Dr Chin Ken   Wong
Research Associate

Dr Chin Ken Wong

PhD, Chemistry (UNSW) 2018

Science
School of Chemistry

I am a currently a postdoc in the School of Chemistry at UNSW Sydney. Prior to this appointment, I held an Alexander von Humboldt Fellowship (2019-2020) at the University of Münster in Germany.

My research interest primarily focuses on innovating approaches to self-assemble block copolymers into complex architectures. Some self-assembly concepts/topics, which I have expertise in, include (i) polymersome (polymer vesicle) shape transformation, (i) hierarchical self-assembly at nanometre to micrometre length scale, and (iii) inverted polymer morphologies such as cubosomes and hexosomes. More recently, I have ventured into using continuous flow setups to explore end-to-end manufacturing of polymer nanoparticles.

Besides my knowledge in block copolymer self-assembly, I have years of experience in soft matter electron microscopy (cryo-TEM, cryo-ET, 3D reconstructions, polymer staining) and a strong personal interest in topological defects in polymer particles.

I am open to collaborations and peer review requests in any of the area of studies listed above.

Below are some of my recent selected publications (in no particular order):

  • Wong* et al. J. Am. Chem. Soc. 2020, 142, 10989–10995
    • Paper on the discovery of topological defects in polymer hexosomes - https://pubs.acs.org/doi/abs/10.1021/jacs.0c02009
  • Wong et al. Angew. Chem. Int. Ed. 2019, 58, 7335 –7340
    • Paper describing a methodology to encapsulate molecules into two separate compartments which are only tens of nanometres apart -https://onlinelibrary.wiley.com/doi/epdf/10.1002/anie.201901880
  • Wong* et al. Chem. Soc. Rev. 201948, 4019-4035
    • Tutorial review on non-spherical polymersomes - https://pubs.rsc.org/en/content/articlelanding/2019/CS/C8CS00856F
  • Wong et al. Prog. Polym. Sci. 2020, 102, 101211
    • Review on making internally ordered microparticles from block copolymers - https://www.sciencedirect.com/science/article/pii/S0079670020300046
  • Qiang, Wong* et al. Angew. Chem. Int. Ed. 202160, 21668-21672
    • Paper describing a method to produce size-controlled janus polymer discs - https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202105235

 

Location
SEB level 7

Publications

  • Journal articles | 2021
    Qiang X; Franzka S; Quintieri G; Dai X; Wong CK; Gröschel AH, 2021, 'Size-Controlled Formation of Polymer Janus Discs.', Angew Chem Int Ed Engl, vol. 60, pp. 21668 - 21672, http://dx.doi.org/10.1002/anie.202105235
    Journal articles | 2021
    Qiang X; Franzka S; Quintieri G; Dai X; Wong CK; Gröschel AH, 2021, 'Size‐Controlled Formation of Polymer Janus Discs', Angewandte Chemie, vol. 133, pp. 21836 - 21840, http://dx.doi.org/10.1002/ange.202105235
    Journal articles | 2021
    Ganda S; Wong CK; Stenzel MH, 2021, 'Corona-Loading Strategies for Crystalline Particles Made by Living Crystallization-Driven Self-Assembly', Macromolecules, vol. 54, pp. 6662 - 6669, http://dx.doi.org/10.1021/acs.macromol.1c00643
    Journal articles | 2021
    Chen C; Janoszka N; Wong CK; Gramse C; Weberskirch R; Gröschel AH, 2021, 'Scalable and Recyclable All-Organic Colloidal Cascade Catalysts.', Angew Chem Int Ed Engl, vol. 60, pp. 237 - 241, http://dx.doi.org/10.1002/anie.202008104
    Journal articles | 2021
    Chen C; Janoszka N; Wong CK; Gramse C; Weberskirch R; Gröschel AH, 2021, 'Skalierbare und wiederverwertbare organische Kolloide als Kaskadenkatalysatoren', Angewandte Chemie, vol. 133, pp. 240 - 245, http://dx.doi.org/10.1002/ange.202008104
    Journal articles | 2020
    Wong CK; Qiang X; Müller AHE; Gröschel AH, 2020, 'Self-Assembly of block copolymers into internally ordered microparticles', Progress in Polymer Science, vol. 102, pp. 101211 - 101211, http://dx.doi.org/10.1016/j.progpolymsci.2020.101211
    Journal articles | 2020
    Wong CK; Heidelmann M; Dulle M; Qiang X; Förster S; Stenzel MH; Gröschel AH, 2020, 'Vesicular Polymer Hexosomes Exhibit Topological Defects', Journal of the American Chemical Society, vol. 142, pp. 10989 - 10995, http://dx.doi.org/10.1021/jacs.0c02009
    Journal articles | 2020
    Tjandra KC; Forest CR; Wong CK; Alcantara S; Kelly HG; Ju Y; Stenzel MH; McCarroll JA; Kavallaris M; Caruso F; Kent SJ; Thordarson P, 2020, 'Modulating the Selectivity and Stealth Properties of Ellipsoidal Polymersomes through a Multivalent Peptide Ligand Display', Advanced Healthcare Materials, vol. 9, http://dx.doi.org/10.1002/adhm.202000261
    Journal articles | 2020
    Gröschel TI; Wong CK; Haataja JS; Dias MA; Gröschel AH, 2020, 'Direct Observation of Topological Defects in Striped Block Copolymer Discs and Polymersomes.', ACS Nano, vol. 14, pp. 4829 - 4838, http://dx.doi.org/10.1021/acsnano.0c00718
    Journal articles | 2020
    Nghiem T-L; Chakroun R; Janoszka N; Chen C; Klein K; Wong CK; Gröschel AH, 2020, 'pH-Controlled Hierarchical Assembly/Disassembly of Multicompartment Micelles in Water.', Macromol Rapid Commun, vol. 41, pp. e2000301, http://dx.doi.org/10.1002/marc.202000301
    Journal articles | 2019
    Piloni A; Wong CK; Chen F; Lord M; Walther A; Stenzel MH, 2019, 'Surface roughness influences the protein corona formation of glycosylated nanoparticles and alter their cellular uptake', Nanoscale, vol. 11, pp. 23259 - 23267, http://dx.doi.org/10.1039/c9nr06835j
    Journal articles | 2019
    Wong CK; Martin AD; Floetenmeyer M; Parton RG; Stenzel MH; Thordarson P, 2019, 'Faceted polymersomes: A sphere-to-polyhedron shape transformation', Chemical Science, vol. 10, pp. 2725 - 2731, http://dx.doi.org/10.1039/c8sc04206c
    Journal articles | 2019
    Wong S; Zhao J; Cao C; Wong CK; Kuchel RP; De Luca S; Hook JM; Garvey CJ; Smith S; Ho J; Stenzel MH, 2019, 'Just add sugar for carbohydrate induced self-assembly of curcumin', Nature Communications, vol. 10, http://dx.doi.org/10.1038/s41467-019-08402-y
    Journal articles | 2019
    Wong CK; Chen F; Walther A; Stenzel MH, 2019, 'Bioactive Patchy Nanoparticles with Compartmentalized Cargoes for Simultaneous and Trackable Delivery', Angewandte Chemie, vol. 131, pp. 7413 - 7418, http://dx.doi.org/10.1002/ange.201901880
    Journal articles | 2019
    Wong CK; Chen F; Walther A; Stenzel MH, 2019, 'Bioactive Patchy Nanoparticles with Compartmentalized Cargoes for Simultaneous and Trackable Delivery', Angewandte Chemie - International Edition, vol. 58, pp. 7335 - 7340, http://dx.doi.org/10.1002/anie.201901880
    Journal articles | 2019
    Wong CK; Stenzel MH; Thordarson P, 2019, 'Non-spherical polymersomes: Formation and characterization', Chemical Society Reviews, vol. 48, pp. 4019 - 4035, http://dx.doi.org/10.1039/c8cs00856f
    Journal articles | 2017
    Wong CK; Mason AF; Stenzel MH; Thordarson P, 2017, 'Formation of non-spherical polymersomes driven by hydrophobic directional aromatic perylene interactions', Nature Communications, vol. 8, http://dx.doi.org/10.1038/s41467-017-01372-z
    Journal articles | 2015
    Wong CK; Laos AJ; Soeriyadi AH; Wiedenmann J; Curmi PMG; Gooding JJ; Marquis CP; Stenzel MH; Thordarson P, 2015, 'Polymersomes Prepared from Thermoresponsive Fluorescent Protein-Polymer Bioconjugates: Capture of and Report on Drug and Protein Payloads', Angewandte Chemie, vol. 127, pp. 5407 - 5412, http://dx.doi.org/10.1002/ange.201412406
    Journal articles | 2015
    Wong CK; Laos AJ; Soeriyadi AH; Wiedenmann J; Curmi PMG; Gooding JJ; Marquis CP; Stenzel MH; Thordarson P, 2015, 'Polymersomes prepared from thermoresponsive fluorescent protein-polymer bioconjugates: Capture of and report on drug and protein payloads', Angewandte Chemie - International Edition, vol. 54, pp. 5317 - 5322, http://dx.doi.org/10.1002/anie.201412406
    Journal articles | 2015
    Jiang Y; Wong CK; Stenzel MH, 2015, 'An Oligonucleotide Transfection Vector Based on HSA and PDMAEMA Conjugation: Effect of Polymer Molecular Weight on Cell Proliferation and on Multicellular Tumor Spheroids', Macromolecular Bioscience, vol. 15, pp. 965 - 978, http://dx.doi.org/10.1002/mabi.201500006

Awards

Alexander von Humboldt Fellow, University of Duisburg-Essen and University of Münster, Germany (2019-2020)

Grants

Media