Dr David Robert Croucher
Conjoint Associate Professor

Dr David Robert Croucher

medicine-health
St Vincent's Clinical School

David completed his undergraduate studies and PhD research at the University of Wollongong, followed by a post-doctoral position at the Garvan Institute, focusing on the functional characterisation of individual proteins in the behaviour of cancer cells. Pursuing the idea that these cancer-related proteins do not act in isolation, but are instead embedded within dynamic networks, David undertook a second post-doctoral position at Systems Biology Ireland in University College Dublin.

After establishing a research group at Systems Biology Ireland, David received a Future Research Leader grant from Cancer Institute NSW and returned to the Garvan Institute as head of the Network Biology group. His research group now focuses on combining computational modelling with novel proteomic and single-cell technologies to investigate how alterations in dynamic signalling networks can lead to tumour progression and therapeutic resistance. 

Phone
+61 2 9355 5820
Location
Network Biology Garvan Institute of Medical Research St Vincent’s Clinical School UNSW Medicine, UNSW Sydney

Publications

  • Book Chapters | 2012
    Dr David Robert Croucher
    Fey D; Croucher DR; Kolch W; Kholodenko BN, 2012, 'Understanding cell fate decisions by identifying crucial system dynamics', in SEMA SIMAI Springer Series, edn. 9788847025707, pp. 83 - 104, http://dx.doi.org/10.1007/978-88-470-2571-4_5
  • Journal articles | 2021
    Dr David Robert Croucher
    Filipe EC; Parker AL; Cadell AL; Major G; Croucher DR; Cox TR, 2021, 'In Vitro 3D Models of Tunable Stiffness', Methods Mol Biol, vol. 2294, pp. 27 - 42, http://dx.doi.org/10.1007/978-1-0716-1350-4_3
    Journal articles | 2021
    Dr David Robert Croucher
    Rajal AG; Marzec KA; McCloy RA; Nobis M; Chin V; Hastings JF; Lai K; Kennerson M; Hughes WE; Vaghjiani V; Timpson P; Cain JE; Watkins DN; Croucher DR; Burgess A, 2021, 'A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma', eLife, vol. 10, http://dx.doi.org/10.7554/eLife.65234
    Journal articles | 2021
    Dr David Robert Croucher
    Han JZR; Hastings JF; Phimmachanh M; Fey D; Kolch W; Croucher DR, 2021, 'Personalized medicine for neuroblastoma: Moving from static genotypes to dynamic simulations of drug response', Journal of Personalized Medicine, vol. 11, http://dx.doi.org/10.3390/jpm11050395
    Journal articles | 2020
    Dr David Robert Croucher
    Cultrone D; Zammit NW; Self E; Postert B; Han JZR; Bailey J; Warren J; Croucher DR; Kikuchi K; Bogdanovic O; Chtanova T; Hesselson D; Grey ST, 2020, 'A zebrafish functional genomics model to investigate the role of human A20 variants in vivo', Scientific Reports, vol. 10, http://dx.doi.org/10.1038/s41598-020-75917-6
    Journal articles | 2020
    Dr David Robert Croucher
    Cipponi A; Goode DL; Bedo J; McCabe MJ; Pajic M; Croucher DR; Rajal AG; Junankar SR; Saunders DN; Lobachevsky P; Papenfuss AT; Nessem D; Nobis M; Warren SC; Timpson P; Cowley M; Vargas AC; Qiu MR; Generali DG; Keerthikumar S; Nguyen U; Corcoran NM; Long GV; Blay J-Y; Thomas DM; McCabe M, 2020, 'MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer', Science
    Journal articles | 2020
    Dr David Robert Croucher
    Gonzalez-Rajal A; Hastings JF; Watkins DN; Croucher DR; Burgess A, 2020, 'Breathing New Life into the Mechanisms of Platinum Resistance in Lung Adenocarcinoma', Frontiers in Cell and Developmental Biology, vol. 8, http://dx.doi.org/10.3389/fcell.2020.00305
    Journal articles | 2020
    Dr David Robert Croucher
    Phimmachanh M; Han JZR; O’Donnell YEI; Latham SL; Croucher DR, 2020, 'Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma', Frontiers in Cell and Developmental Biology, vol. 8, http://dx.doi.org/10.3389/fcell.2020.578770
    Journal articles | 2020
    Dr David Robert Croucher
    Hastings JF; Rajal AG; Latham SL; Han JZR; McCloy RA; O’donnell YEI; Phimmachanh M; Murphy AD; Nagrial A; Daneshvar D; Chin V; Watkins DN; Burgess A; Croucher DR, 2020, 'Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma', eLife, vol. 9, pp. 1 - 25, http://dx.doi.org/10.7554/eLife.53367
    Journal articles | 2020
    Dr David Robert Croucher
    Latham SL; Weiß N; Schwanke K; Thiel C; Croucher DR; Zweigerdt R; Manstein DJ; Taft MH, 2020, 'Myosin-18B Regulates Higher-Order Organization of the Cardiac Sarcomere through Thin Filament Cross-Linking and Thick Filament Dynamics', Cell Reports, vol. 32, http://dx.doi.org/10.1016/j.celrep.2020.108090
    Journal articles | 2020
    Dr David Robert Croucher
    Filipčík P; Latham SL; Cadell AL; Day CL; Croucher DR; Mace PD, 2020, 'A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, pp. 21308 - 21318, http://dx.doi.org/10.1073/pnas.2006429117
    Journal articles | 2020
    Dr David Robert Croucher
    Hastings JF; O'Donnell YEI; Fey D; Croucher DR, 2020, 'Applications of personalised signalling network models in precision oncology', Pharmacology and Therapeutics, vol. 212, http://dx.doi.org/10.1016/j.pharmthera.2020.107555
    Journal articles | 2020
    Dr David Robert Croucher
    Trevelyan SJ; Brewster JL; Burgess AE; Crowther JM; Cadell AL; Parker BL; Croucher DR; Dobson RCJ; Murphy JM; Mace PD, 2020, 'Structure-based mechanism of preferential complex formation by apoptosis signal–regulating kinases', Science Signaling, vol. 13, http://dx.doi.org/10.1126/scisignal.aay6318
    Journal articles | 2019
    Dr David Robert Croucher
    Hastings JF; Skhinas JN; Fey D; Croucher DR; Cox TR, 2019, 'The extracellular matrix as a key regulator of intracellular signalling networks', British Journal of Pharmacology, vol. 176, pp. 82 - 92, http://dx.doi.org/10.1111/bph.14195
    Journal articles | 2019
    Dr David Robert Croucher
    Vennin C; Mélénec P; Rouet R; Nobis M; Cazet AS; Murphy KJ; Herrmann D; Reed DA; Lucas MC; Warren SC; Elgundi Z; Pinese M; Kalna G; Roden D; Samuel M; Zaratzian A; Grey ST; Da Silva A; Leung W; Johns AL; Chantrill LA; Chou A; Steinmann A; Arshi M; Dwarte T; Froio D; Pereira B; Ritchie S; Chambers CR; Metcalf X; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Grimmond SM; Hofmann O; Christ A; Bruxner T; Samra JS; Pavlakis N; High HA; Asghari R; Merrett ND; Pavey D; Das A; Cosman PH; Ismail K; O’Connnor C; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Cooper CL; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forest C; Epari KP; Ballal M; Fletcher DR; Mukhedkar S; Zeps N; Beilin M; Feeney K; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Lawlor RT; Beghelli S; Corbo V; Scardoni M; Bassi C, 2019, 'CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan', Nature Communications, vol. 10, pp. 3637, http://dx.doi.org/10.1038/s41467-019-10968-6
    Journal articles | 2019
    Dr David Robert Croucher
    Kennedy SP; Han JZR; Portman N; Nobis M; Hastings JF; Murphy KJ; Latham SL; Cadell AL; Miladinovic D; Marriott GR; O'Donnell YEI; Shearer RF; Williams JT; Munoz AG; Cox TR; Watkins DN; Saunders DN; Timpson P; Lim E; Kolch W; Croucher DR, 2019, 'Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer', Breast Cancer Research, vol. 21, pp. 43, http://dx.doi.org/10.1186/s13058-019-1127-y
    Journal articles | 2019
    Dr David Robert Croucher
    Castillo L; George S; Lin H-M; Yeung N; Mawson A; Young AI; Law AM; Hastings J; Gallego-Ortega D; Deng N; Croucher D; Swarbrick A; Horvath L; Ormandy CJ; Oakes SR, 2019, 'Flicking the switch off, targeting MCL-1 in the treatment of breast and prostate cancer', Oncology Abstracts, http://dx.doi.org/10.1530/oncolabs.1.p038
    Journal articles | 2018
    Dr David Robert Croucher
    Marini KD; Croucher DR; McCloy RA; Vaghjiani V; Gonzalez-Rajal A; Hastings JF; Chin V; Szczepny A; Kostyrko K; Marquez C; Samantha W; Jayasekara N; Alamgeer M; Boolell V; Han JZR; Waugh T; Lee HC; Oakes SR; Kumar B; Harrison CA; Hedger MP; Lorensuhewa N; Kita B; Barrow R; Robinson BW; De Kretser DM; Wu J; Ganju V; Alejandro Sweet-Cordero E; Burgess A; Martelotto LG; Rossello FJ; Cain JE; Neil Watkins D, 2018, 'Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy', Science Translational Medicine, vol. 10, http://dx.doi.org/10.1126/scitranslmed.aat3504
    Journal articles | 2018
    Dr David Robert Croucher
    Hastings JF; Han JZR; Shearer RF; Kennedy SP; Iconomou M; Saunders DN; Croucher DR, 2018, 'Dissecting multi-protein signaling complexes by bimolecular complementation affinity purification (Bicap)', Journal of Visualized Experiments, vol. 2018, http://dx.doi.org/10.3791/57109
    Journal articles | 2018
    Dr David Robert Croucher
    Rogers S; McCloy RA; Parker BL; Gallego-Ortega D; Law AMK; Chin VT; Conway JRW; Fey D; Millar EKA; O’Toole S; Deng N; Swarbrick A; Chastain PD; Cesare AJ; Timpson P; Caldon CE; Croucher DR; James DE; Watkins DN; Burgess A, 2018, 'MASTL overexpression promotes chromosome instability and metastasis in breast cancer', Oncogene, vol. 37, pp. 4518 - 4533, http://dx.doi.org/10.1038/s41388-018-0295-z
    Journal articles | 2018
    Dr David Robert Croucher
    Conway JRW; Warren SC; Herrmann D; Murphy KJ; Cazet AS; Vennin C; Shearer RF; Killen MJ; Magenau A; Mélénec P; Pinese M; Nobis M; Zaratzian A; Boulghourjian A; Da Silva AM; del Monte-Nieto G; Adam ASA; Harvey RP; Haigh JJ; Wang Y; Croucher DR; Sansom OJ; Pajic M; Caldon CE; Morton JP; Timpson P, 2018, 'Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer', Cell Reports, vol. 23, pp. 3312 - 3326, http://dx.doi.org/10.1016/j.celrep.2018.05.038
    Journal articles | 2016
    Dr David Robert Croucher
    Kennedy SP; Hastings JF; Han JZR; Croucher DR, 2016, 'The under-appreciated promiscuity of the epidermal growth factor receptor family', Frontiers in Cell and Developmental Biology, vol. 4, http://dx.doi.org/10.3389/fcell.2016.00088
    Journal articles | 2016
    Dr David Robert Croucher
    Vouri M; Croucher DR; Kennedy SP; An Q; Pilkington GJ; Hafizi S, 2016, 'Axl-EGFR receptor tyrosine kinase hetero-interaction provides EGFR with access to pro-invasive signalling in cancer cells', Oncogenesis, vol. 5, http://dx.doi.org/10.1038/oncsis.2016.66
    Journal articles | 2016
    Dr David Robert Croucher
    Croucher DR; Iconomou M; Hastings JF; Kennedy SP; Shearer RF; McKenna J; Wan A; Lau J; Aparicio S; Saunders DN, 2016, 'Bimolecular complementation affinity purification (BiCAP) reveals dimer-specific protein interactions for ERBB2 dimers', Science Signaling, vol. 9, pp. ra69 - ra69, http://dx.doi.org/10.1126/scisignal.aaf0793
    Journal articles | 2016
    Dr David Robert Croucher
    Rogers S; Fey D; McCloy RA; Parker BL; Mitchell NJ; Payne RJ; Daly RJ; James DE; Caldon CE; Watkins DN; Croucher DR; Burgess A, 2016, 'PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells', Journal of Cell Science, vol. 129, pp. 1340 - 1354, http://dx.doi.org/10.1242/jcs.179754
    Journal articles | 2016
    Dr David Robert Croucher
    Erami Z; Herrmann D; Warren SC; Nobis M; McGhee EJ; Lucas MC; Leung W; Reischmann N; Mrowinska A; Schwarz JP; Kadir S; Conway JRW; Vennin C; Karim SA; Campbell AD; Gallego-Ortega D; Magenau A; Murphy KJ; Ridgway RA; Law AM; Walters SN; Grey ST; Croucher DR; Zhang L; Herzog H; Hardeman EC; Gunning PW; Ormandy CJ; Evans TRJ; Strathdee D; Sansom OJ; Morton JP; Anderson KI; Timpson P, 2016, 'Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue', Cell Reports, vol. 14, pp. 152 - 167, http://dx.doi.org/10.1016/j.celrep.2015.12.020
    Journal articles | 2016
    Dr David Robert Croucher
    Saunders DN; Croucher D, 2016, 'Dissecting and Deconvoluting Multi-molecular Complexes - Principles of Systems Biology, No. 7', Cell Systems, vol. 3, pp. 3 - 6, http://dx.doi.org/10.1016/j.cels.2016.07.010
    Journal articles | 2015
    Dr David Robert Croucher
    Fey D; Halasz M; Dreidax D; Kennedy SP; Hastings JF; Rauch N; Munoz AG; Pilkington R; Fischer M; Westermann F; Kolch W; Kholodenko BN; Croucher DR, 2015, 'Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients', Science Signaling, vol. 8, http://dx.doi.org/10.1126/scisignal.aab0990
    Journal articles | 2014
    Dr David Robert Croucher
    Freeman R; Niego B; Croucher DR; Pedersen LO; Medcalf RL, 2014, 'T-PA, but not desmoteplase, induces plasmin-dependent opening of a blood-brain barrier model under normoxic and ischaemic conditions', Brain Research, vol. 1565, pp. 63 - 73, http://dx.doi.org/10.1016/j.brainres.2014.03.027
    Journal articles | 2014
    Dr David Robert Croucher
    Duffy FJ; Devocelle M; Croucher DR; Shields DC, 2014, 'Computational survey of peptides derived from disulphide-bonded protein loops that may serve as mediators of protein-protein interactions', BMC Bioinformatics, vol. 15, http://dx.doi.org/10.1186/1471-2105-15-305
    Journal articles | 2013
    Dr David Robert Croucher
    Zheng Y; Zhang C; Croucher DR; Soliman MA; St-Denis N; Pasculescu A; Taylor L; Tate SA; Rod Hardy W; Colwill K; Dai AY; Bagshaw R; Dennis JW; Gingras AC; Daly RJ; Pawson T, 2013, 'Temporal regulation of EGF signalling networks by the scaffold protein Shc1', Nature, vol. 499, pp. 166 - 171, http://dx.doi.org/10.1038/nature12308
    Journal articles | 2013
    Dr David Robert Croucher
    Nguyen LK; Matallanas D; Croucher DR; Von Kriegsheim A; Kholodenko BN, 2013, 'Signalling by protein phosphatases and drug development: A systems-centred view', FEBS Journal, vol. 280, pp. 751 - 765, http://dx.doi.org/10.1111/j.1742-4658.2012.08522.x
    Journal articles | 2013
    Dr David Robert Croucher
    Ortiz-padilla C; Gallego-ortega D; Browne B; Hochgrafe F; Caldon CE; Lyons R; Croucher DR; Rickwood D; Ormandy CJ; Brummer T; Daly RJ, 2013, 'Functional characterization of cancer-associated Gab1 mutations', Oncogene, vol. 32, pp. 2696 - 2702, http://dx.doi.org/10.1038/onc.2012.271
    Journal articles | 2013
    Dr David Robert Croucher
    Croucher DR; Hochgräfe F; Zhang L; Liu L; Lyons RJ; Rickwood D; Tactacan CM; Browne BC; Ali N; Chan H; Shearer R; Gallego-Ortega D; Saunders DN; Swarbrick A; Daly RJ, 2013, 'Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway', Cancer Research, vol. 73, pp. 1969 - 1980, http://dx.doi.org/10.1158/0008-5472.CAN-12-1472
    Journal articles | 2012
    Dr David Robert Croucher
    Fey D; Croucher DR; Kolch W; Kholodenko BN, 2012, 'Crosstalk and signaling switches in mitogen-activated protein kinase cascades', Frontiers in Physiology, vol. 3 SEP, http://dx.doi.org/10.3389/fphys.2012.00355
    Journal articles | 2011
    Dr David Robert Croucher
    Cochran BJ; Saunders D; Croucher DR; Lobov S; Ranson M, 2011, 'Dependence on endocytic receptor binding via a minimal binding motif underlies the differential prognostic profiles of serpinE1 and serpinB2 in cancer', The Journal of Biological Chemistry, vol. 286, pp. 24467 - 24475, http://dx.doi.org/10.1074/jbc.M111.225706
    Journal articles | 2011
    Dr David Robert Croucher
    Daly RJ; Hochgraefe F; Croucher DR; Zhang L; Rickwood D; Browne BC; Tactacan C; Raftery M, 2011, 'A novel tyrosine kinase signaling pathway in human basal breast cancer', CANCER RESEARCH, vol. 71, http://dx.doi.org/10.1158/1538-7445.AM2011-3131
    Journal articles | 2010
    Dr David Robert Croucher
    Hochgrafe F; Zhang L; O'Toole S; Browne BC; Pinese M; Porta cubas A; Lehrbach GM; Croucher DR; Rickwood D; Boulghourjian A; Shearer R; Nair R; Swarbrick A; Faratian D; Mullen P; Harrison DJ; Biankin AV; Sutherland RL; Raftery MJ; Daly RJ, 2010, 'Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells', Cancer research, vol. 70, pp. 9391 - 9401, http://dx.doi.org/10.1158/0008-5472.CAN-10-091
    Journal articles | 2010
    Dr David Robert Croucher
    Croucher DR; Rickwood D; Tactacan C; Musgrove EA; Daly RJ, 2010, 'Cortactin modulates RhoA activation and expression of Cip/Kip cyclin-dependent kinase inhibitors to promote cell cycle progression in 11q13-amplified head and neck squamous cell carcinoma cells', Molecular and Cellular Biology, vol. 30, pp. 5057 - 5070, http://dx.doi.org/10.1128/MCB.00249-10
    Journal articles | 2010
    Dr David Robert Croucher
    Fleuren E; O'Toole S; Millar E; Mcneil CM; Lopez-Knowles E; Boulghourjian A; Croucher DR; Schramek D; Brummer T; Penninger JM; Sutherland RL; Daly RJ, 2010, 'Overexpression of the oncogenic signal transducer Gab2 occurs early in breast cancer development', International Journal of Cancer, vol. 127, pp. 1486 - 1492, http://dx.doi.org/10.1002/ijc.25172
    Journal articles | 2010
    Dr David Robert Croucher
    Lee JA; Croucher DR; Ranson M, 2010, 'Differential endocytosis of tissue plasminogen activator by serpins PAI-1 and PAI-2 on human peripheral blood monocytes', Thrombosis and Haemostasis, vol. 104, pp. 1133 - 1142, http://dx.doi.org/10.1160/TH10-02-0121
    Journal articles | 2010
    Dr David Robert Croucher
    Croucher D; Ranson M; Saunders D, 2010, 'SerpinB2', AfCS-Nature Molecule Pages, http://dx.doi.org/10.1038/mp.a004139.01
    Journal articles | 2009
    Dr David Robert Croucher
    Abdipranoto-Cowley A; Jin SP; Croucher DR; Daniel JA; Henshall SM; Galbraith SA; Mervin K; Vissel B, 2009, 'Activin A is essential for neurogenesis following neurodegeneration', Stem Cells, vol. 27, pp. 1330 - 1346, http://dx.doi.org/10.1002/stem.80
    Journal articles | 2008
    Dr David Robert Croucher
    Croucher DR; Saunders DN; Lobov S; Ranson M, 2008, 'Revisiting the biological roles of PAI2 (SERPINB2) in cancer', Nature Reviews Cancer, vol. 8, pp. 535 - 545, http://dx.doi.org/10.1038/nrc2400
    Journal articles | 2008
    Dr David Robert Croucher
    Cao XR; Lill NL; Boase N; Shi PP; Croucher DR; Shan H; Qu J; Sweezer EM; Place T; Kirby PA; Daly RJ; Kumar S; Yang B, 2008, 'NEDD4 controls animal growth by regulating IGF-1 signalling', Sci Signal. 2008 Oct 14;1(41):ra8., vol. 1, pp. 1 - 10, http://dx.doi.org/10.1126/scisignal.1160940
    Journal articles | 2008
    Dr David Robert Croucher
    Samson AL; Nevin ST; Croucher D; Niego B; Daniel PB; Weiss TW; Moreno E; Monard D; Lawrence DA; Medcalf RL, 2008, 'Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function', Journal of Neurochemistry, vol. 107, pp. 1091 - 1101, http://dx.doi.org/10.1111/j.1471-4159.2008.05687.x
    Journal articles | 2008
    Dr David Robert Croucher
    Lobov S; Croucher DR; Saunders DA; Ranson M, 2008, 'Plasminogen activator inhibitor type 2 inhibits cell surface associated tissue plasminogen activator in vitro', Journal of Thrombosis and Haemostasis, vol. 100, pp. 319 - 329, https://www.ncbi.nlm.nih.gov/pubmed/18690354
    Journal articles | 2008
    Dr David Robert Croucher
    Lobov S; Croucher DR; Saunders DN; Ranson M, 2008, 'Plasminogen activator inhibitor type 2 inhibits cell surface associated tissue plasminogen activator in vitro: Potential receptor interactions', Thrombosis and Haemostasis, vol. 100, pp. 319 - 329, http://dx.doi.org/10.1160/TH08-02-0119
    Journal articles | 2007
    Dr David Robert Croucher
    Croucher DR; Saunders DM; Stillfried GE; Ranson M, 2007, 'A structural basis for differential cell signalling by PAI-1 and PAI-2 in breast cancer cells', Biochemical Journal, vol. 408, pp. 203 - 210, http://dx.doi.org/10.1042/BJ20070767
    Journal articles | 2007
    Dr David Robert Croucher
    Stutchbury T; Al-ejeh F; Stillfried G; Croucher DR; Andrews JG; Irving D; Links MR; Ranson M, 2007, 'Preclinical evaluation of Bi-213-labeled plasminogen activator inhibitor type 2 in an orthotopic murine xenogenic model of human breast carcinoma', Molecular Cancer Therapeutics, vol. 6, pp. 203 - 212, http://dx.doi.org/10.1158/1535-7163.MCT-06-0264
    Journal articles | 2006
    Dr David Robert Croucher
    Croucher D; Saunders DN; Ranson M, 2006, 'The urokinase/PAI-2 complex: A new high affinity ligand for the endocytosis receptor low density lipoprotein receptor-related protein', Journal of Biological Chemistry, vol. 281, pp. 10206 - 10213, http://dx.doi.org/10.1074/jbc.M513645200
    Journal articles | 2006
    Dr David Robert Croucher
    Croucher D; Saunders D; Leung H; Ranson M, 2006, 'ID: 131 A structural basis for differential cell signaling initiated by PAI-1 and PAI-2: Implications for Metastatic Potential', Journal of Thrombosis and Haemostasis, vol. 4, pp. 197 - 197, http://dx.doi.org/10.1111/j.1538-7836.2006.00131.x
    Journal articles | 2006
    Dr David Robert Croucher
    Lobov S; Croucher D; Ranson M, 2006, 'ID: 138 Assessment of known/potential binding sites in the PAI-2 CD-loop for interaction with annexin II and endocytosis receptors', Journal of Thrombosis and Haemostasis, vol. 4, pp. 198 - 198, http://dx.doi.org/10.1111/j.1538-7836.2006.00138.x
    Journal articles | 2006
    Dr David Robert Croucher
    Samson A; Niego B; Daniel P; Weiss T; Croucher D; Lawrence D; Medcalf R, 2006, 'ID: 200 Tissue-type plasminogen activator can promote NMDA-induced neuronal stimulation via LDL receptor and plasmin-dependent mechanisms.', Journal of Thrombosis and Haemostasis, vol. 4, pp. 139 - 139, http://dx.doi.org/10.1111/j.1538-7836.2006.00200.x
    Journal articles | 2004
    Dr David Robert Croucher
    Al-Ejeh F; Croucher D; Ranson M, 2004, 'Kinetic analysis of plasminogen activator inhibitor type-2: Urokinase complex formation and subsequent internalisation by carcinoma cell lines', Experimental Cell Research, vol. 297, pp. 259 - 271, http://dx.doi.org/10.1016/j.yexcr.2004.03.030
    Journal articles |
    Dr David Robert Croucher
    Gonzalez-Rajal A; Marzec KA; McCloy R; Nobis M; Chin V; Hastings JF; Lai K; Kennerson M; Hughes WE; Vaghjiani V; Timpson P; Cain JE; Neil Watkins D; Croucher DR; Burgess A, 'A Non-Genetic, Cell Cycle Dependent Mechanism of Platinum Resistance in Lung Adenocarcinoma', , http://dx.doi.org/10.1101/2020.11.26.400499
    Journal articles |
    Dr David Robert Croucher
    Filipčík P; Latham SL; Cadell AL; Day CL; Croucher DR; Mace PD, 'A cryptic tubulin-binding domain links MEKK1 to microtubule remodelling', , http://dx.doi.org/10.1101/2020.04.07.030676
  • Conference Papers | 2015
    Dr David Robert Croucher
    Kolch W; Fey D; Halasz M; Rauch N; Munoz AG; Pilkington R; Kholodenko BN; Croucher DR; Kennedy SP; Hastings JF; Westermann F; Dreidax D; Fischer M; Duffy D; Krstic A; Schwarzl T, 2015, 'Abstract CN05-03: Personalized cancer diagnostics and therapeutics based on the computational modeling of signal transduction networks', in Pediatric-early drug development, American Association for Cancer Research, presented at Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; November 5-9, 2015; Boston, MA, http://dx.doi.org/10.1158/1535-7163.targ-15-cn05-03
    Conference Papers | 2013
    Dr David Robert Croucher
    Liu L; Chan H; Croucher D; Hochgraefe F; Zhang L; Tactacan C; Daly R, 2013, 'Mechanistic and functional characterization of the atypical kinase SgK269/PEAK1 in breast cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Washington, DC, presented at 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Washington, DC, 06 April 2013 - 10 April 2013, http://dx.doi.org/10.1158/1538-7445.AM2013-2507

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