Dr Chin Ken Wong
Research Associate

Dr Chin Ken Wong

PhD, Chemistry (UNSW) 2018

Science
School of Chemistry

I am a currently a postdoc in the School of Chemistry at UNSW Sydney. Prior to this appointment, I held an Alexander von Humboldt Fellowship (2019-2020) at the University of Münster in Germany.

Link to personal hompage: https://sites.google.com/view/chinkenwong/home

My research interest primarily focuses on innovating approaches to self-assemble block copolymers into complex architectures. Some self-assembly concepts/topics, which I have expertise in, include (i) polymersome (polymer vesicle) shape transformation, (i) hierarchical self-assembly at nanometre to micrometre length scale, and (iii) inverted polymer morphologies such as cubosomes and hexosomes. More recently, I have ventured into using continuous flow setups to explore end-to-end manufacturing of polymer nanoparticles.

Besides my knowledge in block copolymer self-assembly, I have years of experience in soft matter electron microscopy (cryo-TEM, cryo-ET, 3D reconstructions, polymer staining) and a strong personal interest in topological defects in polymer particles.

I am open to collaborations and peer review requests in any of the area of studies listed above.

Below are some of my recent selected publications (in no particular order):

  • Wong* et al. J. Am. Chem. Soc. 2020, 142, 10989–10995
    • Paper on the discovery of topological defects in polymer hexosomes - https://pubs.acs.org/doi/abs/10.1021/jacs.0c02009
  • Wong et al. Angew. Chem. Int. Ed. 2019, 58, 7335 –7340
    • Paper describing a methodology to encapsulate molecules into two separate compartments which are only tens of nanometres apart -https://onlinelibrary.wiley.com/doi/epdf/10.1002/anie.201901880
  • Wong* et al. Chem. Soc. Rev. 201948, 4019-4035
    • Tutorial review on non-spherical polymersomes - https://pubs.rsc.org/en/content/articlelanding/2019/CS/C8CS00856F
  • Wong et al. Prog. Polym. Sci. 2020, 102, 101211
    • Review on making internally ordered microparticles from block copolymers - https://www.sciencedirect.com/science/article/pii/S0079670020300046
  • Qiang, Wong* et al. Angew. Chem. Int. Ed. 202160, 21668-21672
    • Paper describing a method to produce size-controlled janus polymer discs - https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202105235

 

 

Location
SEB level 7
  • Journal articles | 2022
    Ganda S; Wong CK; Biazik J; Raveendran R; Zhang L; Chen F; Ariotti N; Stenzel MH, 2022, 'Macrophage-Targeting and Complete Lysosomal Degradation of Self-assembled Two-Dimensional Poly(ϵ-caprolactone) Platelet Particles', ACS Applied Materials and Interfaces, vol. 14, pp. 35333 - 35343, http://dx.doi.org/10.1021/acsami.2c06555
    Journal articles | 2021
    Chen C; Janoszka N; Wong CK; Gramse C; Weberskirch R; Gröschel AH, 2021, 'Scalable and Recyclable All-Organic Colloidal Cascade Catalysts.', Angew Chem Int Ed Engl, vol. 60, pp. 237 - 241, http://dx.doi.org/10.1002/anie.202008104
    Journal articles | 2021
    Chen C; Janoszka N; Wong CK; Gramse C; Weberskirch R; Gröschel AH, 2021, 'Skalierbare und wiederverwertbare organische Kolloide als Kaskadenkatalysatoren', Angewandte Chemie, vol. 133, pp. 240 - 245, http://dx.doi.org/10.1002/ange.202008104
    Journal articles | 2021
    Ganda S; Wong CK; Stenzel MH, 2021, 'Corona-Loading Strategies for Crystalline Particles Made by Living Crystallization-Driven Self-Assembly', Macromolecules, vol. 54, pp. 6662 - 6669, http://dx.doi.org/10.1021/acs.macromol.1c00643
    Journal articles | 2021
    Qiang X; Franzka S; Quintieri G; Dai X; Wong CK; Gröschel AH, 2021, 'Size-Controlled Formation of Polymer Janus Discs.', Angew Chem Int Ed Engl, vol. 60, pp. 21668 - 21672, http://dx.doi.org/10.1002/anie.202105235
    Journal articles | 2021
    Qiang X; Franzka S; Quintieri G; Dai X; Wong CK; Gröschel AH, 2021, 'Size‐Controlled Formation of Polymer Janus Discs', Angewandte Chemie, vol. 133, pp. 21836 - 21840, http://dx.doi.org/10.1002/ange.202105235
    Journal articles | 2020
    Gröschel TI; Wong CK; Haataja JS; Dias MA; Gröschel AH, 2020, 'Direct Observation of Topological Defects in Striped Block Copolymer Discs and Polymersomes.', ACS Nano, vol. 14, pp. 4829 - 4838, http://dx.doi.org/10.1021/acsnano.0c00718
    Journal articles | 2020
    Nghiem T-L; Chakroun R; Janoszka N; Chen C; Klein K; Wong CK; Gröschel AH, 2020, 'pH-Controlled Hierarchical Assembly/Disassembly of Multicompartment Micelles in Water.', Macromol Rapid Commun, vol. 41, pp. e2000301, http://dx.doi.org/10.1002/marc.202000301
    Journal articles | 2020
    Tjandra KC; Forest CR; Wong CK; Alcantara S; Kelly HG; Ju Y; Stenzel MH; McCarroll JA; Kavallaris M; Caruso F; Kent SJ; Thordarson P, 2020, 'Modulating the Selectivity and Stealth Properties of Ellipsoidal Polymersomes through a Multivalent Peptide Ligand Display', Advanced Healthcare Materials, vol. 9, http://dx.doi.org/10.1002/adhm.202000261
    Journal articles | 2020
    Wong CK; Heidelmann M; Dulle M; Qiang X; Förster S; Stenzel MH; Gröschel AH, 2020, 'Vesicular Polymer Hexosomes Exhibit Topological Defects', Journal of the American Chemical Society, vol. 142, pp. 10989 - 10995, http://dx.doi.org/10.1021/jacs.0c02009
    Journal articles | 2020
    Wong CK; Qiang X; Müller AHE; Gröschel AH, 2020, 'Self-Assembly of block copolymers into internally ordered microparticles', Progress in Polymer Science, vol. 102, pp. 101211 - 101211, http://dx.doi.org/10.1016/j.progpolymsci.2020.101211
    Journal articles | 2019
    Piloni A; Wong CK; Chen F; Lord M; Walther A; Stenzel MH, 2019, 'Surface roughness influences the protein corona formation of glycosylated nanoparticles and alter their cellular uptake', Nanoscale, vol. 11, pp. 23259 - 23267, http://dx.doi.org/10.1039/c9nr06835j
    Journal articles | 2019
    Wong CK; Chen F; Walther A; Stenzel MH, 2019, 'Bioactive Patchy Nanoparticles with Compartmentalized Cargoes for Simultaneous and Trackable Delivery', Angewandte Chemie - International Edition, vol. 58, pp. 7335 - 7340, http://dx.doi.org/10.1002/anie.201901880
    Journal articles | 2019
    Wong CK; Chen F; Walther A; Stenzel MH, 2019, 'Bioactive Patchy Nanoparticles with Compartmentalized Cargoes for Simultaneous and Trackable Delivery', Angewandte Chemie, vol. 131, pp. 7413 - 7418, http://dx.doi.org/10.1002/ange.201901880
    Journal articles | 2019
    Wong CK; Martin AD; Floetenmeyer M; Parton RG; Stenzel MH; Thordarson P, 2019, 'Faceted polymersomes: A sphere-to-polyhedron shape transformation', Chemical Science, vol. 10, pp. 2725 - 2731, http://dx.doi.org/10.1039/c8sc04206c
    Journal articles | 2019
    Wong CK; Stenzel MH; Thordarson P, 2019, 'Non-spherical polymersomes: Formation and characterization', Chemical Society Reviews, vol. 48, pp. 4019 - 4035, http://dx.doi.org/10.1039/c8cs00856f
    Journal articles | 2019
    Wong S; Zhao J; Cao C; Wong CK; Kuchel RP; De Luca S; Hook JM; Garvey CJ; Smith S; Ho J; Stenzel MH, 2019, 'Just add sugar for carbohydrate induced self-assembly of curcumin', Nature Communications, vol. 10, http://dx.doi.org/10.1038/s41467-019-08402-y
    Journal articles | 2017
    Wong CK; Mason AF; Stenzel MH; Thordarson P, 2017, 'Formation of non-spherical polymersomes driven by hydrophobic directional aromatic perylene interactions', Nature Communications, vol. 8, http://dx.doi.org/10.1038/s41467-017-01372-z
    Journal articles | 2015
    Jiang Y; Wong CK; Stenzel MH, 2015, 'An Oligonucleotide Transfection Vector Based on HSA and PDMAEMA Conjugation: Effect of Polymer Molecular Weight on Cell Proliferation and on Multicellular Tumor Spheroids', Macromolecular Bioscience, vol. 15, pp. 965 - 978, http://dx.doi.org/10.1002/mabi.201500006
    Journal articles | 2015
    Wong CK; Laos AJ; Soeriyadi AH; Wiedenmann J; Curmi PMG; Gooding JJ; Marquis CP; Stenzel MH; Thordarson P, 2015, 'Polymersomes Prepared from Thermoresponsive Fluorescent Protein-Polymer Bioconjugates: Capture of and Report on Drug and Protein Payloads', Angewandte Chemie, vol. 127, pp. 5407 - 5412, http://dx.doi.org/10.1002/ange.201412406
    Journal articles | 2015
    Wong CK; Laos AJ; Soeriyadi AH; Wiedenmann J; Curmi PMG; Gooding JJ; Marquis CP; Stenzel MH; Thordarson P, 2015, 'Polymersomes prepared from thermoresponsive fluorescent protein-polymer bioconjugates: Capture of and report on drug and protein payloads', Angewandte Chemie - International Edition, vol. 54, pp. 5317 - 5322, http://dx.doi.org/10.1002/anie.201412406

Alexander von Humboldt Fellow, University of Duisburg-Essen and University of Münster, Germany (2019-2020)

Explore Materials Chain (EXMAC) International Postdoc Travel Grant (2018)

Australian Centre for Nanomedicine Seed Funding (2018)

Australian Centre for Nanomedicine Seed Funding (2016)

Australian Synchrotron Competitive Beamtime and Travel Funding (2016)