 13869, http://dx.doi.org/10.1073/pnas.1409011111

Shaikh S; Cox CD; Nomura T; Martinac B, 2014, 'Energetics of gating MscS by membrane tension in azolectin liposomes and giant spheroplasts', Channels, vol. 8, pp. 321 - 326, http://dx.doi.org/10.4161/chan.28366

Cox CD; Wann KT; Martinac B, 2014, 'Selectivity mechanisms in MscS-like channels: From structure to function', Channels, vol. 8, pp. 5 - 12, http://dx.doi.org/10.4161/chan.27107

Cox CD; Nomura T; Ziegler CS; Campbell AK; Wann KT; Martinac B, 2013, 'Selectivity mechanism of the mechanosensitive channel MscS revealed by probing channel subconducting states', Nature Communications, vol. 4, http://dx.doi.org/10.1038/ncomms3137

Petrov E; Constantine M; Rohde PR; Nomura T; Boris M, 2013, 'Patch-clamp characterization of the Mscs-like mechanosensitive channel from silicibacter pomeroyi', Biophysical Journal, vol. 104, pp. 1426 - 1434, http://dx.doi.org/10.1016/j.bpj.2013.01.055

Vassel N; Cox CD; Naseem R; Morse V; Evans RT; Power RL; Brancale A; Wann KT; Campbell AK, 2012, 'Enzymatic activity of albumin shown by coelenterazine chemiluminescence', Luminescence, vol. 27, pp. 234 - 241, http://dx.doi.org/10.1002/bio.2357

Cox CD; Campbell AK; Wann KT, 2011, 'Outward Currents Through “low” Conductance Non-Mechanosensitive Channels in Escherichia Coli Membranes', Biophysical Journal, vol. 100, pp. 278a - 278a, http://dx.doi.org/10.1016/j.bpj.2010.12.1728

Campbell AK; Matthews SB; Vassel N; Cox CD; Naseem R; Chaichi J; Holland IB; Green J; Wann KT, 2010, 'Bacterial metabolic 'toxins': A new mechanism for lactose and food intolerance, and irritable bowel syndrome', Toxicology, vol. 278, pp. 268 - 276, http://dx.doi.org/10.1016/j.tox.2010.09.001

Nikolaev Y; Cox CD; Ridone P; Rohde PR; Cordero-Morales JF; Vasquez V; Laver DR; Martinac B, 2020, 'Mammalian TRP Ion Channels are Insensitive to Membrane Stretch', in BIOPHYSICAL JOURNAL, CELL PRESS, San Diego, CA, pp. 22A - 22A, presented at 64th Annual Meeting of the Biophysical-Society, San Diego, CA, 15 February 2020 - 19 February 2020, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000513023200104&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Buyan A; Cox CD; Barnoud J; Martinac B; Marrink S-J; Corry B, 2019, 'Understanding Piezo1's Relationship with Lipids', in BIOPHYSICAL JOURNAL, CELL PRESS, Baltimore, MD, Vol. 116, pp. 459A - 459A, presented at 63rd Annual Meeting of the Biophysical-Society, Baltimore, MD, 02 March 2019 - 06 March 2019, http://dx.doi.org/10.1016/j.bpj.2018.11.2481

Ridone P; Pandzic E; Vassalli M; Cox CD; Macmillan AM; Gottlieb PA; Martinac B, 2019, 'Cholesterol-Dependent Piezol Clusters are Essential for Efficient Cellular Mechanotransduction', in BIOPHYSICAL JOURNAL, CELL PRESS, Baltimore, MD, Vol. 116, pp. 377A - 377A, presented at 63rd Annual Meeting of the Biophysical-Society, Baltimore, MD, 02 March 2019 - 06 March 2019, http://dx.doi.org/10.1016/j.bpj.2018.11.2050

Cox CD; Bavi N; Martinac B, 2018, 'Cytoskeleton-Associated Proteins Modulate the Tension Sensitivity of Piezo1', in BIOPHYSICAL JOURNAL, CELL PRESS, San Francisco, CA, Vol. 114, pp. 111A - 111A, presented at 62nd Annual Meeting of the Biophysical-Society, San Francisco, CA, 17 February 2018 - 21 February 2018, http://dx.doi.org/10.1016/j.bpj.2017.11.641

Cox CD; Martinac B, 2016, 'Bending Piezo1: The Effect of Amphipaths on the Gating of a Mechanosensitive Channel', in BIOPHYSICAL JOURNAL, CELL PRESS, Los Angeles, CA, Vol. 110, pp. 349A - 349A, presented at 60th Annual Meeting of the Biophysical-Society, Los Angeles, CA, 27 February 2016 - 02 March 2016, http://dx.doi.org/10.1016/j.bpj.2015.11.1880

Bavi N; Cox CD; Rohde PR; Hill AP; Corry B; Martinac B, 2016, 'The N-Terminal Helix Acts as a Dynamic Membrane Coupler in the Gating Cycle of the Mechanosensitive Channel MscL', in BIOPHYSICAL JOURNAL, CELL PRESS, Los Angeles, CA, Vol. 110, pp. 116A - 116A, presented at 60th Annual Meeting of the Biophysical-Society, Los Angeles, CA, 27 February 2016 - 02 March 2016, http://dx.doi.org/10.1016/j.bpj.2015.11.677

Cox CD; Martinac B, 2015, 'Probing the Mechanosensitivity of Piezo1 Channels', in BIOPHYSICAL JOURNAL, CELL PRESS, Baltimore, MD, Vol. 108, pp. 562A - 562A, presented at 59th Annual Meeting of the Biophysical-Society, Baltimore, MD, 07 February 2015 - 11 February 2015, http://dx.doi.org/10.1016/j.bpj.2014.11.3079

Nikolaev YA; Rohde PR; Cox CD; Laver DR; Martinac B, 2015, 'Mechanosensitivity of TRPC6 Ion Channels', in BIOPHYSICAL JOURNAL, CELL PRESS, Baltimore, MD, Vol. 108, pp. 564A - 564A, presented at 59th Annual Meeting of the Biophysical-Society, Baltimore, MD, 07 February 2015 - 11 February 2015, http://dx.doi.org/10.1016/j.bpj.2014.11.3088

Cox CD; Ng CA; Bavi N; Martinac B, 2014, 'Mechanically-Induced Gating in PKD2L1 (Trpp2): Calcium-Induced Activation Masquerading as Force Sensitivity?', in BIOPHYSICAL JOURNAL, CELL PRESS, San Francisco, CA, pp. 311A - 311A, presented at 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, 15 February 2014 - 19 February 2014, http://dx.doi.org/10.1016/j.bpj.2016.11.1686

Bavi N; Cox CD; Bavi O; Martinac B, 2014, 'Perturbation of Bilayer Surface Tension Differentially Modulates Mechanosensitive Ion Channels', in BIOPHYSICAL JOURNAL, CELL PRESS, San Francisco, CA, pp. 416A - 416A, presented at 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, 15 February 2014 - 19 February 2014, http://dx.doi.org/10.1016/j.bpj.2016.11.2229

Ridone P; Cox C; Vassalli M; Pandzic E; Gottlieb P; Martinac B, 2014, 'Human Piezo1 Membrane Localization and Gating Kinetics are Modulated by Cholesetrol Levels', in BIOPHYSICAL JOURNAL, CELL PRESS, San Francisco, CA, Vol. 112, pp. 533A - 533A, presented at 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, 15 February 2014 - 19 February 2014, http://dx.doi.org/10.1016/j.bpj.2016.11.2883

Cox CD; Campbell AK; Wann KT; Martinac B, 2013, 'The Selectivity of MscS is Determined by the Cytoplasmic Domain', in BIOPHYSICAL JOURNAL, CELL PRESS, Philadelphia, PA, pp. 469A - 469A, presented at 57th Annual Meeting of the Biophysical-Society, Philadelphia, PA, 02 February 2013 - 06 February 2013, http://dx.doi.org/10.1016/j.bpj.2012.11.2590

Cox CD; Campbell AK; Wann KT; Martinac B, 2012, 'A Mechanosensitive Channel (MscS) with Multiple Conducting States Shows Stronger Selectivity for Anions in the Presence of Divalent Cations', in BIOPHYSICAL JOURNAL, CELL PRESS, San Diego, CA, pp. 123A - 123A, presented at 56th Annual Meeting of the Biophysical-Society, San Diego, CA, 25 February 2012 - 29 February 2012, http://dx.doi.org/10.1016/j.bpj.2011.11.688