Dr David Croucher

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David completed his undergraduate studies and PhD research at the University of Wollongong, followed by a post-doctoral position at the Garvan Institute, focusing on the functional characterisation of individual proteins in the behaviour of cancer cells. Pursuing the idea that these cancer-related proteins do not act in isolation, but are instead embedded within dynamic networks, David undertook a second post-doctoral position at Systems Biology Ireland in University College Dublin.

After establishing a research group at Systems Biology Ireland, David received a Future Research Leader grant from Cancer Institute NSW and returned to the Garvan Institute as head of the Network Biology group. His research group now focuses on combining computational modelling with novel proteomic and single-cell technologies to investigate how alterations in dynamic signalling networks can lead to tumour progression and therapeutic resistance.

Phone

+61 2 9355 5820

E-mail

d.croucher@garvan.org.au

Location

Network Biology Garvan Institute of Medical Research St Vincent’s Clinical School UNSW Medicine, UNSW Sydney

Book Chapters | 2021

Filipe EC; Parker AL; Cadell AL; Major G; Croucher DR; Cox TR, 2021, 'In Vitro 3D Models of Tunable Stiffness', in Metastasis: Methods and Protocols, United States, pp. 27 - 42, http://dx.doi.org/10.1007/978-1-0716-1350-4_3

Book Chapters | 2012

Fey D; Croucher DR; Kolch W; Kholodenko BN, 2012, 'Understanding cell fate decisions by identifying crucial system dynamics', in SEMA SIMAI Springer Series, edn. 9788847025707, pp. 83 - 104, http://dx.doi.org/10.1007/978-88-470-2571-4_5
Journal articles | 2023

Chitty JL; Yam M; Perryman L; Parker AL; Skhinas JN; Setargew YFI; Mok ETY; Tran E; Grant RD; Latham SL; Pereira BA; Ritchie SC; Murphy KJ; Trpceski M; Findlay AD; Melenec P; Filipe EC; Nadalini A; Velayuthar S; Major G; Wyllie K; Papanicolaou M; Ratnaseelan S; Phillips PA; Sharbeen G; Youkhana J; Russo A; Blackwell A; Hastings JF; Lucas MC; Chambers CR; Reed DA; Stoehr J; Vennin C; Pidsley R; Zaratzian A; Da Silva AM; Tayao M; Charlton B; Herrmann D; Nobis M; Clark SJ; Biankin AV; Johns AL; Croucher DR; Nagrial A; Gill AJ; Grimmond SM; Chantrill LA; Chou A; Dwarte T; Metcalf XL; Jeong G; Kenyon L; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Hofmann O; Samra JS; Pavlakis N; Arena J; High HA; Asghari R; Merrett ND; Das A; Cosman PH; Ismail K; Stoita A; Williams D; Spigellman A; McLeo D; Kirk J; Kench JG; Grimison P; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forrest C; Ballal M; Fletcher D; Beilin M; Feeney K; Epari K; Mukhedkar S; Zeps N; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J, 2023, 'A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer', Nature Cancer, http://dx.doi.org/10.1038/s43018-023-00614-y

Journal articles | 2023

Conway JRW; Warren SC; Lee YK; McCulloch AT; Magenau A; Lee V; Metcalf XL; Stoehr J; Haigh K; Abdulkhalek L; Guaman CS; Reed DA; Murphy KJ; Pereira BA; Mélénec P; Chambers C; Latham SL; Lenthall H; Deenick EK; Ma Y; Phan T; Lim E; Joshua AM; Walters S; Grey ST; Shi YC; Zhang L; Herzog H; Croucher DR; Philp A; Scheele CLGJ; Herrmann D; Sansom OJ; Morton JP; Papa A; Haigh JJ; Nobis M; Timpson P, 2023, 'Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse', Science Advances, 9, pp. eadf9063, http://dx.doi.org/10.1126/sciadv.adf9063

Journal articles | 2023

Hastings JF; Latham SL; Kamili A; Wheatley MS; Han JZR; Wong-Erasmus M; Phimmachanh M; Nobis M; Pantarelli C; Cadell AL; O’Donnell YEI; Leong KH; Lynn S; Geng FS; Cui L; Yan S; Achinger-Kawecka J; Stirzaker C; Norris MD; Haber M; Trahair TN; Speleman F; De Preter K; Cowley MJ; Bogdanovic O; Timpson P; Cox TR; Kolch W; Fletcher JI; Fey D; Croucher DR, 2023, 'Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma', Science Advances, 9, pp. eabp8314, http://dx.doi.org/10.1126/sciadv.abp8314

Journal articles | 2023

Nguyen T; Lau A; Bier J; Cooke KC; Lenthall H; Ruiz-Diaz S; Avery DT; Brigden H; Zahra D; Sewell WA; Droney L; Okada S; Asano T; Abolhassani H; Chavoshzadeh Z; Abraham RS; Rajapakse N; Klee EW; Church JA; Williams A; Wong M; Burkhart C; Uzel G; Croucher DR; James DE; Ma CS; Brink R; Tangye SG; Deenick EK, 2023, 'Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2', The Journal of experimental medicine, 220, http://dx.doi.org/10.1084/jem.20221020

Journal articles | 2022

Latham SL; O'Donnell YEI; Croucher DR, 2022, 'Non-kinase targeting of oncogenic c-Jun Nterminal kinase (JNK) signaling: the future of clinically viable cancer treatments', Biochemical Society Transactions, 50, pp. 1823 - 1836, http://dx.doi.org/10.1042/BST20220808

Journal articles | 2022

Papanicolaou M; Parker AL; Yam M; Filipe EC; Wu SZ; Chitty JL; Wyllie K; Tran E; Mok E; Nadalini A; Skhinas JN; Lucas MC; Herrmann D; Nobis M; Pereira BA; Law AMK; Castillo L; Murphy KJ; Zaratzian A; Hastings JF; Croucher DR; Lim E; Oliver BG; Mora FV; Parker BL; Gallego-Ortega D; Swarbrick A; O’Toole S; Timpson P; Cox TR, 2022, 'Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis', Nature Communications, 13, pp. 4587, http://dx.doi.org/10.1038/s41467-022-32255-7

Journal articles | 2022

Raftopulos NL; Washaya TC; Niederprum A; Egert A; Hakeem-Sanni MF; Varney B; Aishah A; Georgieva ML; Olsson E; Dos Santos DZ; Nassar ZD; Cochran BJ; Nagarajan SR; Kakani MS; Hastings JF; Croucher DR; Rye K-A; Butler LM; Grewal T; Hoy AJ, 2022, 'Prostate cancer cell proliferation is influenced by LDL-cholesterol availability and cholesteryl ester turnover', CANCER & METABOLISM, 10, http://dx.doi.org/10.1186/s40170-021-00278-1

Journal articles | 2022

Walter S; Ho J; Alvarado R; Smith G; Croucher DR; Liang S; Grayson JW; Mangussi-Gomes J; Van Es SL; Earls P; Rimmer J; Campbell R; Kalish L; Sacks R; Harvey RJ, 2022, 'Mepolizumab decreases tissue eosinophils while increasing type-2 cytokines in eosinophilic chronic rhinosinusitis', Clinical and Experimental Allergy, 52, pp. 1403 - 1413, http://dx.doi.org/10.1111/cea.14152

Journal articles | 2021

Floerchinger A; Murphy KJ; Latham SL; Warren SC; McCulloch AT; Lee YK; Stoehr J; Mélénec P; Guaman CS; Metcalf XL; Lee V; Zaratzian A; Da Silva A; Tayao M; Rolo S; Phimmachanh M; Sultani G; McDonald L; Mason SM; Ferrari N; Ooms LM; Johnsson AKE; Spence HJ; Olson MF; Machesky LM; Sansom OJ; Morton JP; Mitchell CA; Samuel MS; Croucher DR; Welch HCE; Blyth K; Caldon CE; Herrmann D; Anderson KI; Timpson P; Nobis M, 2021, 'Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging', Cell Reports, 36, http://dx.doi.org/10.1016/j.celrep.2021.109689

Journal articles | 2021

Han JZR; Hastings JF; Phimmachanh M; Fey D; Kolch W; Croucher DR, 2021, 'Personalized medicine for neuroblastoma: Moving from static genotypes to dynamic simulations of drug response', Journal of Personalized Medicine, 11, http://dx.doi.org/10.3390/jpm11050395

Journal articles | 2021

Lin HM; Yeung N; Hastings JF; Croucher DR; Huynh K; Meikle TG; Mellett NA; Kwan EM; Davis ID; Tran B; Mahon KL; Zhang A; Stockler MR; Briscoe K; Marx G; Bastick P; Crumbaker ML; Joshua AM; Azad AA; Meikle PJ; Horvath LG, 2021, 'Relationship between circulating lipids and cytokines in metastatic castration‐resistant prostate cancer', Cancers, 13, pp. 4964 - 4964, http://dx.doi.org/10.3390/cancers13194964

Journal articles | 2021

Munoz M; Fletcher E; Skinner O; Jurczyluk J; Kristianto E; Hodson M; Sun S; Ebetino F; Croucher D; Hansbro P; Center J; Rogers M, 2021, 'Bisphosphonate drugs have actions outside the skeleton and inhibit the mevalonate pathway in alveolar macrophages', , http://dx.doi.org/10.1101/2021.08.09.455652

Journal articles | 2021

Munoz MA; Fletcher EK; Skinner OP; Jurczyluk J; Kristianto E; Hodson MP; Sun S; Ebetino FH; Croucher DR; Hansbro PM; Center JR; Rogers MJ, 2021, 'Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages', eLife, 10, http://dx.doi.org/10.7554/eLife.72430

Journal articles | 2021

Rajal AG; Marzec KA; McCloy RA; Nobis M; Chin V; Hastings JF; Lai K; Kennerson M; Hughes WE; Vaghjiani V; Timpson P; Cain JE; Watkins DN; Croucher DR; Burgess A, 2021, 'A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma', eLife, 10, http://dx.doi.org/10.7554/eLife.65234

Journal articles | 2020

Cipponi A; Goode DL; Bedo J; McCabe MJ; Pajic M; Croucher DR; Rajal AG; Junankar SR; Saunders DN; Lobachevsky P; Papenfuss AT; Nessem D; Nobis M; Warren SC; Timpson P; Cowley M; Vargas AC; Qiu MR; Generali DG; Keerthikumar S; Nguyen U; Corcoran NM; Long GV; Blay J-Y; Thomas DM; McCabe M, 2020, 'MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer', Science

Journal articles | 2020

Cultrone D; Zammit N; Self E; Postert B; Han JZR; Bailey J; Warren J; Croucher D; Kikuchi K; Bogdanovic O; Chtanova T; Hesselson D; Grey S, 2020, 'A zebrafish functional genomics model to investigate the role of human A20 variantsin vivo', , http://dx.doi.org/10.1101/2020.02.23.961763

Journal articles | 2020

Cultrone D; Zammit NW; Self E; Postert B; Han JZR; Bailey J; Warren J; Croucher DR; Kikuchi K; Bogdanovic O; Chtanova T; Hesselson D; Grey ST, 2020, 'A zebrafish functional genomics model to investigate the role of human A20 variants in vivo', Scientific Reports, 10, http://dx.doi.org/10.1038/s41598-020-75917-6

Journal articles | 2020

Filipčík P; Latham S; Cadell A; Day C; Croucher D; Mace P, 2020, 'A cryptic tubulin-binding domain links MEKK1 to microtubule remodelling', , http://dx.doi.org/10.1101/2020.04.07.030676

Journal articles | 2020

Filipčík P; Latham SL; Cadell AL; Day CL; Croucher DR; Mace PD, 2020, 'A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers', Proceedings of the National Academy of Sciences of the United States of America, 117, pp. 21308 - 21318, http://dx.doi.org/10.1073/pnas.2006429117

Journal articles | 2020

Gonzalez-Rajal A; Hastings JF; Watkins DN; Croucher DR; Burgess A, 2020, 'Breathing New Life into the Mechanisms of Platinum Resistance in Lung Adenocarcinoma', Frontiers in Cell and Developmental Biology, 8, http://dx.doi.org/10.3389/fcell.2020.00305

Journal articles | 2020

Gonzalez-Rajal A; Marzec KA; McCloy R; Nobis M; Chin V; Hastings JF; Lai K; Kennerson M; Hughes WE; Vaghjiani V; Timpson P; Cain JE; Neil Watkins D; Croucher DR; Burgess A, 2020, 'A Non-Genetic, Cell Cycle Dependent Mechanism of Platinum Resistance in Lung Adenocarcinoma', , http://dx.doi.org/10.1101/2020.11.26.400499

Journal articles | 2020

Hastings JF; O'Donnell YEI; Fey D; Croucher DR, 2020, 'Applications of personalised signalling network models in precision oncology', Pharmacology and Therapeutics, 212, http://dx.doi.org/10.1016/j.pharmthera.2020.107555

Journal articles | 2020

Hastings JF; Rajal AG; Latham SL; Han JZR; McCloy RA; O’donnell YEI; Phimmachanh M; Murphy AD; Nagrial A; Daneshvar D; Chin V; Watkins DN; Burgess A; Croucher DR, 2020, 'Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma', eLife, 9, pp. 1 - 25, http://dx.doi.org/10.7554/eLife.53367

Journal articles | 2020

Latham SL; Weiß N; Schwanke K; Thiel C; Croucher DR; Zweigerdt R; Manstein DJ; Taft MH, 2020, 'Myosin-18B Regulates Higher-Order Organization of the Cardiac Sarcomere through Thin Filament Cross-Linking and Thick Filament Dynamics', Cell Reports, 32, http://dx.doi.org/10.1016/j.celrep.2020.108090

Journal articles | 2020

Phimmachanh M; Han JZR; O’Donnell YEI; Latham SL; Croucher DR, 2020, 'Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma', Frontiers in Cell and Developmental Biology, 8, http://dx.doi.org/10.3389/fcell.2020.578770

Journal articles | 2020

Trevelyan SJ; Brewster JL; Burgess AE; Crowther JM; Cadell AL; Parker BL; Croucher DR; Dobson RCJ; Murphy JM; Mace PD, 2020, 'Structure-based mechanism of preferential complex formation by apoptosis signal–regulating kinases', Science Signaling, 13, http://dx.doi.org/10.1126/scisignal.aay6318

Journal articles | 2019

Castillo L; George S; Lin H-M; Yeung N; Mawson A; Young AI; Law AM; Hastings J; Gallego-Ortega D; Deng N; Croucher D; Swarbrick A; Horvath L; Ormandy CJ; Oakes SR, 2019, 'Flicking the switch off, targeting MCL-1 in the treatment of breast and prostate cancer', Oncology Abstracts, http://dx.doi.org/10.1530/oncolabs.1.p038

Journal articles | 2019

Hastings JF; Skhinas JN; Fey D; Croucher DR; Cox TR, 2019, 'The extracellular matrix as a key regulator of intracellular signalling networks', British Journal of Pharmacology, 176, pp. 82 - 92, http://dx.doi.org/10.1111/bph.14195

Journal articles | 2019

Kennedy SP; Han JZR; Portman N; Nobis M; Hastings JF; Murphy KJ; Latham SL; Cadell AL; Miladinovic D; Marriott GR; O'Donnell YEI; Shearer RF; Williams JT; Munoz AG; Cox TR; Watkins DN; Saunders DN; Timpson P; Lim E; Kolch W; Croucher DR, 2019, 'Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer', Breast Cancer Research, 21, pp. 43, http://dx.doi.org/10.1186/s13058-019-1127-y

Journal articles | 2019

Vennin C; Mélénec P; Rouet R; Nobis M; Cazet AS; Murphy KJ; Herrmann D; Reed DA; Lucas MC; Warren SC; Elgundi Z; Pinese M; Kalna G; Roden D; Samuel M; Zaratzian A; Grey ST; Da Silva A; Leung W; Johns AL; Chantrill LA; Chou A; Steinmann A; Arshi M; Dwarte T; Froio D; Pereira B; Ritchie S; Chambers CR; Metcalf X; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Grimmond SM; Hofmann O; Christ A; Bruxner T; Samra JS; Pavlakis N; High HA; Asghari R; Merrett ND; Pavey D; Das A; Cosman PH; Ismail K; O’Connnor C; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Cooper CL; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forest C; Epari KP; Ballal M; Fletcher DR; Mukhedkar S; Zeps N; Beilin M; Feeney K; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Lawlor RT; Beghelli S; Corbo V; Scardoni M; Bassi C, 2019, 'CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan', Nature Communications, 10, pp. 3637, http://dx.doi.org/10.1038/s41467-019-10968-6

Journal articles | 2018

Conway JRW; Warren SC; Herrmann D; Murphy KJ; Cazet AS; Vennin C; Shearer RF; Killen MJ; Magenau A; Mélénec P; Pinese M; Nobis M; Zaratzian A; Boulghourjian A; Da Silva AM; del Monte-Nieto G; Adam ASA; Harvey RP; Haigh JJ; Wang Y; Croucher DR; Sansom OJ; Pajic M; Caldon CE; Morton JP; Timpson P, 2018, 'Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer', Cell Reports, 23, pp. 3312 - 3326, http://dx.doi.org/10.1016/j.celrep.2018.05.038

Journal articles | 2018

Hastings JF; Han JZR; Shearer RF; Kennedy SP; Iconomou M; Saunders DN; Croucher DR, 2018, 'Dissecting multi-protein signaling complexes by bimolecular complementation affinity purification (Bicap)', Journal of Visualized Experiments, 2018, http://dx.doi.org/10.3791/57109

Journal articles | 2018

Marini KD; Croucher DR; McCloy RA; Vaghjiani V; Gonzalez-Rajal A; Hastings JF; Chin V; Szczepny A; Kostyrko K; Marquez C; Samantha W; Jayasekara N; Alamgeer M; Boolell V; Han JZR; Waugh T; Lee HC; Oakes SR; Kumar B; Harrison CA; Hedger MP; Lorensuhewa N; Kita B; Barrow R; Robinson BW; De Kretser DM; Wu J; Ganju V; Alejandro Sweet-Cordero E; Burgess A; Martelotto LG; Rossello FJ; Cain JE; Neil Watkins D, 2018, 'Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy', Science Translational Medicine, 10, http://dx.doi.org/10.1126/scitranslmed.aat3504

Journal articles | 2018

Rogers S; McCloy RA; Parker BL; Gallego-Ortega D; Law AMK; Chin VT; Conway JRW; Fey D; Millar EKA; O’Toole S; Deng N; Swarbrick A; Chastain PD; Cesare AJ; Timpson P; Caldon CE; Croucher DR; James DE; Watkins DN; Burgess A, 2018, 'MASTL overexpression promotes chromosome instability and metastasis in breast cancer', Oncogene, 37, pp. 4518 - 4533, http://dx.doi.org/10.1038/s41388-018-0295-z

Journal articles | 2016

Croucher DR; Iconomou M; Hastings JF; Kennedy SP; Shearer RF; McKenna J; Wan A; Lau J; Aparicio S; Saunders DN, 2016, 'Bimolecular complementation affinity purification (BiCAP) reveals dimer-specific protein interactions for ERBB2 dimers', Science Signaling, 9, pp. ra69 - ra69, http://dx.doi.org/10.1126/scisignal.aaf0793

Journal articles | 2016

Erami Z; Herrmann D; Warren SC; Nobis M; McGhee EJ; Lucas MC; Leung W; Reischmann N; Mrowinska A; Schwarz JP; Kadir S; Conway JRW; Vennin C; Karim SA; Campbell AD; Gallego-Ortega D; Magenau A; Murphy KJ; Ridgway RA; Law AM; Walters SN; Grey ST; Croucher DR; Zhang L; Herzog H; Hardeman EC; Gunning PW; Ormandy CJ; Evans TRJ; Strathdee D; Sansom OJ; Morton JP; Anderson KI; Timpson P, 2016, 'Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue', Cell Reports, 14, pp. 152 - 167, http://dx.doi.org/10.1016/j.celrep.2015.12.020

Journal articles | 2016

Kennedy SP; Hastings JF; Han JZR; Croucher DR, 2016, 'The under-appreciated promiscuity of the epidermal growth factor receptor family', Frontiers in Cell and Developmental Biology, 4, http://dx.doi.org/10.3389/fcell.2016.00088

Journal articles | 2016

Rogers S; Fey D; McCloy RA; Parker BL; Mitchell NJ; Payne RJ; Daly RJ; James DE; Caldon CE; Watkins DN; Croucher DR; Burgess A, 2016, 'PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells', Journal of Cell Science, 129, pp. 1340 - 1354, http://dx.doi.org/10.1242/jcs.179754

Journal articles | 2016

Saunders DN; Croucher D, 2016, 'Dissecting and Deconvoluting Multi-molecular Complexes - Principles of Systems Biology, No. 7', Cell Systems, 3, pp. 3 - 6, http://dx.doi.org/10.1016/j.cels.2016.07.010

Journal articles | 2016

Vouri M; Croucher DR; Kennedy SP; An Q; Pilkington GJ; Hafizi S, 2016, 'Axl-EGFR receptor tyrosine kinase hetero-interaction provides EGFR with access to pro-invasive signalling in cancer cells', Oncogenesis, 5, http://dx.doi.org/10.1038/oncsis.2016.66

Journal articles | 2015

Fey D; Halasz M; Dreidax D; Kennedy SP; Hastings JF; Rauch N; Munoz AG; Pilkington R; Fischer M; Westermann F; Kolch W; Kholodenko BN; Croucher DR, 2015, 'Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients', Science Signaling, 8, http://dx.doi.org/10.1126/scisignal.aab0990

Journal articles | 2014

Duffy FJ; Devocelle M; Croucher DR; Shields DC, 2014, 'Computational survey of peptides derived from disulphide-bonded protein loops that may serve as mediators of protein-protein interactions', BMC Bioinformatics, 15, http://dx.doi.org/10.1186/1471-2105-15-305

Journal articles | 2014

Freeman R; Niego B; Croucher DR; Pedersen LO; Medcalf RL, 2014, 'T-PA, but not desmoteplase, induces plasmin-dependent opening of a blood-brain barrier model under normoxic and ischaemic conditions', Brain Research, 1565, pp. 63 - 73, http://dx.doi.org/10.1016/j.brainres.2014.03.027

Journal articles | 2013

Croucher DR; Hochgräfe F; Zhang L; Liu L; Lyons RJ; Rickwood D; Tactacan CM; Browne BC; Ali N; Chan H; Shearer R; Gallego-Ortega D; Saunders DN; Swarbrick A; Daly RJ, 2013, 'Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway', Cancer Research, 73, pp. 1969 - 1980, http://dx.doi.org/10.1158/0008-5472.CAN-12-1472

Journal articles | 2013

Nguyen LK; Matallanas D; Croucher DR; Von Kriegsheim A; Kholodenko BN, 2013, 'Signalling by protein phosphatases and drug development: A systems-centred view', FEBS Journal, 280, pp. 751 - 765, http://dx.doi.org/10.1111/j.1742-4658.2012.08522.x

Journal articles | 2013

Ortiz-padilla C; Gallego-ortega D; Browne B; Hochgrafe F; Caldon CE; Lyons R; Croucher DR; Rickwood D; Ormandy CJ; Brummer T; Daly RJ, 2013, 'Functional characterization of cancer-associated Gab1 mutations', Oncogene, 32, pp. 2696 - 2702, http://dx.doi.org/10.1038/onc.2012.271

Journal articles | 2013

Zheng Y; Zhang C; Croucher DR; Soliman MA; St-Denis N; Pasculescu A; Taylor L; Tate SA; Rod Hardy W; Colwill K; Dai AY; Bagshaw R; Dennis JW; Gingras AC; Daly RJ; Pawson T, 2013, 'Temporal regulation of EGF signalling networks by the scaffold protein Shc1', Nature, 499, pp. 166 - 171, http://dx.doi.org/10.1038/nature12308

Journal articles | 2012

Fey D; Croucher DR; Kolch W; Kholodenko BN, 2012, 'Crosstalk and signaling switches in mitogen-activated protein kinase cascades', Frontiers in Physiology, 3 SEP, http://dx.doi.org/10.3389/fphys.2012.00355

Journal articles | 2011

Cochran BJ; Saunders D; Croucher DR; Lobov S; Ranson M, 2011, 'Dependence on endocytic receptor binding via a minimal binding motif underlies the differential prognostic profiles of serpinE1 and serpinB2 in cancer', The Journal of Biological Chemistry, 286, pp. 24467 - 24475, http://dx.doi.org/10.1074/jbc.M111.225706

Journal articles | 2011

Daly RJ; Hochgraefe F; Croucher DR; Zhang L; Rickwood D; Browne BC; Tactacan C; Raftery M, 2011, 'A novel tyrosine kinase signaling pathway in human basal breast cancer', CANCER RESEARCH, 71, http://dx.doi.org/10.1158/1538-7445.AM2011-3131

Journal articles | 2010

Croucher D; Ranson M; Saunders D, 2010, 'SerpinB2', AfCS-Nature Molecule Pages, http://dx.doi.org/10.1038/mp.a004139.01

Journal articles | 2010

Croucher DR; Rickwood D; Tactacan C; Musgrove EA; Daly RJ, 2010, 'Cortactin modulates RhoA activation and expression of Cip/Kip cyclin-dependent kinase inhibitors to promote cell cycle progression in 11q13-amplified head and neck squamous cell carcinoma cells', Molecular and Cellular Biology, 30, pp. 5057 - 5070, http://dx.doi.org/10.1128/MCB.00249-10

Journal articles | 2010

Fleuren E; O'Toole S; Millar E; Mcneil CM; Lopez-Knowles E; Boulghourjian A; Croucher DR; Schramek D; Brummer T; Penninger JM; Sutherland RL; Daly RJ, 2010, 'Overexpression of the oncogenic signal transducer Gab2 occurs early in breast cancer development', International Journal of Cancer, 127, pp. 1486 - 1492, http://dx.doi.org/10.1002/ijc.25172

Journal articles | 2010

Hochgrafe F; Zhang L; O'Toole S; Browne BC; Pinese M; Porta cubas A; Lehrbach GM; Croucher DR; Rickwood D; Boulghourjian A; Shearer R; Nair R; Swarbrick A; Faratian D; Mullen P; Harrison DJ; Biankin AV; Sutherland RL; Raftery MJ; Daly RJ, 2010, 'Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells', Cancer research, 70, pp. 9391 - 9401, http://dx.doi.org/10.1158/0008-5472.CAN-10-091

Journal articles | 2010

Lee JA; Croucher DR; Ranson M, 2010, 'Differential endocytosis of tissue plasminogen activator by serpins PAI-1 and PAI-2 on human peripheral blood monocytes', Thrombosis and Haemostasis, 104, pp. 1133 - 1142, http://dx.doi.org/10.1160/TH10-02-0121

Journal articles | 2009

Abdipranoto-Cowley A; Jin SP; Croucher DR; Daniel JA; Henshall SM; Galbraith SA; Mervin K; Vissel B, 2009, 'Activin A is essential for neurogenesis following neurodegeneration', Stem Cells, 27, pp. 1330 - 1346, http://dx.doi.org/10.1002/stem.80

Journal articles | 2008

Cao XR; Lill NL; Boase N; Shi PP; Croucher DR; Shan H; Qu J; Sweezer EM; Place T; Kirby PA; Daly RJ; Kumar S; Yang B, 2008, 'NEDD4 controls animal growth by regulating IGF-1 signalling', Sci Signal. 2008 Oct 14;1(41):ra8., 1, pp. 1 - 10, http://dx.doi.org/10.1126/scisignal.1160940

Journal articles | 2008

Croucher DR; Saunders DN; Lobov S; Ranson M, 2008, 'Revisiting the biological roles of PAI2 (SERPINB2) in cancer', Nature Reviews Cancer, 8, pp. 535 - 545, http://dx.doi.org/10.1038/nrc2400

Journal articles | 2008

Lobov S; Croucher DR; Saunders DA; Ranson M, 2008, 'Plasminogen activator inhibitor type 2 inhibits cell surface associated tissue plasminogen activator in vitro', Journal of Thrombosis and Haemostasis, 100, pp. 319 - 329, https://www.ncbi.nlm.nih.gov/pubmed/18690354

Journal articles | 2008

Lobov S; Croucher DR; Saunders DN; Ranson M, 2008, 'Plasminogen activator inhibitor type 2 inhibits cell surface associated tissue plasminogen activator in vitro: Potential receptor interactions', Thrombosis and Haemostasis, 100, pp. 319 - 329, http://dx.doi.org/10.1160/TH08-02-0119

Journal articles | 2008

Samson AL; Nevin ST; Croucher D; Niego B; Daniel PB; Weiss TW; Moreno E; Monard D; Lawrence DA; Medcalf RL, 2008, 'Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function', Journal of Neurochemistry, 107, pp. 1091 - 1101, http://dx.doi.org/10.1111/j.1471-4159.2008.05687.x

Journal articles | 2007

Croucher DR; Saunders DM; Stillfried GE; Ranson M, 2007, 'A structural basis for differential cell signalling by PAI-1 and PAI-2 in breast cancer cells', Biochemical Journal, 408, pp. 203 - 210, http://dx.doi.org/10.1042/BJ20070767

Journal articles | 2007

Stutchbury T; Al-ejeh F; Stillfried G; Croucher DR; Andrews JG; Irving D; Links MR; Ranson M, 2007, 'Preclinical evaluation of Bi-213-labeled plasminogen activator inhibitor type 2 in an orthotopic murine xenogenic model of human breast carcinoma', Molecular Cancer Therapeutics, 6, pp. 203 - 212, http://dx.doi.org/10.1158/1535-7163.MCT-06-0264

Journal articles | 2006

Croucher D; Saunders D; Leung H; Ranson M, 2006, 'ID: 131 A structural basis for differential cell signaling initiated by PAI-1 and PAI-2: Implications for Metastatic Potential', Journal of Thrombosis and Haemostasis, 4, pp. 197 - 197, http://dx.doi.org/10.1111/j.1538-7836.2006.00131.x

Journal articles | 2006

Croucher D; Saunders DN; Ranson M, 2006, 'The urokinase/PAI-2 complex: A new high affinity ligand for the endocytosis receptor low density lipoprotein receptor-related protein', Journal of Biological Chemistry, 281, pp. 10206 - 10213, http://dx.doi.org/10.1074/jbc.M513645200

Journal articles | 2006

Lobov S; Croucher D; Ranson M, 2006, 'ID: 138 Assessment of known/potential binding sites in the PAI-2 CD-loop for interaction with annexin II and endocytosis receptors', Journal of Thrombosis and Haemostasis, 4, pp. 198 - 198, http://dx.doi.org/10.1111/j.1538-7836.2006.00138.x

Journal articles | 2006

Samson A; Niego B; Daniel P; Weiss T; Croucher D; Lawrence D; Medcalf R, 2006, 'ID: 200 Tissue-type plasminogen activator can promote NMDA-induced neuronal stimulation via LDL receptor and plasmin-dependent mechanisms.', Journal of Thrombosis and Haemostasis, 4, pp. 139 - 139, http://dx.doi.org/10.1111/j.1538-7836.2006.00200.x

Journal articles | 2004

Al-Ejeh F; Croucher D; Ranson M, 2004, 'Kinetic analysis of plasminogen activator inhibitor type-2: Urokinase complex formation and subsequent internalisation by carcinoma cell lines', Experimental Cell Research, 297, pp. 259 - 271, http://dx.doi.org/10.1016/j.yexcr.2004.03.030
Preprints | 2022

Wahlroos S; Portman N; Bonder C; Hjorth M; Wilkinson A; Hastings J; Croucher D; Febbraio M; Gallego-Ortega D; Lim E, 2022, Exercise-induced modulation of the immune microenvironment in pre-clinical breast cancer models., , http://dx.doi.org/10.21203/rs.3.rs-1789675/v1

Preprints | 2019

Hastings JF; Gonzalez-Rajal A; Han JZR; McCloy RA; O’Donnell YEI; Phimmachanh M; Murphy AD; Nagrial A; Daneshvar D; Chin V; Watkins DN; Burgess A; Croucher DR, 2019, Dynamic analysis of pulsed cisplatin identifies effectors of resistance in lung adenocarcinoma, , http://dx.doi.org/10.1101/775924

Preprints | 2019

Trevelyan SJ; Brewster JL; Burgess AE; Crowther JM; Cadell AL; Parker BL; Croucher DR; Dobson RCJ; Murphy JM; Mace PD, 2019, Mechanism of preferential complex formation by Apoptosis Signal-regulating Kinases, , http://dx.doi.org/10.1101/693663

Conference Papers | 2015

Kolch W; Fey D; Halasz M; Rauch N; Munoz AG; Pilkington R; Kholodenko BN; Croucher DR; Kennedy SP; Hastings JF; Westermann F; Dreidax D; Fischer M; Duffy D; Krstic A; Schwarzl T, 2015, 'Abstract CN05-03: Personalized cancer diagnostics and therapeutics based on the computational modeling of signal transduction networks', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), presented at Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; November 5-9, 2015; Boston, MA, http://dx.doi.org/10.1158/1535-7163.targ-15-cn05-03

Conference Papers | 2013

Liu L; Chan H; Croucher D; Hochgraefe F; Zhang L; Tactacan C; Daly R, 2013, 'Mechanistic and functional characterization of the atypical kinase SgK269/PEAK1 in breast cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Washington, DC, presented at 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Washington, DC, 06 April 2013 - 10 April 2013, http://dx.doi.org/10.1158/1538-7445.AM2013-2507

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Dr David Croucher