Dr Daisy Shu
Senior Lecturer

Dr Daisy Shu

  • Postdoctoral Training 2019-2022, Saint-Geniez Lab, Harvard Medical School
  • PhD 2015-2019, Lovicu Lab, The University of Sydney
  • BOptom (Hons), BSci 2008-2012, UNSW
Medicine & Health
School of Optometry and Vision Science

Dr. Daisy Shu is a Scientia Senior Lecturer in the School of Optometry and Vision Science at the University of New South Wales in 2023. The Shu lab explores the role of mitochondria and metabolism in retinal eye diseases including age-related macular degeneration and proliferative vitreoretinopathy. She is focused on the molecular mechanisms of epithelial-mesenchymal transition and endothelial-mesenchymal transition in lens and retinal disease. Dr. Shu is the course convener for OPTM6423 (Therapeutics and the Posterior Eye) for Masters Optometry students. Dr. Shu graduated with a Bachelor of Optometry and Vision Science in 2012 from UNSW Sydney and a PhD in 2019 at the University of Sydney under the mentorship of Prof. Frank Lovicu, concentrating on growth factor signaling pathways in cataract formation. Dr. Shu completed her postdoctoral training in molecular mechanisms underpinning age-related macular degeneration under the mentorship of Dr. Magali Saint-Geniez at Harvard Medical School in 2022 and was promoted to Faculty Instructor in the Department of Ophthalmology of Harvard Medical School at Schepens Eye Research Institute of Mass Eye and Ear.

Dr. Shu serves many leadership roles including Vice President for International Society of Eye Research (ISER) for the Asia-Pacific Region and serves on several committees including the ARVO Board of Trustees, ARVO Women in Eye and Vision Research (WEAVR) Leadership Committee, ARVO Professional Development and Education Committee and the ASIP Committee for Career Development. Daisy is passionate about science communication and science advocacy. Her advocacy efforts have been recognized by the ARVO Emerging Advocate Award in 2021. She co-hosts a podcast called “Behind Our Science” supported by ASIP and The Histochemical Society and actively updates her social media platforms @EyeDaisyShu on Twitter and Instagram.

Mobile
0418460073
Phone
+61-2-9348-1982
Location
School of Optometry and Vision Science, Faculty of Medicine and Health, Level 3, Room 3.059, North Wing, Rupert Myers Building UNSW SYDNEY 2052
  • Journal articles | 2023
    Fitch TC; Frank SI; Li YK; Saint-Geniez M; Kim LA; Shu DY, 2023, 'Real-Time Analysis of Bioenergetics in Primary Human Retinal Pigment Epithelial Cells Using High-Resolution Respirometry', Journal of Visualized Experiments, 2023, http://dx.doi.org/10.3791/64572
    Journal articles | 2023
    Karg MM; Moorefield M; Hoffmann E; Philipose H; Krasniqi D; Hoppe C; Shu DY; Shirahama S; Ksander BR; Saint-Geniez M, 2023, 'Correction: Microglia preserve visual function in the aging retina by supporting retinal pigment epithelial health (Immunity & Ageing, (2023), 20, 1, (53), 10.1186/s12979-023-00358-4)', Immunity and Ageing, 20, http://dx.doi.org/10.1186/s12979-023-00388-y
    Journal articles | 2023
    Karg MM; Moorefield M; Hoffmann E; Philipose H; Krasniqi D; Hoppe C; Shu DY; Shirahama S; Ksander BR; Saint-Geniez M, 2023, 'Microglia preserve visual function loss in the aging retina by supporting retinal pigment epithelial health', Immunity and Ageing, 20, http://dx.doi.org/10.1186/s12979-023-00358-4
    Journal articles | 2023
    Ng PQ; Saint-Geniez M; Kim LA; Shu DY, 2023, 'Divergent Metabolomic Signatures of TGFβ2 and TNFα in the Induction of Retinal Epithelial-Mesenchymal Transition', Metabolites, 13, http://dx.doi.org/10.3390/metabo13020213
    Journal articles | 2023
    Shu DY; Chaudhary S; Cho KS; Lennikov A; Miller WP; Thorn DC; Yang M; McKay TB, 2023, 'Role of Oxidative Stress in Ocular Diseases: A Balancing Act', Metabolites, 13, http://dx.doi.org/10.3390/metabo13020187
    Journal articles | 2023
    Shyam R; Shu DY; Zuniga-Sanchez E; Vasudevan D, 2023, 'Editorial: Molecular mechanisms in ocular development and disease', Frontiers in Cell and Developmental Biology, 11, http://dx.doi.org/10.3389/fcell.2023.1244123
    Journal articles | 2022
    Butcher ER; Shu DY; Frank S; Saint‐Geniez M, 2022, 'Mitochondrial Transplantation as a Novel Therapeutic for Retinal Metabolic Dysfunction‐Driven Disease', The FASEB Journal, 36, http://dx.doi.org/10.1096/fasebj.2022.36.s1.r2669
    Journal articles | 2022
    Karg MM; Moorefield M; Hoffmann E; Shu D; Krasniqi D; Philipose H; Ksander BR; Saint‐Geniez M, 2022, 'Microglia Prevent the Loss of Visual Function in the Aging Retina by Maintaining the Health of Retinal Pigment Epithelial Cells', The FASEB Journal, 36, http://dx.doi.org/10.1096/fasebj.2022.36.s1.r5839
    Journal articles | 2022
    Shu DY; Frank SI; Fitch TC; Karg MM; Butcher ER; Nnuji-John E; Kim LA; Saint-Geniez M, 2022, 'Dimethyl Fumarate Blocks Tumor Necrosis Factor-Alpha-Driven Inflammation and Metabolic Rewiring in the Retinal Pigment Epithelium', Frontiers in Molecular Neuroscience, 15, http://dx.doi.org/10.3389/fnmol.2022.896786
    Journal articles | 2022
    Shu DY; Frank SI; Karg MM; Butcher ER; Nnuji‐John E; Shah R; Gollapalli D; Saint‐Geniez M, 2022, 'Contrasting Metabolic Profiles of TGFβ2 and TNFα in the Induction of Retinal Epithelial‐Mesenchymal Transition (EMT)', The FASEB Journal, 36, http://dx.doi.org/10.1096/fasebj.2022.36.s1.0r785
    Journal articles | 2021
    Shu D; Butcher E; Cai S; Senthilkumar I; Frank S; Gollapalli D; Saint‐Geniez M, 2021, 'Metabolic Reprogramming of the Retinal Pigment Epithelium Drives TGFβ2‐Induced Epithelial‐Mesenchymal Transition', The FASEB Journal, 35, http://dx.doi.org/10.1096/fasebj.2021.35.s1.03272
    Journal articles | 2021
    Shu DY; Butcher ER; Saint-Geniez M, 2021, 'Suppression of pgc-1α drives metabolic dysfunction in tgfβ2-induced emt of retinal pigment epithelial cells', International Journal of Molecular Sciences, 22, http://dx.doi.org/10.3390/ijms22094701
    Journal articles | 2021
    Shu DY; Lovicu FJ, 2021, 'Insights into bone morphogenetic protein—(BMP-) signaling in ocular lens biology and pathology', Cells, 10, http://dx.doi.org/10.3390/cells10102604
    Journal articles | 2021
    Shu DY; Ng K; Wishart TFL; Chui J; Lundmark M; Flokis M; Lovicu FJ, 2021, 'Contrasting roles for BMP-4 and ventromorphins (BMP agonists) in TGFβ-induced lens EMT', Experimental Eye Research, 206, http://dx.doi.org/10.1016/j.exer.2021.108546
    Journal articles | 2021
    Wishart TFL; Flokis M; Shu DY; Das SJ; Lovicu FJ, 2021, 'Hallmarks of lens aging and cataractogenesis', Experimental Eye Research, 210, http://dx.doi.org/10.1016/j.exer.2021.108709
    Journal articles | 2020
    Lovicu FJ; Flokis M; Wojciechowski M; Mao B; Shu D, 2020, 'Understanding Fibrotic Cataract: Regulation of TGFβ-Mediated Pathways Leading to Lens Epithelial to Mesenchymal Transition (EMT)', 日本白内障学会誌, 32, pp. 23 - 32, http://dx.doi.org/10.14938/cataract.12-004
    Journal articles | 2020
    Ong K; Shu D, 2020, 'Evaluating the difference between autorefraction and subjective refraction may guide “fudge factor” for IOL power selection for cataract surgery after previous LASIK', Asian Journal of Ophthalmology, 17, pp. 98 - 100
    Journal articles | 2020
    Saint-Geniez M; Cai S; Satish S; Senthilkumar I; Shu DY; Butcher E; Frank S, 2020, 'Pathological induction of PGC‐1β by RelB/NF‐κB promotes RPE oxidative damage and choroidal neovascularization', The FASEB Journal, 34, pp. 1 - 1, http://dx.doi.org/10.1096/fasebj.2020.34.s1.05249
    Journal articles | 2020
    Shu DY; Butcher E; Cai S; Senthilkumar I; Frank S; Saint-Geniez M, 2020, 'Paradoxical Effect of TNFα on Mitochondrial Function and Metabolic Activity in the Retinal Pigment Epithelium (RPE)', The FASEB Journal, 34, pp. 1 - 1, http://dx.doi.org/10.1096/fasebj.2020.34.s1.02450
    Journal articles | 2020
    Shu DY; Butcher E; Saint-Geniez M, 2020, 'EMT and ENDMT: Emerging roles in age-related macular degeneration', International Journal of Molecular Sciences, 21, pp. 1 - 26, http://dx.doi.org/10.3390/ijms21124271
    Journal articles | 2020
    Zheng Q; Jones FK; Leavitt SV; Ung L; Labrique AB; Peters DH; Lee EC; Azman AS; Adhikari B; Wahl B; Sarnowski C; Antiporta DA; Erchick DJ; Perez-Saez J; Ssekasanvu J; Lee KH; White L; Kostandova NS; Menezes NP; Albaugh NW; Gupta N; Jiwani SS; Hegde ST; Srivastava S; Aung T; Zhang Y; Norton G; Kalra A; Khaitan A; Shah D; Kaur J; Kasi K; Patel L; Dhingra LS; Agarwal M; Garg S; Goel U; Gill VJS; Khan E; Patwari A; Khaloo P; Joshi D; Blagg E; Pence E; Nelson HK; Fan J; Forbes L; Schlussel M; Etyemez S; Song S; Mohan U; Sun Y; Jang S; Frumento N; Sivakumar A; Hartner AM; Karandikar V; Yan Z; Beiter ER; Song J; Wedlund L; Singer M; Rahman RS; Virk ZM; Abar A; Tiu B; Adamson TM; Paudel K; Yao H; Wang Y; Li-Rodenborn ER; Ozdemir I; McLean MG; Rattigan S; Borgert BA; Moreno CA; Quigley NE; Li C; Kaur N; Gimbrone C; Scales SE; Zuniga-Moya JC; Babigumira PA; Igwe CC; Wang HE; Hsieh L; Misra S; Bruton K; Byng D; Miranda-Schaeubinger M; Uddin MN; Ticehurst JR; Laney E; Bhadauria A; Gupta V; Selles MC; Kartik A; Singh A; Garg D; Saini J, 2020, 'HIT-COVID, a global database tracking public health interventions to COVID-19', Scientific Data, 7, http://dx.doi.org/10.1038/s41597-020-00610-2
    Journal articles | 2019
    Ong K; Ong RM; Shu D, 2019, 'Diluting 5-fluorouracil with normal saline reduces patient discomfort', Asian Journal of Ophthalmology, 16, pp. 229 - 230
    Journal articles | 2019
    Rosales MAB; Shu DY; Iacovelli J; Saint-Geniez M, 2019, 'Erratum: Correction: Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration (Life science alliance (2019) 2 3 PII: e201900436)', Life science alliance, 2, http://dx.doi.org/10.26508/lsa.201900436
    Journal articles | 2019
    Rosales MAB; Shu DY; Iacovelli J; Saint-Geniez M, 2019, 'Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration', Life Science Alliance, 2, http://dx.doi.org/10.26508/lsa.201800212
    Journal articles | 2019
    Shu DY; Hutcheon AEK; Zieske JD; Guo X, 2019, 'Epidermal Growth Factor Stimulates Transforming Growth Factor-Beta Receptor Type II Expression In Corneal Epithelial Cells', Scientific Reports, 9, http://dx.doi.org/10.1038/s41598-019-42969-2
    Journal articles | 2019
    Shu DY; Lovicu FJ, 2019, 'Enhanced EGF receptor-signaling potentiates TGFβ-induced lens epithelial-mesenchymal transition', Experimental Eye Research, 185, http://dx.doi.org/10.1016/j.exer.2019.107693
    Journal articles | 2019
    Shu DY; Wojciechowski M; Lovicu FJ, 2019, 'ERK1/2-mediated EGFR-signaling is required for TGFβ-induced lens epithelial-mesenchymal transition', Experimental Eye Research, 178, pp. 108 - 121, http://dx.doi.org/10.1016/j.exer.2018.09.021
    Journal articles | 2018
    Wojciechowski MC; Shu DY; Lovicu FJ, 2018, 'ERK1/2-Dependent Gene Expression Contributing to TGFβ-Induced Lens EMT', Current Eye Research, 43, pp. 986 - 997, http://dx.doi.org/10.1080/02713683.2018.1464193
    Journal articles | 2017
    Kichkin E; Visvanathan A; Lovicu FJ; Shu DY; Das SJ; Reddel SW; McCann EP; Zhang KY; Williams KL; Blair IP; Phillips WD, 2017, 'Postnatal Development of Spasticity Following Transgene Insertion in the Mouse βIV Spectrin Gene (SPTBN4)', Journal of Neuromuscular Diseases, 4, pp. 159 - 164, http://dx.doi.org/10.3233/JND-160197
    Journal articles | 2017
    Shu DY; Lovicu FJ, 2017, 'Myofibroblast transdifferentiation: The dark force in ocular wound healing and fibrosis', Progress in Retinal and Eye Research, 60, pp. 44 - 65, http://dx.doi.org/10.1016/j.preteyeres.2017.08.001
    Journal articles | 2017
    Shu DY; Wojciechowski MC; Lovicu FJ, 2017, 'Bone morphogenetic protein-7 suppresses TGFβ2-induced epithelial-mesenchymal transition in the lens: Implications for cataract prevention', Investigative Ophthalmology and Visual Science, 58, pp. 781 - 796, http://dx.doi.org/10.1167/iovs.16-20611
    Journal articles | 2017
    Wojciechowski MC; Mahmutovic L; Shu DY; Lovicu FJ, 2017, 'ERK1/2 signaling is required for the initiation but not progression of TGFβ-induced lens epithelial to mesenchymal transition (EMT)', Experimental Eye Research, 159, pp. 98 - 113, http://dx.doi.org/10.1016/j.exer.2017.03.012
  • Conference Papers | 2017
    Shu DY; Ong K; Lovicu FJ, 2017, 'Histopathology of Subcapsular Cataract in a Patient with Atopic Dermatitis', in Optometry and Vision Science, pp. 270 - 276, http://dx.doi.org/10.1097/OPX.0000000000001011
    Reports |
    Daisy Shu DS, How do cataracts form and how can they be prevented?, Experiment, http://dx.doi.org/10.18258/9993, http://dx.doi.org/10.18258/9993

2019: Shu DY. Cancer Research Foundation Cell Imaging Grant for the EVOS M7000 Imaging System (AMF7000), USD$78, 315, Thermo Fisher Scientific

July 2020 – July 2021: Shu DY. Fight for Sight Leonard & Robert Weintraub Postdoctoral Fellowship, USD$22, 500. Fight for Sight United States

July 2021 – July 2023: Shu DY. Postdoctoral Fellowship Program in Macular Degeneration Research, USD$200, 000. BrightFocus Foundation

2022-2022: Shu DY. Interstellar Initiative by the Japan Agency for Medical Research and Development (AMED) and the New York Academy of Sciences. The initiative aims to increase international and interdisciplinary collaboration uniting scientists within the early stages of their careers and catalyzing scientific advancement 2700000JPY (18598USD). nyas.org/interstellar

2023-2026: Kim LA & Shu DY. The Role of the Rho-Kinase Pathway in Proliferative Vitreoretinopathy. Department of Defence Congressionally Directed Medical Research Programs Vision Research Program Investigator-Initiated Research Award ($500K USD)

2021: ProteinTech Best Postdoc Mentor Award Finalist 2021 (Link)

2021: ARVO Emerging Advocate Award (Link)

2024: ASIP Young Scientist Leadership Award (Link).

 

  1. Shu DY, Ong K, Lovicu FJ. Histopathology of subcapsular cataract in a patient with atopic dermatitis. Optometry and Vision Science 2017; 94(2): 270-276. (Link)
  2. Shu DY, Wojciechowski M, Lovicu FJ. Bone morphogenetic protein (BMP)-7 suppresses TGFβ2-induced epithelial-mesenchymal transition (EMT) in the lens: implications for cataract prevention. Investigative Ophthalmology and Visual Science 2017; 58(2): 781-796. (Link)
  3. Wojciechowski M, Mahmutovic L, Shu DY, Lovicu FJ. ERK1/2 signaling is required for the initiation but not progression of TGFβ-induced lens epithelial to mesenchymal transition (EMT). Experimental Eye Research 2017; 159:98-113. (Link)
  4. Kichkin E, Visvanathan A, Lovicu FJ, Shu DY, Das SJ, Reddel SW, McCann EP, Zhang KY, Williams KL, Blair IP, Phillips WD. Postnatal development of spasticity following transgene insertion in the mouse βIV spectrin gene (SPTBN4). Journal of Neuromuscular Diseases 2017; 4(2): 159-164. (Link)
  5. Shu DY, Lovicu FJ. Myofibroblast transdifferentiation: the dark force in ocular wound healing and fibrosis. Progress in Retina and Eye Research 2017; 60: 44-65. (Link)
  6. Wojciechowski M, Shu DY, Lovicu FJ. ERK1/2-dependent gene expression contributing to TGFβ-induced lens EMT. Current Eye Research 2018; doi: 10.1080/02713683.2018.1464193. (Link)
  7. Shu DY, Wojciechowski M, Lovicu FJ. ERK1/2-mediated EGFR-signaling is required for TGFβ-induced lens epithelial-mesenchymal transition. Experimental Eye Research 2019; 178: 108-121. (Link)
  8. Rosales MA, Shu DY, Iacovelli J, Saint-Geniez M. Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration. Life Science Alliance. 2019; 2(3):e201800212. (Link)
  9. Shu DY, Hutcheon, AEK, Zieske, JD, Guo, XQ. Epidermal growth factor stimulates transforming growth factor-beta receptor type II expression in corneal epithelial cells. Scientific Reports. 2019; 9.8079: 1-11. (Link)
  10. Shu DY, Lovicu, FJ. Enhanced EGF receptor-signaling potentiates TGFβ-induced lens epithelial-mesenchymal transition. Experimental Eye Research. 2019; 185: 1-9. (Link)
  11. Shu DY, Butcher E, Saint-Geniez M. EMT and EndMT: Emerging Roles in Age-Related Macular Degeneration. International Journal of Molecular Sciences. 2020; 21(12), 4271. (Link)
  12. Zheng Q, Jones FK, Leavitt SV, Ung L, Labrique A, Peters D, Lee E, Azman A, HIT-COVID Collaboration. HIT-COVID, a global database tracking public health interventions to COVID-19. Scientific Data. 2020; 7, 286. (Link)
  13. Shu DY, Ng K, Wishart TFL, Chui J, Lundmark M, Flokis M, Lovicu FJ. Contrasting roles for BMP-4 and ventromorphins (BMP agonists) in TGFβ-induced lens EMT. Exp Eye Res. 2021 Mar 24;206:108546. doi: 10.1016/j.exer.2021.108546. Epub ahead of print. PMID: 33773977. (Link)
  14. Shu DY, Butcher ER, Saint-Geniez M. Suppression of PGC-1α Drives Metabolic Dysfunction in TGFβ2-Induced EMT of Retinal Pigment Epithelial Cells. International Journal of Molecular Sciences. 2021; 22(9):4701. (Link)
  15. Wishart T, Flokis M, Shu DY, Das S, Lovicu FJ. Hallmarks of lens aging and cataractogenesis. Experimental Eye Research. 2021, p.108709. (Link)
  16. Shu DY and Lovicu FJ 2021. Insights into Bone Morphogenetic Protein—(BMP-) Signaling in Ocular Lens Biology and Pathology Cells 10, no. 10: 2604. https://doi.org/10.3390/cells10102604
  17. Shu DY, Frank SI, Fitch TC, Karg MM, Butcher ER, Nnuji-John E, Kim LA and Saint-Geniez M (2022) Dimethyl Fumarate Blocks Tumor Necrosis Factor-Alpha-Driven Inflammation and Metabolic Rewiring in the Retinal Pigment Epithelium. Front. Mol. Neurosci. 15:896786. doi: 10.3389/fnmol.2022.896786
  18. Fitch TC, Frank SI, Li KY, Saint-Geniez M, Kim LA, Shu DY. Real-Time Analysis of Bioenergetics in Primary Human Retinal Pigment Epithelial Cells Using High-Resolution Respirometry. J. Vis. Exp. e64572, In-press (2023) https://www.jove.com/t/64572
  19. Shu DY, Chaudhary S, Cho KS, Lennikov A, Miller WP, Thorn DC, Yang M, McKay TB. Role of Oxidative Stress in Ocular Diseases: A Balancing Act. Metabolites 2023, 13, 187. https://doi.org/10.3390/metabo13020187
  20. Ng PQ, Saint-Geniez M, Kim LA, Shu DY. Divergent Metabolomic Signatures of TGFβ2 and TNFα in the Induction of Retinal Epithelial-Mesenchymal Transition. Metabolites. 2023; 13(2):213. https://doi.org/10.3390/metabo13020213
  21. Shyam R, Shu DY, Zuniga-Sanchez E and Vasudevan D (2023) Editorial: Molecular mechanisms in ocular development and disease. Front. Cell Dev. Biol. 11:1244123. doi: 10.3389/fcell.2023.1244123. https://www.frontiersin.org/articles/10.3389/fcell.2023.1244123/full

My online NCBI Bibliography can be accessed here.

 

My Teaching

Course Convener for OPTM6423 Therapeutics and the Posterior Eye